synthesis of aminoalkylpyrazoles and -isoxazoles from cyclic β-(trifluoroacetyl) enamines
TRANSCRIPT
2007
Isoxazole derivativesR 0240 Synthesis of Aminoalkylpyrazoles and -isoxazoles from Cyclic β-(Trifluoroacetyl)
Enamines. — The trifluroacetylation of cyclic imines (I) in the presence of LDA leads to β-(trifluoroacetyl) enamines (III). They produce aminoalkylpyrazoles [cf. (V)] and -isoxazoles (VI) on reaction with hydrazines or hydroxylamine, respectively. — (NENAJDENKO*, V. G.; PRONIN, S. V.; BALENKOVA, E. S.; Russ. Chem. Bull. 56 (2007) 2, 336-344; Dep. Chem., Lomonosov Moscow State Univ., Moscow 119992, Russia; Eng.) — R. Staver
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