tamm–horsfall protein
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TammHorsfall protein 1
TammHorsfall protein
Uromodulin
Identifiers
Symbols UMOD[1]
; ADMCKD2; FJHN; HNFJ; HNFJ1; MCKD2; THGP; THP
External IDs OMIM: 191845[2]
MGI: 102674[3]
HomoloGene: 2522[4]
GeneCards: UMOD Gene[5]
Gene Ontology
Molecular functioncalcium ion binding
[6]
Cellular componentspindle pole
[7]
extracellular space[8]
Golgi apparatus[9]
basolateral plasma membrane[10]
apical plasma membrane[11]
extrinsic to membrane[12]
anchored to membrane[13]
cytoplasmic vesicle[14]
membrane raft[15]
cilium membrane[16]
primary cilium[17]
Biological processcellular defense response
[18]
excretion[19]
negative regulation of cell proliferation[20]
response to organic substance[21]
chemical homeostasis
[22]
metanephric ascending thin limb development[23]
metanephric distal convoluted tubule development[24]
metanephric thick ascending limb development[25]
regulation of ion homeostasis[26]
Sources: Amigo[27]
/ QuickGO[28]
RNA expression pattern
More reference expression data[29]
Orthologs
Species Human Mouse
Entrez 7369[30]
22242[31]
Ensembl ENSG00000169344 [32]
ENSMUSG00000030963 [33]
UniProt P07911[34]
Q91X17[35]
https://en.wikipedia.org/w/index.php?title=UniProthttps://en.wikipedia.org/w/index.php?title=UniProthttps://en.wikipedia.org/w/index.php?title=UniProthttps://en.wikipedia.org/w/index.php?title=UniProthttps://en.wikipedia.org/w/index.php?title=UniProthttp://www.uniprot.org/uniprot/Q91X17http://www.uniprot.org/uniprot/P07911https://en.wikipedia.org/w/index.php?title=UniProthttp://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000030963;db=corehttp://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000169344;db=corehttps://en.wikipedia.org/w/index.php?title=Ensemblhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=22242&rn=1http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=7369&rn=1https://en.wikipedia.org/w/index.php?title=Entrezhttp://biogps.org/gene/7369/https://en.wikipedia.org/w/index.php?title=File:PBB_GE_UMOD_206716_at_tn.pnghttp://www.ebi.ac.uk/QuickGO/GProtein?ac=P07911http://amigo.geneontology.org/cgi-bin/amigo/gp-assoc.cgi?gp=UniProtKB:P07911http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:2000021http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0072233http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0072221http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0072218http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0048878http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0010033http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0008285http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0007588http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0006968http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0072372http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0060170http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0045121http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0031410http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0031225http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0019898http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0016324http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0016323http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0005794http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0005615http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0000922http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0005509https://en.wikipedia.org/w/index.php?title=Gene_Ontologyhttp://www.genecards.org/cgi-bin/carddisp.pl?id_type=entrezgene&id=7369https://en.wikipedia.org/w/index.php?title=GeneCardshttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=2522https://en.wikipedia.org/w/index.php?title=HomoloGenehttp://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:102674https://en.wikipedia.org/w/index.php?title=Mouse_Genome_Informaticshttp://omim.org/entry/191845https://en.wikipedia.org/w/index.php?title=Mendelian_Inheritance_in_Manhttp://www.genenames.org/data/hgnc_data.php?hgnc_id=12559https://en.wikipedia.org/w/index.php?title=Human_Genome_Organisation -
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TammHorsfall protein 2
RefSeq (mRNA) NM_001008389[36]
NM_009470[37]
RefSeq (protein) NP_001008390[38]
NP_033496[39]
Location (UCSC) Chr 16:
20.3420.37 Mb[40]
Chr 7:
119.46119.48 Mb[41]
PubMed search [42] [43]
The TammHorsfall glycoprotein (THP) also known as uromodulin is a glycoprotein that in humans is encoded
by the UMOD gene.[][]
Up to 150 mg/day of uromodulin may be excreted in the urine, making it the most abundant
protein in normal urine.
