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iv J. Hydrocephalus, Vol. 2, No. 3 2010

HRF subject I-X

Subject I. Definition and Terminology of Hydrocephalus

Subject II. Classification of Hydrocephalus

Subject III. Pathophysiology 1. Cerebrospinal Fluid (CSF) Physiology

Pathophysiology 2. Intracranial Pressure (ICP) Physiology

Pathophysiology 3. Miscellaneous

Subject IV. Hydrocephalus Chronology

Subject V. Specific Forms of Hydrocephalus

1. Pathogenic Concepts 1) Congenital Hydrocephalus

2) Acquired Hydrocephalus

3) Idiopathic

2. Pathophysiological Concepts 1) Intracranial Pressure (ICP)

2) Cerebrospinal Fluid (CSF)

3) Miscellaneous

3. Chronological Concepts 1) Phase

2) Progression

4. Miscellaneous

Subject VI. Associated Congenital Anomalies/ Syndrome and Underlying Conditions

Subject VII. Diagnostic Procedures for Hydrocephalus

Subject VIII. Treatment Modalities in Hydrocephalus

Subject IX. Experimental Hydrocephalus and Invention

1. Hydrocephalus Model

2. Diagnostic and Therapeutic Methodology and Invention

3. Miscellaneous

Subject X. Ethics & Moral/ Society/ Education in Hydrocephalus Medicine and Science

1. Medico-ethics/ Medico-social/ Medico-legal/ Medico-economical Issue

2. Federation/ Society/ Association/ Research Foundation/ Study Group

and Education for Hydrocephalus

3. Miscellaneous

The 10 Major Subjects in Hydrocephalus Research Fields

Journal of Hydrocephalus

vJ. Hydrocephalus, Vol. 2, No. 3 2010

Journal of Hydrocephalus

Journal of HydrocephalusVolume 2, Number 3　2010

Japanese Society for Hydrocephalus and CSF Disorders The 3rd Annual Meeting The Masters 2010

第3回日本水頭症脳脊髄液学会学術集会プログラム・抄録日時：2010 年 11 月 28 日（日）9：00 －

会場：順天堂大学 10 号館 1 階カンファレンスルーム

会長：稲垣　隆介

■ 会場のご案内

　Japanese Society for Hydrocephalus and CSF Disorders–JSHCSF– officers

　　　日本水頭症脳脊髄液学会役員名簿■ ご挨拶　　第 3 回日本水頭症脳脊髄液学会（JSHCSF）　会長　稲垣　隆介

■ プログラム■ 抄　　録

HYDROCEPHALUS RESEARCH WORLD RECORD RANKING [1950 ─ 2008] The list of Top 10 researchers ……………………………………………………………………………………21

vi J. Hydrocephalus, Vol. 2, No. 3 2010

�J. Hydrocephalus, Vol. 2, No. 3 2010

Journal of HydrocephalusJapanese Edition

November 28, 2010

日本水頭症脳脊髄液学会JSHCSF

（略称：日本水頭症 CSF学会）［英文略称：JSHCSF］

第3回日本水頭症脳脊髄液学会学術集会プログラム・抄録

Japanese Society for Hydrocephalus and CSF DisordersThe 3rd Annual Meeting The Masters 2010

President: Takayuki INAGAKI

日時：2010 年 11 月 28 日（日）9：00 －会場：順天堂大学 10 号館 1 階

　カンファレンスルーム

会長：稲垣隆介　関西医科大学脳神経外科

� J. Hydrocephalus, Vol. 2, No. 3 2010

●発表のご案内　本学会では出来るだけゆっくり講演をいただき，討論もじっくりできるように時間配分を発表 10 分，討論 5 分をしています．発表いただきます先生，座長の労をおとりいただく先生にはよろしくお願いします．

　発表はデータを USB，CD でお持ちいただいても良いですし，ご自身のコンピューターをお持ちいただいても結構です．ただし，ビデオなどをお持ちの場合はご自身のコンピューターをお持ちいただくことをおすすめします．

2010 年 11 月 28 日（日）9：00 －会場：順天堂大学 10 号館 1 階カンファレンスルーム

●会場のご案内順天堂大学 10 号館 1階カンファレンスルーム〒113-8421　東京都文京区本郷 2-1-1

　JR 御茶ノ水駅・丸の内線御茶ノ水駅▶徒歩 5 分　千代田線新御茶ノ水駅▶徒歩 7 分

10 号館1階カンファレンスルーム


日本水頭症脳脊髄液学会Japanese Society for Hydrocephalus and CSF Disorders

JSHCSF

役員 officers（ABC 順）

■ 顧問 (Advisory Board) ……………………………………………………………………………………………………………………

森　惟明 (Koreaki Mori) 佐藤　潔 (Kiyoshi Sato) 佐藤　修 (Osamu Sato)

塩田浩平 (Kohei Shiota)

■ 理事 (Executive Board Officers) ………………………………………………………………………………………………………

理事長 President 大井静雄 (Shizuo Oi)

副理事長 Vice President 新井　一 (Hajime Arai)

事務局担当理事 Head Quater Secretary 宮嶋雅一 (Masakazu Miyajima)

庶務・会計理事 Secretary & Treasurer 稲垣隆介 (Takayuki Inagki)

会計監査理事 Andit 三宅裕治 (Hiroji Miyake)

理　事 Officers 伊達　勲 (Isao Date) 堀　智勝 (Tomokatsu Hori)

石川正恒 (Masatsune Ishikawa) 澤本和延 (Kazunobu Sawamoto)

白根礼造 (Reizo Shirane) 鈴木倫保 (Michiyasu Suzuki)

田代　弦 (Yuzuru Tashiro)

■ 学術集会会長 (Congress President) …………………………………………………………………………………………………

第 3 回学術集会会長稲垣隆介 (Takayuki Inagaki)

■ 評議員 (Council Members) ……………………………………………………………………………………………………………

赤井卓也 (Takuya Akai) 藤井幸彦 (Yukihiko Fujii) 門脇親房 (Chikafusa Kadowaki)

梶本宣永 (Motonaga Kajimoto) 数井裕光 (Hiromitsu Kazui) 加藤美穂子 (Mihoko Kato)

間瀬光人 (Mitsuhito Mase) 三木　保 (Tamotsu Miki) 室井　愛 (Ai Muroi)

西山健一 (Kenichi Nishiyama) 野中雄一郎 (Yuichiro Nonaka) 野村貞宏 (Sadahiro Nomura)

小野成紀 (Shigeki Ono) 朴　永銖 (Park Young-soo) 橋本卓雄 (Sadao Hashimoto)

橋本正明 (Masaaki Hashimoto) 濱田秀雄 (Hideo Hamada) 林　央周 (Chikao Hayashi)

斉藤和恵 (Kazue Saito) 篠田正樹 (Masaki Shinoda) 下川尚子 (Naoko Shimokawa)

下地一彰 (Kazuaki Shimoji) 高橋麻由 (Mayu Takahashi) 山田晋也 (Shinya Yamada)

山本哲也 (Tetsuya Yamamoto) 吉野雅美 (Masami Yoshino)


日本水頭症脳脊髄液学会JSHCSF

（略称：日本水頭症 CSF学会）［英文略称：JSHCSF］第3回日本水頭症脳脊髄液学会学術集会

ご　挨　拶

　国際水頭症脳脊髄液学会が開催されたことを契機として，日本水頭症脳脊髄液学会が設立さ

れてすでに 3 年が経過しました．ほとんどの方がご存じと思いますが，Anthony Marmarou 先

生が国際水頭症脳脊髄液学会での発表は小児に関する報告と大人に関する報告がそれぞれ半数，

また，臨床研究と基礎研究がそれぞれ半分程度であることが望ましいと述べられたことがきっか

けで，日本にも同じような学会ができました．残念ながら，Marmarou 先生が急逝されました

ので，国際水頭症脳脊髄液学会の今後の展開は不明ですが，本会は，同じように水頭症研究に

携わる研究者が，研究を通して忌憚のない意見交換ができる学会になればと希望しております．

　本学会では，一般演題（すべてシンポジウム）を主とする年と，優秀論文（英文ファースト

オーサー）を招待講演として発表いただく年とを一年ごとに繰り返すよう予定を立てておりま

す．今年は過去に英文で発表いただいた優秀論文を招待講演としてお願いする年にあたってお

りましたが，過去約 10 年に 200 編以上の日本からの優秀な論文があり，選考が思ったより手間

取り，一部の先生にしか発表のご案内が出来ず，申し訳ありませんでした．日本からの論文の

詳細につきましては，聖路加病院脳神経外科，篠田正樹先生に述べていただく予定です．

　昨年は基礎研究の代表者として McAllister 先生に，臨床研究の代表者として Walker 先生に

講演をいただきました．今年は大人の研究の代表者として Williams 先生，子供の研究の代表者

として Kestle 先生にご講演をしていただくこととなっております．私自身も楽しみにしており

ます．なお，両先生に講演をお願いできることになりましたのは順天堂大学医学部，新井一教授，

東京慈恵会医科大学小児脳神経外科，大井静雄教授のご尽力によるものです．深謝いたします．

　有意義な会になることを祈念して，ご挨拶とさせていただきます．

　2010年 11月

第 3 回日本水頭症脳脊髄液学会（JSHCSF）会長　稲垣　隆介


プログラム 2010 年 11 月 28 日（日）

9 : 00- 開会挨拶　　大会会長　稲垣隆介　関西医科大学脳神経外科

9 : 05-10 : 25

■ シンポジウム 1 　座長　伊達　勲，橋本正明，數井裕光

演題 1 杏林大学脳神経外科の 2010 年における成人水頭症診療の現状と課題

平岩直也 1），野口明男 1），門脇親房 2），塩川芳昭 1）

1）杏林大学医学部付属病院，2）杉並リハビリテーション病院

演題 2 水頭症手術における CHPV with or without SiphonGuard の比較検討

橋本正明，塚田利幸，吉田優也公立能登総合病院脳神経外科

演題 3 Adjustable MIETHKE gravitational valve - ProGAV programmable valve 破損

門脇親房 1, 3），新田勇介 2, 3），宮崎　寛 2, 3）

1）杉並リハビリテーション病院，2）久我山病院脳神経外科，3）杏林大学医学部脳神経外科

演題 4 心拍同期脳実質内水拡散係数（delta-ADC）の変動：特発性正常圧水頭症における検討

大沢知士 1），間瀬光人 1），宮地利明 2），菅　博人 2），出村光一朗 1），笠井治昌 3），山田和雄 1）

1）名古屋市立大学大学院医学研究科脳神経外科学，2）金沢大学大学院医学系研究科保健学科，3）名古屋市立大学病院中央放射線部

演題 5 NAT（Neural Activity Topography）解析を用いた特発性正常圧水頭症における CSF tap test による脳波変化の検討

石井良平 1），青木保典 1），數井裕光 1），和田民樹 1），カヌエトレオニデス 1），岩瀬真生 1），武者利光 2），松崎晴康 2），今城　郁 3），山本大介 1），杉山博通 1），髙屋雅彦 1），野村慶子 1），吉山顕次 1），武田雅俊 1）

1）大阪大学大学院医学系研究科精神医学教室，2）脳機能研究所，3）日本光電

10 : 25-11 : 25

■ シンポジウム 2 座長　白根礼造，西山健一，田代　弦

演題 6 奇形症候群に伴う脳室拡大に対する水頭症手術

原田敦子 1），西山健一 1），吉村淳一 1），山田謙一 2），岡本浩一郎 1），藤井幸彦 1）

1）新潟大学脳研究所脳神経外科学分野，2）新潟大学脳研究所統合脳機能研究センター

演題 7 水頭症と心肺合併症─タコつぼ型心筋症を呈した小児急性水頭症例の提示も併せて─

篠田正樹，藤井本晴，松川東俊，山本大輔，住吉壮介，村形　敦，石川陵一聖路加国際病院脳神経外科


演題 8 水頭症におけるドーパミン作働性黒質─線条体路の機能的変化

田代　弦静岡県立こども病院脳神経外科

演題 9 Long-standing overt ventriculomegaly in adults（LOVA）と考えられた 3 症例に対する治療上の問題点

小野成紀，石田穣治，安原隆雄，黒住和彦，伊達　勲岡山大学大学院脳神経外科

11 : 30-12 : 30

　特別講演 1 座長　石川正恒

The Paradox of Hydrocephalus: Simplicity and Complexity Michael Williams Medical Director of the LifeBridge Health Brain & Spine Institute

……………………………………… 昼食（役員会） ………………………………………

13 : 30-14 : 00

■ シンポジウム 3 座長　宮嶋雅一，三宅裕治

演題 10 Efficacy of intraoperative irrigation with saline for preventing shunt infection

Hayashi T, Shirane R, Yokosawa M, Kimiwada T, Tominaga T

Department of Neurosurgery, Miyagi Children’s Hospital

演題 11 Analysis of neuronal cell death in the cerebral cortex of H-Tx rats with compensated hydrocephalus

Nonaka Y, Miyajima M, Ogino I, Nakajima M, Arai H

Department of Neurosurgery and Research Institute for Diseases of Old Age, Juntendo University School

of Medicine

14 : 10-15 : 10

　特別講演 2 座長　新井　一

Lesson learned in clinical trials in pediatric hydrocephalus John Kestle Department of Neurosurgery, Primary Children’s Medical Center, University of Utah

15 : 10-15 : 40

　理事長講演座長　佐藤　修

水頭症の定義と分類 Hydrocephalus research update-controversies in definition and classification of hydrocephalus 大井静雄

東京慈恵会医科大学脳神経外科


15: 50-16 : 50

■ シンポジウム 4 座長　門脇親房，間瀬光人

演題 12 Noninvasive estimation of intracranial compliance in idiopathic NPH using MRI

Mase M, Miyachi T, Kasai H, Demura K, Osawa T, Hara M, Shibamoto Y, Yamada K

Department of Neurosurgery and Restorative Neuroscience, Graduate School of Medical Sciences,

Nagoya City University

演題 13 Lumboperitoneal shunt placement using computed tomography and fluoroscopy in conscious patients

