1

Coating of Coating of Pharmaceutical Pharmaceutical

ProductsProducts

2

Convertible Coating……………………………………………………….

………………………………………………………...........................................................….

Non-Convertible Coating. ………………………………………………………………………………….…..

……………………………………………………………………………………...

3

Purpose of CoatingPurpose of Coating::1. Protection against light, air and moisture.

2. Protecting API against digestive fluids.

3. Ensure Controlled Release

4. Avoiding Side effects, masking taste.

5. Ensure eligible appearance.

6. Increase drug safety by better identification.4

5

6

7

8

Core types

9

10

Core Related Factors affecting Coating process:

11

12

Coating EquipmentCoating Equipment

Coating Liquid

Polymer (Film former). Solvent ( Vehicle ). Plasticizer. Opacifier. Colorant. Flavoring agents and Sweeteners. Wetting agent. Anti-adherent. Others.

13

Polymer . Function: film former.A.Immediate Release coating polymers: Readily soluble in aqueous media. a. Cellulose Derivatives: HPMC, HPC,MC. (Have good mechanical properties).

b. Vinyl Derivatives: PVP, PVA.

14

B. Modified Release Coating Polymers a. Extended Release Coating polymers: - They are dissolved in organic solvent or dispersed in aqueous medium, such as (EC). b. Enteric Coating polymers - Methacrylic acid and polyacrylate derivatives such as Eudragit. - Phthalate esters like cellulose acetate phthalate (CAP).

15

Plasticizers- Increasing elasticity of the coat.

- They have low molecular weight.

- Alter the physical properties of the

polymer.

- Examples:

PEG, Phthalate esters, Castor oil,

monoglycerides and coconut oil. 16

Coating PansCoating Pans

Conventional Coating Pans.

Perforated Coating Pans.

Air suspension Coating systems.

17

18

19

20

21

22

23

24

25

26

27

28

29

30

31

32

33

34

35

36

37

38

CoatingCoating ProblemsProblemsLogo Bridging

Twinning

39

CoatingCoating ProblemsProblems

Logo Infilling

40

Coating problemsCoating problems

Core Erosion

41

CoatingCoating ProblemsProblemsPicking and Sticking

42

Tablet to tablet color variation

43

CoatingCoating problemsproblems

CoatingCoating problemsproblemsOrange peel

roughness

Cracking

44

CoatingCoating ProblemsProblems

Peeling

45

CoatingCoating ProblemsProblems

Edge Chipping & Erosion

46

Thank You for

Your Attention … 47