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Univ.-Prof. Dr. med. habil. Kathrin Reetz

Imaging in Neurodegenerative Diseases Department of Neurology, RWTH Aachen University

Pauwelsstr. 30, 52074 Aachen, Germany &

JARA BRAIN Institute II of Research Center Jülich GmbH, 52425 Jülich, Germany

phone: +49-(0)241-80 85522 fax: +49-(0)241-80 3336516 email: kreetz@ukaachen.de

www.neurologie.ukaachen.de www.neuroscience-aachen.de/research-group-reetz.html

Curriculum vitae

BIOGRAPHICAL INFORMATION Date and place of birth: 08. February 1978 in Leipzig, Germany (maiden name Lasek) Family status: married, two sons born 16. September 2008 in New York, USA and

08. April 2013 in Cologne, Germany WORK EXPERIENCE

05/2015 Foundation and Head of the Euregional Huntington Center Aachen (EHZA) at the Department for Neurology, RWTH Aachen University, Aachen, Germany (Director: Prof. J.B. Schulz)

04/2014 W2-Professorship for Imaging in Neurodegenerative Diseases at the Department for Neurology, RWTH Aachen University, Aachen, Germany (Director: Prof. J.B. Schulz)

Since 03/2013 Head of the Movement Disorders Clinic at the Department of Neurology, RWTH Aachen University, Aachen, Germany (Director: Prof. J.B. Schulz)

Since 10/2011 Head of the Memory Clinic at the Department of Neurology, RWTH Aachen University, Aachen, Germany (Director: Prof. J.B. Schulz)

Since 10/2011 Senior physician at the Department of Neurology, RWTH Aachen University, Aachen, Germany (Director: Prof. J.B. Schulz)

Since 09/2011 Habilitation/Venia Legendi (Neurology) – Faculty of Medicine, RWTH Aachen University, Habilitation Thesis on Imaging the impact of genes on neurodegenerative disorders

05/2011 Board Certification in Neurology 02/2009 – 10/2011 Resident at the Department of Neurology, RWTH Aachen University,

Aachen, Germany (Director: Prof. J.B. Schulz) 01/2010 – 12/2010 Resident at the Department of Psychiatry, Psychotherapy and

Psychosomatic, RWTH Aachen University, Aachen, Germany (Director: Prof. F. Schneider)

02/2009 – 04/2014 JARA Brain “Juniorprofessur” in Translational Brain Research in Psychiatry and Neurology at the Department of Neurology, RWTH Aachen University and Research Centre Jülich, Germany

10/2007 – 01/2009 Postdoctoral Research Fellow at the Center for Neurosciences, Feinstein Institute for Medical Research, North Shore University Hospital, New York, USA (Director: Prof. D. Eidelberg) and Movement Disorders Clinic, Department of Neurology, Beth Israel Medical Center, New York, NY, USA (Director: Prof. Dr. S. Bressman)

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01/2006 –12/2006 Postdoctoral Research Fellow at the Institute for Systemics Neurosciences at the Medical University Hamburg-Eppendorf, Hamburg, Germany (Director: Prof. C. Büchel, Principal Investigators: Prof. F. Binkofski and Prof. H.R. Siebner)

10/2004 – 09/2007 Member of the NeuroImage Nord Research Group at the Department of Neurology, University of Luebeck, Luebeck, Germany (Director: Prof. F. Binkofski)

07/2004 – 09/2007 Resident at the Department of Neurology, University of Luebeck, Luebeck, Germany (Director: Prof. D. Kömpf)

MEDICAL THESIS

08/1999 – 08/2004 „Functional and biochemical investigation of Annexin A7 in mice and human myocard“ Lab of myocardial physiology and molecular cardiology (Director: Prof. R.H.G. Schwinger) at the Department of Cardiology, Clinic III, University of Cologne, Cologne, Germany (Director: Prof. Dr. E. Erdmann)

degree (25 August 2004): summa cum laude RESEARCH GRANTS

2016-2020 DFG International Research Training Group (IRTG 2150) of JARA BRAIN and University of Pennsylvania: „The Neuroscience of modulating aggression and impulsivity in psychopathology“ (Antragsteller: Habel, Herpertz-Dahlmann, Konrad, Mathiak, Nickl-Jockschat, Reetz, Schneider, Shah, Spehr, Vernaleken)

2016-2018 Research Grant from the Faculty of Medicine, RWTH Aachen University (IZKF, 125/16): Exploring the neural mechanisms underlying essential tremor. (Holtbernd, Reetz; 79.925 €)