Nakajima M, Bando K, Miyajima M, Arai H

Department of Neurosurgery, Juntendo University, Tokyo

演題 14 2001 年以降の日本発の髄液・水頭症関連論文

篠田正樹，藤井本晴，山本大輔，村形　敦，松川東俊，石川陵一聖路加国際病院脳神経外科

演題 15 先天性水頭症の前方視的多施設共同調査（COE-Fetal Hydrocephalus Top 10 Japan）によるガイドライン

大井静雄 1），稲垣隆介 2），小野成紀 3），伊達　勲 3），高橋里史 4）

1）東京慈恵会医科大学脳神経外科，2）関西医科大学脳神経外科，

3）岡山大学医学部脳神経外科，4）慶應義塾大学医学部脳神経外科

16 : 50-17 : 20

　会長講演座長　大井静雄

先天奇形に伴う水頭症研究，今後の展望稲垣隆介

関西医科大学脳神経外科

17:20- 第 4 回 JSHCSF 学会のお知らせ　　三宅裕治　17:25- 理事長挨拶　　　　　　　　　　　大井静雄　東京慈恵会医科大学


PROGRAM Sunday 28th November 2010

9 : 00- Opening Remark: Takayuki Inagaki （Scientific Program Chairman）

9 : 05-10 : 25

■ Symposium 1 　Moderators: Isao Date, Masaaki Hashimoto, Hiromitsu Kazui

1 Current Treatment Strategy for Adult Hydrocephalus at Kyorin University Hospital

Naoya Hiraiwa 1), Akio Noguchi 1), Chikafusa Kadowaki 2), Yosiaki Shiokawa 1)

1) Department of Neurosurgery, Kyorin University, 2) Suginami Rehabilitation Hospital

2 Comparison of CHPV shunt sysrtem with or without SiphonGuard in treating Hydrocephalus patients

Masaaki Hashimoto, Toshiyuki Tsukada, Yuya YoshidaDepartment of Neurosurgery, Noto General Hospital

3 An Experience of Broken Shunt Valve: Adjustable MIETHKE gravitational Valve- ProGAV Programmable Valve

Chikafusa Kadowaki 1, 3), Yusuke Nitta 2, 3), Hiroshi Miyazaki 2, 3) 1) Suginami Rehabilitation Hospital, 2) Department of Neurosurgery Kugayama Hospital,3) Department of Neurosurgery, Kyorin University

4 The Measurement of Delta-ADC in the iNPH patientsTomoshi Osawa 1), Mitsuhito Mase 1), Toshiaki Miyachi 2), Hiroto Kan 2), Koichiro Demura 1), Harumasa Kasai 3), Kazuo Yamada 1)

1) Department of Neurosurgery, Nagoya City University, 2) Deparment of Health Science, Kanazawa University,3) Department of Radiology, Nagoya City University

5 EEG Analysis using Neural Activity Topography in iNPH patients before and after CSF Tap Test

Ryohei Ishii 1), Yasunori Aoki 1), Hiromitsu Kazui 1), Tamiki Wada 1), Leonides Canuet 1), Masao Iwase 1), Toshimitsu Musha 2), Haruyasu Matsuzaki 2), Kaoru Imajo 3), Daisuke Yamamoto 1), Hiromichi Sugiyama 1), Masahiko Takaya 1), Keiko Nomura 1), Kenji Yoshiyama 1), Masatoshi Takeda 1)

1) Department of Psychiatry Osaka University, 2) Institute of Brain Function Osaka University, 3) Nippon Koden


10 : 25-11: 25

■ Symposium 2 　Moderators: Reizo Shirane, Kenichi Nishiyama, Yuzuru Tashiro

6 Treatment Strategy of Ventriculomegaly in the Patients with Multiple Anomaly Syndrome

Atsuko Harada 1), Kenichi Nishiyama 1), Junichi Yoshimura 1), Kenichi Yamada 2), Koichiro Okamoto 1), Yukihiko Fujii 1)

1) Department of Neurosurgery, Brain Research Institute, Niigata University, 2) Department of Functional Neurology and Neurosurgery, Brain Institute, Niigata University

7 Hydrocephalus Patient Associated with Cardio-Pulmonary Complication: Review of the Literature and Case Report

Masaki Shinoda, Motoharu Fujii, Hidetoshi Matsukawa, Daisuke Yamanoto, Sosuke Sumiyoshi, Atsushi Murakata, Ryoichi IshikawaDepartment of Neurosurgery, St Luke’s International Hospital

8 Functional Injury of Dopaminergic Pathway in HydrocephalusYuzuru TashiroDepartment of Neurosurgery, Shizuoka Children’s Hospital　

9 The Problems in Treating Patients with Long-Standing Overt Ventriculomegary in Adauls (LOVA)

Shigeki Ono, Joji Ishida, Takao Yasuhara, Kazuhiko Kurozumi, Isao DateDepartment of Neurosurgery, Okayama University

11 : 30-12: 30

　Special Lecture 1 　Moderator: Masatsune Ishikawa

Tha Paradox of Hydrocephalus: Simplicity and ComprexityMichael WilliamsMedical Director of the LifeBridge Health Brain & Spine Institute

…………………………………………… Lunch ……………………………………………

13 : 30-14: 00

■ Symposium 3 (Invited) 　Moderators: Masakazu Miyajima, Hiroji Miyake

10 Efficacy of intraoperative irrigation with saline for preventing shunt infectionHayashi T, Shirane R, Yokosawa M, Kimiwada T, Tominaga TDepartment of Neurosurgery, Miyagi Children’s Hospital

11 Analysis of neuronal cell death in the cerebral cortex of H-Tx rats with compensated hydrocephalus

Nonaka Y, Miyajima M, Ogino I, Nakajima M, Arai HDepartment of Neurosurgery and Research Institute for Diseases of Old Age, Juntendo University School of Medicine

�0 J. Hydrocephalus, Vol. 2, No. 3 2010

14 : 10-15: 10

　Special Lecture 2 　Moderator: Hajime Arai

Lesson learned in clinical trials in pediatric hydrocephalusJohn KestleDepartment of Neurosurgery, Primary Children’s Medical Center, University of Utah

15 : 10-15: 40

　Presidential Address 　Moderator: Osamu Sato

Hydrocephalus research update-controversies in definition and classification of hydrocephalus

Shizuo OiDepartment of Neurosurgery Women’s & Children’s Medical Center, Tokyo Jikei University

15 : 50-16: 50

■ Symposium 4 (Invited) 　Moderators: Chikafusa Kadowaki, Mitsuto Mase

12 Noninvasive estimation of intracranial compliance in idiopathic NPH using MRIMase M, Miyachi T, Kasai H, Demura K, Osawa T, Hara M, Shibamoto Y, Yamada KDepartment of Neurosurgery and Restorative Neuroscience, Graduate School of Medical Sciences, Nagoya City University

13 Lumboperitoneal shunt placement using computed tomography and fluoroscopy in conscious patients

Nakajima M, Bando K, Miyajima M, Arai HDepartment of Neurosurgery, Juntendo University, Tokyo

14 The Review of Published Papers from Japan. From 2001 to PresentMasaki Shinoda, Motoharu Fujii, Daisuke Yamamoto, Atsushi Murakata, Hidetoshi Matsukawa, Ryoichi IshikawaDepartment of Neurosurgery St. Luke’s International Hospital

15 Guideline for Fetal Hydrocephalus (COE-Fetal Hydrocephalus Top 10 Japan)Shizuo Oi 1), Takayuki Inagaki 2), Shigeki Ono 3), Isao Date 3), Satoshi Takahashi 4)

1) Department of Neurosurgery Women’s & Children’s Medical Center, Tokyo Jikei University, 2) Department of Neurosurgery, Kansai Medical University, 3) Department of Neurosurgery, Okayama University, 4) Department of Neurosurgery, Keio University

16 : 50-17: 20

　Program Chairman Lecture 　Moderators: Shizuo Oi

Research of Congenital Hydrocephalus. Present and Future PerspectiveTakayuki InagakiDepartment of Neurosurgery, Kansai Medical University

17:20- Information of 4th Annual Meeting of JSFCSF by Hiroji Miyake17:25- Closing Remark: Shizuo Oi　President of the Society

��J. Hydrocephalus, Vol. 2, No. 3 2010

Symposium 1

1杏林大学脳神経外科の 2010 年における成人水頭症診療の現状と課題Current Treatment Strategy for Adult Hydrocephalus at Kyorin University Hospital

平岩直也 1），野口明男 1），門脇親房 2），塩川芳昭 1）

Naoya Hiraiwa 1), Akio Noguchi 1), Chikafusa Kadowaki 2), Yosiaki Shiokawa 1)

1）杏林大学医学部付属病院，2）杉並リハビリテーション病院

　【目的】杏林大学脳神経外科における成人水頭症診療について，その治療成績と課題を検討する【対象・方法】2006年 1月から 2010年 4月までに経験した 18歳以上の V-P shunt例 98症例を対象とし，水頭症の基礎疾患，診断，術式，デバイス選択，術後合併症の頻度などについて後方視的に検討した．【結果】対象は延べ 98症例（男 41

例，女 57例，平均年齢 62.9歳）で，基礎疾患は SAHが 60.2%，腫瘍 13.3%，ICH 9.2%，INPH 5.1%であった．臨床症状は意識障害が最も多く 77.3%，活動性低下 8.2%，歩行障害 14.4%，失禁 4.1%，頭痛 9.3%，発熱 5.2%であった．診断方法は，CT 58.3%，MRI 1%，脳槽造影 25.0%，シャント造影 3.1%，シャント閉塞・感染 8.3%であった．平均手術時間は 1時間 30分，穿刺部位は右側 67.0%，左側 33.0%，前角 8.2%，後角 91.8%，頭蓋形成術を伴うものは 14例であった．バルブ選択は STRATA®36.1%，proGAV®21.6%，Hakim®17.5%，Delta®15.5%であった．手術評価は CT上での各種 indexの測定を行った．術後合併症は感染 4例，AEDH 1例，急性閉塞 3例などであった．【考察】多くの症例が SAHや ICHによる二次性のものであり，診断方法は CTが多い傾向にあった．バルブ選択は，各社の圧可変式バルブが多かったが固定圧バルブとの差は認めなかった．合併症発生は，統計上低年齢・血管障害で優位に多かった．

2

水頭症手術における CHPV with or without SiphonGuard の比較検討Comparison of CHPV shunt sysrtem with or without SiphonGuard in treating Hydrocephalus patients

橋本正明，塚田利幸，吉田優也Masaaki Hashimoto, Toshiyuki Tsukada, Yuya Yoshida公立能登総合病院脳神経外科

　当院では 1993年より CHPVを使用しシャント手術を行ってきた．2003年より従来のシャントシステムに関わるOverdrainage （OD）問題を解決すべく，CHPV with SiphonGuard （SG）を主体として使用している．今回は 2次性くも膜下出血術後（SAH）および特発性正常圧水頭症（iNPH）症例に注目し，SG有無での合併症の状況を比較検討した．SAH群は 130例（CHPV/with SG = 103/21），iNPH群 180例（94/86）を対象とした．CHPV群ではSAH, iNPH群とも 8%の OD関連合併症を経験したが，with SG群では 2003年以降 7年の経過においても，現在のところ iNPH 1例にのみ recovery可能な硬膜下水腫を経験しているのみとなっており，OD問題はほとんど消失した良好な経過となっている．2003以降，起立歩行を術後ゴールとしている症例には原則 with SGで望んでおり，SG

使用率は SAH 79%，iNPH 100%で，合併症率も低下し CHPV with SGの有効性を実感している．今後の臨床試験において programmable valve with or without Anti-siphon device適否の問題が Outcome, 合併症，更には QOLの面からも明らかにされることを期待している．

抄　　録

�� J. Hydrocephalus, Vol. 2, No. 3 2010

3

Adjustable MIETHKE gravitational valve - ProGAV programmable valve 破損An Experience of Broken Shunt Valve: Adjustable MIETHKE gravitational Valve-ProGAV Programmable Valve

門脇親房 1, 3），新田勇介 2, 3），宮崎　寛 2, 3）

Chikafusa Kadowaki 1, 3), Yusuke Nitta 2, 3), Hiroshi Miyazaki 2, 3)

1）杉並リハビリテーション病院，2）久我山病院脳神経外科，3）杏林大学医学部脳神経外科

　水頭症に対して広く使われている可変圧バルブ，現在，わが国では 4種の可変圧バルブが流通し，それぞれについてのトラブルが報告されている．今回，ProGAV可変圧バルブにおいて，まったく圧が設定できなくなるトラブルを経験したので報告する．【症例】2009/10/28右中大脳動脈瘤破裂によるくも膜下出血を発症した 52歳の男性．その後，水頭症の合併に対する ProGAVシャントシステムを用いたシャント術を受け，2010/2/17から左マヒ及び高次脳機能障害に対する回復期リハビリテーションに入った．シャント当初の ProGAV設定圧は 16 cmH2O，当院入院時は 12 cmH2O．その後，脳室サイズの狭小化と正中構造のシャント側への偏移があり，3/17に 15 cmH2Oへ，5/12

に 17 cmH2Oと段階的に圧変更し，脳室サイズの拡張をみた．ところが，神経症状の悪化はないものの，6/11では4 cmH2Oに自然に変わっていた．同日，X線透視下にてバルブを確認したところ，本来ロックされる圧設定ローターがロックされず，小さな磁力であっても容易に設定圧が変わってしまうことが判明した．【結論】圧変更が簡単に出来ることが可変圧バルブの大きな利点であるが，その圧変更機構から問題となる強力な磁場環境による影響のみならず，何らかの外力もしくは不適切な操作によりバルブに加わりバルブ圧設定機構が壊れてしまうことがあることも，シャント後の経過をみる上で留意しておく必要がある．

4

心拍同期脳実質内水拡散係数（delta-ADC）の変動：特発性正常圧水頭症における検討The Measurement of Delta-ADC in the iNPH patients

大沢知士 1），間瀬光人 1），宮地利明 2），菅　博人 2），出村光一朗 1），笠井治昌 3），山田和雄 1） Tomoshi Osawa 1), Mituhito Mase 1), Toshiaki Miyachi 2), Hiroto Kan 2), Koichiro Demura 1), Harumasa Kasai 3), Kazuo Yamada 1)

