NorC subunit

10 20 30 40 50 60 70 80 90 100 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....| 1141613 ----------------------------------MKKTEIWYLLISLTTVIGFAVLIYYSILRVNPSVVP------------------------------ 1142558 -----------------------------------MRLRTFILISSASLAIFVLSVRFSWKIDIPIS--------------------------------- 1142557 -----------------------------------LKLRTFILISISSFALFALTVKFSWALDYPMS--------------------------------- 1140225 -----------------------------------LKLRTFILISLSSFALFAWVVKSSWALDAPMS--------------------------------- 1140226 -----------------------------------MKLRTFILISLSSFALFAWVVKSSWALDAPMS--------------------------------- 1142559 -----------------------------------VKLRVFILISLVSYGTFIGANYFSSHLAVPMS--------------------------------- 1142556 -----------------------------------LKLRTFLLFSSLSLVLFVGITLISARLPFPMP--------------------------------- 1142560 -------------------------------------------------VLFVAITLVSSRLPSPMP--------------------------------- 1142732 -----------------------------------MKLRTFLILSILSFGLFVGVTLISARLPFPMT--------------------------------- 1222482 ----------------------------MSCGTGGSSCETPRRRGAFLVLAILALIFVALSIFSFLK-SRH----------------------------- 1112544 -------MEIGWIETTIGALFATVVLTLWLSRGSGWLEPRFWRNAAVVSSLIMSGILVYLTIDSLNQIREG--------------SARVPAYTVINKAIG 1112653 -------MEIGWIETTIGALFATVVLTLWLSRGSGWLEPRFWRNAAVVSSLIMSGILVYLTIDSLNQIREG--------------SARVPAYAVINREIG 1112654 -------MEIGWIETTIGALFATVVLTLWLSRGSGWLEPRFWRNAAVVSSLIMSGILVYLTVDSVNQIREG--------------SARVPAYTVINHEIG 1281324 -------MQLGWLEITLFSIVLTIVVSALFVRGKNWLDPGFWAVFALVGSLVMFSVLWLLTFDSLKKMSFG--------------SKRVPSPTVINHRVG 1030986 -------MSFGWLEVVVASLLITLVGGTILTRGRSWLDPVFWKRFAIVGSLVMFVFLWILTFDTLSKTSVG--------------TDRVPNPTVINKKIG 1032043 -------MSVGWLEVVVATLFISIVVSLILARGRHWLEPGFWKIAAVITSSVMAITLVLLTVDTSRQISMG--------------SKRVPSPSVINREIG 1241031 ----------------------------MDNKPSVWTSNRFWRRSATWVTGVSAVLLIFLTFDSMAQMQMG-----TAQDIKNKVDKRIPSPVVINYKID 1240766 -----------------------------VAKRSVWSDNRFWQRTAAWITGFASVLLIWLTFDTSAQISMG-----TDADIQNGVTKRVPGPTVINYKIT 1242289 ---------------------------MAEKKASVWTSISFWRRSAAWVTGFATILLIFLTFDTMSQIRMGTDKELQEEVATGKETRRIPAPTVINYHID 1241030 ---------------------------MANKNVSVWTSIPFWRRSAAWVTGFATILLIWLSFDTLGQISMG-----TAADLKNGVDKRVPAASVINYKID 1241223 -----------------------------MAKTSVWSDNRFWQRSAAWITGFAAVLLIWLTFDTAGQISMG-----TDADLQNKVTKRVPGPTVINYKIT 1211829 -----------------------------MATSQWWASESFWRKTAIWVTGGSFVALILLTMDTIPQISTG--------------SKRVPAYSVINYRIE 1220409 ----------------------------MGTSPPVWASESFWKKVAIWVTAGSFVILVILTFDTLSKTAVG--------------GSRVQSYSVINRSID 1222655 -----------------------------MNATPLWASETFWKKTAIWVTAISFLLLIGLTFDSMAKVSAG-------------STTRVPAYSVINKKID 1222652 ----------------------------MNEPLPFWASETFWKKTAIWVTSGSFVLLILLTFDSLAKISAG--------------GSRVPAYSVINKDIS 1222541 -----------------------------MNEEPLWASESFWKKVAIWVTAGSFLILVVLTLDSLSQTSAG--------------GTRVPAYAVINKKID 1222748 -----------------------------MNETPLWASESFWKKTAIWVTAGSFLILVVLTFDSLKQTTAG--------------TQRVPAYDVINKKID 1230031 ------------------------------------MTEGQSKVVFWVGTLTSAALFLALTVDTHRE-FDR----------------------------- 1222638 ------------------------------------MTKRQSRLFFLVSTACFSLVFLALTLHSHTR-FGE----------------------------- 1210461 ------------------------------------MTKRQGRLFFIICTLISATAFIGLTVDSHRR-FPG----------------------------- 1210008 ------------------------------------MNKRQTRLFAIVATGISAAVFLLLTFDSHRK-FDA----------------------------- 1211479 ------------------------------------MNKRQTRLFAIVATGISAAVFLLLTFDSHRK-FDA----------------------------- 1040279 -----------------------------------MLSKKQARAFFLGGTLVTFLVFIGLTIYSFSV-END----------------------------- 1041884 -----------------------------------MLSKSQAQAFFLGGTLVTFLIFIGLTVYSMMP-SND----------------------------- 1042313 -----------------------------------MLSKSQARTFFLGGTAVTFLIFIGLTIYSMAP-SND----------------------------- 1042464 -----------------------------------MLSKSQARTFFLGGTVVTFLIFIGLTIYSMAP-SND----------------------------- 1230080 -----------------------------------------------MGTVLCSAAFVLLTIDTFRR-IPK-----------------------------

1250766 -----------------------------------MLSKSQARAFFLGGTFLFSAIFVFLTIDSVRQ-NDT----------------------------- 1251518 -----------------------------------MLSKSQARAFFLGGTFLFSAIFVFLTIDSVRQ-NDT----------------------------- 1252508 -----------------------------------MLTKSQARWFFLGGTALFAALFIGLTFDTLAR-VPA----------------------------- 1200380 --------------------------------MSEVLTKSAARNIFYGGTAFFFIVFVGLVGHSVST-VND----------------------------- 1201239 --------------------------------MSETLTKAAARNIFYGGTAFFFAVFVALTVHSVSK-ANA----------------------------- 1201278 ----------------------------------------------------------MLSIDSHLYVVNE----------------------------- 1200560 --------------------------------MSEILTKSRARNVFYGGSLFFIAVFVGLTVQSHNYVVST----------------------------- 1200559 --------------------------------MSEILTKSRARNVFYGGSLFFIAVFVGLTVQSHSYVVSR----------------------------- 1200561 --------------------------------MSEILTKSRARNVFYGGSLFFIAVFVGLTVQSHSHVVSR----------------------------- 1200562 -------------------------------------------------------MFVALTAQSHRFIVKT----------------------------- 1202538 -------------------------------------------------------MFVALTAQSHRFIVKT----------------------------- 1200590 --------------------------------MAEILTKSRARNIFYGGSIFFVVIFVAMTVHSHKYVVQT----------------------------- 1200985 --------------------------------MAEFLTKSRARNVFYGGSIFFVVVFIGMTVHSHRYVVTT----------------------------- 