Gene
The human UMOD gene is located on chromosome 16. While several transcript variants may exist for this gene, the
full-length natures of only two have been described to date. These two represent the major variants of this gene and
encode the same isoform.[]
Protein
THP is a GPI-anchored glycoprotein. It is not derived from blood plasma but is produced by the thick ascending
limb of the loop of Henle of the mammalian kidney. While the monomeric molecule has a MW of approximately 68
kDa, it is physiologically present in urine in large aggregates of up to several million Da.[]
When this protein is
concentrated at low pH, it forms a gel. TammHorsfall protein is a high abundant protein in mammalian urine. A
recent list of the most abundant proteins in urine has been published (table 1 of[44]
), where uromodulin represents the
16th most concentrated one (results based on MSMS determinations). It is the matrix of urinary casts derived from
the secretion of renal tubular cells.
Function
Uromodulin excretion in urine following proteolytic cleavage of the ectodomain of its
glycophosphatidylinositol-anchored counterpart that is situated on the luminal cell surface of the loop of Henle.
Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. The excretion of uromodulin
in urine may provide defense against urinary tract infections caused by uropathogenic bacteria.[]
The function of THP is not well understood. Studies using THP deficient mice revealed that THP may have a role in
regulatory physiology and actually participates in transporter function.[]
A role in bacterial binding and sequestration
is suggested by studies showing that Escherichia coli expressing MS (mannose-sensitive) pili or fimbriae can be
trapped by TammHorsfall protein via its mannose-containing side chains.[]
https://en.wikipedia.org/w/index.php?title=Escherichia_colihttps://en.wikipedia.org/w/index.php?title=Urinary_tract_infectionshttps://en.wikipedia.org/w/index.php?title=Loop_of_Henlehttps://en.wikipedia.org/w/index.php?title=Glycophosphatidylinositolhttps://en.wikipedia.org/w/index.php?title=Urinary_castshttps://en.wikipedia.org/w/index.php?title=Urinehttps://en.wikipedia.org/w/index.php?title=Proteinhttps://en.wikipedia.org/w/index.php?title=Dalton_%28unit%29https://en.wikipedia.org/w/index.php?title=Atomic_mass_unithttps://en.wikipedia.org/w/index.php?title=Kidneyhttps://en.wikipedia.org/w/index.php?title=Thick_ascending_limb_of_the_loop_of_Henlehttps://en.wikipedia.org/w/index.php?title=Thick_ascending_limb_of_the_loop_of_Henlehttps://en.wikipedia.org/w/index.php?title=Blood_plasmahttps://en.wikipedia.org/w/index.php?title=Glycoproteinhttps://en.wikipedia.org/w/index.php?title=Glycophosphatidylinositolhttps://en.wikipedia.org/w/index.php?title=Urinehttps://en.wikipedia.org/w/index.php?title=Genehttps://en.wikipedia.org/w/index.php?title=Glycoproteinhttp://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=22242http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=7369https://en.wikipedia.org/w/index.php?title=PubMedhttp://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm9&position=chr7:119462866-119479255http://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg19&position=chr16:20344374-20367623http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_033496http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001008390http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_009470http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001008389 -
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TammHorsfall protein 3
Clinical significance
Uropontin, nephrocalcin and uromodulin (this protein) are the three known urinary glycoproteins that affect the
formation of calcium-containing kidney stones or calculus. TammHorsfall protein is part of the matrix in renal
calculi but a role in kidney stone formation remains debatable. However, decreased levels of TammHorsfall in
urine have been found to be a good indicator of kidney stones.[]
Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2
(MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile
onset of hyperuricemia, gout, and progressive renal failure.[]
Antibodies to TammHorsfall protein have been seen in various forms of nephritis (e.g., Balkan nephropathy),
however, it remains unclear whether there is any (patho-)physiologic relevance to these findings.[]
In multiple myeloma, there is often protein cast in the distal convoluted tubule and collecting duct of the kidneys,
mainly consisting of immunoglobulin light chain known as Bence Jones protein, but often also contain
TammHorsfall protein.[][45]
HistoryThe glycoprotein was first purified by Tamm and Horsfall from the urine of healthy individuals.