1）名古屋市立大学大学院医学研究科脳神経外科学，2）金沢大学大学院医学系研究科保健学科，3）名古屋市立大学病院中央放射線部　

　【背景および目的】特発性正常圧水頭症（iNPH）の症状発現機序については，脳室拡大や間質性浮腫による物理学的あるいは代謝的な神経あるいは軸索機能障害などの関与が示唆されるが，依然明らかでない．本研究の目的はiNPHにおける脳実質内の水分子動態をMRIを用いて測定し，症状発現機序について検討することである．

【方法】対象は手術により症状の改善した iNPH確定例（iNPH群，n = 6）である．術前に 1.5T MRI装置を用い，前頭葉，側頭葉，後頭葉白質における局所の ADC（apparent diffusion coefficient）および delta-ADC値を得た．Delta-ADCとは 1心拍中の ADCの変動値で，心拍同期した diffusion echo planner imaging （b = 0, 1000 s/mm2）を行い，1心拍中20 phaseの ADC値の最大値と最小値の差を pixel by pixelに計算して求めた．対照として健常者（control群 , n = 12）にも同様の撮像を行い，両群を比較した．

【結果】iNPH群の delta-ADC値はコントロール群に比べ全領域で有意に高値であった．ADC値も同様に iNPH群の方が有意に大きかったが，有意差は delta-ADC値の方がより大きかった．Delta-ADCと ADC値の間には有意な相関関係は認められなかった．

【考察】delta-ADCと ADCは必ずしも類似の情報ではなく，ADCが主に細胞内外の水分量に依存するのに対し，delta-ADCは水の周期的変動や量に依存していると考えられる．

【結論】delta-ADCは iNPH群で有意に高値を示しており，iNPHにおける脳局所の水分動態の新たな指標として，さらに非侵襲的診断マーカーとしての可能性が示唆される．


5

NAT（Neural Activity Topography）解析を用いた特発性正常圧水頭症における CSF tap test による脳波変化の検討EEG Analysis using Neural Activity Topography in iNPH patients before and after CSF Tap Test

青木保典 1），數井裕光 1），石井良平 1），和田民樹 1），カヌエトレオニデス 1），岩瀬真生 1），武者利光 2），松崎晴康 2），今城　郁 3），山本大介 1），杉山博通 1），髙屋雅彦 1），野村慶子 1），吉山顕次 1），武田雅俊 1）　Ryohei Ishii 1), Yasunori Aoki 1), Hiromitsu Kazui 1), Tamiki Wada 1), Leonides Canuet 1), Masao Iwase 1), Toshimitsu Musha 2), Haruyasu Matsuzaki 2), Kaoru Imajo 3), Daisuke Yamamoto 1), Hiromichi Sugiyama 1), Masahiko Takaya 1), Keiko Nomura 1), Kenji Yoshiyama 1), Masatoshi Takeda 1)

1）大阪大学大学院医学系研究科精神医学教室，2）脳機能研究所，3）日本光電

　特発性正常圧水頭症（iNPH）は，歩行障害，認知障害，尿失禁を有するが，これらの症状が髄液短絡術により改善可能なため注目されている．脳波は，精神神経疾患の鑑別・病態把握に広く用いられているが，その目視による波形の判読には熟練を要する．NAT解析は，デジタル記録された脳波記録から脳波パワーの分散（パワーバリアンス）を計算し，これを健常者からのパワーバリアンスのずれとして Zスコア表示したもので，波形の同期性を定量化する解析法である．　今回我々は，CSF tap testにより症状改善が見られた definite iNPH患者 8名と iNPHが疑われたが CSF tap testにより症状改善が見られなかった possible iNPH患者 8名の CSF tap test前後の脳波 NAT解析を行った．その結果，症状改善群では，CSF tap test前後で，a，b帯域それぞれで前頭部のパワーバリアンスが減少し，かつ d帯域で後頭部のパワーバリアンスの増加が見られた．症状非改善群では，CSF tap test前後で，パワーバリアンスの有意な変化は見られなかった．また，CSF tap test前後の脳波パワー解析も行ったが，症状改善群において有意な変化は見られなかった．このことから，CSF tap testによる脳波の変化は脳波パワー変化としては現れないが，脳波の同期性に関連するパワーバリアンスの変化として現れることが明らかになった．具体的には，CSF tap testによって症状改善したiNPH患者群では，前頭部において主に a，b帯域のニューロン活動の同期性が増加し，かつ後頭部における d帯域のニューロン活動の同期性が減少した．この結果より両領域において，神経活動が改善した可能性が示唆された．今後さらに iNPHの症例数を増やして検討していく予定である．

[Key words] NAT解析，脳波，特発性正常圧水頭症，iNPH，Tap test


Symposium 2

6

奇形症候群に伴う脳室拡大に対する水頭症手術Treatment Strategy of Ventriculomegaly in the Patients with Multiple Anomaly Syndrome

原田敦子 1），西山健一 1），吉村淳一 1），山田謙一 2），岡本浩一郎 1），藤井幸彦 1）

Atsuko Harada 1), Kenichi Nishiyama 1), Junichi Yoshimura 1), Kenichi Yamada 2), Koichiro Okamoto 1), Yukihiko Fujii 1)

1）新潟大学脳研究所脳神経外科学分野，2）新潟大学脳研究所統合脳機能研究センター

　CT/MRI画像所見で脳室拡大を来す奇形症候群のなかには，診断や予後予測に苦慮する例が少なくない．発達遅滞を伴うことも多く，水頭症手術の適応と時期の判断が難しい．脳室拡大，発達遅滞に進行性頭囲拡大を伴った奇形症候群 3例の経験を報告し，水頭症手術のあり方を考察する．　症例 1は Sotos症候群と症候学的に診断された 2才男児．Sotos症候群は巨頭症を呈する症候群として知られ，出生前から始まる過成長，骨年齢の促進，特異顔貌，精神発達遅滞を特徴とする．進行性の頭囲拡大，発達遅滞がみられたため，生後 11ヶ月の時点で脳室腹腔短絡術（以下 VPS）を行った．術後お座りは可能となったが，重度発達遅滞がみられる．症例 2は Schinzel-Giedion症候群（以下 SGS）が症候学的に疑われる 6才男児．SGSは特異顔貌，全身骨の形態異常，腎泌尿器奇形，重度発達遅滞を呈する症候群である．出生時より頭囲拡大あり，頚定もみられないため，1才 5か月時に VPS施行．術後まもなく頚定，お座りが可能となり，現在独歩している．症例 3はSjögren-Larsson症候群（以下 SLS）と症候学的に診断された 9か月男児．SLSは脂質代謝異常により先天性魚鱗癬，痙性麻痺，重度発達遅滞を呈する症候群である．出生時より進行する頭囲拡大と CT所見で脳室拡大がみられているが，SLSの不良な機能予後に関する情報を伝えて以降はご家族が治療に消極的なため，現在まで経過観察となっている．　症例 1, 2では乳児期後期以降になって進行性頭囲拡大を理由に VPSを施行した結果，一定の効果を得た．重度の発達遅滞を来すとされる奇形症候群でも，水頭症手術を前向きに考慮すべき例もあると思われる．

7

水頭症と心肺合併症─タコつぼ型心筋症を呈した小児急性水頭症例の提示も併せて─Hydrocephalus Patient Associated with Cardio-Pulmonary Complication: Review of the Literature and Case Report

篠田正樹，藤井本晴，松川東俊，山本大輔，住吉壮介，村形　敦，石川陵一Masaki Shinoda, Motoharu Fujii, Hidetoshi Matsukawa, Daisuke Yamanoto, Sosuke Sumiyoshi, Atsushi Murakata, Ryoichi Ishikawa聖路加国際病院脳神経外科

　循環器疾患の合併は中枢神経系疾患においてしばしば認められるが，昨今中枢神経系疾患が主たる原因となりうる病態として注目を集めている概念にタコつぼ心筋症がある．拡張型・肥大型・拘束型などの心筋症に属さない分類不能心筋症の一つで，左室心尖部が収縮しなくなり，左室がタコつぼのような形態を呈する．ストレスによる心尖部の機能・収縮不全が一因ともいわれ，成人の脳血管障害などで多く報告されており，可逆性異常循環病態として中枢原性肺水腫との関連性も指摘されている．成人では前方循環の動脈瘤破裂によるくも膜下出血症例などが多く報告されている．第 4脳室拡大を合併した急性水頭症患者でタコつぼ心筋症・中枢原性肺水腫を合併した小児例自験例を提示しその病態を検討する．


8

水頭症におけるドーパミン作働性黒質─線条体路の機能的変化Functional Injury of Dopaminergic Pathway in Hydrocephalus

田代　弦Yuzuru Tashiro静岡県立こども病院脳神経外科　

　【目的】今回我々は，脳内神経伝達系の循環路，即ちサーキットとしての機能変化を観察するために，ドーパミン作働性黒質─線条体─黒質神経路を検索した．【方法】成人Wistar系ラット大槽内に 25%, 0.05 mlのカオリン水溶液を注入して水頭症を作成した．対象群としては同齢ラット大槽内へ，0.05 mlの生理食塩水を注入した．先ず黒質・線条体でのドーパミン免疫染色により産生機能の変化を観た．次いで前シナプス機能として，anatomical tracerを用いてドーパミンの軸索輸送の変化を，また後シナプス機能としてドーパミン D1, D2 受容体の変化を解析した．【結果】黒質内のドーパミン産生細胞は水頭症 4週間目のラットより減少し，8週目で著しく減少した．黒質─線条体路の tracer標識神経線維の数も同じく 4週目に減少し始め，8週目で著減した．線条体内の D1受容体は 2 ～ 4週目という早期に減り始めたのに対し，D2受容体は 8週目になって初めて優位に減少した．【結論】経時的な水頭症の進行に伴い，ドーパミン神経路において産生機能・軸索輸送・受容体全てに，時間的ズレが多少あるものの機能的変化を認めた．

9

Long-standing overt ventriculomegaly in adults（LOVA）と考えられた 3 症例に対する治療上の問題点The Problems in Treating Patients with Long-Standing Overt Ventriculomegary in Adauls (LOVA)

小野成紀，石田穣治，安原隆雄，黒住和彦，伊達　勲Shigeki Ono, Joji Ishida, Takao Yasuhara, Kazuhiko Kurozumi, Isao Date岡山大学大学院脳神経外科

　Long-standing overt ventriculomegaly in adults（LOVA）は Oi（J Neurosurg, 2000）らによって提唱された概念で，小児期以降に生じたと考えられる脳室拡大が成人期に軽微な頭痛や正常圧水頭症症状などで発症する，頭囲拡大を伴う水頭症と定義されている．本疾患では，シャントなどの治療により，硬膜下血腫や水腫などの合併症がおこりやすいことも知られており治療選択に難渋することも多い．今回我々は，最近，LOVA，あるいはその類似症例と考えられる 3症例を経験したので，その治療法について文献的考察を交えて考察する．症例 1は 20歳，男性．頭痛の精査で来院，CT，MRIにて側脳室，第三脳室の著明な拡大と中脳水道狭窄を認めたため，治療目的で入院となった．治療は第三脳室底開窓術を施行，術後，頭痛は軽快，脳室も縮小傾向となった．症例 2は 36歳，女性．羞明，頭重感，集中力のなさを主訴に来院．CT，MRIにて側脳室，第三脳室の著明な拡大と中脳水道狭窄を認めたため，第三脳室底開窓術を施行した．施行後より羞明，集中力のなさは消失したが低髄液圧症状を訴え，約 6カ月症状が継続した．その間，画像上は若干の脳室縮小を認めた．症例 3は 24歳，男性．小児期から軽度発達遅滞があった．性格変化，集中力のなさなどを主訴に来院．CT，MRIにて全脳室の著明な拡大を認めたため，Codman-Hakim programmable

vale, anti-siphon にて脳室─腹腔シャントを施行した．施行後，会話は流暢となり，性格も明るさを増したが，術後数日で低髄液圧症状を訴えるようになった．以上のように，長期にわたり進行した脳室拡大に対する治療法として原因によりシャントや第三脳室底開窓術が行われるが，軽微な脳圧変化による新たな症状の出現に対応可能な方策が求められると考えられた．


The Paradox of Hydrocephalus: Simplicity and Complexity

Michael Williams

Michael A. Williams, MD, FAAN is Medical Director of the Sandra and Malcolm Berman Brain & Spine Institute at Sinai Hospital of Baltimore. He was Chair of the American Academy of Neurology (AAN) Ethics, Law and Humanities Committee from 2003-2009. Dr. Williams received his MD and Neurology training at Indiana University Medical Center, finishing in 1989. After a fellowship in Neurosciences Critical Care at Johns Hopkins Hospital, he joined the Department of Neurology faculty in 1991 where he was an NCCU attending physician and also established the Adult Hydrocephalus Center. He served on the Johns Hopkins Hospital Ethics Committee from 1992-2007, and was Co-Chair from 1999-2007. He was on the John Hopkins University Bioethics Institute Faculty from 1996-2007. He moved to Sinai Hospital in 2007 to become Medical Director of the Brain & Spine Institute, where he also established and directs their Adult Hydrocephalus Program. Dr. Williams’ research and publications in hydrocephalus represent the systematic analysis of specialized clinical care, and include demonstration of best methods for diagnosing normal pressure hydrocephalus (NPH), evidence that there is significant recovery with treatment; descriptions of new syndromes, the use of physiologic monitoring to diagnose hydrocephalus and related disorders, and demonstration of the national economic impact of treating or not treating NPH. He co-chaired the first-ever NINDS Workshop on hydrocephalus in 2005, and was on the steering committee for the 2009 NINDS and Hydrocephalus Association supported conference, “Improving outcomes in hydrocephalus: Bridging the gap between basic science and clinical management”. In 2008, he helped create the International Society for Hydrocephalus and CSF Disorders, and hosted their first scientific conference in September 2009. He has either taught or been director for courses related to hydrocephalus and disorders of intracranial pressure at the American Academy of Neurology (AAN) annual meeting for many years. He is actively involved in patient advocacy with the Hydrocephalus Association, and is a member of the Scientific Advisory Panel to the Intracranial Hypertension Research Foundation. While Chair of the AAN’s ELHC, he led the development of updated AAN guidelines for the physician expert witness, an AAN position statement on laws and regulations concerning life-sustaining treatment, including artificial nutrition and hydration, and the addition to the AAN Code of Professional Conduct of a prohibition against neurologist participation in legally authorized executions. Since 2005, he has been the Associate Editor for Ethics for Continuum: Lifelong Learning in Neurology, the American Academy of Neurology’s self-study continuing medical education publication. Dr. Williams has served on advisory committees for the Institute of Medicine, the U.S. Department of Health and Human Services, and the United Network for Organ Sharing. He has given invited lectures at the American Bar Association, the National Academy of Elder Law Attorneys, and at AAAS/Dana Foundation-sponsored Judicial Seminars on Emerging Issues in Neuroscience.