1201169 --------------------------------MAEFLTKSRARNVFYGGSIFFVVVFIGMTVHSHRYVVTT----------------------------- 1200838 --------------------------------MSEFLTKARARNVFYGGSLFFVVVFVAMTAQSHRFIVEK----------------------------- 1201222 --------------------------------------------------MFFVVVFVAMTAHSHRFIVNT----------------------------- 1201843 --------------------------------MSEILTKSRARNVFYGGSLFFVVVFVAMTVHSHRYIVET----------------------------- 1200477 --------------------------------MSEIMTKNMARNVFYGGSIFFILIFGALTVHSHIYARTK----------------------------- 1200238 --------------------------------MKDVMTKGMARNIFYGGSLFFLAIFLGLTAHSHFYIVNT----------------------------- 1202651 --------------------------------MREVMTKSMARNIFYGGSLFFIVIFVGLSVHSHYYIVNT----------------------------- 1200589 --------------------------------MRDVLTTSMARNIFYGGSLFFILIFVGLSVHSHRYIVTT----------------------------- 1200983 --------------------------------MRDVLTTSMARNIFYGGSLFFILIFVGLSVHSHRYIVTT----------------------------- 1200641 --------------------------------MREVMTKSMARNIFYGGSLFFILIFLALSAHSHMYIRST----------------------------- 1200666 --------------------------------MREVMTKSMARNIFYGGSLFFIIIFVGLSAHSHLYITST----------------------------- 1201844 --------------------------------MREVMTKSMARNIFYGGSLFFILIFLALSAHSHLYIVN------------------------------ 1202650 --------------------------------MREVMTKSMARNIFYGGSLFFILIFLALSAHSHLYIVN------------------------------ 1201266 --------------------------------MSEILTKSTARNIFYGGTLFFFTIFVGLTLHSRHYILTK----------------------------- 1220025 --------------------------------MSDGLTKAAARNIFFGGSLFFFILFAALTAHSHWYIVNH----------------------------- 122X009 --------------------------------MADGLTKSAARNIFYGGSLFFFLLFAALTAHSHWYMVNK----------------------------- 1222498 --------------------------------MMEGLSRTAARNIFFGGSLFFFVIFVALTAHSHWYIVTQ----------------------------- 1202231 --------------------------------MTERFTKAAARNIFYGGSLFFFATFVALTALSHNYIVNT----------------------------- 1202317 --------------------------------MSERFTKAAARNIFYGGSIFFFIVFIGLTAQTHYYIRTS----------------------------- 1201839 --------------------------------MSERFTKAAARNIFYGGSIFFFIIFVGLTAQTDYYIRTT----------------------------- 1202563 --------------------------------MSERFTKAAARNIFYGGSIFFFVIFVGLTAQTDHYIRTT----------------------------- 1211833 --------------------------------MAEYLTKSAARNIFYGGSIFFLVVFATLTIHTHFYMVNV----------------------------- 1222407 --------------------------------MAERLTKSAARNIFYGGSFFFLGVFVILTIHSHLYIKNT----------------------------- 1222409 --------------------------------MAERLTKSAARNIFYGGSFFFLVVFLILGIDSHLYIKNT----------------------------- 1220458 --------------------------------MAERLTKSAARNIFYGGSFFFLVIFLILGIDSHLYIKNT----------------------------- 1221136 --------------------------------MAERLTKSAARNIFYGGSFFFLVIFLILGIDSHLYIKNT----------------------------- 1210459 --------------------------------MSERLTKSAARNIFYGGTAFFIVLFIALSVHTHLYIVNT----------------------------- 1210460 --------------------------------MSERFTKSAARNIFYGGTAFFLLLFIALSIHTHLYIVNS-----------------------------

1202251 --------------------------------MSERFTKSAARNVFYGGSIFFFVVFVGLTAQSHWHIVTT----------------------------- 1200095 --------------------------------MAERLTKSAARNVFYGGSAFFFAIFIGLTAHSHYYMATT----------------------------- 1200094 --------------------------------MAERLTKSAARNVFYGGSAFFFAIFLGLTAHSHYYMVTT----------------------------- 1200962 --------------------------------MAERLTKSAARNVFYGGSAFFFAIFLGLTAHSHYYMVTT----------------------------- 1200556 --------------------------------MAERLTKTAARNVFYGGSAFFFAIFVGLTAHSHYYIRTV----------------------------- 122X013 --------------------------------MAERLTKTGARNVFYGGSIFFFAIFVGLTAHSHRYIRTT----------------------------- 1200022 --------------------------------MAERLTKTGARNVFYGGSIFFFAIFVGLTAHSHYYMRTT----------------------------- 1200097 --------------------------------MAERLTKTGARNVFYGGSIFFFAIFVGLTAHSHYYMKTT----------------------------- 1200098 --------------------------------MAERLTKTGARNVFYGGSIFFFAIFVGLTAHSHYYMKTT----------------------------- 1200099 --------------------------------MAERLTKTGARNVFYGGSIFFFAIFVGLTAHSHYYMKTT----------------------------- 1200100 --------------------------------MAERLTKTGARNVFYGGSIFFFAIFVGLTAHSHYYMKTT----------------------------- 1200101 --------------------------------MAERLTKTGARNVFYGGSIFFFAIFVGLTAHSHYYMKTT----------------------------- 1201159 --------------------------------MAERLTKTGARNVFYGGSIFFFAIFVGLTAHSHYYMKTT----------------------------- 1201161 --------------------------------MAERLTKTGARNVFYGGSIFFFAIFVGLTAHSHYYMKTT----------------------------- 121X007 -------------------------------------------------SFFFFAIFVGLTAHSHYYMRTT----------------------------- 121X008 --------------------------------MAERLTKTGARNVFYGGSIFFFAIFVGLTAHSHYYMKTT----------------------------- 1200644 --------------------------------MAERLTKTGARNVFYGGSIFFFAIFVGLTAHSHYYMKTE----------------------------- 1201814 --------------------------------MAERLTKTGARNVFYGGSIFFFAIFVGLTAHSHYYMKTE----------------------------- 1200571 --------------------------------MAERLTKSAARNVFFGGSAFFFAIFIGLTAHSHYYIATK----------------------------- 1201236 --------------------------------MAERLTKSAARNVFFGGSAFFFAIFIGLTAHSHYYIATK----------------------------- 1200568 --------------------------------MAERLTKSAARNVFYGGSAFFFAIFVGLTAHSHYYIVNT----------------------------- 1242219 --------------------------------MSERITKNMARNIYFGGGLFAILVFTGLTIDTVKQ-IPK----------------------------- 1241897 --------------------------------MTERITKSMAKNIYYGGGTFALMIFIALSFDTVHQ-IPK----------------------------- 