2016-2018 Research Grant from the Faculty of Medicine, RWTH Aachen University (IZKF, 124/16): Identification of presymptomatic markers in neurodegenerative diseases – characterisation of patients with a REM-sleep behavior disorder. (Maier, Reetz; 98.777 €)

2016-2018 Research Grant from the Faculty of Medicine, RWTH Aachen University (IZKF): Sodium-channels in the pathophysiology of Huntington’s disease. (Meents, Lambert; Collaboration Partners: Reetz, Feldmeyer, Zenke; 99.901,50 €)

2016-2018 Research Grant from the Faculty of Medicine, RWTH Aachen University (IZKF, 08/16): Investigating the sensitivity of restings-state connectivity as a biomarker in Huntington’s disease: A longitudinal MRI study. (Dogan, Reetz, 24.920 €)

2014-2019 Selbstständige BMBF-Forschungsgruppen in den Neurowissen-schaften „Metabolic Imaging in Neurodegenerative Diseases (MIND)“. (Reetz, 1.374.000 €)

2014-2016 Research Grant from the Alzheimer Forschung Initiative “A new treatment tool for early Alzheimer's disease”. (Reetz, 79.400 €)

2012-2014 Research Grant from the Faculty of Medicine, RWTH Aachen University (23/12): Evidence for gender-specific emotional impairment in Parkinson’s disease? (Reetz, 79.800 €)

2012-2015 Juniorprofessur – JARA BRAIN Translationale Hirnforschung in Psychiatrie und Neurologie, German Research Foundation (DFG within the second RWTH Aachen Excellence Initiative (126.225 €)

2011-2014 Cooperative Project Grant from the IZKF, Faculty of Medicine, RWTH Aachen University (N4-4): Impulsivitiy and Aggression. (Habel, Reetz, 179.110 € total)

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2009-2012 Juniorprofessur – JARA BRAIN Translationale Hirnforschung in Psychiatrie und Neurologie, German Research Foundation (DFG, ZUK32/1) within the RWTH Aachen Excellence Initiative. (700.000 €)

2008-2009 Research Award of the German Research Foundation (DFG, RE2841/1-1): Polymodal neuroimaging in genetically determined Parkinson’s disease. (Reetz, 132.532 €)

2008-2009 Research Award from the Medical Faculty of the University of Luebeck, Germany (FUL: A09-2005): Neuroimaging correlates using MRI and ultrasound to map structural changes of the substantia nigra in genetically determined and idiopathic Parkinson’s disease patients and other movement disorders. (Reetz, 66.800 €)

2007-2011 Graduiertenschule „Computation in life sciences and medicine“ Projekte 12a,b, German Research Foundation (DFG), Binkofski, Reetz, Schweikard, Trillenberg, Maehle, 60.000 €)

2005-2006 Research Award from the Medical Faculty of the University of Luebeck, Germany (FUL: E06-2008): Structural and functional imaging determinates for clinical and preclinical compensation mechanisms in Parkin- and PINK1-associated parkinsonism. (Lasek, 66.800 €)

CLINICAL AND OBSERVATIONAL STUDIES CLINICAL STUDIES Since 02/2016 A Parallel-Group, Double-Blind, Long Term Safety and Efficacy Trial of

MK-8931 (SCH 900931) in Subjects with Amnestic Mild Cognitive Impairment due to Alzheimer’s Disease (Prodromal AD), (PI)

Since 06/2015 A phase III, randomized, placebo-controlled, parallel-group, double-blind clinical trial to study the efficacy and safety of MK-8931 (SCH900931) in subjects with amnestic mild cognitive impairment due to Alzheimer’s disease (prodromal AD), (PI)

Since 10/2015 An open label extension study to investigate the long term safety, tolerability and efficacy of PF-02545920 in subjects with Huntington’s disease who previously completed study A8241021 (PI)

Since 02/2015 A phase 2, randomized, placebo controlled, double blind proof-of-concept study of the efficacy and safety of PF-02545920 in subjects with Huntington’s disease (PI)

Since 10/2014 A dose escalation, proof of concept, phase IIa study to investigate the safety and tolerability, the pharmacokinetic and the pharmacodynamic of BN82451B, administered twice daily over 4 weeks, in male patients with Huntington’s disease