Special Lecture 1


Symposium 3

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Efficacy of intraoperative irrigation with saline for preventing shunt infection

Hayashi T, Shirane R, Yokosawa M, Kimiwada T, Tominaga TDepartment of Neurosurgery, Miyagi Children’s Hospital, Sendai

OBJECT: The rate of infection following shunt procedures is unacceptably high. The authors have hypothesized that the key to reducing the shunt infection rate is in reducing bacteria in the operating field and wound. This hypothesis has been tested in a prospective nonrandomized controlled manner. METHODS: Data obtained in all patients undergoing shunt insertions or revisions for hydrocephalus performed between October 1, 2003, and June 12, 2009, were reviewed. Starting in August 2006, we began routinely irrigating the operating field and wound with saline solution from a syringe. Prior to this, we had not used any irrigation techniques, providing an adequate control group (Group A) for the effect of the irrigation technique. Prior to November 2007, we used saline containing amikacin for irrigation (Group B). After that date, we used saline only for irrigation (Group C). RESULTS: A total of 150 shunt procedures were performed in 79 girls and 71 boys during the study period. The mean age of all patients was 44.0 +/- 59.1 months. Groups A, B, and C comprised 61, 40, and 49 shunt procedures, respectively. There was no statistical difference in age among the 3 groups. Nine infections occurred within 90 days in the postoperative period. The overall infection rate was 6.0%. Eight infections occurred before introducing the irrigation procedure (infection rate 13.1%). One infection was noted after introducing irrigation (Group B [0.0%] + Group C [2.0%]; combined B and C infection rate = 1.1%). There was a statistical difference in the infection rate between Group A and Groups B and C combined (p = 0.003), Groups A and B (p = 0.021), and Groups A and C (p = 0.035). In contrast, no statistical difference was observed between Groups B and C (p > 0.99). Six of the 9 infections were due to staphylococcal species. CONCLUSIONS: An irrigation technique used to reduce bacteria in the operating field and wound is effective for preventing shunt infection. Irrigation alone, and not antibiotics, contributed to the prophylaxis of shunt infection.

11

Analysis of neuronal cell death in the cerebral cortex of H-Tx rats with compensated hydrocephalus

Nonaka Y, Miyajima M, Ogino I, Nakajima M, Arai HDepartment of Neurosurgery and Research Institute for Diseases of Old Age, Juntendo University School of Medicine

OBJECT: Some cases of compensatory hydrocephalus have been reported in which cognitive deficiency progresses despite the absence of progressive ventricular dilation. In this study, the differentially expressed genes in compensated hydrocephalic H-Tx rat cortices were determined. A molecular mechanism that induces neuronal death in the cerebral cortex of compensated hydrocephalus is proposed. METHODS: The cerebral cortices of 8-week-old H-Tx rats with spontaneously arrested hydrocephalus (hH-Tx) and nonhydrocephalic H-Tx (nH-Tx) control rats were subjected to cDNA microarray analysis followed by canonical pathway analysis. RESULTS: In the hH-Tx rats, many genes in the amyloidal processing pathway showed altered expression, including Akt3 and p38 MAPK. These latter genes are involved in tau protein phosphorylation, and their increased expression in hydrocephalus was confirmed by real-time polymerase chain reaction analysis. Immunohistological and immunoblot analysis revealed elevated phosphorylated tau expression in the cerebral cortex neurons of the hH-Tx rats. CONCLUSIONS: The accumulation of phosphorylated tau protein in the cerebral cortex may be one of the mechanisms by which later cognitive dysfunction develops in patients with compensated hydrocephalus. More work needs to be done to determine if the accumulation of phosphorylated tau in the cortex can help predict which patients may decompensate thus requiring more aggressive treatment for compensated hydrocephalus.


Lesson learned in clinical trials in pediatric hydrocephalus

John KestleDepartment of Neurosurgery, Primary Children’s Medical Center, University of Utah

John Kestle was born in Toronto and educated at the University of Western Ontario (BSc Biology 1980; MD 1984) and at McMaster University (MSc, Epidemiology and Biostatistics 1989). He did a surgical internship at St. Michael’s Hospital in Toronto (1984-1985) before training in neurosurgery at the University of Toronto. At the end of neurosurgical training, he completed a six month fellowship in peripheral nerve surgery with Drs. Alan Hudson and Susan McKinnon and a one year fellowship in pediatric neurosurgery at the Hospital for Sick Children in Toronto. Dr. Kestle joined the faculty of the University of British Columbia in 1992 and was on the Surgical staff at British Columbia’s Children’s Hospital in Vancouver for six years. In 1998, he joined the faculty at the University of Utah and Primary Children’s Medical Center. He is currently Professor of Neurosurgery and Chief of the Division of Pediatric Neurosurgery. His clinical practice has been exclusively in pediatric neurosurgery with a specific interest in pediatric epilepsy surgery. His research is in clinical trials methodology and he has developed a multi-center network for running clinical trials in pediatric neurosurgery. He is Chair of the Hydrocephalus Clinical Research Network, a network for clinical research in hydrocephalus with seven participating centers and a data center in Salt Lake City. He has published 120 articles and chapters. He mentors neurosurgical residents in the MPH program in clinical research methods, epidemiology and biostatistics.

Hydrocephalus research update-controversies in definition and classification of hydrocephalus

Shizuo OiDepartment of Neurosurgery Women’s & Children’s Medical Center, Tokyo Jikei University

Classification of hydrocephalus is the most crucial but the most complicated academic challenge within the hydrocephalus research field. The major difficulty in this challenge arises from the fact that the classification is based on almost all subjects in hydrocephalus research, i.e., definition and terminology of hydrocephalus, pathophysiology, hydrocephalus chronology, specific forms of hydrocephalus, associated congenital anomalies/syndrome and underlying conditions, diagnostic procedures for hydrocephalus, and treatment modalities in hydrocephalus. The current status of the classification of hydrocephalus in individual subgroups was reviewed and summarized from publications in the last 60 years (1950-2010), and discussed focusing on the variety of characteristics in hydrocephalus, with more and more new aspects recently disclosed not only in fetal and pediatric but also in adult hydrocephalus. A recently-reported classification of hydrocephalus, “Multi-categorical Hydrocephalus Classification” provides comprehensive coverage of the entire aspects of hydrocephalus with current important classification categories and subtypes.

Presidential Address

Special Lecture 2


Symposium 4

12

Noninvasive estimation of intracranial compliance in idiopathic NPH using MRI

Mase M, Miyachi T, Kasai H, Demura K, Osawa T, Hara M, Shibamoto Y, Yamada KDepartment of Neurosurgery and Restorative Neuroscience, Graduate School of Medical Sciences, Nagoya City University

BACKGROUND: The pathophysiology of idiopathic normal pressure hydrocephalus (I-NPH) is still unclear and the diagnosis is sometimes difficult. The aim of this study was to assess the biophysics of I-NPH by measuring intracranial compliance using cine MRI. METHODS: The study included patients with I-NPH (I-NPH group, n = 13), brain atrophy or asymptomatic ventricular dilation (VD group, n = 10), and healthy volunteers (control group, n = 13). Net blood flow (bilateral internal carotid and vertebral arteries and jugular veins) and cerebrospinal fluid (CSF) flow in the subarachnoid space at the C2 cervical vertebral level were measured using phase-contrast cine MRI. CSF pressure gradient (PG (p-p)) and intracranial volume changes (VC (p-p)) during a cardiac cycle were calculated. FINDINGS: The compliance index (CI = VC (p-p)/PG (p-p)) in the I-NPH group was significantly lower than in the control and VD groups, whereas no difference was found between the control and VD groups. CI values of I-NPH patients after the tap test were larger than those before. These results clearly show that the intracranial compliance of I-NPH is relatively low compared to that of brain atrophy or normal subject. The increase of CI after a tap test also supports this finding. CONCLUSIONS: It is possible to estimate intracranial compliance as CI non-invasively using cine MRI. CI could become a useful method for the diagnosis of I-NPH.

13

Lumboperitoneal shunt placement using computed tomography and fluoroscopy in conscious patients

Nakajima M, Bando K, Miyajima M, Arai HDepartment of Neurosurgery, Juntendo University, Tokyo

The authors have developed a minimally invasive lumboperitoneal shunt placement procedure conducted after administration of a local anesthetic. The procedure involves placing a guide wire and a peel-away sheath under fluoroscopic and CT guidance. Between June 2004 and August 2006, 40 patients (21 men and 19 women; mean age 72.5 years [range 33-86 years]) underwent surgery. A Codman Hakim programmable valve system (82-3844, Codman & Shurtleff, Inc.) was used for the procedure. The mean operating time was 53 minutes, and 7 patients (17.5%) developed shunt dysfunction complications. These complications comprised an infected shunt valve in 2 patients, postoperative lower-limb pain in 1 patient, and shunt obstruction (caused by debris and hemorrhage) at the ventral and lumbar ends in 2 patients each. This procedure is less invasive than conventional lumboperitoneal shunt insertion and could be performed as an outpatient surgery for treatment of idiopathic normal-pressure hydrocephalus.


14

2001 年以降の日本発の髄液・水頭症関連論文The Review of Published Papers from Japan. From 2001 to Present

篠田正樹，藤井本晴，山本大輔，村形　敦，松川東俊，石川陵一Masaki Shinoda, Motoharu Fujii, Daisuke Yamamoto, Atsushi Murakata, Hidetoshi Matsukawa, Ryoichi Ishikawa聖路加国際病院脳神経外科

　日本水頭症脳脊髄液学会設立の目的の一つに，若い水頭症研究者が研究に夢を持てるような素地を作るということがある．そのためには，今後も日本から優秀な論文が発信されることが望まれる．日本からはいままでにも世界的に評価の高い論文報告がされている．会設立に当たり，日本の論文レビューを行ったが，今回は 2001年以降2010年 10月までの日本発の水頭症関連論文 257編（English literatureに限る）について Reviewを行った．本レビューでは 2例以下の症例報告は除外した．現在の日本の水頭症研究の現状について報告する．

15

先天性水頭症の前方視的多施設共同調査（COE-Fetal Hydrocephalus Top 10 Japan）によるガイドラインGuideline for Fetal Hydrocephalus (COE-Fetal Hydrocephalus Top 10 Japan)

大井静雄 1），稲垣隆介 2），小野成紀 3），伊達　勲 3），高橋里史 4）

Shizuo Oi 1), Takayuki Inagaki 2), Shigeki Ono 3), Isao Date 3), Satoshi Takahashi 4)

1）東京慈恵会医科大学脳神経外科，2）関西医科大学脳神経外科，3）岡山大学医学部脳神経外科，4）慶應義塾大学医学部脳神経外科

　本年度までに行った前方視的多施設共同調査の結果を報告するとともに，ガイドラインにつき検討を加え報告する．

先天奇形に伴う水頭症研究，今後の展望Research of Congenital Hydrocephalus. Present and Future Perspective

稲垣隆介Takayuki Inagaki関西医科大学付属枚方病院

　著者が今までに行ってきた水頭症研究の一部を報告するとともに（主に Hy-3マウス，Spdマウス，脊髄髄膜瘤に合併する水頭症の発症原因に関する研究など），日本の水頭症研究，特に世界における位置づけ，さらには今後の展望について報告する．

Program Chairman Lecture


Hydrocephalus ResearchWorld Record Ranking

1950-2008

水頭症研究世界歴代ランキング “Hydrocephalus” Original English papers publication as the “fi rst author” Data Base : Pub MedPeriod : 1950-2008Date of Retrieval : November 27, 2008On- line searching formula : hydrocephalus [majr] Limits: Publication Date from 1950, Journal Article, EnglishTotal Number : 7,494 papers “Cerebrospinal Fluid” original English papers publication as the “fi rst author” Data Base : Pub MedPeriod : 1950-2008Date of Retrieval : December 2, 2008On-line searching formula : “cerebrospinal fl uid” [majr] Limits: Publication Date from 1950, Journal Article, EnglishTotal Number : 4,901 papers * Confirmed by “Hydrocephalus Research World Record Ranking” [HRWRR] committee of “Journal of Hydrocephalus”.** Submission by the fi rst author of any other original English paper (s), which is (are) not cited by the above on-line search formula, shall be accepted with approval of the HRWRR Committee. (See the submission guideline)

World Academy of Hydrocephalus

World Academy of Hydrocephalus


“Hydrocephalus”1950-2008

17 11 47 8 76 6 107 5

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d

Hydrocephalus Research World Record Ranking

Rank First Author Papers Rank First Author Papers Rank First Author Papers Rank First Author Papers

1 J. Lorber 30 31 M. A. Poca 9 76 A. N. Guthkelch 6 107 C. Raftopoulos 52 H. C. Jones 25 31 M. Bergsneider 9 76 B. K. Owler 6 107 C. Sainte-Rose 52 S. Oi 25 31 N. Buxton 9 76 B. Tew 6 107 D. F. Kohn 54 M. R. Del Bigio 24 31 P. M. Black 9 76 C. Wikkelso 6 107 D. Goh 55 C. Di Rocco 22 31 R. S. Tubbs 9 76 D. Yashon 6 107 D. M. Frim 55 U. Meier 22 31 S. E. Borgesen 9 76 F. A. Chervenak 6 107 E. Alexander, Jr. 57 T. H. Milhorat 21 31 W. G. Bradley, Jr. 9 76 H. Miyake 6 107 E. R. Cardoso 58 K. M. Laurence 19 47 A. Mohanty 8 76 J. Malm 6 107 F. Takei 59 A. E. James, Jr. 18 47 A. Sahar 8 76 J. R. Kestle 6 107 G. S. Liptak 5

