Title --AB-PCHetacillinMCI-PC--

Author(s) , ; ,

Citation (1969), 15(5): 382-392

Issue Date 1969-05

URL http://hdl.handle.net/2433/119995

Right

Type Departmental Bulletin Paper

Textversion publisher

Kyoto University

382

155

19695

ABPCHetacillinMCIPC

URINARY INFECTION OF RESISTANT GRAM NEGATIVE

BACILLI

SYNERGISTIC ACTION OF AMINOBENZYL PENICILLIN OR

HETACILLIN AND CLOXACILLIN

Hideo MiTsuyA and K6zi OBATA

From the DePartment of Urology Aragoya University School of Medicine Nagoya JaPan

ChairmanProf K Shimizu IL4 D

There is the tendency of increase of urinary tract infection with resistant gramnegative

bacjlli

AminobenzylPC and hetacillin Versapen were administrated to flve cases with various

urinarytract infections of resistant strains The effective results were obtained in three cases

but the alterations or superinfections were observed in two cases

The main strains of chronic urinary tract infection in Nagoya University Hospital were

Klebsiella and E coli that were highly resistant against the classical broad spectrum antibiotics

Ten cases of urinary infections with resistant gram negative bacilli were treated by ABPC

or hetacillin Versapen and MCIPC The synergistic action of ABPC or hetacillin and MCI

PC was found in seven cases of Klebsiella Rettgerella and Ps aeruginosa infections