03/2013 – 10/2015 A randomized, placebo controlled, parallel-group, double-blind efficacy and safety trial of MK-8931 with a long term double-blind extension in subjects with mild to moderate Alzheimer’s disease

01/2010 – 10/2013 BA1113043; Modulation of beta-amyloid levels in CSF and plasma by GSK933776 in patients with mild Alzheimer’s disease or mild cognitive impairment

01/2010 – 07/2013 A phase 3, double-blind double-dummy, placebo- and active-controlled dose-range-finding efficacy and safety study of Preladenant in subjects with early Parkinson’s disease

06/2009 – 12/2012 A double-blind placebo-controlled study of the safety, tolerability and efficacy of 12 months’ treatment with ACI-91 in patients with mild to moderate Alzheimer’s disease

03/2009 – 12/2012 Medical nutrition in prodromal Alzheimr’s disease, a double-blind controlled 24-month study

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OBSERVATIONAL STUDIES Since 05/2016 European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease

Initiative (ESMI) – Longitudinal cohort study Since 02/2016 Multizentrische Beobachtungsstudie für Levodopa/Carbidopa Intestinal

Gel bei Patienten mit einem Parkinson-Syndrom Since 11/2015 Europäisches Register für Patienten mit einer Spinocerebellären Ataxie

(SCA1, 2, 3 oder 6), (EuroSCA, www.ataxia-study-group.net) Since 11/2015 Europäisches Register für Träger einer Mutation einer Spinocerebellären

Ataxie (SCA1, 2, 3 oder 6), (RISCA; www.ataxia-study-group.net) Since 08/2014 Enroll-HD – eine weltweite, prospektive Beobachtungsstudie in einer

globalen Kohorte mit der Huntington Krankheit (www.enroll-hd.org), (PI) Since 05/2013 REM-Traum-Schlaf-Verhaltensstörung (Deutsches RBD Register), (PI) Since 06/2012 Europäisches Friedreich Ataxie Netzwerk (EFACTS, www.e-facts.eu) Since 01/2010 Parkinson’s Disease Netzwerk (Landscape) 10/2009 – 08/2014 European Huntington’s Disease Network (Registry) GCP TRAININGS 04/2010, 11/2012, 11/2014 Advanced GCP-Training course, Clinical Trial Center Aachen (CTC-A),

RWTH Aachen University and University of Cologne 10/2009 GCP-Training course, Clinical Trial Center Aachen (CTC-A), Uniklinik

RWTH Aachen MEMBERSHIPS / PEER-REVIEW JOURNALS / ADVISORY BOARD

Memberships German Society for Neurology (DGN), Organization for Human Brain Mapping (OHBM), Deutscher Hochschulverband (DHV), International Parkinson and Movement Disorders Society (MDS), German RBD Study Group (GRBD), European Huntington’s Network (EHDN)

Peer-Review Journals American Journal of Neuroradiology (AJNR), Applied Neuropsychology, Assessment (ASMNT), Biological Psychiatry, Brain, Brain Imaging and Behaviour, Brain Structure and Function (BSF), British Medical Journal (BMJ), Cortex, European Archives of Psychiatry + Clinical Neuroscience, Investigative Opthalmology & Visual Science (iOVS); Journal of Neurology, Neurosurgery & Psychiatry (JNNP), Movement Disorders, Nature Clinical Practical Neurology, Neurobiology of Disease, Neuroscience, Neuroscience & Biobehavioral Reviews, NeuroImage, NeuroImage Clinical, Neurology, Neurological Research, Neuroscience, PloS One, Psychiatry Research, Somatosensory & Motor Research

Grants Margarete von Wrangell-Habilitationsprogramm for Women, Medical Research Council (MRC), Medical Faculty of the Ruhr University in Bochum (FoRUM), Medizinische Fakultät Universität Berlin, Start (RWTH Aachen)

Medical Supervision Huntington self-help group in Aachen (since 2010) and Cologne (since 2015)

Advisory Board Friedreich Ataxie Development Association Working Groups European Huntington’s Network (EHDN) Imaging Working Group;

European Spinocerebellar Ataxia Type 3/Machado-Joseph Disease Initiative (ESMI) Imaging Working Group

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PUBLICATIONS Number of Publications (peer reviewed) 67 First-/Last authorship 16/18 Total Impact Factor 334.82 Average Impact Factor 5.32 Hirsch-Index/ i10-index 24/38 Total number of citations 1581 10 MOST IMPORTANT PUBLICATIONS