10 K. Mori 15 47 C. M. Bannister 8 76 L. Granholm 6 107 H. Hamada 511 E. L. Foltz 14 47 D. D. Matson 8 76 M. Castro-Gago 6 107 H. J. Hoffman 511 H. L. Rekate 14 47 F. Epstein 8 76 M. Gangemi 6 107 H. Kalter 513 E. Fernell 13 47 H. L. Brydon 8 76 M. Mataro 6 107 J. Jansen 513 H. E. James 13 47 P. Klinge 8 76 M. Michejda 6 107 J. Ransohoff 515 A. J. Raimondi 12 47 R. H. Pudenz 8 76 M. Tullberg 6 107 J. Sotelo 515 R. Bayston 12 47 R. O. Weller 8 76 N. Aoki 6 107 J. Vanneste 517 A V K lk iA. V. Kulkarni 11 47 S H kiS. Hakim 8 76 N T kiN. Tamaki 6 107 K OkK. Oka 517 A. Whitelaw 11 47 U. Kehler 8 76 P. Upadhyaya 6 107 K. P. Braun 517 J. E. Scarff 11 47 W. Serlo 8 76 P. W. Hanlo 6 107 K. Shulman 517 J. H. Piatt, Jr. 11 59 G. Kaiser 7 76 R. J. Edwards 6 107 K. Welch 517 J. H. Salmon 11 59 I. K. Pople 7 76 R. Kumar 6 107 M. A. Barnes 517 M. Czosnyka 11 59 J. F. Martinez-Lage 7 76 T. Fukuhara 6 107 M. J. Fritsch 523 D. B. Shurtleff 10 59 J. M. Fletcher 7 76 T. Lundar 6 107 M. Matsumae 523 G. A. Bateman 10 59 J. P. McAllister, 2n 7 76 T. P. Naidich 6 107 M. Vinchon 523 G. Cinalli 10 59 J. T. Tans 7 76 T. Takano 6 107 P. L. Longatti 523 G. M. Hochwald 10 59 M. Dennis 7 76 V. Etus 6 107 P. S. Sorensen 523 H. Yamada 10 59 M. Jouet 7 76 W. J. Gardner 6 107 P. W. Hayden 523 J. K. Krauss 10 59 M. Kiefer 7 76 Y. Ersahin 6 107 R. J. Hudgins 523 J. M. Drake 10 59 M. Tisell 7 107 A. B. Jamjoom 5 107 R. T. Johnson 523 P. K. Eide 10 59 N. G. Harris 7 107 A. Hill 5 107 S. Nakamura 531 A. Adeloye 9 59 N. R. Graff-Radfor 7 107 A. J. Boon 5 107 S. S. Nadvi 531 D. C. McCullough 9 59 P. Steinbok 7 107 A. R. Hansen 5 107 S. Tuli 531 D. G. McLone 9 59 R. F. Jones 7 107 B. Hagberg 5 107 T. Barreca 531 E. P. Strecker 9 59 S. C. Stein 7 107 B. Magnaes 5 107 T. Greitz 531 F. Jensen 9 59 S. Duckett 7 107 B. Simms 5 107 T. Lopponen 531 H. Andersson 9 59 S. Sood 7 107 B. Vachha 5 107 V. Rohde 531 H. D. Portnoy 9 76 A. L. Amacher 6 107 B. Williams 5 107 W. H. Clewell 531 J. L. Emery 9 76 A. Larsson 6 107 C. B. Wilson 531 K. Shapiro 9 76 A. Marmarou 6 107 C. Cedzich 5

Journal of HydrocephalusWorld Academy of Hydrocephalus


“Cerebrospinal Fluid”1950-2008

“Cerebrospinal Fluid”

1950-2008Rank First Author Papers Rank First Author Papers Rank First Author Papers

1 H. Davson 18 37 C. Nilsson 5 65 G. Du Boulay 42 A. A. Artru 17 37 D. Oreskovic 5 65 H. Al-Sarraf 43 M. Spiegel-Adolf 14 37 D. R. Enzmann 5 65 H. F. Cserr 43 O. Gilland 14 37 E. M. Wright 5 65 H. L. Rekate 45 E. A. Bering, Jr. 10 37 G. Di Chiro 5 65 H. M. Canelas 45 W. W. Tourtellotte 10 37 H. D. Portnoy 5 65 H. Takizawa 47 B. Vigh 9 37 H. Link 5 65 J. B. Green7 E. Kovacs 9 37 I. Johnston 5 65 J. B. Rubin 47 M. W. Bradbury 9 37 I. R. Cameron 5 65 J. Booij 4

10 A. Sahar 8 37 J. Bekaert 5 65 J. D. Miller 410 B. P. Vogh 8 37 J. Clausen 5 65 J. De Reuck 410 G. M. Hochwald 8 37 J. D. Fenstermacher 5 65 J. P. Lakke 410 O. Sato 8 37 J. G. McComb 5 65 K. G. Go 414 A. Chodobski 7 37 K. Welch 5 65 K. Jensen 414 B. Mokri 7 37 L. Odessky 5 65 K. Ono 414 D. G. Potts 7 37 M. Czosnyka 5 65 M. Boulton 414 H. W. Ryder 7 37 M. Javid 5 65 M. C. Chamberlain 414 M. Lindvall 7 37 M. Oehmichen 5 65 M. Johnston 414 P. P. Harnish 7 37 P. H. Hashimoto 5 65 M. Kosteljanetz 414 R. A. Fishman 7 37 R. Grant 5 65 M. Lindvall-Axelss

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o 414 S. Javaheri 7 37 R. J. Schain 5 65 M. Sandberg-Wollheim 414 T. H. Maren 7 37 R. M. Schmidt 5 65 N. H. Bass 423 A. E. James, Jr. 6 37 R. Sornas 5 65 P. Cinque 423 A. Lithander 6 37 R. W. Cutler 5 65 P. Winkler 423 A. N. Martins 6 37 W. W. Oppelt 5 65 R. A. Bhadelia 423 D. Greitz 6 65 A. Saifer 4 65 R. A. Mitchell 423 D. J. Reed 6 65 B. K. Siesjo 4 65 R. K. Jakoby 423 H. C. Jones 6 65 B. L. Wise 4 65 R. Spector 423 H. G. Sullivan 6 65 B. Williams 4 65 S. Bogoch 423 I. Vigh-Teichmann 6 65 C. B. Wilson 4 65 S. H. Bigner 423 J. R. Pappenheimer 6 65 C. M. Plum 4 65 S. Nakamura 423 J. W. Severinghaus 6 65 D. Bowsher 4 65 S. R. Heisey 423 M. Farstad 6 65 D. G. Davies 4 65 T. O. Kleine 423 M. Pollay 6 65 E. F. Rabe 4 65 V. Kronholm 423 R. E. Albright, Jr. 6 65 E. Roboz 4 65 W. G. Bradley, Jr. 423 T. H. Milhorat 6 65 F. Garcia-Bengochea 4 65 W. H. Sweet37 A. Guseo 5 65 F. H. Sklar 4 65 W. I. Schievink 437 A. Marmarou 5 65 F. Plum 4 116 A. Ames, 3rd 337 A. V. Lorenzo 5 65 F. R. Domer 4 116 A. B. Butler 3

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22J. Hydrocephalus Volume 1 / Number 1 / May 2009

Journal of Hydrocephalus World Academy of Hydrocephalus


Rank First Author Papers Rank First Author Papers Rank First Author Papers116 A. D. Dayan 3 116 J. E. O'Connell 3 116 S. E. Borgesen 3116 A. K. Datta 3 116 J. L. Melnick 3 116 S. Majcherczyk 3116 A. Lowenthal 3 116 J. L. Sherman 3 116 S. Pelc 3116 A. Migliore 3 116 J. Lofgren 3 116 S. Seyfert 3116 A. N. Salt 3 116 J. M. Pearce 3 116 T. Ishibashi 3116 A. Naess 3 116 J. N. Cumings 3 116 T. J. Seabrook 3116 A. Peter 3 116 J. R. Atkinson 3 116 T. Lundar 3116 A. Petzold 3 116 J. Sedlacek 3 116 U. Ponten 3116 A. Pfefferbaum 3 116 K. Higashi 3 116 V. Fencl 3116 A. Walsted 3 116 K. Shulman 3 116 V. Kurtcuoglu 3116 A. Zakharov 3 116 L. Berg 3 116 W. A. Bonadio 3116 B. M. Greenwood 3 116 M. A. Maktabi 3 116 W. E. Stern 3116 C. P. Maurizi 3 116 M. A. Stoodley 3 116 W. F. House 3116 D. A. Nixon 3 116 M. B. Bowers, Jr. 3 116 W. H. Oldendorf 3116 D. G. Gomez 3 116 M. B. Segal 3116 D. G. McDowall 3 116 M. Buckell 3116 D. H. Harter 3 116 M. C. Calhoun 3116 D. K. Anderson 3 116 M. C. Henry-Feugea 3116 D. W. Palmer 3 116 M. D. Deck 3116 E. Appel 3 116 M. G. Marrosu 3116 E. E. Nattie 3 116 M. H. Wykoff 3116 E. G. Pavlin 3 116 M. J. Madonick 3116 E. P. Strecker 3 116 M. Pashenkov 3116 G. A. Rosenberg 3 116 M. R. Patel 3116 G. Bergstrand 3 116 M. W. Brightman 3116 G. Brocklehurst 3 116 O. Baledent 3116 G. D. Silverberg 3 116 P. C. Doherty 3116 G. Magram 3 116 P. E. Manconi 3116 G. Nagra 3 116 P. G. Osborne 3116 G. Schroth 3 116 P. Gideon 3116 H. H. Loeschcke 3 116 P. Kivisakk 3116 H. J. Safi 3 116 P. M. Black 3116 H. L. Rosomoff 3 116 R. G. Petersdorf 3116 H. S. Chang 3 116 R. H. Wilkins 3116 I. Leusen 3 116 R. K. Parkkola 3116 J. B. Posner 3 116 R. Katzman 3116 J. D. Mann 3 116 R. S. Bourke 3116 J. De Bersaques 3 116 S. Angelow 3116 J. E. Guinane 3 116 S. C. Wayte 3



“Hydrocephalus” Original English papers published as the “first author” (Nov.27, 2008) Ranking No.1-No.10

cran bifid l

#2 1985 and resistance l 90 0014-4886

"Hydrocephalus" Original English papers published as the "first author"(Nov.27,2008) Ranking No.1-No.47 (676 papers)

Rank Author No Year Title Journal Vol Pages ISBN/ISSN

1 J. Lorber #1 1961 The diagnosis and management of hydrocephalus in infancy N Z Med J 60 416-8 0028-8446(Print)

J. Lorber #2 1961 Systematic ventriculographic studies in infants born with meningomyelocele andencephalocele. The incidence and development of hydrocephalus

Arch DisChild

36 381-9 0003-9888(Print)

J. Lorber #3 1964 Two cases of achondroplasia Proc R SocMed

57 836-7 0035-9157(Print)

J. Lorber #4 1964 Spina bifida cystica. Heredit ary features Nurs Times 60 411-2 0954-7762(Print)

J. Lorber;J. L. Emery #5 1964 Intracerebral cysts complicating ventricular needling in hydrocephalic infants: Aclinico-pathological study

Dev MedChild Neurol

6 125-39 0012-1622(Print)

J. Lorber #6 1965 The family history of spina befida cystica Pediatrics 35 589-95 0031-4005(Print)

J. Lorber;U. Bassi #7 1965 The aetiology of neonatal hydrocephalus(Excluding cases with spina bifida) Dev MedChild Neurol

7 289-94 0012-1622(Print)

J. Lorber;D. Pickering #8 1966 Incidence and treatment of post-meningitic hydrocephalus in the newborn Arch DisChild

41 44-501468-2044(Electronic

J. Lorber #9 1967 Recovery of vision following prolonged blindness in children with hydrocephalusor following pyogenic meningitis

Clin Pediatr(Phila)

6 699-703

0009-9228(Print)

J. Lorber #10 1968 Puncture porencephaly Dev MedChild Neurol

10 233-4 0012-1622(Print)

J. Lorber #11 1968 The results of early treatment of extreme hydrocephalus Dev MedChild Neurol

Suppl16:21-9

0012-1622(Print)

J. Lorber;R. B. Zachary #12 1968 Primary congenital hydrocephalus. Long-term results of controlled therapeutictrial

Arch DisChild

43 516-271468-2044(Electronic

J. Lorber #13 1969Ventriculo-cardiac shunts in the first week of life. Results of a controlled trial inthe treatment of hydrocephalus in infants born with spina bifida cystica orcranium bifidumium um

Dev MedChild NeurolSupplSupp

20 13-22 0419-0238(Print)

J. Lorber;A. K. Tunstill #14 1969 The Sheffield Congenital Anomalies Research Unit Med BiolIllus

19 100-4 0025-6978(Print)

J. Lorber #15 1971 Medical and surgical aspects in the treatment of congenital hydrocephalus Neuropadiatrie

2 239-46 0028-3797(Print)

J. Lorber #16 1972 The use of isosorbide in the treatment of hydrocephalus Dev MedChild Neurol

27 87-93 0419-0238(Print)

J. Lorber #17 1973 Isosorbide in the medical treatment of infantile hydrocephalus J Neurosurg 39 702-11 0022-3085(Print)

J. Lorber #18 1973 Neonatal E. coli meningitis, hydrocephalus, respiratory distress syndrome, fullrecovery after temporary blindness

Proc R SocMed

66 221-2 0035-9157(Print)

J. Lorber;U. S. Bhat #19 1974 Posthaemorrhagic hydrocephalus. Diagnosis, differential diagnosis, treatment, andlong-term results

Arch DisChild

49 751-621468-2044(Electronic

J. Lorber #20 1975 Ethical problems in the management of myelomeningocele and hydrocephalus.The Milroy Lecture 1975

J R CollPhysicians

10 47-60 0035-8819(Print)

J. Lorber #21 1975 Isosorbide in the treatment of infantile hydrocephalus. Observations with a newdrug

Clin Pediatr(Phila)

14 916-9 0009-9228(Print)

J. Lorber #22 1975 Isosorbide in treatment of infantile hydrocephalus Arch DisChild

50 431-61468-2044(Electronic

J. Lorber #23 1976 The medical treatment of hydrocephalus using isosorbide Mod ProblPaediatr

18 178-80 0303-884X(Print)

J. Lorber #24 1976 Ethical problems in the management of myelomingocele and hydrocephalus. 2 Nurs Times 72 suppl:9-11

0954-7762(Print)

J. Lorber #25 1976 Ethical problems in the management of myelomeningocele and hydrocephalus-1 Nurs Times 72 suppl:5-8

0954-7762(Print)

J. Lorber #26 1981 Is your brain really necessary? Nurs Mirror 152 29-30 0029-6511(Print)

J. Lorber;V. Pucholt #27 1981 When is a shunt no longer necessary? An investigation of 300 patients withhydrocephalus and myelomeningocele: 11-22 year follow up

Z Kinderchir 34 327-9 0174-3082(Print)

J. Lorber;S. Salfield;T.Lonton

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2 H. C. Jones #1 1984 The development of congenital hydrocephalus in the mouse Z Kinderchir 39Suppl 2

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#7 1991 The cerebral cortex in congenital hydrocephalus in the H-Tx rat: a quantitativelight microscopy study

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#8 1993 Inherited hydrocephalus in H-Tx rat pups: treatment monitored with magneticresonance imaging

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H. C. Jones;M. Fagbohun #10 1994 The cranial vault in infantile hydrocephalus: changes in the skull bones in the H-Tx Rat

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#11 1995 Shunt treatment at two postnatal ages in hydrocephalic H-Tx rats quantified usingMR imaging

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#12 1995 Learning deficits in congenitally hydrocephalic rats and prevention by early shunttreatment

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#13 1996 Spatial learning and visual discrimination tests in hydrocephalic rat pupsperformed using the Morris water maze

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H. C. Jones;B. A. Lopman #16 1998 The relation between CSF pressure and ventricular dilatation in hydrocephalicHTx rats

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#18 2000 Progressive tissue injury in infantile hydrocephalus and prevention/reversal withshunt treatment

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#23 2003 Characteristics of hydrocephalus expression in the LEW/Jms rat strain withinherited disease

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U. Meier;J. Lemcke #19 2006Is it possible to optimize treatment of patients with idiopathic normal pressurehydrocephalus by implanting an adjustable Medos Hakim valve in combinationwith a Miethke shunt assistant?


