supplementary fig. 1

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Supplementary Fig. 1 B. Con Tgase-2 siRNA (40 nM) Tgase-2 siRNA (80 nM) TGF-b1 - + Con TGF-b1 CTM (100 mM) CTM (500 mM) CTM (0 mM) Supplementary Fig. 2

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Supplementary Fig. 1. TGF- b 1. Con. CTM (100 m M ). CTM (500 m M ). CTM (0 m M ). Supplementary Fig. 2. B. TGF- b 1. -. +. Con. Tgase-2 siRNA (40 nM ). Tgase-2 siRNA (80 nM ). Supplementary Fig. 3. CTM ( m M ). 0. Control. 100. 500. 1000. TGF- b 1 (100 pM ). - PowerPoint PPT Presentation

TRANSCRIPT

Page 1: Supplementary Fig. 1

Supplementary Fig. 1

B.

Con

Tgase-2 siRNA (40 nM)

Tgase-2 siRNA (80 nM)

TGF-b1

- +

Con

TGF-b1

CTM (100 mM) CTM (500 mM)CTM (0 mM)

Supplementary Fig. 2

Page 2: Supplementary Fig. 1

CTM (mM)

Control 100 500 10000

TGF-b1 (100 pM)

Control TGF-b1

Tgase 2 siRNA 40nM

Mock TGF-b1Control TGF-b1Control

Tgase 2 siRNA 80nM

Supplementary Fig. 3

Supplementary Fig. 4

Page 3: Supplementary Fig. 1

N-cad (2) siRNA 40nM

Mock TGF-b1Control TGF-b1Control

N-cad (2) siRNA 80nM

TGF-b1Control

Supplementary Fig. 5

N-Cad

- + - + - + TGF-β1

Con 40 80

β-actin

Ncad(2) siRNA (nM)

Mock

Supplementary Fig. 6

Page 4: Supplementary Fig. 1

Control TGF-b

A549WT

A549TG2

40 80 160Control

Control TGF-bmock

JNK1 siRNA (nM)

Supplementary Fig. 7

Page 5: Supplementary Fig. 1

A549TG2

40 80 160Control

JNK2 siRNA (nM)

Control TGF-b

A549WT

Control TGF-b

JNK2 siRNA

mock

Supplementary Fig. 8

Page 6: Supplementary Fig. 1

Supplementary Fig. 9

Con TGF- 1b

Supplementary Fig. 10

Non 0 50 100 200 5000

20

40

60

80

100

TGF-b1 (pM)

Ce

ll p

roli

fera

tio

n (

%)

Supplementary Fig. 11

E-Cad

N-Cad

β-actin

Tgase 2

0 50 100 200 500

TGF-b1 (pM), 48 h

E-Cad

N-Cad

β-actin

Tgase 2

0 2 5 15 24 48 h

TGF-b1 (100 pM)

Supplementary Fig. 12

Page 7: Supplementary Fig. 1

Supplementary Fig. 13

E-Cad

Con TGF-β1

N-Cad

DAPI

Con TGF-β1

Control TGF- 1b

H838 H1299 H1703 H838 H1299 H1703

N-Cad

β-actin

Tgase-2

pJNK

PP2A

Supplementary Fig. 14

Page 8: Supplementary Fig. 1

N-cad siRNA 40nM

TGF-b1Control TGF-b1Control

N-cad siRNA 80nM

TGF-b1Control

Mock

- + - + - + TGF-b1 (100 pM)

Con 40 80

N-cad siRNA (nM)

Mock

*#

#*P<0.05 compared with Con(-)

#P<0.05 compared with Con(+)

Mig

rati

on

(fo

ld)

Supplementary Fig. 15

Page 9: Supplementary Fig. 1

Control TGF-b

A549WT

Control TGF-b

JNK1 siRNA

mock

A549TG2

40 80 160Control

JNK1 siRNA (nM)

JNK1 siRNA

Con TGF-b1 Con

A549WT A549TG2

Inv

as

ion

(fo

ld)

Con TGF-b1

JNK1 siRNA(nM)

40 80 160Mock

*

*

**

*

Supplementary Fig. 16

Page 10: Supplementary Fig. 1

A549TG2

40 80 160Control

JNK2 siRNA (nM)

Control TGF-b

A549WT

Control TGF-b

JNK2 siRNA

mock

Inv

as

ion

(fo

ld)

JNK2 siRNA

Con TGF-b1 Con

A549WT A549TG2

Con TGF-b1

JNK2 siRNA(nM)

40 80 160Mock

*

*

**

*

Supplementary Fig. 17