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pplemental Figure 1. Codon L576P CTT → CCT Wild type Mutation

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Supplemental Figure 1. Codon L576P CTT →　 CCT. Wild type. Mutation. Supplemental Figure 2. DM440 DM366. nM. 0 10 100 1000. 0 10 100 1000. Src. p- Src. FAK. p-FAK. P130. p-P130. DM6 DM738. Actin. WM3211. nM. - PowerPoint PPT Presentation

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Supplemental Figure 1.

Codon L576P CTT →　 CCT

Wild type Mutation

DM440 DM366

Srcp-Src

FAKp-FAKP130p-P130Actin

0 10 100 1000 0 10 100 1000nM

Srcp-SrcFAKp-FAKP130p-P130

Actin

DM6 DM738 0 10 100 1000 0 10 100 1000 0 10 100 1000nM

WM3211

Supplemental Figure 2.

Src-predicted dysregulation

% in

hibi

tion

cell

pro

life

rati

wit

h 10

00nM

das

atin

ib a

lone

Supplemental Figure 3.

0.1 0.2 0.3 0.4 0.5 0.6 0.7

-10

f(x) = 77.0862545040333 x − 18.8516123329777R² = 0.501655589597122

DM6

DM443

DM366

DM738

PRMel

DM440

Model1(Control)

0 4hr 8hr 16hr 24hr

Model 2

Model 3

Model 4

Model 5

Model 6

Model 7

Model 8

Harvest

Dasatinib Harvest

Dasatinib

Harvest

Dasatinib

Dasatinib Dasatinib

Harvest

Supplemental Figure 4.

Src

p-Src

FAKp-FAK

P130

p-P130

Actin

Model number1 2 3 4 5 6 7 8

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