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suppl figure 2

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dOrai MSVWTTANNSGLETPTKSPITSSVPRAARSSAVITTGNHQQHHFQHVVAAAVAAATSVATGHQ Orai1 --------------------------------------------------------------- Orai2 --------------------------------------------------------------- Orai3 --------------------------------------------------------------- dOrai FQQQFPLHAHPHPQHHSNSPTGSGSNSNNSAGFQRTSISNSLLQFP--PPPPPSSQNQAKPRG Orai1 ------MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIG Orai2 --------------------------------MSAELNVPIDPSAPACPEPGHKGMDYRDWVR Orai3 -----------------------MKGGEGDAGEQAPLNPEGES--------PAGSATYREFVH dOrai HHRTASSSMSQSGEDLHSPTYLSWRKLQLSRAKLKASSKTSALLSGFAMVAMVEVQLDHDTNV Orai1 QSY-----SEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDY Orai2 RSY-----LELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQY Orai3 RGY-----LDLMGASQHSLRALSWRRLYLSRAKLKASSRTSALLSGFAMVAMVEVQLESDHEY dOrai PPGMLIAFAICTTLLVAVHMLALMISTCILPNIETVCNLHSISLVHESPHERLHWYIETAWAF Orai1 PPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAF Orai2 PRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGF Orai3 PPGLLVAFSACTTVLVAVHLFALMVSTCLLPHIEAVSNIHNLNSVHQSPHQRLHRYVELAWGF dOrai STLLGLILFLLEIAILCWVKFYDLSPP------------------------------------ Orai1 STVIGTLLFLAEVVLLCWVKFLPLKKQPGQPRP---------------------TSKPPASGA Orai2 STVLGILLFLAEVVLLCWIKFLPVDARRQPGP-------------------------PPGPGS Orai3 STALGTFLFLAEVVLVGWVKFVPIGAPLDTPTPMVPTSRVPGTLAPVATSLSPASNLPRSSAS dOrai ---------------------------AAWSACVVLIPVMIIFMAFAIHFYRSLVSHKYEVTV Orai1 AANVSTSGIT-------------PGQAAAIASTTIMVPFGLIFIVFAVHFYRSLVSHKTDRQF Orai2 H----------------------TGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHN Orai3 AAPSQAEPACPPRQACGGGGAHGPGWQAAMASTAIMVPVGLVFVAFALHFYRSLVAHKTDRYK dOrai SGIREL---EMLKEQMEQ-DHLEHHNNIRNNGMNYGASGDIV Orai1 QELNELAEFARLQDQLDHR---GDHPLTPGSHYA-------- Orai2 REIEEL---HKLKVQLDGHERSLQVL---------------- Orai3 QELEEL---NRLQGELQAV----------------------- Suppl Figure 2

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Page 1: Suppl Figure 2

dOrai   MSVWTTANNSGLETPTKSPITSSVPRAARSSAVITTGNHQQHHFQHVVAAAVAAATSVATGHQOrai1   ---------------------------------------------------------------Orai2   ---------------------------------------------------------------Orai3   ---------------------------------------------------------------                                                                 

dOrai   FQQQFPLHAHPHPQHHSNSPTGSGSNSNNSAGFQRTSISNSLLQFP--PPPPPSSQNQAKPRGOrai1   ------MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGOrai2   --------------------------------MSAELNVPIDPSAPACPEPGHKGMDYRDWVROrai3   -----------------------MKGGEGDAGEQAPLNPEGES--------PAGSATYREFVH

dOrai   HHRTASSSMSQSGEDLHSPTYLSWRKLQLSRAKLKASSKTSALLSGFAMVAMVEVQLDHDTNVOrai1   QSY-----SEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYOrai2   RSY-----LELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYOrai3   RGY-----LDLMGASQHSLRALSWRRLYLSRAKLKASSRTSALLSGFAMVAMVEVQLESDHEY

dOrai   PPGMLIAFAICTTLLVAVHMLALMISTCILPNIETVCNLHSISLVHESPHERLHWYIETAWAFOrai1   PPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFOrai2   PRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFOrai3   PPGLLVAFSACTTVLVAVHLFALMVSTCLLPHIEAVSNIHNLNSVHQSPHQRLHRYVELAWGF

dOrai   STLLGLILFLLEIAILCWVKFYDLSPP------------------------------------Orai1   STVIGTLLFLAEVVLLCWVKFLPLKKQPGQPRP---------------------TSKPPASGAOrai2   STVLGILLFLAEVVLLCWIKFLPVDARRQPGP-------------------------PPGPGSOrai3   STALGTFLFLAEVVLVGWVKFVPIGAPLDTPTPMVPTSRVPGTLAPVATSLSPASNLPRSSAS                                    

dOrai   ---------------------------AAWSACVVLIPVMIIFMAFAIHFYRSLVSHKYEVTVOrai1   AANVSTSGIT-------------PGQAAAIASTTIMVPFGLIFIVFAVHFYRSLVSHKTDRQFOrai2   H----------------------TGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNOrai3   AAPSQAEPACPPRQACGGGGAHGPGWQAAMASTAIMVPVGLVFVAFALHFYRSLVAHKTDRYK 

dOrai   SGIREL---EMLKEQMEQ-DHLEHHNNIRNNGMNYGASGDIVOrai1   QELNELAEFARLQDQLDHR---GDHPLTPGSHYA--------Orai2   REIEEL---HKLKVQLDGHERSLQVL----------------Orai3   QELEEL---NRLQGELQAV-----------------------                      

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