U. Meier;J. Lemcke #20 2006 Clinical outcome of patients with idiopathic normal pressure hydrocephalus threeyears after shunt implantation


U. Meier;J. Lemcke #21 2006First clinical experiences in patients with idiopathic normal-pressurehydrocephalus with the adjustable gravity valve manufactured by Aesculap(proGAV(Aesculap))

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Bull

in 33

T. H. Milhorat #14 1974 Failure of choroid plexectomy as treatment for hydrocephalus SurgGynecol

139 505-8 0039-6087(Print)

T. H. Milhorat;M. K.Hammock;D. L. Breckbill

#15 1975 Acute unilateral hydrocephalus resulting from oedematous occlusion of foramenof Monro: complication of intraventricular surgery

J NeurolNeurosurg

38 745-8 0022-3050(Print)

T. H. Milhorat;J. E.McClenathan

#16 1975 Direct cardiac shunt for hydrocephalus of infancy and childhood. Technical note J Neurosurg 42 605-8 0022-3085(Print)

T. H. Milhorat;T. Chien;M.Majd;D. L. Breckbill

#17 1976 Unreliability of combined pneumoencephalography and scinticisternography J Nucl Med 17 54-6 0161-5505(Print)

T. H. Milhorat;M. K.Hammock;T. Chien;D. A.Davis

#18 1976 Normal rate of cerebrospinal fluid formation five years after bilateral choroidplexectomy. Case report J Neurosurg 44 735-9

0022-3085(Print)

T. H. Milhorat;M. K.Hammock;D. A. Davis;J.D. Fenstermacher

#19 1976 Choroid plexus papilloma. I. Proof of cerebrospinal fluid overproduction Childs Brain 2 273-890302-2803(Print)

T. H. Milhorat #20 1987 Acute hydrocephalus after aneurysmal subarachnoid hemorrhage Neurosurgery

20 15-20 0148-396X(Print)

T. H. Milhorat #21 1992 Classification of the cerebral edemas with reference to hydrocephalus andpseudotumor cerebri

Childs NervSyst

8 301-6 0256-7040(Print)

8 K. M. Laurence #1 1957 The urinary phenolsulphonphthalein (phenol red) excretion test in hydrocephalus Arch DisChild

32 413-6 0003-9888(Print)

K. M. Laurence #2 1958 The natural history of hydrocephalus Lancet 2 1152-4 0140-6736(Print)

K. M. Laurence #3 1959 Some applications of the urinary phenolsulphonphthalein excretion test inhydrocephalus and related conditions

Brain 82 551-65 0006-8950(Print)

K. M. Laurence #4 1959 The pathology of hydrocephalus Ann R CollSurg Engl

24 388-401

0035-8843(Print)

K. M. Laurence #5 1960 The natural history of hydrocephalus PostgradMed J

36 662-7 0032-5473(Print)

K. M. Laurence #6 1960 Infantile hydrocephalus: its diagnosis and natural history Q RevPediatr

15 5-12

K. M. Laurence #7 1960 Hydrocephalus and disability Cereb PalsyBull

2 170-9

K. M. Laurence #8 1960 Hydrocephalus and disability Cereb PalsyBull

2 170-9

K. M. Laurence;S. Coates #9 1962 Further thoughts on the natural history of hydrocephalus Dev MedChild Neurol

4 263-7 0012-1622(Print)

K. M. Laurence #10 1964 A case of unilateral megalencephalyC Dev MedChild Neurol

6 585-90 0012-1622(Print)

K. M. Laurence #11 1964 The natural history of spina bifida cystica: Detailed analysis of 407 cases Arch DisChild

39 41-57 0003-9888(Print)

K. M. Laurence #12 1966 The survival of untreated spina bifida cystica Dev MedChild Neurol

Suppl11:10-9

0012-1622(Print)

K. M. Laurence #13 1967 Brain damage in hydrocephalic patients Proc R SocMed

60 1265-6 0035-9157(Print)

K. M. Laurence;S. Coates #14 1967 Spontaneously arrested hydrocephalus. Results of the re-examination of 82survivors from a series of 182 unoperated cases

Dev MedChild Neurol

Suppl13:4-13

0012-1622(Print)

K. M. Laurence;C. O.Carter;P. A. David

#15 1968 Major central nervous system malformations in South Wales. II. Pregnancyfactors, seasonal variation, and social class effects

Br J PrevSoc Med

22 212-22 0007-1242(Print)

K. M. Laurence;C. O.Carter;P. A. David

#16 1968 Major central nervous system malformations in South Wales. I. Incidence, localvariations and geographical factors

Br J PrevSoc Med

22 146-60 0007-1242(Print)

K. M. Laurence #17 1969 Neurological and intellectual sequelae of hydrocephalus Arch Neurol 20 73-81 0003-9942(Print)

K. M. Laurence #18 1979 The biology of choroid plexus papilloma in infancy and childhood ActaNeurochir

50 79-90 0001-6268(Print)

K. M. Laurence #19 1984 Genetic aspects of "uncomplicated" hydrocephalus and its relationship to neuraltube defect

Z Kinderchir 39Suppl 2

96-9 0174-3082(Print)

9A. E. James, Jr.;F. H.DeLand;F. J. Hodges,3rd;H. N. Wagner, Jr.

#1 1970 Normal-pressure hydrocephalus. Role of cisternography in diagnosis JAMA 2131615-

220098-7484(Print)

A. E. James, Jr.;J. P.Dorst;E. S. Mathews;V. A. #2 1972 Hydrocephalus in achondroplasia studied by cisternography Pediatrics 49 46-9 0031-4005

(Print)

A. E. James, Jr.;P. F.New;E. R. Heinz;F. J.Hodges;F. H. DeLand

#3 1972 A cisternographic classification of hydrocephalus

Am JRoentgenolRadium TherNucl Med

115 39-490002-9580(Print)

A. E. James, Jr.;E. P.Strecker

#4 1973 Use of silastic to produce communicating hydrocephalus InvestRadiol

8 105-10 0020-9996(Print)

A. E. James, Jr.;E. P.Strecker;M. Bush

#5 1973 A catheter technique for the production of communicating hydrocephalus Radiology 106 437-9 0033-8419(Print)

A. E. James, Jr.;E. P.Strecker;G. Novak;B.Strecker;G. Novak;B.

#6 1973 Correlation of serial cisternograms and cerebrospinal fluid pressure measurementsin experimental communicating hydrocephalusexperimental communicating hydrocephalus

Neurology 23 1226-33

0028-3878(Print)(Print)

A. E. James, Jr.;W. J.Flor;M. Bush;T. Merz;B.

#7 1974 An experimental model for chronic communicating hydrocephalus J Neurosurg 41 32-7 0022-3085(Print)


Neurochirur 0028

(Print)

A. E. James, Jr.;W. J.Flor;T. Merz;E. P.Strecker;B. Burns

#8 1974 A pathophysiologic mechanism for ventricular entry of radiopharmaceutical andpossible relation to chronic communicating hydrocephalus


122 38-430002-9580(Print)

A. E. James, Jr.;E.Sperber;E. P. Strecker;C.Digel;G. Novak;M. Bush

#9 1974Use of serial cisternograms to document dynamic changes in the development ofcommunicating hydrocephalus: a clinical and experimental study

Acta NeurolScand

50 153-700001-6314(Print)

A. E. James, Jr.;E. P.Strecker;E. Sperber;W. J.Flor;T. Merz;B. Burns

#10 1974 An alternative pathway of cerebrospinal fluid absorption in communicatinghydrocephalus. Transependymal movement Radiology 111 143-6

0033-8419(Print)

A. E. James, Jr.;B.Burns;W. F. Flor;E. P.Strecker;T. Merz;M.

#11 1975 Pathophysiology of chronic communicating hydrocephalus in dogs (Canisfamiliaris). Experimental studies J Neurol Sci 24 151-78

0022-510X(Print)

A. E. James, Jr.;M. H.Epstein;T. C. Smith

#12 1975 In vitro measurement of respiration of choroid plexus cells in communicatinghydrocephalus

InvestRadiol

10 366-70 0020-9996(Print)

A. E. James, Jr.;M.Epstein;G. Novak;B. Burns

#13 1977 Evaluation of cerebrospinal fluid production in the development ofcommunicating hydrocephalus

Radiology 122 143-7 0033-8419(Print)

A. E. James, Jr.;W. J.Flor;G. R. Novak;E. P.Strecker;B. Burns;M.

#14 1977 Experimental hydrocephalus Exp Eye Res 25Suppl 435-59

0014-4835(Print)

A. E. James, Jr.;G.Novak;A. L. Bahr;B. Burns

#15 1977 The production of cerebrospinal fluid in experimental communicatinghydrocephalus

Exp BrainRes

27 553-7 0014-4819(Print)

A. E. James, Jr.;G. R.Novak;E. P. Strecker;W. J.Flor

#16 1977 The central canal of the spinal cord in experimental hydrocephalus: preliminaryresults Radiology 125 417-20

0033-8419(Print)

A. E. James, Jr.;W. J.Flor;G. R. Novak;E. P.Strecker;B. Burns

#17 1978Evaluation of the central canal of the spinal cord in experimentally inducedhydrocephalus J Neurosurg 48 970-4

0022-3085(Print)

A. E. James, Jr.;W. J.Flor;G. R. Novak;J. L.Ribas;J. L. Parker;W. L.

#18 1980 The ultrastructural basis of periventricular edema: preliminary studies Radiology 135 747-50 0033-8419(Print)

10 K. Mori;A. J. Raimondi #1 1975 Submicroscopic changes in the periventricular white matter of hydrocephalic chmouse

NipponGeka Hokan

44 159-68 0003-9152(Print)

K. Mori;H. Handa #2 1977 Subdural haematoma (effusion) and internal hydrocephalus Neurochirurgia (Stuttg)

20 154-61 0028-3819-3819(Print)

K. Mori;T. Murata;Y.Nakano;H. Handa

#3 1977 Periventricular lucency in hydrocephalus on computerized tomography Surg Neurol 8 337-40 0090-3019(Print)

K. Mori;H. Handa;T.Murata;Y. Nakano

#4 1980 Periventricular lucency in computed tomography of hydrocephalus and cerebralatrophy

J ComputAssist

4 204-9 0363-8715(Print)

K. Mori;K. Fujito;Y.Kamimura

#5 1984 Binding assay for muscarinic cholinergic receptors in kaolin inducedhydrocephalus

NipponGeka Hokan

53695-702

0003-9152(Print)

K. Mori;M. Morimoto;Y.Kamimura

#6 1985 Post-traumatic epidural hematoma in two patients with long-standing "arrested"hydrocephalus

Childs NervSyst

1 288-90 0256-7040(Print)

K. Mori #7 1990 Hydrocephalus--revision of its definition and classification with special referenceto "intractable infantile hydrocephalus"

Childs NervSyst

6 198-204

0256-7040(Print)

K. Mori;K. Tsutsumi;M.Kurihara;T. Kawaguchi;M.Niwa

#8 1990 Alteration of atrial natriuretic peptide receptors in the choroid plexus of rats withinduced or congenital hydrocephalus

Childs NervSyst

6 190-3 0256-7040(Print)

K. Mori;H. Miyake;M.Kurisaka;T. Sakamoto

#9 1993 Immunohistochemical localization of superoxide dismutase in congenitalhydrocephalic rat brain

Eur J PediatrSurg

3 Suppl1

35 0939-7248(Print)

K. Mori;H. Miyake;M.Kurisaka;T. Sakamoto

#10 1993 Immunohistochemical localization of superoxide dismutase in congenitalhydrocephalic rat brain

Childs NervSyst

9 136-41 0256-7040(Print)

K. Mori #11 1995 Current concept of hydrocephalus: evolution of new classifications Childs NervSyst

11523-31;discussi

0256-7040(Print)

K. Mori;J. Shimada;M.Kurisaka;K. Sato;K.Watanabe

#12 1995 Classification of hydrocephalus and outcome of treatment Brain Dev 17 338-480387-7604(Print)

K. Mori #13 2000 Actualities in hydrocephalus classification and management possibilities Neurol Res 22 127-30 0161-6412(Print)

K. Mori #14 2001 Management of idiopathic normal-pressure hydrocephalus: a multiinstitutionalstudy conducted in Japan


K. Mori;M. Maeda;S.Asegawa;J. Iwata

#15 2002Quantitative local cerebral blood flow change after cerebrospinal fluid removal inpatients with normal pressure hydrocephalus measured by a double injectionmethod with N-isopropyl-p-[(123)I] iodoamphetamine

