supplementary fig. 1
DESCRIPTION
Supplementary Fig. 1. TGF- b 1. Con. CTM (100 m M ). CTM (500 m M ). CTM (0 m M ). Supplementary Fig. 2. B. TGF- b 1. -. +. Con. Tgase-2 siRNA (40 nM ). Tgase-2 siRNA (80 nM ). Supplementary Fig. 3. CTM ( m M ). 0. Control. 100. 500. 1000. TGF- b 1 (100 pM ). - PowerPoint PPT PresentationTRANSCRIPT
Supplementary Fig. 1
B.
Con
Tgase-2 siRNA (40 nM)
Tgase-2 siRNA (80 nM)
TGF-b1
- +
Con
TGF-b1
CTM (100 mM) CTM (500 mM)CTM (0 mM)
Supplementary Fig. 2
CTM (mM)
Control 100 500 10000
TGF-b1 (100 pM)
Control TGF-b1
Tgase 2 siRNA 40nM
Mock TGF-b1Control TGF-b1Control
Tgase 2 siRNA 80nM
Supplementary Fig. 3
Supplementary Fig. 4
N-cad (2) siRNA 40nM
Mock TGF-b1Control TGF-b1Control
N-cad (2) siRNA 80nM
TGF-b1Control
Supplementary Fig. 5
N-Cad
- + - + - + TGF-β1
Con 40 80
β-actin
Ncad(2) siRNA (nM)
Mock
Supplementary Fig. 6
Control TGF-b
A549WT
A549TG2
40 80 160Control
Control TGF-bmock
JNK1 siRNA (nM)
Supplementary Fig. 7
A549TG2
40 80 160Control
JNK2 siRNA (nM)
Control TGF-b
A549WT
Control TGF-b
JNK2 siRNA
mock
Supplementary Fig. 8
Supplementary Fig. 9
Con TGF- 1b
Supplementary Fig. 10
Non 0 50 100 200 5000
20
40
60
80
100
TGF-b1 (pM)
Ce
ll p
roli
fera
tio
n (
%)
Supplementary Fig. 11
E-Cad
N-Cad
β-actin
Tgase 2
0 50 100 200 500
TGF-b1 (pM), 48 h
E-Cad
N-Cad
β-actin
Tgase 2
0 2 5 15 24 48 h
TGF-b1 (100 pM)
Supplementary Fig. 12
Supplementary Fig. 13
E-Cad
Con TGF-β1
N-Cad
DAPI
Con TGF-β1
Control TGF- 1b
H838 H1299 H1703 H838 H1299 H1703
N-Cad
β-actin
Tgase-2
pJNK
PP2A
Supplementary Fig. 14
N-cad siRNA 40nM
TGF-b1Control TGF-b1Control
N-cad siRNA 80nM
TGF-b1Control
Mock
- + - + - + TGF-b1 (100 pM)
Con 40 80
N-cad siRNA (nM)
Mock
*#
#*P<0.05 compared with Con(-)
#P<0.05 compared with Con(+)
Mig
rati
on
(fo
ld)
Supplementary Fig. 15
Control TGF-b
A549WT
Control TGF-b
JNK1 siRNA
mock
A549TG2
40 80 160Control
JNK1 siRNA (nM)
JNK1 siRNA
Con TGF-b1 Con
A549WT A549TG2
Inv
as
ion
(fo
ld)
Con TGF-b1
JNK1 siRNA(nM)
40 80 160Mock
*
*
**
*
Supplementary Fig. 16
A549TG2
40 80 160Control
JNK2 siRNA (nM)
Control TGF-b
A549WT
Control TGF-b
JNK2 siRNA
mock
Inv
as
ion
(fo
ld)
JNK2 siRNA
Con TGF-b1 Con
A549WT A549TG2
Con TGF-b1
JNK2 siRNA(nM)
40 80 160Mock
*
*
**
*
Supplementary Fig. 17