1242165 --------------------------------MTERITKSMAKNIYYGGGLFALLVFVGLTFDTVQQ-VPK----------------------------- 1222646 ---------------------------------------------------------------------------------------------------- 1200379 --------------------------------MNEKMTISMARNIFFGGSLFFVLVFLGLTLGTMRS-LPE----------------------------- 1211822 --------------------------------MSQGFTSQMARNIFYGGTVFFVLLFAALVFHTETK-IPE----------------------------- 1211216 -----------------------------MSQSQSGFTKQMARNMFYGGSVFFALLFAVIVFHTERQ-IPK----------------------------- 1212639 -----------------------------MSQSHSGFTKQMARNMFYGGTVFFALLFAAIVFDSERR-IPE----------------------------- 1210218 --------------------------------MSGAFTKSMARNIFYGGTVFFFLLFLALSFDTHSQ-LPK----------------------------- 1222533 --------------------------------MSSGFTKGMARNIFYGGAMFFFLLFVGLSVDTVVNRLPD----------------------------- 1210764 --------------------------------MSSAFTKSAARNIFYGGAVFFFLLFIGLTFDTMTT-LPK----------------------------- 1210042 --------------------------------MSGTFTKAMARNIFYGGTVFFFLLLVALTVDTTTN-LHK----------------------------- 1211830 --------------------------------MSETFTKGMARNIFYGGAVFFFLLFLALTFDTVQG-LPK----------------------------- 1211226 --------------------------------MSGIFTKSMARNIFYGGTTFFFLLFLALTFDTERE-LPN----------------------------- 1212642 --------------------------------MSGIFTKSMARNIFYGGTTFFFLLFLALTFDTERE-LPN----------------------------- 1211877 --------------------------------MATRFTKSMARNIFMGGSLFFFLLFLALTFDTNQK-LPK----------------------------- 1211614 --------------------------------MSASFTKSTARNIFYGGAVFFFLLFLALTFDTTQA-LPK----------------------------- 1212641 --------------------------------MSASFTKSTARNIFYGGAVFFFLLFLALTFDTTQA-LPK----------------------------- 1210041 --------------------------------MSGIMTKSMARNIFYGGSMFFFLLFLALTFHTEKE-LPK----------------------------- 1212645 --------------------------------MSGAFTKSMARNIFFGGTVFFFLLFLALSFDSTAT-LPK-----------------------------

1222649 --------------------------------------------------MFFFLLLVGLTFDTMRV-LPE----------------------------- 1220318 --------------------------------MPEKFSKNAARNIYYGGSLFFILLFLALTYQTTQA-LPQ----------------------------- 1220520 --------------------------------------------------MFFILLFLALTYHTEKT-LPE----------------------------- 1220524 --------------------------------MSETFTKGMARNIYFGGSVFFILLFLALTYHTEKT-LPE----------------------------- 1220519 --------------------------------MSETFTKGMARNIYFGGSVFFILLFLALTYHTEKT-LPE----------------------------- 1220521 --------------------------------MSETFTKGMARNIYFGGSVFFILLFLALTYHTEKT-LPE----------------------------- 1220523 --------------------------------MSETFTKGMARNIYFGGSVFFILLFLALTYHTEKT-LPE----------------------------- 1220525 --------------------------------MSETFTKGMARNIYFGGSVFFILLFLALTYHTEKT-LPE----------------------------- 1211162 --------------------------------MPETFTKGMARNIYFGGSVFFILIFLALTFHTEKQ-FPE----------------------------- 1222643 --------------------------------MSETFTKGMARNIYFGGSVFFILIFLALTFHSEQT-FPE----------------------------- 1220965 --------------------------------MSETFTKGMARNIYFGGSVFFFLVFLGLTYHTEQT-FPE----------------------------- 122X012 --------------------------------MSETFTKGMARNIYFGGSVFFFLVFLGLTYHTEQT-FPE----------------------------- 122X011 --------------------------------MSDTFTKGMARNIYFGGSIFFFLIFLALTYHTEQT-FPE----------------------------- 1222648 --------------------------------MSDTFTKGMARNIYFGGSIFFFLIFLALTYHTEQT-FPE----------------------------- 1222644 --------------------------------MSETFTKGMARNIYFGGSVFFFLIFLALTYHSEQT-FPA----------------------------- 1222647 --------------------------------MSETFTKGMARNIYFGGSVFFFLIFLALTYHTEQT-FPA----------------------------- 1220624 --------------------------------MAEKFTKSMARNIYYGGSFFFLLLLFGLSVDTVRQ-LPK----------------------------- 1220385 --------------------------------MAERFTKSMARNIYLGGSAFFVLLFLALTFDTQLRAMPE----------------------------- 1220839 --------------------------------MAERFTKSMARNIYLGGSTFFILLFLILTFDTQSRALPE----------------------------- 1220203 --------------------------------MSESFTKGMARNIYYGGSIFFFLIFLALTFHTVKE-MPK----------------------------- 1220490 --------------------------------MSDTFTKGMARNIYYGGSVFFLLLFAALTMHTTKE-MPK----------------------------- 1220491 --------------------------------MSDTFTKGMARNIYYGGSVFFLLLFAALTMHTTIE-MPK-----------------------------

110 120 130 140 150 160 170 180 190 200 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....| 1141613 -------------------------------------------PEAAAGKELWERQGCMQCHAIMGSGGYSASDLTDVVTR------------------- 1142558 -------------------------------------------QEASAGKDVWQSHNCVSCHTLLGQGGYVGEDLTHIMAK------------------- 1142557 -------------------------------------------EEAVAGKEVWQRYNCVSCHTLFGNGGYVGGDLTHITAE------------------- 1140225 -------------------------------------------EEAVAGKEVWQRYNCVSCHTLFGNGGYVGGDLTQITAR------------------- 1140226 -------------------------------------------EEAVAGKEVWQRYNCVSCHTLFGNGGYVGGDLTQITAR------------------- 1142559 -------------------------------------------EGAISGKQVWQRHECVSCHTIFGNGGYVGADMTHIVAQ------------------- 1142556 -------------------------------------------EQAVAGKLVWQRHNCISCHSLFGNGGYAGEDLTHITGQ------------------- 1142560 -------------------------------------------ESAVAGKLVWQRNNCVSCHTLFGHGGYEGDDLTHITAK------------------- 1142732 -------------------------------------------EQALAGKLVWQRHNCVSCHTLFGNGGYVGDDLTHVATK------------------- 1222482 --------------------------------QVTPDTVSFGPYQAVDGKRVFQAYNCMGCHTMVGNGAYLGPDLTEEYKRVGPAWLAAFLPSAGGWPTT 1112544 LKRDYEKRRDIPVIG-----------EEVGFFDK-VWSEEEAYTLVNKGKMTLQSRNCMDCHTLLGNGAYFAPDLTRAWLD--PKW-E------------ 1112653 LKRDYEKRRDLPVIG-----------EETGFFGR-VWSEAEAYSLVNKGKMTLQSRNCMDCHTLLGNGAYFAPDLTRAWLD--PKW-E------------ 1112654 LKRDYEKRRDVPVIG-----------EEVGFFGK-VWSEAEAYALVNKGKMTLQSRNCMDCHTLLGNGAYFAPDLTRAWLD--PKW-E------------ 1281324 YSYDPDRKMFVPTIG-----------EEELFFGK-KWSEKEAFQLITKGKLAIQSRNCMDCHTLLGNGAYFAPDLTKSWLD--PKW-D------------ 1030986 YEMDAEKGYFMPVIL-----------GDEPLFGK-TYTEEEATQLLVKGKLVIQSRNCMDCHTLLGNGAYYAPDLTKAWLD--PKW-E------------ 1032043 YVYDAERMAMVPALG-----------KEVGLFGR-VWSEEEAEKLVTKGKLVIQSRNCMDCHTLLGNGAYYAPDLTKAWLD--PKW-E------------