ActaNeurochir(Wien)

144

255-62;discussion 262-

3

0001-6268(Print)

11 E. L. Foltz;D. B. Shurtleff #1 1963 Five-Year comparative study of hydrocephalus in children with and withoutoperation(113 cases)

J Neurosurg 20 1064-79

0022-3085(Print)

E. L. Foltz;D. B. Shurtleff #2 1966 Conversion of communicating hydrocephalus to stenosis or occlusion of theaqueduct during ventricular shunt


E. L. Foltz #3 1968 Hydrocephalus--the value of treatment South Med J 61 443-54 0038-4348(Print)

E. L. Foltz;R. Kronmal;D.B. Shurtleff

#4 1973 Chapter 10. To treat or not to treat: a neurosurgeon's perspective ofmyelomeningocele

ClinNeurosurg

20 147-63 0069-4827(Print)


“Cerebrospinal Fluid” Original English papers published as the “first author” (Dec.2, 2008) Ranking No.1-No.10

"Cerebrospinal Fluid" Original English papers published as the "first author" (Dec.2,2008) Ranking No.1-No.10 Rank Author No Year Title Journal Volume Pages ISBN/ISSN

1 H. Davson;C. Purvis #1 1954 Cryoscopic apparatus suitable for studies on aqueous humour and cerebro-spinalfluid J Physiol 124 12-3P

0022-3751(Print)

H. Davson;C. P. Luck #2 1955 The distribution of bicarbonate between aqueous humour, cerebrospinal fluid andplasma in several mammalian species J Physiol 130 48-9P 0022-3751

(Print)

H. Davson;C. P. Luck #3 1956 A comparative study of the total carbon dioxide in the ocular fluids, cerebrospinalfluid, and plasma of some mammalian species J Physiol 132 454-64

0022-3751(Print)

H. Davson;C. P. Luck #4 1957The effect of acetazoleamide on the chemical composition of the aqueous humourand cerebrospinal fluid of some mammalian species and on the rate of turnover of24Na in these fluids

J Physiol 137 279-93 0022-3751(Print)

H. Davson;H. V. Smith #5 1957 Physiological aspects of the penetration of drugs into the cerebrospinal fluid Proc R SocMed

50 963-6 0035-9157(Print)

H. Davson;C. R.Kleeman;E. Levin

#6 1962 Quantitative studies of the passage of different substances out of the cerebrospinalfluid

J Physiol 161 126-42 0022-3751(Print)

H. Davson;E. Spaziani #7 1962 Effect of hypothermia on certain aspects of the cerebrospinal fluid Exp Neurol 6 118-28 0014-4886(Print)

H. Davson #8 1963 The cerebrospinal fluid ErgebPhysiol

52 20-72 0080-2042(Print)

H. Davson;M. Pollay #9 1963 The turnover of 24Na in the cerebrospinal fluid and its bearing on the blood-brainbarrier

J Physiol 167 247-55 0022-3751(Print)

H. Davson;M. Bradbury #10 1965 The fluid exchange of the central nervous system Symp SocExp Biol

19 349-64 0081-1386(Print)

H. Davson #11 1966 Formation and drainage of the cerebrospinal fluidSci BasisMed AnnuRev

238-590080-7729(Print)

H. Davson;C. A. Purvis;M.B. Segal

#12 1969 Measurement of resistance to flow of cerebrospinal fluid J Physiol 202 62P-64P 0022-3751(Print)

H. Davson;M. B. Segal #13 1969 Effect of cerebrospinal fluid on volume of distribution of extracellular markers Brain 92 131-6 0006-8950(Print)

H. Davson;G.Hollingsworth;M. B. Segal

#14 1970 The mechanism of drainage of the cerebrospinal fluid Brain 93 665-78 0006-8950(Print)

H. Davson;M. B. Segal #15 1971 Secretion and drainage of the cerebrospinal fluid Acta NeurolLatinoam

1 ppl 1:99-0001-6306(Print)

H. Davson;K. Welch #16 1971 The permeation of several materials into the fluids of the rabbit's brain J Physiol 218 337-510022-3751(Print)

H. Davson #17 1972 Dynamic aspects of cerebrospinal fluidDev MedChild NeurolSuppl

27 1-160419-0238(Print)

H. Davson;F. R. Domer;J.R. Hollingsworth

#18 1973 The mechanism of drainage of the cerebrospinal fluid Brain 96 329-36 0006-8950(Print)

2 A. A. Artru;M. Nugent;J.D. Michenfelder

#1 1982 Enflurane causes a prolonged and reversible increase in the rate of CSFproduction in the dog

Anesthesiology

57 255-60 0003-3022(Print)

A. A. Artru;M. Nugent;J.D. Michenfelder

#2 1982 Closed recirculatory spinal subarachnoid perfusion for determining CSF dynamics J Neurosurg 56 368-720022-3085(Print)

A. A. Artru #3 1983 Effects of halothane and fentanyl on the rate of CSF production in dogs AnesthAnalg

62 581-5 0003-2999(Print)

A. A. Artru #4 1984 Effects of enflurane and isoflurane on resistance to reabsorption of cerebrospinalfluid in dogs

Anesthesiology

61 529-33 0003-3022(Print)

A. A. Artru #5 1984 Isoflurane does not increase the rate of CSF production in the dog Anesthesiology

60 193-7 0003-3022(Print)

A. A. Artru #6 1984 Effects of halothane and fentanyl anesthesia on resistance to reabsorption of CSF J Neurosurg 60 252-6 0022-3085(Print)

A. A. Artru;T. F. Hornbein #7 1986 Closed ventriculocisternal perfusion to determine CSF production rate andpressure

Am J Physiol 251 R996-9 0002-9513(Print)

A. A. Artru #8 1987 Reduction of cerebrospinal fluid pressure by hypocapnia: changes in cerebralblood volume, cerebrospinal fluid volume, and brain tissue water and electrolytes

J CerebBlood FlowMetab

7 471-90271-678X(Print)

A. A. Artru;T. F. Hornbein #9 1987 Prolonged hypocapnia does not alter the rate of CSF production in dogs duringhalothane anesthesia or sedation with nitrous oxide

Anesthesiology

67 66-71 0003-3022(Print)

A. A. Artru #10 1988Dose-related changes in the rate of cerebrospinal fluid formation and resistance toreabsorption of cerebrospinal fluid following administration of thiopental,midazolam, and etomidate in dogs

Anesthesiology

69 541-6 0003-3022(Print)

A. A. Artru #11 1988 Muscle relaxation with succinylcholine or vecuronium does not alter the rate ofCSF production or resistance to reabsorption of CSF in dogs

Anesthesiology

68 392-60003-3022(Print)

A. A. Artru;R. A. Katz #12 1988 Comparison of spinal needles, epidural catheters, and cordis lumbar catheters forintraoperative removal of cerebrospinal fluid

Neurosurgery

22 101-4 0148-396X(Print)

A. A. Artru #13 1990 The rate of CSF formation, resistance to reabsorption of CSF, and aperiodicanalysis of the EEG following administration of flumazenil to dogs

Anesthesiology

72 111-70003-3022(Print)

A. A. Artru #14 1993 Propofol combined with halothane or with fentanyl/halothane does not alter therate of CSF formation or resistance to reabsorption of CSF in rabbits

J NeurosurgAnesthesiol

5 250-70898-4921(Print)


Journal of HydrocephalusWorld Academy of Hydrocephalus



A. A. Artru #15 1993Rate of cerebrospinal fluid formation, resistance to reabsorption of cerebrospinalfluid, brain tissue water content, and electroencephalogram during desfluraneanesthesia in dogs


5 178-86 0898-4921(Print)

A. A. Artru;C. M.Bernards;D. S. Mautz;K.M. Powers

#16 1997Intravenous lidocaine decreases but cocaine does not alter the rate of cerebrospinalfluid formation in anesthetized rabbits


9 31-430898-4921(Print)

A. A. Artru;T. Momota #17 2000 Rate of CSF formation and resistance to reabsorption of CSF during sevofluraneor remifentanil in rabbits


12 37-430898-4921(Print)

3 M. Spiegel-Adolf;H. T.Wycis

#1 1951 Ultraspectrophotometry of cerebrospinal fluids in tumors of the central nervoussystem

ConfinNeurol

11 87-97 0010-5678(Print)

M. Spiegel-Adolf;H. T.Wycis;E. A. Spiegel

#2 1951 Chemical analysis of spectrophotometric findings in the cerebrospinal fluid J Nerv MentDis

113 529-37 0022-3018(Print)

M. Spiegel-Adolf #3 1952 Cerebrospinal fluid Prog NeurolPsychiatry

7 275-91 0079-6506(Print)


8 283-99 0079-6506(Print)

M. Spiegel-Adolf;C. W.Umlauf;E. G. Szekely

#5 1953 Effects of convulsions induced by various types of electric stimulation upon thecerebrospinal fluid

JNeuropatholExp Neurol

12 363-67 0022-3069(Print)


9 283-3040079-6506(Print)

M. Spiegel-Adolf;H. W.Baird, 3rd;E. G. Szekely;H.T. Wycis

#7 1954 Cerebrospinal fluid studies in infant children with cerebral palsy and otherneurologic disorders Pediatrics 14 215-21

0031-4005(Print)


10 293-3150079-6506(Print)


11 145-680079-6506(Print)


12 277-3010079-6506(Print)

M. Spiegel-Adolf;H. Baird,3rd;D. Kollias

#11 1957 Lipases in the cerebrospinal fluid in various neurological conditions, especiallyinfantile amaurotic idiocy (Tay-Sachs disease)

ConfinNeurol

17 310-5 0010-5678(Print)


16 283-309 0079-6506(Print)


18 392-4100079-6506(Print)


20 455-81 0079-6506(Print)

3 O. Gilland #1 1965 CSF dynamic diagnosis of spinal block. II. The spinal CSF pressure-volume curve Acta NeurolScand

41 487-960001-6314(Print)

O. Gilland #2 1965CSF dynamic diagnosis of spinal block IV: demands on electromanometricequipment

Acta NeurolScand Suppl

13 Pt 1 75-1050065-1427(Print)

O. Gilland #3 1965 CSF dynamic diagnosis of spinal block 3: an equation for block influence oncisterno-lumbar electromanometrics

Acta NeurolScand Suppl

13 Pt 1 47-74 0065-1427(Print)

O. Gilland #4 1966 Cerebrospinal fluid dynamic diagnosis of spinal block V. Uniform lumbarelectromanometrics

Neurology 16 1110-7 0028-3878(Print)

O. Gilland #5 1966 CSF dynamic diagnosis of spinal block. VII. Reliability of lumbarelectromanometrics

Acta NeurolScand

42 ppl 21:450001-6314(Print)

O. Gilland #6 1966 CSF dynamic diagnosis of spinal block. VI. Reliability of combined cisterno-lumbar electromanometrics

Acta NeurolScand

42 uppl 21:1-0001-6314(Print)

O. Gilland #7 1968 Cerebrospinal fluid Prog NeurolPsychiatry

23 338-51 0079-6506(Print)

O. Gilland #8 1969 Normal cerebrospinal-fluid pressure N Engl JMed

280 904-5 0028-4793(Print)

O. Gilland #9 1969 How to take the headache out of spinal taps Headache 8 154-8 0017-8748(Print)

O. Gilland #10 1969 Cerebrospinal fluid Prog NeurolPsychiatry

24 272-910079-6506(Print)

O. Gilland;F. Chin;W. B.Anderson;J. R. Nelson

#11 1969 A cinemyelographic study of cerebrospinal fluid dynamics


106 369-750002-9580(Print)

O. Gilland #12 1970 Lumbar electromanometrics. New equipment and long-term accuracy evaluationin 100 patients

Acta NeurolScand

46 uppl 43:2 0001-6314(Print)

O. Gilland #13 1970 Cerebrospinal fluidProg NeurolPsychiatry

25 214-370079-6506(Print)

O. Gilland #14 1971 Cerebrospinal fluidProg NeurolPsychiatry

26 329-610079-6506(Print)

5 E. A. Bering, Jr. #1 1951 A simplified apparatus for constant ventricular drainage J Neurosurg 8 450-2 0022-3085(Print)

E. A. Bering, Jr. #2 1954 Water exchange in the brain and cerebrospinal fluid; studies on theintraventricular instillation of deuterium (heavy water) J Neurosurg 11 234-42

0022-3085(Print)


E. A. Bering, Jr. #3 1955Choroid plexus and arterial pulsation of cerebrospinal fluid; demonstration of thechoroid plexuses as a cerebrospinal fluid pump

AMA ArchNeurolPsychiatry

73 165-720096-6886(Print)

E. A. Bering, Jr. #4 1957 Problems of the dynamics of the cerebrospinal fluid with particular reference tothe formation of cerebrospinal fluid and its relationship to cerebral metabolism

ClinNeurosurg

5 discussio0069-4827(Print)

E. A. Bering, Jr. #5 1958 Composition of cerebrospinal fluid under varying conditions Neurology 8 129-30 0028-3878(Print)

E. A. Bering, Jr. #6 1959 Cerebrospinal fluid production and its relationship to cerebral metabolism andcerebral blood flow Am J Physiol 197 825-8

0002-9513(Print)

E. A. Bering, Jr. #7 1959Cerebrospinal fluid production and its relationship to cerebral metabolism andcerebral blood flow Am J Physiol 197 825-8

0002-9513(Print)

E. A. Bering, Jr.;O. Sato #8 1963 Hydrocephalus: Changes in formation and absorption of cerebrospinal fruidwithin the cerbral ventricles J Neurosurg 20 1050-63 0022-3085

(Print)

E. A. Bering, Jr. #9 1966 Cerebrospinal fluid Prog NeurolPsychiatry

21 358-73 0079-6506(Print)

E. A. Bering, Jr. #10 1974 The cerebrospinal fluid and the extracellular fluid of the brain. Introductoryremarks Fed Proc 33 2061-6

0014-9446(Print)

5W. W. Tourtellotte;R. N.Dejong;S. Janich;K.Gustafson

#1 1962A study of lipids in the cerebrospinal fluid (and serum). VIII. Further commentson the normal lipid profile

Med Bull(Ann Arbor)

28 114-260196-5336(Print)

W. W. Tourtellotte #2 1963 Multiple sclerosis and cerebrospinal fluid Med ClinNorth Am

47 1619-28 0025-7125(Print)

W. W. Tourtellotte;R. J.Allen;A. F. Haerer;S. A.Kelly;K. A. Gustafson;E. R.Bryan;R. N. Dejong

#3 1963 A study of lupids in the cerebrospinal fluid. IX. Two new laboratory observationson the cerebrospinal fluid in tay-saches disease

Trans AmNeurolAssoc

88 104-7 0065-9479(Print)

W. W. Tourtellotte;K. C.Quan;A. F. Haerer;E. R.Bryan

#4 1963 Neoplastic cells in the cerebrospinal fluid. Report of a case of metasticmelanoblastoma.

