2006

Azetidine derivativesR 0045 The Simple and Selective Synthesis of 3-Amino-2,2-difluorocarboxylic Esters and

Difluoro-β-Lactams Using Ethyl Bromodifluoroacetate in the Presence of Rhodi-um Catalyst. — A series of 13 imines is subjected to rhodium-catalyzed Reformatsky reaction, to give the corresponding difluoro-β-lactams. The addition of equimolar amounts of MgSO4·7H2O leads to formation of 3-amino-2,2-difluorocarboxylic esters. — (SATO, K.; TARUI, A.; MATSUDA, S.; OMOTE, M.; ANDO*, A.; KUMADAKI, I.; Tetrahedron Lett. 46 (2005) 45, 7679-7681; Fac. Pharm. Sci., Setsunan Univ., Hirakata, Osaka 573-01, Japan; Eng.) — Roy

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