1241031 YQLNRKRGHEVPIIGGMDANGNSKYEEKEKFFGRDDYSEKEARALIHKGKLTIQAKNCMDCHTLLGNGAYYAPDLTKAWLD--PTWDT------------ 1240766 YEMNKKRQHEIPVIGGMNAEGTSAFQEKEKFFGRDDWSEQEAGELLHLGKLASQTKNCMNCHTLLGNGAYYAPDLTKAWLD--PAW-G------------ 1242289 YKYNEKRGLEVPVIG-----------KKEPFFGK-EWSPKEAAALLHLGKLTSQAKNCMDCHTLLGNGAYYAPDLTKAWLD--PMW-E------------ 1241030 YKYSKKRGHEVPVIG-----------EKQPFFGK-EWSEKEADQLLHLGKLTSQAKNCMNCHTLLGNGAYFAPDLTKAWLD--PAWQN------------ 1241223 YEMSTKRGHEVPVIG-----------EKEKFFGRDDWSEEEAGALLHLGKLGSQTKNCMNCHTLLGNGAYYAPDLTKAWLD--PAWQN------------ 1211829 YKFDETRHVQVPVIG-----------AKEPLFGK-ELNEEEAEALVKLGKLTTQAKNCMNCHTLLGNGAYYAPDLTKAWLD--QYW-G------------ 1220409 YRFDYILNRYRPVFG-----------GDEPLFGR-SLSEDEAAALVTQGKKTVQAKNCMNCHTLLGNGAYYAPDLTKAWLD--PDW-G------------ 1222655 YRFDAKLNRYTPVID-----------GDAPLFGK-SLSDEEAERLVTLGKKTFQAKNCINCHTILGNGAYYAPDLTKSWLD--PNW-------------- 1222652 YRFDKQLQRYQPVIL-----------GDAPLFGK-MLSETEAEQLVALGKKTTQAKNCMNCHTLLGNGAYYAPDLTKAWLD--QAWGG------------ 1222541 YQYQEKLHKSIPVVG-----------EDEFLFGR-EFSEEEARQLVDLGKKTSQAKNCMNCHTLLGNGAYYAPDLTKAWLD--KGW-------------- 1222748 YQFDKELNKFMPVIG-----------GEELLFGK-EYTEEEARELVDLGKKTTQAKNCMNCHTLLGNGAYYAPDLTKAWLD--QGW-------------- 1230031 -----------------------------------LTNADALDEQVVAGKRAFEARNCNDCHTILGFGGYYAPDLTRAHAR----I-G------------ 1222638 -----------------------------------LTNADKMDAQVIAGKDVWHSNNCINCHTLLGEGAYYAPDLTKITQQ----R-G------------ 1210461 -----------------------------------LTNEDKLTPEIIRGKDVWHNNNCINCHTLLGEGGYYAPDLTKITQQ----R-G------------ 1210008 -----------------------------------LTNAESITPAVVHGKDVWHKNNCINCHTIFGEGAYYAPDLTKITKL----R-G------------ 1211479 -----------------------------------LTNAESITPAVVHGKDVWHKNNCINCHTIFGEGAYYAPDLTKITKL----R-G------------ 1040279 -----------------------------------QSNHENITEAVVRGKNIWESNNCMGCHTILGEGAYYAPELTKVVDRMNMKYDG------------ 1041884 -----------------------------------QSNHENITEEVKRGKHLWEENNCMGCHSILGEGGYYAPELTKVVDR----K-G------------ 1042313 -----------------------------------QSNHLNITEQVIKGKHLWETNNCMGCHSILGEGGYYAPELTKVIDR----K-G------------ 1042464 -----------------------------------QSNHQNITEQVIKGKHIWETNNCMGCHAILGEGGYYAPELTKVIDR----K-G------------ 1230080 -----------------------------------QTNQIEMTDAVVRGKHLFDRNNCMGCHTILGEGAYYAPELTKVWER----R-G------------ 1250766 -----------------------------------RTNAQNLTEDVLKGKEIWEKNNCMGCHTLLGEGAYYAPDLTKVVER----R-G------------ 1251518 -----------------------------------RTNAQNLTEDVLKGKEIWEKNNCMGCHTLLGEGAYYAPDLTKVVER----R-G------------ 1252508 -----------------------------------QTRAENLTEPVKRGKLIFDQNNCMGCHTILGEGAYYAPELTRVMER----R-D------------ 1200380 -----------------------------------MEKSHPVTPSVAAGKHVWEKNACIDCHTIMGEGAYFAPELGNVWVR----Y-G------------ 1201239 -----------------------------------IAAANPVTPSVAAGKHVWEKHSCINCHTLMGEGAYYAPELGNVWVR----F-G------------ 1201278 -----------------------------------STAKAPLTDEVVLGKHVWEKHSCINCHTLHGEGAYFAPEVGNVMTR----W-G------------ 1200560 --------------------------------------TPALTDEVILGKHVWERNSCINCHTLHGEGAYFAPEVGNVMTR----W-G------------ 1200559 -----------------------------------STTSMPLTDEVRLGKEVWERNSCINCHTLHGEGAYFAPEVGNVMTR----W-G------------ 1200561 -----------------------------------STTSMPLTDEVRLGKEVWERNSCINCHTLHGEGAYFAPEVGNVMTR----W-G------------ 1200562 -----------------------------------STAGAPITEEVRLGKEVWERNSCINCHTLHGEGAYFAPEVGNVMTR----W-G------------ 1202538 -----------------------------------STAGAPITEEVRLGKEVWERNSCINCHTLHGEGAYFAPEVGNVMTR----W-G------------ 1200590 -----------------------------------STAGMGLSEEVIHGKHVWERHSCINCHTLHGEGAYFAPEVGNVMTR----W-G------------ 1200985 -----------------------------------STSGMPLTEAVALGKRVWERHSCINCHTLHGEGAYFAPEVGNVMTR----W-G------------ 1201169 -----------------------------------STAGMPLTEAVALGKRVWERHSCINCHTLHGEGAYFAPEVGNVMTR----W-G------------ 1200838 -----------------------------------STAGMELSEEVVKGKHIWERHSCINCHTLHGEGAYFAPEVGNVMTR----W-G------------ 1201222 -----------------------------------STAGMELTDEVRQGKHVWERHSCINCHTLHGEGAYFAPEVGNVMTR----W-G------------ 1201843 -----------------------------------STAGMPLTDEVRLGKHVWERASCINCHTLHGEGAYFAPEVGNVMTR----W-G------------ 1200477 -----------------------------------AVDESQLTPSVVEGKHIWERNACIDCHTLLGEGAYFAPELGNVMKR----W-G------------ 1200238 -----------------------------------STASMELTDSVVLGKKVWEDKTCVNCHSILGEGAYFAPEVGNVMTR----W-G------------ 1202651 -----------------------------------STDRAGLTDSVAAGKHIWEKHACVNCHTILGEGAYFAPEVGNVMTR----W-G------------