[]It was later
detected in the urine of all mammals studied.
References
[1] http:/ /www.genenames. org/data/hgnc_data. php?hgnc_id=12559
[2] http:/ /omim. org/entry/191845
[3] http:/ /www.informatics. jax.org/searches/accession_report. cgi?id=MGI:102674
[4] http:/ /www.ncbi. nlm.nih. gov/entrez/query. fcgi?cmd=Retrieve& db=homologene& dopt=HomoloGene& list_uids=2522
[5] http:/ /www.genecards. org/cgi-bin/carddisp.pl?id_type=entrezgene& id=7369
[6] http:/
/
amigo.
geneontology.
org/
cgi-bin/
amigo/
go.
cgi?view=details&
search_constraint=terms&
depth=0&
query=GO:0005509[7] http:/ /amigo. geneontology. org/cgi-bin/amigo/go. cgi?view=details&search_constraint=terms&depth=0& query=GO:0000922
[8] http:/ /amigo. geneontology. org/cgi-bin/amigo/go. cgi?view=details&search_constraint=terms&depth=0& query=GO:0005615
[9] http:/ /amigo. geneontology. org/cgi-bin/amigo/go. cgi?view=details&search_constraint=terms&depth=0& query=GO:0005794
[10] http://amigo. geneontology. org/cgi-bin/amigo/go. cgi?view=details&search_constraint=terms&depth=0& query=GO:0016323
[11] http://amigo. geneontology. org/cgi-bin/amigo/go. cgi?view=details&search_constraint=terms&depth=0& query=GO:0016324
[12] http://amigo. geneontology. org/cgi-bin/amigo/go. cgi?view=details&search_constraint=terms&depth=0& query=GO:0019898
[13] http://amigo. geneontology. org/cgi-bin/amigo/go. cgi?view=details&search_constraint=terms&depth=0& query=GO:0031225
[14] http://amigo. geneontology. org/cgi-bin/amigo/go. cgi?view=details&search_constraint=terms&depth=0& query=GO:0031410
[15] http://amigo. geneontology. org/cgi-bin/amigo/go. cgi?view=details&search_constraint=terms&depth=0& query=GO:0045121
[16] http://amigo. geneontology. org/cgi-bin/amigo/go. cgi?view=details&search_constraint=terms&depth=0& query=GO:0060170
[17] http://amigo. geneontology. org/cgi-bin/amigo/go. cgi?view=details&search_constraint=terms&depth=0& query=GO:0072372
[18] http://amigo. geneontology. org/cgi-bin/amigo/go. cgi?view=details&search_constraint=terms&depth=0& query=GO:0006968
[19] http://amigo. geneontology. org/cgi-bin/amigo/go. cgi?view=details&search_constraint=terms&depth=0& query=GO:0007588
[20] http://amigo. geneontology. org/cgi-bin/amigo/go. cgi?view=details&search_constraint=terms&depth=0& query=GO:0008285
[21] http://amigo. geneontology. org/cgi-bin/amigo/go. cgi?view=details&search_constraint=terms&depth=0& query=GO:0010033
[22] http://amigo. geneontology. org/cgi-bin/amigo/go. cgi?view=details&search_constraint=terms&depth=0& query=GO:0048878
[23] http://amigo. geneontology. org/cgi-bin/amigo/go. cgi?view=details&search_constraint=terms&depth=0& query=GO:0072218
[24] http://amigo. geneontology. org/cgi-bin/amigo/go. cgi?view=details&search_constraint=terms&depth=0& query=GO:0072221
[25] http://amigo. geneontology. org/cgi-bin/amigo/go. cgi?view=details&search_constraint=terms&depth=0& query=GO:0072233
[26] http://amigo. geneontology. org/cgi-bin/amigo/go. cgi?view=details&search_constraint=terms&depth=0& query=GO:2000021
[27] http://amigo. geneontology. org/cgi-bin/amigo/gp-assoc. cgi?gp=UniProtKB:P07911
[28] http://www.ebi.ac.uk/QuickGO/GProtein?ac=P07911
[29] http://biogps. org/gene/7369/
[30] http://www.ncbi.nlm. nih.gov/entrez/query. fcgi?db=gene& cmd=retrieve& dopt=default& list_uids=7369& rn=1
[31] http://www.ncbi.nlm. nih.gov/entrez/query. fcgi?db=gene& cmd=retrieve& dopt=default& list_uids=22242& rn=1
[32] http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000169344;db=core
[33] http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000030963;db=core