1. Reetz K, Dogan I, Costa AS, Dafotakis M, Fedosov K, Giunti P, Parkinson MH, Sweeney MG, Mariotti C, Panzeri M, Nanetti L, Arpa J, Sanz-Gallego I, Durr A, Charles P, Boesch S, Nachbauer W, Klopstock T, Karin I, Depondt C, Vom Hagen JM, Schols L, Giordano IA, Klockgether T, Burk K, Pandolfo M and Schulz JB. Biological and clinical characteristics of the European Friedreich's Ataxia Consortium for Translational Studies (EFACTS) cohort: a cross-sectional analysis of baseline data. The Lancet Neurology. 2015; 14(2):174-82. (IF 21.82)

2. Nellessen N, Rottschy C, Eickhoff SB, Ketteler ST, Kuhn H, Shah NJ, Schulz JB, Reske M, Reetz K. Specific and disease stage-dependent episodic memory-related brain activation patterns in Alzheimer's disease: A coordinate-based meta-analysis. Brain Struct Funct. 2015; 220(3):1555-71. (IF 7.84)

3. Werner C, Dogan I, Sass C, Mirzazade S, Schiefer J, Shah NJ, Schulz JB, Reetz K. Altered resting-state connectivity in Huntington's Disease. Hum Brain Mapp 2014;35(6):2582-2593. (IF 5.88)

4. Jacobi H*, Reetz K*, Tezenas du Montcel S, Bauer P, Mariotti C, Nanetti L, Rakawicz M, Sulek A, Durr A, Chrales P, Filla A, Antenora A, Schöls L, Schicks J, Infante J, Kang J-S, Timmann D, Di Fabo R, Masciullo M, Baliko L, Bela M, Boesch S, Bürk K, Peltz A, Schultz, JB, Dufaure-Gare I, Klockgether T. 2013. Biological and clinical characteristics of individuals at risk for spinocerebellar ataxia types 1, 2, 3, and 6 in the longitudinal RISCA study: analysis of baseline data. The Lancet Neurology 2013; 12(7):650-658. (IF 23.46) *shared first authorship

5. Reetz K, Costa A, Mirzazade S, Lehmann A, Juzek A, Rakowicz M, Boguslawska R, Schöls L, Mariotti C, Grisoli M, Dürr A, van de Warrenburg B, Timmann D, Pandolfo M, Bauer M, Jacobi H, Hauser TK, Klockgether T, Schulz JB. Genotype specific patterns of atrophy progression is more sensitive than clinical decline in SCA1, SCA3 and SCA6. Brain 2013;136:905-917. (IF 5.94)

6. Reetz K, Dogan I, Rolfs A, Binkofski F, Schulz JB, Laird AR, Fox PT, Eickhoff SB. Investigating function and connectivity of morphometric findings - Exemplified on cerebellar atrophy in spinocerebellar ataxia 17 (SCA17). Neuroimage 2012; 62: 1354-66. (IF 5.94)

7. Reetz K, Romanzetti S, Dogan I, Sass C, Werner CJ, Schiefer J, Schulz JB, Shah NJ. Increased brain tissue sodium concentration in Huntington's Disease - A sodium imaging study at 4T. Neuroimage 2012; 63: 517-524. (IF 5.94)

8. Reetz K, Lencer R, Steinlechner S, Gaser C, Hagenah J, Buchel C, Petersen D, Kock N, Djarmati A, Siebner HR, Klein C, Binkofski F. Limbic and frontal cortical degeneration is associated with psychiatric symptoms in PINK1 mutation carriers. Biol Psychiatry 2008, 64(3): 241-247. (IF 8.67)

9. Binkofski F*, Reetz K*, Gaser C, Hilker R, Hagenah J, Hedrich K, van Eimeren T, Thiel A, Buchel C, Pramstaller PP, Siebner HR, Klein C. Morphometric fingerprint of asymptomatic Parkin and PINK1 mutation carriers in the basal ganglia. Neurology 2007; 69(9): 842-850. (IF 7.04) *shared first authorship

10. Lasek K, Lencer R, Gaser C, Hagenah J, Walter U, Wolters A, Kock N, Steinlechner S, Nagel M, Zuhlke C, Nitschke MF, Brockmann K, Klein C, Rolfs A, Binkofski F. Morphological basis for the spectrum of clinical deficits in spinocerebellar ataxia 17 (SCA17). Brain 2006; 129: 2341-2352. (IF 9.60)

Aachen, 28 June 2016