1200589 -----------------------------------STDAATLTAEVEHGKHLWEIHGCVNCHSILGEGAYFAPELGNVMTR----W-G------------ 1200983 -----------------------------------STDAATLTEGVEHGKNLWEIHGCVNCHTILGEGAYFAPELGNVMTR----W-G------------ 1200641 -----------------------------------STNAETLTASVADGKHVWEKHACINCHSILGEGAYFAPELGNVMTR----W-G------------ 1200666 -----------------------------------STNAATLTESVAAGKRVWEDKACINCHTILGEGAYFAPEVGNVMTR----W-G------------ 1201844 -----------------------------------SPNSAKLDESVIRGKHVWEKHACINCHSIMGEGAYFAPEVANVMTR----W-G------------ 1202650 -----------------------------------SENSAKLDESVVRGKHVWEKHACINCHTIMGEGAYYAPEVANVMTR----W-G------------ 1201266 -----------------------------------GTDQANLTDAVVRGKRIWESKACFDCHTILGEGARFAPEVGNVFIR----W-G------------ 1220025 -----------------------------------STDHAGMTDSVVAGKEVWEEHNCINCHTILGEGAYFGPEMGNVWTR----F-G------------ 122X009 -----------------------------------STDNEGLTESVVAGKHIWEKNMCINCHSIMGEGAYFAPELSNVWER----Y-G------------ 1222498 -----------------------------------STDHAGLTDSVKHGKAVWEEHSCINCHTLLGEGAYFAPELGNVWIR----Y-G------------ 1202231 -----------------------------------STDKKTLTDAVARGKHVWERNACINCHTLLGEGAYFAPELGNVWLR----Y-G------------ 1202317 -----------------------------------STDEATLTDSVQRGKHVWEKNACINCHTLLGEGAYFAPELGNVWVR----Y-G------------ 1201839 -----------------------------------STASAELSDSVRRGKHVWEKNSCINCHTLLGEGAYFAPELGNVWVR----Y-N------------ 1202563 -----------------------------------SASDSGLTDSVRRGKHVWEKNSCINCHTLLGEGAYFAPELGNVWVR----Y-G------------ 1211833 -----------------------------------ATDESTLTESVVRGKHVWERHSCINCHSLLGEGAYFAPELGNVWIR----Y-G------------ 1222407 -----------------------------------STDESTLTEAVARGKHVWERHACINCHTLLGEGAYFAPELGNVWVR----Y-G------------ 1222409 -----------------------------------STDESTLTESVARGKHVWERHACIDCHSLLGEGAYFAPELGNVWVR----Y-G------------ 1220458 -----------------------------------STDESTLTESVARGKHVWERHACIDCHSLLGEGAYFAPELGNVWVR----Y-G------------ 1221136 -----------------------------------STDESTLTESVARGKHVWERHACIDCHSLLGEGAYFAPELGNVWVR----Y-G------------ 1210459 -----------------------------------STDETTLTESVTRGKHVWERNACINCHSLLGEGAYFAPELGNVWVR----Y-G------------ 1210460 -----------------------------------STDQATLTPSVAQGKQVWEHNACINCHSLLGEGAYFAPELGNVWVR----Y-G------------ 1202251 -----------------------------------STDEATLSESVIRGKHVWEKNSCINCHSILGEGAYFAPEVGNVWIR----Y-G------------ 1200095 -----------------------------------STDASTLTSSVARGKHVWEKNSCINCHTLLGEGAYFAPEVGNVWDR----W-G------------ 1200094 -----------------------------------STNAATLSDSVARGKHVWERNSCINCHTLLGEGAYFAPEVGNVWDR----W-G------------ 1200962 -----------------------------------STKASTLSDGVARGKHVWEKNSCINCHTLLGEGAYFAPEVGNVWDR----W-G------------ 1200556 -----------------------------------STDETKLTESVARGKHVWEKNACINCHTLDGEGAYFAPELSNVWIR----W-G------------ 122X013 -----------------------------------STDETTLNDSVARGKHVWEKNSCINCHTLLGEGAYFAPELGNVWVR----Y-G------------ 1200022 -----------------------------------STDESTLTESVARGKHVWEKNSCINCHTLLGEGAYFAPELGNVWKR----Y-G------------ 1200097 -----------------------------------STDESTLTSGVARGKHVWEKNSCINCHTLLGEGAYFAPELGNVWKR----W-G------------ 1200098 -----------------------------------STDESTLTSGVARGKHVWEKNSCINCHTLLGEGAYFAPELGNVWKR----W-G------------ 1200099 -----------------------------------STDESTLTSGVARGKHVWEKNSCINCHTLLGEGAYFAPELGNVWKR----W-G------------ 1200100 -----------------------------------STDESTLTSGVARGKHVWEKNSCINCHTLLGEGAYFAPELGNVWKR----W-G------------ 1200101 -----------------------------------STDESTLTSGVARGKHVWEKNSCINCHTLLGEGAYFAPELGNVWKR----W-A------------ 1201159 -----------------------------------STDESTLTSGVARGKHVWEKNSCINCHTLLGEGAYFAPELGNVWKR----W-A------------ 1201161 -----------------------------------STDESTLTSGVARGKHVWEKNSCINCHTLLGEGAYFAPELGNVWKR----W-A------------ 121X007 -----------------------------------STDETTLTDAVARGKHVWEKNSCINCHTLLGEGAYFAPELGNVWKR----F-G------------ 121X008 -----------------------------------STDESTLTDAVARGKHIWEKNSCINCHTLLGEGAYFAPELGNVWKR----W-G------------ 1200644 -----------------------------------STDETTLTDSVARGKHVWEKNSCINCHTLLGEGAYFAPELGNVWKR----W-G------------ 1201814 -----------------------------------STDESTLTDSVARGKHVWEKNSCINCHTLLGEGAYFAPEIGNVWKR----W-G------------ 1200571 -----------------------------------STDAETLTPAVARGKHVWEKNSCINCHTLLGEGAYFAPELSNVWVR----W-G------------ 1201236 -----------------------------------STDAETLTPAVARGKHVWEKNSCINCHTLLGEGAYFAPELSNVWVR----W-G------------

1200568 -----------------------------------STNQATLTDGVARGKHVWEKNACINCHTLLGEGAYFAPEIGNVWQR----W-G------------ 1242219 -----------------------------------LSHDDKITESVARGKVVWEENNCVGCHTIMGEGAYYAPELGNAFPR----L-------------- 1241897 -----------------------------------RSNQQNMTASVVAGKKLWEANDCVGCHTLIGEGAYYAPELMNVFQR----R-G------------ 1242165 -----------------------------------RSNAQNLTESVAAGKHLWEVNNCVGCHTILGEGAYYAPELGNVFLR----R-G------------ 1222646 -------------------------------------------PQIAMGKALWEKNDCIGCHTLLGEGAYFAPELGNVYQR----F-G------------ 1200379 -----------------------------------RDHRENITPQVALGKKVWEDNNCVGCHTLLGEGAYFAPELGNVYLR----R-G------------ 1211822 -----------------------------------RSKAGDITPAVVRGKHLWETRNCIGCHTLLGEGAYFAPELGNVYAR----R-G------------ 1211216 -----------------------------------RSNAQAITPAVVAGKKIWETRNCIGCHTLLGEGAYFAPELGNVYQR----R-G------------ 1212639 -----------------------------------RSNAQAITPAVVAGKKIWETRNCIGCHTLLGEGAYFAPELGNVYKR----RGG------------ 1210218 -----------------------------------RDMRANITPQIAEGKKLWETNDCIGCHTLLGEGAYFAPELGNVIVR----Y-G------------ 1222533 -----------------------------------RDNRAAINDQVARGKEIWEVNNCIGCHTLLGEGAYFAPELGNVYAR----R-G------------ 1210764 -----------------------------------RDNRANLTDSALRGKHIWETRNCIGCHTLMGEGAYFAPELGNVYAR----R-G------------ 1210042 -----------------------------------SDNSANLTPQVVAGKHIWETRNCIGCHTLLGEGAYFAPELGNVYTR----R-G------------ 