http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000030963;db=corehttp://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000169344;db=corehttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=22242&rn=1http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=7369&rn=1http://biogps.org/gene/7369/http://www.ebi.ac.uk/QuickGO/GProtein?ac=P07911http://amigo.geneontology.org/cgi-bin/amigo/gp-assoc.cgi?gp=UniProtKB:P07911http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:2000021http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0072233http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0072221http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0072218http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0048878http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0010033http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0008285http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0007588http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0006968http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0072372http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0060170http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0045121http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0031410http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0031225http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0019898http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0016324http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0016323http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0005794http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0005615http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0000922http://amigo.geneontology.org/cgi-bin/amigo/go.cgi?view=details&search_constraint=terms&depth=0&query=GO:0005509http://www.genecards.org/cgi-bin/carddisp.pl?id_type=entrezgene&id=7369http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=2522http://www.informatics.jax.org/searches/accession_report.cgi?id=MGI:102674http://omim.org/entry/191845http://www.genenames.org/data/hgnc_data.php?hgnc_id=12559https://en.wikipedia.org/w/index.php?title=Urinehttps://en.wikipedia.org/w/index.php?title=Frank_Horsfallhttps://en.wikipedia.org/w/index.php?title=Glycoproteinhttps://en.wikipedia.org/w/index.php?title=Bence_Jones_proteinhttps://en.wikipedia.org/w/index.php?title=Multiple_myelomahttps://en.wikipedia.org/w/index.php?title=Danubian_endemic_familial_nephropathyhttps://en.wikipedia.org/w/index.php?title=Nephritishttps://en.wikipedia.org/w/index.php?title=Hyperuricemiahttps://en.wikipedia.org/w/index.php?title=Medullary_cystic_kidney_diseasehttps://en.wikipedia.org/w/index.php?title=Kidney_stones -
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TammHorsfall protein 4
[34] http://www.uniprot. org/uniprot/P07911
[35] http://www.uniprot. org/uniprot/Q91X17
[36] http://www.ncbi.nlm. nih.gov/entrez/viewer.fcgi?val=NM_001008389
[37] http://www.ncbi.nlm. nih.gov/entrez/viewer.fcgi?val=NM_009470
[38] http://www.ncbi.nlm. nih.gov/entrez/viewer.fcgi?val=NP_001008390
[39] http://www.ncbi.nlm. nih.gov/entrez/viewer.fcgi?val=NP_033496
[40] http://genome.ucsc. edu/cgi-bin/hgTracks?org=Human& db=hg19& position=chr16:20344374-20367623
[41] http://genome.ucsc. edu/cgi-bin/hgTracks?org=Mouse& db=mm9& position=chr7:119462866-119479255
[42] http://www.ncbi.nlm. nih.gov/sites/entrez?db=gene& cmd=Link& LinkName=gene_pubmed& from_uid=7369
[43] http://www.ncbi.nlm. nih.gov/sites/entrez?db=gene& cmd=Link& LinkName=gene_pubmed& from_uid=22242
[44] Nagaraj et Mann, 2011, PUBMED link: http://www.ncbi.nlm. nih.gov/pubmed/21126025
[45][45] Page 455 (Multiple Myeloma) in: 8th edition.
Further reading
Scolari F, Viola BF, Ghiggeri GM, et al. (2003). "Towards the identification of (a) gene(s) for autosomal
dominant medullary cystic kidney disease.".J. Nephrol.16 (3): 3218. PMID 12832729 (http://www.ncbi.
nlm.nih.gov/pubmed/12832729).