Nb significant side effect was observed in this series

Candida

1

1

Table 1Staphylococcus

Ecoll2

34

2

5

2E coli

Klebsiella

383

Table 11 16

penicillin

Staphylococcus

Streptococcus

Enterococcus

Corynebacterium

E coli

Klebsiella

Cloaca

Pseudomonas

Proteus

Candida

30fe6

11

2

3

22

6

6

5

4

2

9

100

Klebsiella

point1actamasepeni

cillinasepenicillin

Pseudomonas68

Proteus7910 Klebsiel1a7911 E coli7910

8

penicillin

Sabathrc

CHCHCO

l1

HC CH CNCHCOOK o Versapen

Potassium hetacillin

Cl E

ll H N eLCH Xo

71penicillincepha

losporin

lactamase

methicillin oxacillin cloxacillin nafcillln

lactamase

activeenterb

12

ABPChetacilinVersapen

MCIPC

ABPCMCIPC

ABPCaminobenzyl penicillinampi

cillin

broad spectrumpenicillin

6Daaminophenylacetamidopenicillin acid

34

Versapen potassium salt of 622dimethy15oxo4pheny

1imidazolidinyl33dimethyl7oxo4thio1azabi

cyclo 320heptane2carboxylic acid

potassium hetaci1in

penicillinABPC

1516

ABPC

ampicillin

hetacillin

1 XgHcoNHPH lcHS X g gil

NH O CNCHCOOH ABPC Aminobenzyl penicillin

fi fi TcoNHpHLpff S?C

D

CONCHCooNaH20

Prostaphlin Cloxacillin

Fgi 1

384

Tuano heta

cillinampicillin

173

hetacillinampicillin

24617

hetacillin ampicillin

hetacillinampicillin

6hetacillinampicillin

hetacillin

13

ampicillin

penicillin

methici1inDMPC oxaciilinMPIPC

cloxacillinMCIPC dicloxacillinMDCIPC

MCIPC

Prostaphlin

Prostaphlincloxacillin

5methy13ochloropheny14isoxazolyLpenicillin

MCIPC Prostaphlinspec

trum penici1

1inase

Prostaphlin500mg1

15mcgm16

348500mg1

49mcgm16

33ABPC

89

ABPChetacillin allergy

20peni

cillin allergyPC penicillin

GBrownPCG a1

1ergy395ABPC allergy

21ABPC

ABPC

PCG

iABPC 510mg5

20cc anaphylaxy

ABPChetacillinanaphylaxy

ABPChetacillinTC

CP

GOT GPT LDH

20689

129

ABPC

10

769d1419d110u CCF

GOT 40u GPT 20u a1ph10u

ABPC

1TP599d110u

CCF GOT 14 GPT 6 alph542

TP zo9 CCF

1TP 70365

CCF GOT 16 GPT 12 alph62

ABPC 129

I ABPChetacillinVersaPen

1968Klebsiella

ABPChetacillin

Table 25

Tabe 3

tetracycline

chloramphenico1

TC CMABPC

hetacillinVersapen

Table 4

ABPCVersapen5

32

Versapen 16capE coli

2

ABPC

4E coliKlebsiella5

Pseudomonas aeruginosaE coliCloaca

Versapen

Ecoli

385

Table 2 ABPChetacillinVersapen

6Q E cQli

i65 TUR Micrococcus141 E coli

53 TUR E coli5 28

1 pseudorpfpas aeruginesa

Table 3 Table 2

pc SM TC cp 1 KM NA cER CL

1 E coli

2 Micrococcus

3 1 E coii

4 E coli

5 Pseudomonas aeruginosa

Table 4

1 lE coli lVersapnap1

1

2 1 MicrococcusPC Ig1 1 1

3 E coli1Versapen L25g1

2Versapen lg

2

7

39

1

4 IE coli 1 ABpclg 12

5 Pseudomonas aeruginosa DABPC lgQABPC500mg

1

P

3

Ecoli Cloaca

3 41

1400C

Ecoli

30010492001133

mm68mgd1 BUN 11Omgd1

O9mgd139N

Versapen 1000mg5500cc

6250rag

236C

Versapen 11000mg3

12V6rsapen

2

Versapen

Fig2

Klebsiella

ABPCVer

sapen

ABPC

5

386

Versap 12so mg etsap000

Fig2 3

45

Kleb

siellaE CQli

ABPC

MCIPC

H ABPCMCIPC

1968

Table 5

ABPCe hetacillinVersapenMCI

PCTable 510

63

1

Table

5tetracyclineTC chloram

phenicolCP tetracyclihe01eandonycin

TCOL tetracyclinenovobiocin

ABPCMCIPC

1 64

TUR

KlebsiellaStreptococcus faecalis TC OL CP

TUIK1b11 TC NB ABPC

3

4

62

17

VUR

Pseudomonas aeruginosaCloaca

RettgerellaStreptococcus faecalis

TC CP ABPC

TC CP ABPC

1 54K1bll 1 Tc NB oL cp

628 1 b11 Tc NB oL cp

764Klb11 TGABPC865IK1ba11

92 Klb11

CP

1 TC oL cp cER

10 58 lKlebsiella HStreptococcufaeca1s

TC OL

Table 6

387

i

2

3

4

5

6

7

8

9

10

Klebsiella

Klebsiella

Pseudomonas aeruginosa

Rettgerella

Klebsiella

Klebsiella

Klebsiella

Klebsiella

Klebsiella

Klebsiella

PC SM TC

cp

KM

NA CER CL

TCNB ABPC colistinCL

2Kleb

siellaTable 6

colistinnalidixic acid

Table 7

1

2

3

4

5

6

7

8

9

10

Klebsiella

Strept faec

Klebsiella

Pseud aerug

Cloaca

Rettgerella

Strept faec

Klebsiella

Klebsiella

Klebsiella

Klebsiella

Klebsiella

Klebsiella

Strept faec

Versapen 19

Prostaphling

Versapen 159

Prostaphlin 19

Versapen 159

Prostaphlin 19

Versapen 2259

Prostaphlin 19

ABPC 15g

MCIPC 750mg

PC 300

Prostaphlin lg

Versapen 19

Prostaphlin 19

1ABPC lg 2 ABPC 1sg

MCI750mg

2

1

1

1

3

3

4

10

5

4

340 1

3TTC1

3

MCIPC104

10

310

t

TCABPC

388

ABPCVersapenMCIPC

Table 7

ABPC110159MCIPC

119ABPC

VersapenMCIPCTable 7

73

Klebsiella2

1 64

1TUR

3goC

398821nm

42010412800

tetracycline

chloramphenico1 Ver

sapen 1000mg3

Prostaphlin 500mg2

38Versapen MCIPC

5 10009

C1C 0009

Fig31

630 10009 010 000q

Fig4 9

68S

2

Fig3

9 27

Sigmamycin 159

9

KlebsiellaCloaca

10439

Kefiin 2g23

Versapen1000mg5

Prostaphlin

500mg3

Versapen Prostaphlin5

Fig4

balance

1

E coli Klebsiella

Pseudomonas Proteus Citrobactor

22

Ecoli Klebsiella

hospital infection

2324

Ecoli Kleb

siella Cloaca Citrobactor Proteus Pseudo

monas

E coli Kleb

389

siella Pseudomonas Proteus

425

1968

Klebsiella

ABPCMCI

Klebsiella

Klebsiella

tetracycline chloramphenico1

strepto

mycin kanamycin colistin gentamycin

aminosidin

262T

penicillin

urosepsisG

ABPCheta

cillinsPectrum

penicillin

ABPChetacillinpenicillinase

spectrum14

penicillinasepenicillinase

penicillinmethicillinDM

PC oxacillin MPIPC cloxacillin MCI

PC dicloxacillinMDCIPC

penicillinase

penicillinase

Gourevitch1962benzyl

penicillinstaphylococcal penicillinase

39e

penicillinasebenzy1

PCmethicillinoxacillin

HamiltonMiller

penicillinaseanti

penicillinase penicillin

1128

Penicillinasepenicillin

penicillin

1949Barber

29Tacking

penicillinase penicillin

3

penicillinpenicillinase

penicillinase

penicillinase

penicillinase

311

penicillinaseStrePtococ

cus aueusE coli7910

Proteus79le Klebsiella91 Pseudomo

nas68penicillinase

32Shirley1965sulfa tetracy

cline chloramphenicol nitrofurantoin nalidi

xic acid mandelamine colistin kanamycin

Pseudo