1211830 -----------------------------------RDHRENITDSVVRGKHIWETRNCVGCHTILGEGAYFAPELGNVYKR----RGG------------ 1211226 -----------------------------------RDNRAAITPEVAAGKHIWETRNCLGCHTLLGEGAYFAPELGNVYKR----RGG------------ 1212642 -----------------------------------RDNRAAITPEVAAGKHIWEVNNCLGCHTLLGEGAYFAPELGNVYKR----RGG------------ 1211877 -----------------------------------RDNSQNLTASVIHGKKLWETNNCIGCHTLLGEGAYFAPELGNVYKR----R-G------------ 1211614 -----------------------------------RDNRVNLTEQVARGKNIWETRNCIGCHTLLGEGAYFAPELGNVYQR----R-G------------ 1212641 -----------------------------------RDNRVNLTEQVARGKNIWETRNCIGCHTLLGEGAYFAPELGNVYQR----R-G------------ 1210041 -----------------------------------RDNRENLTPAVIAGKKIWETRNCIGCHTLLGEGAYFAPELGNVYVR----R-G------------ 1212645 -----------------------------------RDNRANLTPAVANGKKIWETRNCIGCHTLLGEGAYFAPELGNVYPR----R-G------------ 1222649 -----------------------------------RDNRENITEEVAHGKELWEKNNCVGCHSIMGEGAYFAPELANVFDR----Y-------------- 1220318 -----------------------------------RDHRDQLTEAVARGKEIWEENNCIGCHTLMGEGAYFAPELANVFDR----R-G------------ 1220520 -----------------------------------RTNEAAMSAAVVRGKLVWEQNNCVGCHTLLGEGAYFAPELGNVVGR----R-G------------ 1220524 -----------------------------------RTNEAAMSAAVVRGKLVWEQNNCVGCHTLLGEGAYFAPELGNVVGR----R-G------------ 1220519 -----------------------------------RTNEAAMSAAVVRGKLVWEQNNCVGCHTLLGEGAYFAPELGNVVGR----R-G------------ 1220521 -----------------------------------RTNEAAMSAAVVRGKLVWEQNNCVGCHTLLGEGAYFAPELGNVVGR----R-G------------ 1220523 -----------------------------------RTNEAAMSAAVVRGKLVWEQNNCVGCHTLLGEGAYFAPELGNVVGR----R-G------------ 1220525 -----------------------------------RTNEAAMSAAVVRGKLVWEQNNCVGCHTLLGEGAYFAPELGNVVGR----R-G------------ 1211162 -----------------------------------RTNEAQMTEAVVRGKLVWEQNNCVGCHTILGEGAYFAPELGNVYER----R-G------------ 1222643 -----------------------------------RTNEHLMNEAVVRGKLIWEQNNCIGCHTLLGEGAYFAPELGNVFIR----R-G------------ 1220965 -----------------------------------RTNASEMTEAVVRGKAVWENNNCIGCHSLLGEGAYFAPELGNVFVR----R-G------------ 122X012 -----------------------------------RTNESEMTEAVVRGKEVWENNNCIGCHSLLGEGAYFAPELGNVFVR----R-G------------ 122X011 -----------------------------------RSNQAQLTESVIRGKGVWERNNCIGCHTLLGEGAYFAPELGNVVNR----R-G------------ 1222648 -----------------------------------RSNQAQLTESVIRGKGVWERNNCIGCHTLLGEGAYFAPELGNVVNR----R-G------------ 1222644 -----------------------------------RSNEAQLSESVVRGKLVWEQNNCVGCHTLLGEGAYFAPELGNVFQR----R-G------------ 1222647 -----------------------------------RSNVDQLTEAVVRGKGVWERNNCIGCHTLLGEGAYFAPELGNVFKR----R-G------------ 1220624 -----------------------------------RENRDALTEHVVKGKGLWETNNCIGCHSLMGEGAYYAPELANVFDR----R-------------- 1220385 -----------------------------------RDNRDELTEQVVRGKHLWEENNCVGCHSIMGEGAYFAPELANVFDR----R-G------------ 1220839 -----------------------------------RDNRDQLTEQVVNGKHVWENNNCVGCHSLMGEGAYFAPELANVFDR----R-G------------ 1220203 -----------------------------------RDNRENITEAVERGKHLWEKNNCIGCHTLIGEGAYFAPELMNVYDR----R--------------

1220490 -----------------------------------SDHRENLTESVARGKTVWEDNNCIGCHTLVGEGAYYAPELGNVYFR----R-------------- 1220491 -----------------------------------SDHRENLTESVARGKTVWEDNNCIGCHTLVGEGAYYAPELGNVYFR----R-------------- 99% * ^ ^ ^ ^

210 220 230 240 250 260 270 280 290 300 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....| 1141613 ----------------RGEGWLEEFFLEPPLMEPSH------RR---HPGLAGAEIVHMLTFLRLVDEIDNLDWPPAPLITVPEDLETKD---------- 1142558 ----------------RSPDEINAFFRHPPVIPPHQ-----EEK---HPSLTPLETQDIIAYFEYMRTIPTLGWPPTPIKLESGDIL------------- 1142557 ----------------RTPDYLMTLFNNPPVLPPHQ-----KET---HTSLTEKETLAMIAYFEYLNTIPTLGWPPQPKELKGGDVR------------- 1140225 ----------------RSPEQLSDFFSNPPVIPPHQ-----KET---HVALTEEETQAMTAYFDYLNTIPTLGWPPQPRVLEGGDAP------------- 1140226 ----------------RSPEQLSDFFSNPPVIPPHQ-----KET---HVALTEEETQAMTAYFDYLNTIPTLGWPPQPRVLEGGDAP------------- 1142559 ----------------RGSEYVLNYLVKPPVMLPNR-----KLH---HPGLSGSEATQIVEYFEYLDKIPTLGWPPQPQKAEKES--------------- 1142556 ----------------ETPSFLVNYLIKPPVIPPNK-----YTH---HPGLDKRDAQNLVSYLEFVHTIPTLGWPPEPK--------------------- 1142560 ----------------VKSSYLINYLVQPPLMRPNK-----HTH---HPSLNEEDAHNLVNYLEFVHTIPTLGWPPQPKNVEEDS--------------- 1142732 ----------------ETPAYLINYLVQPPVMRPNK-----LAH---HPALNEMDAVNLVHYLEFVQTIPTLGWPPQREKAEKDS--------------- 1222482 AAVRAQLLDPNQQADTGTDSIEAYLKKFPG---AAQRIERRGGGTTMMPNLPFSKDEIGQLIAYLKYTSAMNTEGWPPK------------VEVEGFDHR 1112544 ------TMVKGMTGKATKEEAMAEWLQHPD----RYPTF--VRR---MPNLGLSEEEAKALVAFLKWMSAIDTNGFPDRFAGVQ---------------- 1112653 ------TMVKSMTGKATKEEAMAEWLQHPD----RYPTF--SRR---MPNLGLSEEEAKALVAFLKWMSAIDTNGFPDRFAGVQ---------------- 1112654 ------AMVMPMTGKATREEAMAEWLQHPD----RYPTF--ARR---MPNLRLTEEEARALVAFLKWMSAIDTNGFPDRFAAAE---------------- 1281324 ------TMIKPMVGAETKEEAISKWLQNPE----YYATW--QRR---MPNLKIDDQEARAIVGYLKFMSAIDTNGFPDHFGQSALAY------------- 1030986 ------KIMMPMTGAKTKEEAMVKFLMHPD----KYATW--TRR---MPNLHITEEEAKAVVAYLKWMAAINTNGFPDHFGRSKLVKLD----------- 1032043 ------KQLMPMTGAKTREEAMRAFLMNPD----KYPTW--VRR---MPNLKLSEDEAMAVVAYLKWMSTIDTNGFPANFPEVKVSQ------------- 1241031 ----------LAPAYGGKEHAIAKFLQNPP----AMAMH--ERK---MPNLGITEDEAKAVVAYLKFMSAIDTNGFPRNFGKIKGAVDARK--------- 1240766 ----PEGSMMGMTSKETKEEAMAEFLQNPS----QYPTH--ARM---MPNLGITAEEAKGLVAFLKHMATIDTNGFPRNFGKIQGAVNGK---------- 1242289 ------KTMPAMTNKKTKEEAMVAFLTHPE----RYPTH--ARM---MPNLGITEKEAMGLVAFLKHMSAIDTNGFPRGFSKGVKEYQTGGTYAQ----- 1241030 -----GGPLQGMTGKKTVEEAMAEFLQHPS----QYPTH--ARM---MPDLGITAEEAKGLVAFLKQMSSIDTNGFPRGFSKTLKTFEAGGTYAH----- 