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W I K O ) LL

3 i o 1 a a- D i vi 6 ion

--- unsuthcr i z d per son L

Opari tad by the Univarsi9 of Chieago

under

Contrao t Pi-31-109-ang-38

REPOSITORY

COUfCTION

BOX No.

FOLOER 1 0 9 9 0 9 8 A

Geo~ge Sicher, Group Lea6er Sylvanus Tyler

b e h v i c r o r the circulstlng ?rhits blood c e 1 ! s i n terms

of these da*ta, ex?

I n the I j ~ h t of the statistical nroF.rtje.5 of the series 2,

of counts, what coi!lX 36 ssser'ie6 cboat. the significance

of nn oxxrve i l change ir, 1-mnhocyte level d' t h e m e ex-

Dosed s-.hject..

This launchzr! an extended aml laborius invss t ig . i t i on of these data, The

- calculated f o r the colynorq'ns Et?d ly?+rhocy*es of h o subjects. !r. an nuto-

day i is correlated wi L i i tho count f o r the s m e efsalcnf, ir, the saxe subject

1099098%

t ' l t i e s , covariances of lagged serlesc

s t and i n a l i n e a r re la t ions3ip t o eac:: othep, s o that the s h i p of the curves

presentad b t 3 l ~ ~ (Fizures 1 or 2 ) is esseritially t:he same as would anpear fo r

The covariancp ar.d th corre la t ion

dia,mms"

-The tm curves of F j . b g e 1 are the self-lag varj.ances for the lynpho-

The log intervalv proceed in s'ueps

"Usr! i n g k p s of fim clays to

cytes of 'cm rale agbjects, XS an6 RF,

of one day Tor t!ie first. twenty days,

the s ixt ie th <ay,.. The orc7Imte scale {self-lo.g mri;;nce) incrsases from

.

t o p to bottori becarise the vcrr'ance Zecreases K S Cie eorrelekion coefficient

increases

The diagram sho- t y o kinds of behavior, Thc..:'~! is c ??-notme i w r e e e a

a d d i t t o n the re is a periodic behavior tY3ich is very prcmmnced fo r long i??ter-

vala greater t han <;went;. !lays

i n the v a r i a t i o n of the lyr?hocyte l eve l of circuiatinz blood,

The naves z fgn icy the existence of ri-?:.iodicitics

33 t h e 2iagram

f o r ES, nronuuriced peaks CEKL 'be seen et 25 zind Lj 5aysZ Since L5 c 3 . p i s neerly

- 1 % -

FIGURE 1.

SELF L A G VARIANCES OF LYMPHS

I

I5

2c

2!

C H - 3 7 P A

lo 20 30 40 50 60

L A G (k) IN DAYS

) SUBJECT E S O - - - - O

R F

10990980

3

.3c

.2(

.I z c a -I W

(L 0 V

0

a

c -

c M b -

FIGURE 2

cy- 37sJ-

CORRELOGRAM FOR POLYS AND LYMPHS

I I I I t 0 20 30 40 50 0

1 0 9 9 0 9 8 E L A G - D A Y S

h g an? do no t q n p a r to roach zero 1p-101 muck b e f o x e0 days.-

ference nay b described by saying tht the kw~ systemn have d i f f ~ r o r i t

This dif-

in succession cn Q single ' n d i v i d u a l , %:le me are c los ing i n on the aD?.ution,

,

the a m w w w i l l R o t be rm?y 3oon, a-d rneazx5fle t!:.~ i n t e r c r e + d t i o n of* szvera:!

sets af data OF t%s t p e must r e m i n i n -?,ou5t,

c. - 9 , :!nal;wis or blood 2ic;ture cjf v;!iite m d t : la50rntoL-y personn;rl. i@e

The follow- blood counts on 238 w h i t e r n l e laborat.wy emloyes nert: a n a f y s d ,

ing variables vrerc: invest€ga4ted:

1,

2 hena t o c r i t

3 - r e d blood cell coaqt.

L S absolute polymorp3onuclear count

l o p r i t h m of 50 rrinute sedi7antatior .

absolu te 1.ym-hccyte ccunt

'_ 1

10 9 9 0 9 8 6

1, logarithm of GO ninute sedimenta%ion

2" !le!ilatoc?-it

3? m d bloo3 cell count

4 I)

5.3 absolute ly??hocyk cez'r cGunt

6 , age in years et time cf cnmt,

absolute ?olynorphonuclear leuocyte cell coiint

mite malo laboratory personnel,

P 2 3 4

J

Table '- Fourth order correlat ion coefficients f o r tne same variables and

ponulation as i n Table 1

1 2 3

1

5 6

. l i e n the e f f o c t of other variables is re?oved, t:?e 9ol-yzorph and

lyr--:iocyte coi:nts a m not, s i g n i f i c a n t l y ifpwndent on .iso The net de-

wr&nce of hemtocri t anc! r ~ ? count on age is i n t e re s t ' ng because the

fomer cones out s i t h a s i g n i f i c a n t nositive ccrre1atfon :.-bile t!v latter

has a s iLmi f i can t negative c o r r e h t i o n with age I'

ne i;a t i v e par tia 1 c o r r e l a t i o n s with se diza n ta t i o n ,,

The results Tndicate t ha t several independent f r c t o i s a m necessary

9 0 t h hzve signlficsnt

t o account f o r t he r.ornal blood r;icture, Kore nil1 :& s ~ i d about t h i s

later

are essent ia i iy rate of :nortafity Ci:tgrar,s, b-t ti;o nethod of computation,

1 0 9 9 0 9 8 1 ,

TIME AFTER IRRADIATION (days)

9 snl

-A7Y c C H - 37Pk

TrME AFTER IRRADIATION ( d a y s )

10990980

- - t f ? P ’ - C H - 3 7 Y 4

4

0 CD

i

OC

-6 0 M 6

I I I I I I I I I I I I I I

P /

/

/‘ /

/ /

1 m’ /

/ /

Dt

G u -

b I I I I I 0

0 0 0 0 0 fl 0 - 0 0 0 0

w rn (u

- I 0.0

7 -0.01 -

m o

0- w 7 6 t- 7 4 I- cn

3 cu -0.IC

1 I I I I I .o I

I I I I I I

300 r cr--

Is

TIME AFTER IRRADIATION (days)

-30- -

-

- - - -

1 -

- - -

CH- 37Y 2 4

-.99 " \ > -90 (Y

- 0 L

-e C -

-.70 >* 0

-W

-so 8 - - .30

-.20 2 -

w -.IO l-

Q Cr I l- -03 4

-05

- I O.O(

>- I- .A 6 I- U 0 z

-

-cn' -LO(

m o 3 (u -0.1' 0 - W

200-300 r

U w 1"'

I I I I 1 I I 1 .Ol 870 750 0 30 I50 270 390 5 IO 630

TIME AFTER IRRADIATION ( d a y s )