Rindler MJ, Naik SS, Li N, et al. (1991). "Uromodulin (Tamm-Horsfall glycoprotein/uromucoid) is aphosphatidylinositol-linked membrane protein.".J. Biol. Chem.265 (34): 207849. PMID 2249987 (http://
www.ncbi.nlm. nih.gov/pubmed/2249987).
Muchmore AV, Decker JM (1985). "Uromodulin: a unique 85-kilodalton immunosuppressive glycoprotein
isolated from urine of pregnant women.". Science229 (4712): 47981. doi: 10.1126/science.2409603 (http://dx.
doi.org/10.1126/science.2409603). PMID 2409603 (http://www.ncbi.nlm. nih.gov/pubmed/2409603).
Pennica D, Kohr WJ, Kuang WJ, et al. (1987). "Identification of human uromodulin as the Tamm-Horsfall
urinary glycoprotein.". Science236 (4797): 838. doi: 10.1126/science.3453112 (http://dx.doi.org/10.1126/
science.3453112). PMID 3453112 (http://www.ncbi.nlm.nih. gov/pubmed/3453112).
Hession C, Decker JM, Sherblom AP, et al. (1987). "Uromodulin (Tamm-Horsfall glycoprotein): a renal ligand
for lymphokines.". Science237 (4821): 1479
84. doi: 10.1126/science.3498215 (http:/
/
dx.
doi.
org/
10.
1126/science.3498215). PMID 3498215 (http://www.ncbi.nlm.nih. gov/pubmed/3498215).
Prasadan K, Bates J, Badgett A, et al. (1995). "Nucleotide sequence and peptide motifs of mouse uromodulin
(Tamm-Horsfall protein)--the most abundant protein in mammalian urine.".Biochim. Biophys. Acta1260 (3):
32832. PMID 7873609 (http://www.ncbi.nlm.nih.gov/pubmed/7873609).
Huang ZQ, Kirk KA, Connelly KG, Sanders PW (1994). "Bence Jones proteins bind to a common peptide
segment of Tamm-Horsfall glycoprotein to promote heterotypic aggregation." (http://www.ncbi.nlm.nih. gov/
pmc/articles/PMC288501).J. Clin. Invest.92 (6): 297583. doi: 10.1172/JCI116920 (http://dx.doi.org/10.
1172/JCI116920). PMC 288501 (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC288501). PMID 8254051
(http://www.ncbi. nlm.nih.gov/pubmed/8254051).
Rhodes DC, Hinsman EJ, Rhodes JA (1994). "Tamm-Horsfall glycoprotein binds IgG with high affinity.".KidneyInt.44 (5): 101421. doi: 10.1038/ki.1993.343 (http://dx.doi. org/10.1038/ki.1993.343). PMID 8264130
(http://www.ncbi. nlm.nih.gov/pubmed/8264130).
Fukushima K, Watanabe H, Takeo K, et al. (1993). "N-linked sugar chain structure of recombinant human
lymphotoxin produced by CHO cells: the functional role of carbohydrate as to its lectin-like character and
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External links
GeneReviews/NCBI/NIH/UW entry on UMOD-Related Kidney Disease Includes: Familial Juvenile
Hyperuricemic Nephropathy, Medullary Cystic Kidney Disease 2 (http://www.ncbi.nlm.nih.gov/bookshelf/
br.fcgi?book=gene&part=mckd2)
OMIM entries on UMOD-Related Kidney Disease Includes: Familial Juvenile Hyperuricemic Nephropathy,
Medullary Cystic Kidney Disease 2 (http://www.ncbi.nlm.nih.gov/omim/
162000,191845,603860,609886,162000,191845,603860,609886)
TammHorsfall protein deposition (http://www.mcw.edu/chorus/to-go/02058.html)
http://www.mcw.edu/chorus/to-go/02058.htmlhttp://www.ncbi.nlm.nih.gov/omim/162000,191845,603860,609886,162000,191845,603860,609886http://www.ncbi.nlm.nih.gov/omim/162000,191845,603860,609886,162000,191845,603860,609886http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=mckd2http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=mckd2http://www.ncbi.nlm.nih.gov/pubmed/12477932https://en.wikipedia.org/w/index.php?title=PubMed_Identifierhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241https://en.wikipedia.org/w/index.php?title=PubMed_Centralhttp://dx.doi.org/10.1073%2Fpnas.242603899http://dx.doi.org/10.1073%2Fpnas.242603899https://en.wikipedia.org/w/index.php?title=Digital_object_identifierhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC139241http://www.ncbi.nlm.nih.gov/pubmed/12471200https://en.wikipedia.org/w/index.php?title=PubMed_Identifierhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1757206https://en.wikipedia.org/w/index.php?title=PubMed_Centralhttp://dx.doi.org/10.1136%2Fjmg.39.12.882http://dx.doi.org/10.1136%2Fjmg.39.12.882https://en.wikipedia.org/w/index.php?title=Digital_object_identifierhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1757206http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1757206http://www.ncbi.nlm.nih.gov/pubmed/11982485https://en.wikipedia.org/w/index.php?title=PubMed_Identifierhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222653https://en.wikipedia.org/w/index.php?title=PubMed_Centralhttp://dx.doi.org/10.1042%2FBJ20020643http://dx.doi.org/10.1042%2FBJ20020643https://en.wikipedia.org/w/index.php?title=Digital_object_identifierhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222653http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222653http://www.ncbi.nlm.nih.gov/pubmed/11932463http://www.ncbi.nlm.nih.gov/pubmed/11932463https://en.wikipedia.org/w/index.php?title=PubMed_Identifierhttp://www.ncbi.nlm.nih.gov/pubmed/11730273https://en.wikipedia.org/w/index.php?title=PubMed_Identifierhttp://www.ncbi.nlm.nih.gov/pubmed/10765940http://www.ncbi.nlm.nih.gov/pubmed/10765940https://en.wikipedia.org/w/index.php?title=PubMed_Identifierhttp://dx.doi.org/10.1002%2F1529-0131%28200004%2943%3A4%3C925%3A%3AAID-ANR26%3E3.0.CO%3B2-Bhttp://dx.doi.org/10.1002%2F1529-0131%28200004%2943%3A4%3C925%3A%3AAID-ANR26%3E3.0.CO%3B2-Bhttps://en.wikipedia.org/w/index.php?title=Digital_object_identifierhttp://www.ncbi.nlm.nih.gov/pubmed/10330352https://en.wikipedia.org/w/index.php?title=PubMed_Identifierhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1377908http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1377908https://en.wikipedia.org/w/index.php?title=PubMed_Centralhttp://dx.doi.org/10.1086%2F302414https://en.wikipedia.org/w/index.php?title=Digital_object_identifierhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC1377908http://www.ncbi.nlm.nih.gov/pubmed/9884403http://www.ncbi.nlm.nih.gov/pubmed/9884403https://en.wikipedia.org/w/index.php?title=PubMed_Identifierhttp://dx.doi.org/10.1093%2Fglycob%2F9.1.21https://en.wikipedia.org/w/index.php?title=Digital_object_identifierhttp://www.ncbi.nlm.nih.gov/pubmed/9873244http://www.ncbi.nlm.nih.gov/pubmed/9873244https://en.wikipedia.org/w/index.php?title=PubMed_Identifierhttp://dx.doi.org/10.1159%2F000030292https://en.wikipedia.org/w/index.php?title=Digital_object_identifier -
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Article Sources and Contributors 6
Article Sources and ContributorsTammHorsfall protein Source: https://en.wikipedia.org/w/index.php?oldid=551285664 Contributors: Andrew Su, Arcadian, Bobjgalindo, Boghog, Cornwell77, Crystallina, Dcoetzee,
Gcgmd, Giftlite, Iamgerard, Isoxyl, K.murphy, LittleWink, Mikael Hggstrm, Mtnchkn, NickCT, Peytonbland, Spikey1973, Szalzala, Tarek, The Anome, Tony1, Vedran12, 22 anonymous edits
Image Sources, Licenses and Contributorsfile:PBB_GE_UMOD_206716_at_tn.png Source: https://en.wikipedia.org/w/index.php?title=File:PBB_GE_UMOD_206716_at_tn.pngLicense: GNU Free Documentation License
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