1241223 -----DGTMQAMTGKSTKEEAMAEFLQHPS----TYPTH--ARM---MPDLGITAEEAKGLVAFLKHMSSIDTNGFPRNFGKIQGAVNGK---------- 1211829 -------------SKEVREVQMVEFIKDPS----DKLHNSLGRR---MPKLDITDEEARGVVAFLKWMSSIDTNGFPYNFKSIEQEN------------- 1220409 -------------SVEEREARMLAFLLDPE----KNAVTFSSGRK--MPRLGITDAEAHAIVAFLKWMSAIDTNGFPTNFKTIGHQED------------ 1222655 ------------VDETNREILMLAFLQDPP----GNSRSYGTGRR--MPDLGITEDEARGLIAFLKWTAAIDTNGFPHNFKTLYAQENP----------- 1222652 ---------------AGRETAMAQFLLDPE----KYAHTYGSNRK--MPNLGITEEEARGVVAFLKWMSAIDTNGFPHNFKAIGAEEE------------ 1222541 ------------INTELREDMLMKFLMDPE----KNARTYGSDRK--MPNLGITEAEAKGLIAFLKWMSSIDTNGFPYNFKTIYAEE------------- 1222748 ----------I--SPEMREDMMLQFLMNPE----KNARTFGTGRK--MPNLGITEAEARGVVAFLKWMSSIDTNGFPYNFKTLYAED------------- 1230031 ------------------EEGIRRRLAHPE------QVFRASYRK--MPQQRLSAAELDGMVRFLRWVDGIENNDWPPQ--------------------- 1222638 ------------------EAYLAAFLSNPS-KFYSEQRHRR--I---MPNPELSETEIDDVIAFLDWVSQIDNQGWPPR--PILVSGATFPGTNTQKASG 1210461 ------------------TPYLTAFLKDPS-QFYSEEKHRR--L---MPNPKLSDAEISEVITFLDWVGHIDNQGWPPR--PIIVSGTTIPGTDVGQSPT 1210008 ------------------EAYLKAYLKDPS-KFYDEQRHRR--L---MPKQDLSDEDIAGLIAFFDWVSNVDNQGWPPR--PILVTGSTLPGADRSAAQQ 1211479 ------------------EAYLKAYLKDPS-KFYDEQRHRR--L---MPKQDLSDEDIAGLIAFFDWVSNVDNQGWPPR--PILVTGSTLPGADRSAAQQ 1040279 ----------------QGEEVIKSILMSPV-P-WQP--NGR--K---MVAYEMTEQEAEDMVEFFKWIGEIDLNGFDRIVSPLAKEDN------------

1041884 ------------------EPIIKAILMSPV-P-WQP--NGR--K---MVAYNMSEEDAEAMIEYFKWIGEIDLNGFDHMVSPLAKDKAKGK--------- 1042313 ------------------APMVKAILQSPI-P-WAP--NGR--K---MVAYNMSDEDAEAMVEYFKWIGGIDLNGFDRIVSPLAKDKIKD---------- 1042464 ------------------APMVKAILQSPI-P-WAP--NGR--K---MVAYEMSDEDAEAMVEYLKWIGEIDLNGFERIVSPLAKDKIKD---------- 1230080 ------------------EIFIKSMLRDPQ-A-MYP--NDR--K---MTNYHFTEEEINDLTAFLKWIGTMDLNGFPPK--------------------- 1250766 ------------------VSWIDVFLDDPQ-A-MFP--GER--K---MVKYNFTKEEKGQVIAFLDWVGKIDANGWPPK--------------------- 1251518 ------------------VSWIDVFLDDPQ-A-MFP--GER--K---MVKYNFTKEEKGQVIAFLDWVGKIDANGWPPK--------------------- 1252508 ------------------PEWIRVFIKDPE-A-MYP--GRR--K---MVKYDFTDEQIDDLIAFFTWTGKMDLNGFPPK--------------------- 1200380 ---------GREDAAAARDGLKNWIKSMP--T-GIE--GRR--Q---MPHFDITEKELDDLVDFFKWTSEVNTQNWPPKVSG------------------ 1201239 ---------GKEDASGAREALKAWMKGQP--S-GVE--GRR--Q---MPQFNLTETELDNLADFFKWTSEVDTQNWPPKVSG------------------ 1201278 ---------VLDDPDDAAETLGSWMESQP--S-GIE--GRR--Q---MPYFKLTEEEVRGLSEFLRWADKTNTQDWPPNDAG------------------ 1200560 ---------VLDDPDAAAEMLGGWMDAQP--S-GVE--GRR--Q---MPHFELTDEEKRGLSEFLRWADQMNTQSWPPNDAG------------------ 1200559 ---------VLDDPDAAAEMLGGWIDAQP--S-GIE--GRR--Q---MPHFALTDEEKRGLSEFLRWADKMNTQSWPPNDAG------------------ 1200561 ---------VLDDPDAAAEMLGGWIDAQP--S-GIE--GRR--Q---MPHFALTDEEKRGLSEFLRWADKMNTQSWPPNDAG------------------ 1200562 ---------VADDPEGAFDILKGWMEAQP--S-GIE--GRR--Q---MPHFEITDEEMRGLAEFLRWADQTNTQNWPPNDAG------------------ 1202538 ---------VADDPEGAFDILKGWMEAQP--S-GIE--GRR--Q---MPHFEITDEEMRGLAEFLRWADQTNTQNWPPNDAG------------------ 1200590 ---------VQDSPEDAFEILKGWMESQP--S-GTP--GRR--Q---MPNFNLTDEDIRGLAEFLRWADQTDTQGWPPNDAG------------------ 1200985 ---------VQDEPEEAFEILNSWMESQP--S-GVE--GRR--Q---MPYFELTEEETRGLAEFLRWADQTDTQGWPPNDAG------------------ 1201169 ---------VQDEPEEAFEILNSWMESQP--S-GVE--GRR--Q---MPYFELTEEETRGLAEFLRWADQTDTQGWPPNDAG------------------ 1200838 ---------VLDEPEEAFEMLDAWMKSQP--T-GIE--GRR--Q---MPQFNLTEEETRALSEFLRWADQTDTQNWPPNDAG------------------ 1201222 ---------VLDDPEAAYEMLDGWMKAQP--S-GVE--GRR--Q---MPYFELTEEETKALSEFLRWADQTDTQNWPPNDAG------------------ 1201843 ---------VLDDPEGAYEILNGWMQAQP--S-GVE--GRR--Q---MPFFDLTEEETRALAEFLRWADQTDTQNWPPNDAG------------------ 1200477 ---------VQDDPDSAFETLKGWMESMP--T-GIE--GRR--Q---MPRFDLTDEEFRALSDFLLWTGTINTQNWPPNDAG------------------ 1200238 ---------VVDDPEAAFETLKGWIQAMP--T-GIE--GRR--Q---MPYFELTDEEIRGLSDFLIWTDKIDAQGWPPNDAG------------------ 1202651 ---------VADDPDAAAETLKAWMEAMP--T-GIE--GRR--Q---MPSFRLSDEEYRQLADFLLWTNKIRTQDWPPNDAG------------------ 1200589 ---------VEDDPDAAFEALKGWMDAMP--T-GIE--GRR--Q---MPNFGLNDEEYRALSDFLLWTNTIRNQDWPPNDAG------------------ 1200983 ---------VEDDPEAAFETLKGWMDAMP--T-GIE--GRR--Q---MPNFGLNDEEYRALSDFLLWTNTIRNQDWPPNDAG------------------ 1200641 ---------VQDDPDAAFEMLKGWMEAQP--T-GIE--GRR--Q---MPRFDLSDTEMRNLSDFLLWTNTIDTQGWPPNDAG------------------ 1200666 ---------VLDDPELAFETLKGWMESQP--S-GIE--GRR--Q---MPQFHLTDEEIRDLSNFLIWTDKIDAQDWPPNDAG------------------ 1201844 ---------VLDDPESAFESLKGWMEAQP--T-GIP--GRR--Q---MPRFNLSDEEIRDLANFLIWTDNIDAQDWPPNDAG------------------ 1202650 ---------VLDDPESAFEALKGWMEAQP--T-GIP--GRR--Q---MPNFNLSDEEIRDLANFLIWTDNIDAQGWPPNEAG------------------ 1201266 ---------GDKDPKAAHEMIKDWMKSQP--S-GVA--GRR--Q---MPQFNLSDNELDDLADFLEWVSRTNTQGWPPGKAG------------------ 1220025 ---------GHRSPEGARAAIAGWIRAQP--T-GAP--GRR--Q---MPYFEINDEEMDALIDFLEWTDNIDTQDWPPHPSG------------------ 122X009 ---------GHQNPEAARAGLAAWIRAQP--L-GTQ--GRR--Q---MPAYDFTDEEMSSLIDFLEWTDGIDDQDWPPHPAG------------------ 1222498 ---------GLESPEGARAGIKTWMQIQP--T-GVP--GRR--Q---MPNFNLTDAELDALVDFFEWMSRINTQGWPPNVAG------------------ 1202231 ---------GDKDPEGAVLALKSWMAAQP--S-GIE--GRR--Q---MPQFHLTDGEVEDLAAFLEWTSRINTQNWPPKLSG------------------ 1202317 ---------GREDPTGAREALTAWMHSQP--S-GIE--GRR--Q---MPDFHLTDQEVNDLIDFLEFTSRVKTQGWPPKTSG------------------ 1201839 ---------GLEDPKAAREGLFAWMHSQP--S-GVE--GRR--Q---MPDFKLSDQETNDLIDFLEFTSRVKTQGWPPKASG------------------ 1202563 ---------GLEDPKSAREGLTAWLHSQP--S-GVE--GRR--Q---MPDFHLSDQETNDLIDFLEFTSHVKTQGWPPKASG------------------ 1211833 ---------GNQSPEGARAGLKAWMRAQP--T-GVA--GRR--Q---MPQFNLSEQELDDLVDFLEWTSRIDTLGWPPGISG------------------ 1222407 ---------GREDPAGARAALKAWMRAQP--L-GIE--GRR--Q---MPQFNLTEQELDDLIDFLEWTSRIDTLGWPPNVAG------------------ 1222409 ---------GRENPEGARMGIKAWMKVQP--T-GVE--GRR--Q---MPQFNLTEQELDDLVDFFEWTSRIDTLGWPPNNAG------------------