Neurology 13 866-8 0028-3878(Print)

W. W. Tourtellotte;A. F.Haerer

#5 1964A study of lipids in the cerebrospinal fluid (and serum). Present state ofknowledge in health and disease

RevNeuropsiquiatr

27 339-560034-8597(Print)

W. W. Tourtellotte;A. F.Haerer;J. A. Parker

#6 1964 A study of the blood-cerebrospinal fluid-central nervous system barrier in multiplesclerosis. II. A possible model study for other diseases

RevNeuropsiquiatr

27 260-76 0034-8597(Print)

W. W. Tourtellotte;L. N.Metz;E. R. Bryan;R. N.Dejong

#7 1964Spontaneous subarachnoid hemorrhage. Factors affecting the rate of clearing ofthe cerebrospinal fluid Neurology 14 301-6

0028-3878(Print)

W. W. Tourtellotte;R. J.Allen;A. F. Haerer;E. R.Bryan

#8 1965 Study of lipids in cerebrospinal fluid and serum Arch Neurol 12 300-100003-9942(Print)

W. W. Tourtellotte #9 1967 Cerebrospinal fluid examination in meningoencephalitis Mod Treat 4 879-97 0026-8526(Print)

W. W. Tourtellotte;H.Itabashi;R. P. Tucker;E. R.Bryan

#10 1968 Cerebrospinal fluid cytologyTrans AmNeurolAssoc

93 288-90065-9479(Print)

7 B. Vigh;I. Vigh-Teichmann;B. Aros

#1 1970 Ultrastructure of the CSF contacting neurons of the spinal cord in the newt,triturus cristatus

ActaMorpholAcad SciHung

18 369-82 0001-6217(Print)

B. Vigh;I. Vigh-Teichmann;S.Koritsanszky;B. Aros

#2 1971 Ultrastructure of the spinal CSF contacting neuronal system in the white leghornchicken

ActaMorpholAcad SciHung

19 9-240001-6217(Print)

B. Vigh;I. Vigh-Teichmann #3 1973 Comparative ultrastructure of the cerebrospinal fluid-contacting neurons Int Rev Cytol 35 189-251 0074-7696(Print)

B. Vigh;I. Vigh-Teichmann;B. Aros

#4 1975 Comparative ultrastructure of cerebrospinal fluid-contacting neurons andpinealocytes

Cell TissueRes

158 409-240302-766X(Print)

B. Vigh;I. Vigh-Teichmann;M. J. Manzanoe Silva;A. N. van den Pol

#5 1983Cerebrospinal fluid-contacting neurons of the central canal and terminal ventriclein various vertebrates

Cell TissueRes

231 615-210302-766X(Print)

B. Vigh;I. Vigh-Teichmann #6 1992 Cytochemistry of CSF-contacting neurons and pinealocytes Prog BrainRes

91 299-3060079-6123(Print)

B. Vigh;I. Vigh-Teichmann #7 1993 Development of the photoreceptor outer segment-like cilia of the CSF-contactingpinealocytes of the ferret (Putorius furo)

Arch HistolCytol

56 485-930914-9465(Print)

B. Vigh;I. Vigh-Teichmann #8 1998 Actual problems of the cerebrospinal fluid-contacting neurons Microsc ResTech

41 57-83 1059-910X(Print)

B. Vigh;M. J. Manzano eSilva;C. L. Frank;C.Vincze;S. J. Czirok;A.Szabo;A. Lukats;A. Szel

#9 2004 The system of cerebrospinal fluid-contacting neurons. Its supposed role in thenonsynaptic signal transmission of the brain

HistolHistopathol

19 607-28 0213-3911(Print)



7 E. Kovacs #1 1953 Nucleases in the cerebrospinal fluid. I. Ribonuclease in normal, neurologicallynormal, and in pathological CSF's

Can J MedSci

31 437-46 0316-4403(Print)

E. Kovacs #2 1953 Autolysis in normal and pathological cerebrospinal fluids Can J MedSci

31 358-660316-4403(Print)

E. Kovacs #3 1953 Further studies on the neurolytic properties of spinal fluid in health and disease Can J MedSci

31 109-160316-4403(Print)

E. Kovacs #4 1954 Nucleases in the cerebrospinal fluid. II. Desoxyribonuclease in health and disease J Pediatr 45 569-740022-3476(Print)

E. Kovacs #5 1954 Ultraviolet light absorption in normal and in pathological cerebrospinal fluidsCan JBiochemPhysiol

32 526-38

E. Kovacs #6 1955 Nucleases in the cerebrospinal fluid. IV. Dephosphorylation of nucleic acids bythe CSF, especially of poliomyelitis patients J Pediatr 47 340-6

0022-3476(Print)

E. Kovacs #7 1955 Nucleases in the cerebrospinal fluid. III. Simultaneous determination of ribo- anddesoxyribonuclease in the CSF of patients with poliomyelitis J Pediatr 46 691-8

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E. Kovacs #8 1955 Lecithinases in normal and in pathological cerebrospinal fluids (CSF) ICan JBiochemPhysiol

33 99-106

E. Kovacs;R. K.Baratawidjaja;A. WalmsleyHewson;N. A. Labzoffsky

#9 1963Demonstration of poliovirus in isolated leucocytes, blood and C.S.F. smears ofinfected monkey by immunofluorescence and biological means. (BRIEFREPORT)

ArchGesamteVirusforsch

14 143-60003-9012(Print)

7M. W. Bradbury;J.Stubbs;I. E. Hughes;P.Parker

#1 1963 The distribution of potassium, sodium, chloride and urea between lumbarcerebrospinal fluid and blood serum in human subjects Clin Sci 25 97-105

0009-9287(Print)

M. W. Bradbury;H. Davson #2 1964 The transport of urea, creatinine and certain monosaccharides between blood andfluid perfusing the cerebral ventricular system of rabbits J Physiol 170 195-211

0022-3751(Print)

M. W. Bradbury;W.Lathem

#3 1965A flow of cerebrospinal fluid along the central canal of the spinal cord of therabbit and communications between this canal and the sacral subarachnoid space J Physiol 181 785-800

0022-3751(Print)

M. W. Bradbury;C. R.Leeman;Bagdoyanh;A.Berberian

#4 1968 The calcium and magnesium content of skeletal muscle, brain, and cerebrospinalfluid as determined by atomic bsorption flame photometry

J Lab ClinMed

71 884-920022-2143(Print)

M. W. Bradbury;J.Crowder;S. Desai;J. M.Reynolds;M. Reynolds;N.R. Saunders

#5 1972 Electrolytes and water in the brain and cerebrospinal fluid of the foetal sheep andguinea-pig J Physiol 227 591-610

0022-3751(Print)

M. W. Bradbury #6 1978 Proportion of cerebrospinal fluid draining into jugular lymphatic trunks of the cat[proceedings] J Physiol 276 67P-68P

0022-3751(Print)

M. W. Bradbury;D. F. Cole #7 1980 The role of the lymphatic system in drainage of cerebrospinal fluid and aqueoushumour

J Physiol 299 353-65 0022-3751(Print)

M. W. Bradbury;R. J.Westrop

#8 1983 Factors influencing exit of substances from cerebrospinal fluid into deep cervicallymph of the rabbit J Physiol 339 519-34

0022-3751(Print)

M. W. Bradbury #9 2000 Hugh Davson--his contribution to the physiology of the cerebrospinal fluid andblood-brain barrier

Cell MolNeurobiol

20 7-110272-4340(Print)

10 A. Sahar #1 1966 Free acetylcholine in the cerebrospinal fluid after brain operationsJ NeurolNeurosurgPsychiatry

29 77-90022-3050(Print)

A. Sahar;G. M.Hochwald;A. R. Sadik;J.Ransohoff

#2 1969 Cerebrospinal fluid absorption in animals with experimental obstructivehydrocephalus Arch Neurol 21 638-44

0003-9942(Print)

A. Sahar;G. M.Hochwald;J. Ransohoff

#3 1970 Cerebrospinal fluid and cranial sinus pressures. Relationship in normal andhydrocephalic cats Arch Neurol 23 413-8

0003-9942(Print)


#4 1970 Experimental hydrocephalus: cerebrospinal fluid formation and ventricular size asa function of intraventricular pressure J Neurol Sci 11 81-91

0022-510X(Print)


#5 1970 Passage of cerebrospinal fluid into cranial venous sinuses in normal andexperimental hydrocephalic cats Exp Neurol 28 113-22

0014-4886(Print)

A. Sahar #6 1972 Choroidal origin of cerebrospinal fluid Isr J Med Sci 81 594-60021-2180(Print)

A. Sahar #7 1972 The effect of pressure on the production of cerebrospinal fluid by the choroidplexus J Neurol Sci 16 49-58

0022-510X(Print)

A. Sahar;E. Tsipstein #8 1978 Effects of mannitol and furosemide on the rate of formation of cerebrospinal fluid Exp Neurol 60 584-910014-4886(Print)

10 B. P. Vogh #1 1980 The relation of choroid plexus carbonic anhydrase activity to cerebrospinal fluidformation: study of three inhibitors in cat with extrapolation to man

J PharmacolExp Ther

213 321-310022-3565(Print)

B. P. Vogh;M. R.Langham, Jr.

#2 1981 The effect of furosemide and bumetanide on cerebrospinal fluid formation Brain Res 221 171-830006-8993(Print)

B. P. Vogh;D. R. Godman #3 1982 Cerebrospinal fluid formation in rats and cats during treatment with timololCan JPhysiolPharmacol

60 1138-430008-4212(Print)

B. P. Vogh;D. R. Godman #4 1984 Addition of the effects of norepinephrine and acetazolamide to decrease formationof cerebrospinal fluid

J PharmacolExp Ther

229 207-90022-3565(Print)

B. P. Vogh;D. R. Godman #5 1985Timolol plus acetazolamide: effect on formation of cerebrospinal fluid in cats andrats

Can JPhysiolPharmacol

63 340-30008-4212(Print)



B. P. Vogh;D. R.Godman;T. H. Maren

#7 1987 Effect of AlCl3 and other acids on cerebrospinal fluid production: a correction J PharmacolExp Ther

243 35-9 0022-3565(Print)

B. P. Vogh;D. R. Godman #8 1989 Effects of inhibition of angiotensin converting enzyme and carbonic anhydrase onfluid production by ciliary process, choroid plexus, and pancreas

J OculPharmacol

5 303-11 8756-3320(Print)

10 G. M. Hochwald;A. Sahar #1 1971 Effect of spinal fluid pressure on cerebrospinal fluid formation Exp Neurol 32 30-40 0014-4886(Print)

G. M. Hochwald;F.Epstein;C. Malhan;J.Ransohoff

#2 1972 The role of the skull and dura in experimental feline hydrocephalusDev MedChild NeurolSuppl

27 65-90419-0238(Print)

G. M. Hochwald;W. E.Lux, Jr.;A. Sahar;J.

#3 1972 Experimental hydrocephalus. Changes in cerebrospinal fluid dynamics as afunction of time Arch Neurol 26 120-9 0003-9942

(Print)G. M. Hochwald;A.Wald;J. DiMattio;C.

#4 1974 The effects of serum osmolarity on cerebrospinal fluid volume flow Life Sci 15 1309-16 0024-3205(Print)

G. M. Hochwald;A.Wald;C. Malhan

#5 1974 The effect of osmotic gradients on cerebrospinal fluid production and its sodiumion content, and on brain water content

Trans AmNeurolAssoc

99 219-21 0065-9479(Print)


#6 1975 The role of spinal fluid bulk flow in limiting brain water content changes Trans AmNeurol

100 202-4 0065-9479(Print)


#7 1976 The sink action of cerebrospinal fluid volume flow. Effect on brain water content Arch Neurol 33 339-44 0003-9942(Print)

G. M. Hochwald;S.Nakamura;M. B. Camins

#8 1981 The rat in experimental obstructive hydrocephalus Z Kinderchir 34 403-10 0174-3082(Print)

10 O. Sato #1 1967 The effect of dexamethasone on cerebrospinal fluid production rate in the dog No ToShinkei

19 485-92 0006-8969(Print)

O. Sato;E. A. Bering #2 1967 Extra-ventricular formation of cerebrospinal fluid No ToShinkei

19 883-5 0006-8969(Print)

O. Sato;T. Asai;Y.Amano;M. Hara;R.Tsugane;M. Yagi

#3 1972Extraventricular origin of the cerebrospinal fluid: formation rate quantitativelymeasured in the spinal subarachnoid space of dogs J Neurosurg 36 276-82

0022-3085(Print)

O. Sato;M. Hara;T. Asai;R.Tsugane;N. Kageyama

#4 1973 The effect of dexamethasone phosphate on the production rate of cerebrospinalfluid in the spinal subarachnoid space of dogs


O. Sato;R. Tsugane;N.Kageyama

#5 1974 Cerebrospinal fluid pulsatile force and focal ventricular dilatation in cases ofgrowing skull fracture

Neurochirurgia (Stuttg)

17 1-11 0028-3819(Print)

O. Sato #6 1975 Letter: Effect of dexamethasone on CSF formation J Neurosurg 42 368-9 0022-3085(Print)

O. Sato;E. A. Bering,Jr.;M. Yagi;R. Tsugane;M.Hara;Y. Amano;T. Asai

#7 1975 Bulk flow in the cerebrospinal fluid system of the dog Acta NeurolScand

51 1-110001-6314(Print)

O. Sato #8 1990 Trying to bridge a gap Childs NervSyst

6 241-4 0256-7040(Print)


the 10 major subjects inhydrocephalus research...

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