1220458 ---------GRENPEGARMALKAWMKVQP--T-GVE--GRR--Q---MPQFNLTEQELDDLVDFLEWTSRIDTLGWPPNNAG------------------ 1221136 ---------GRENPEGARMALKAWMKVQP--T-GVE--GRR--Q---MPQFNLTEQELDDLVDFLEWTSRIDTLGWPPNNAG------------------ 1210459 ---------GRDHAEGARMGLKAWMRAQP--T-RVP--GRR--Q---MPQFNLSEQELDDLIDFFEWTSRIDTQGWPPNTAG------------------ 1210460 ---------GREHPEGARMGLKAWMRAQP--T-GVP--GRR--Q---MPQFNLSEQELDNLIDFLEWVSRIDTQGWPPNTAG------------------ 1202251 ---------GKDDPQAAREGLIAWMRSQP--S-GVE--GRR--Q---MPQFHLTDQELNDLVDFLEWTSRIDTQKWPPNDAG------------------ 1200095 ---------GKEDPASARETLKAWMQSQP--S-GAE--GRR--Q---MPQFNLTDQELNDLADFLQWVSTIKRQDWPPNKAG------------------ 1200094 ---------GREDPAAAREMLKSWMQSQP--S-GAP--GRR--Q---MPQFNLTDQELNDLADFLQWADTIKRQDWPPNKAG------------------ 1200962 ---------GREDSAAAREMLKSWMQSQP--S-GAP--GRR--Q---MPQFNLTDQELNDLADFLQWTDTIKRQDWPPNKAG------------------ 1200556 ---------GDKDPASAREALHAWMAAQP--S-GIE--GRR--Q---MPQFNLTEEEVNDLADFLEWVSKMNTQAWPPNQAG------------------ 122X013 ---------GKDDPESARDSLKAWMAAQP--S-GIE--GRR--Q---MPQFNLTEQELNDLADFLEWTSKINTQNWPPNDAG------------------ 1200022 ---------GVEDKETARDSIKAWMAAQP--T-GIE--GRR--Q---MPQFNLTEQELDDLVDFLEWTSRIKTQNWPPNEAG------------------ 1200097 ---------GDTDPESARETLKAWMAAQP--S-GIE--GRR--Q---MPQFSLSDQELDDLADFLEWTSRIKTQNWPPNDAG------------------ 1200098 ---------GDTDPESARETLKAWMAAQP--S-GIE--GRR--Q---MPQFSLSDQELDDLADFLEWTSRIKTQNWPPNDAG------------------ 1200099 ---------GDTDPESARETLKAWMAAQP--S-GIE--GRR--Q---MPQFSLSDQELDDLADFLEWTSRIKTQNWPPNDAG------------------ 1200100 ---------GDTDPESARETLKAWMAAQP--S-GIE--GRR--Q---MPQFSLSDQELDDLADFLEWTSRIKTQNWPPNDAG------------------ 1200101 ---------GDTDPESARETLKAWMAAQP--S-GIE--GRR--Q---MPQFSLSDQELDDLADFLEWTSRIKTQNWPPNDAG------------------ 1201159 ---------GDTDPESARETLKAWMAAQP--S-GIE--GRR--Q---MPQFSLSDQELDDLADFLEWTSRIKTQNWPPNDAG------------------ 1201161 ---------GDTDPESARETLKAWMAAQP--S-GIE--GRR--Q---MPQFSLSDQELDDLADFLEWTSRIKTQNWPPNDAG------------------ 121X007 ---------GEADPDGARDTLKAWMAAQP--T-GIE--GRR--Q---MPQFNLTEQELNDLADFLEWTSRIKTQNWPPNEAG------------------ 121X008 ---------GEEDPEGARETMKAWMQAQP--T-GIE--GRR--Q---MPQFNLSEQELNDLADFLEWTSRIKTQNWPPNEAG------------------ 1200644 ---------GESDPEGARETLKSWMAAQP--S-GAE--GRR--Q---MPQFKLTEQELNDLADFLEWTSRIKTQNWPPNEAG------------------ 1201814 ---------GESDPEGARETLKSWMAAQP--S-GAE--GRR--Q---MPQFNLTEQELNDLADFLEWTSRIKTQNWPPNEAG------------------ 1200571 ---------GDKDPAQAREMLKSWMASQP--S-GVP--GRR--Q---MPQFHLTDQEVGDLADFLEWTSKIKTQHWPPNDAG------------------ 1201236 ---------GDKDPAQAREMLKSWMASQP--S-GVP--GRR--Q---MPQFHLTDQEVGDLADFLEWTSKIKTQHWPPNDAG------------------ 1200568 ---------GDQDPAAGREMLKAWMAAQP--S-GVH--GRR--Q---MPQFNLTDQEVSDLADFLEWTSTIKTQSWPPNKAG------------------ 1242219 ---------GANDEAAFKTYLVGWMAAQP--L-DTP--DRR--K---MPQFHLSPEQVNNLADFLIWTSRVNNQEWPPNIKG------------------ 1241897 ---------GGDE-GAFKAYMQGWMAAQP--L-DTP--NRR--K---MPQFHLTDKEVNNLADFLIWTSKVNANEWPPTIEG------------------ 1242165 ----------GGDKEAFKAYMQGWMAAQP--L-SEP--NRR--K---MPQFNLTPEQVDNLSDFLIWTSKIDANEWPPNIEG------------------ 1222646 ---------------NSTDAIKGFIASRP--KDGIP--GRR--S---MPQFNFSDEELSALAEFLKYASGINTAGWPPNIQG------------------ 1200379 ------------GKDGGIDFIKDWIRAQP--S-GVE--GRR--Q---MPQFNLTEEELDAVATFLKWTSEINTAGWPPNIEG------------------ 1211822 -----------------PDFIKSWIKAMP--T-HTP--GRR--Q---MPQFNFTEGQLDDLVEFLRWTNGVDAEKWPPNIEG------------------ 1211216 -----------------PEFIKAWMAAQP--T-HVE--GRR--Q---MPQFNLDAKQLDDLVEFLKWTGEINTEKWPPNIEG------------------ 1212639 ------------------DFIKVWMKVQP--T-GVA--HRR--Q---MPQFNLTDQQLDELVEFLKWTGEINTEKWPPNIEG------------------ 1210218 -----------------EEGTKAFIQARP--KEGIP--GRR--S---MPQFNFTDEQLNAIVAFLKHVNSINTNNWPPNSQG------------------ 1222533 -----------------PEFIKMWIKMQP--T-GTP--GRR--Q---MPNFHLTDEELDDLVAFLKYVNGVDTANWPPNIEG------------------ 1210764 -----------------PDFIRTWMKIQP--S-GAP--GRR--Q---MPNFQLTDAQLDDLVAFLKYASEVNTSKWPPNIEG------------------ 1210042 -----------------PEFIKAWIQSQP--T-GAP--GRR--Q---MPQFHLTDQELDDLVAFLKYTSGIDAQKWPPNIEG------------------ 1211830 ------------------DFIKAWIKSQP--T-GVP--GRR--Q---MPQFNLTDQQLDDVVEFLKWTSEINTNNWPPNIEG------------------ 1211226 ------------------DFIKGWMQAMP--T-GAP--GRR--Q---MPQFNLTDEELDQLVAFLKYTSEINTANWPPNIEG------------------ 1212642 ------------------DFIKGWMQAMP--T-GAP--GRR--Q---MPQFNLTDEELDQLVAFLKYTSEINTANWPPNIEG------------------ 1211877 -----------------PDFIKAWIKGQP--T-GVP--GRR--Q---MPQFNFTDKELDDLVDFLKYSSEIDTNNWPPNIEG------------------

1211614 -----------------PEFIKAWIKGQP--T-GAP--GRR--Q---MPQFHLTDGELDDLVAFLKYSSEINTNNWPPNIEG------------------ 1212641 -----------------PEFIKAWIKGQP--T-GAP--GRR--Q---MPQFHLTDGELDDLVAFLKYSSEINTNNWPPNIEG------------------ 1210041 -----------------PDFIKAWIKAQP--T-GTP--GRR--Q---MPQFNLTEQELDDLVAFLKYASEINSAKWPPNIEG------------------ 1212645 -----------------GDFIKAWIKGQP--S-GAP--GRR--Q---MPQFNLTEQQLDDLVAFLKYTSEINTANWPPNIEG------------------ 1222649 ---------GQGDEQAFRAYLQSWMAIQP--L-KAP--GRR--Q---MPQFNLSPEEVDALAAFLIWTSRIDDNDWPPNIQG------------------ 1220318 ------------GEQAFTAFLKAWMAAQP--L-DVP--GRR--K---MPQFNLSEQQVEDLAEFLKWTSKIDDNNWPPNIEG------------------ 1220520 ------------GEEGFNTFLQAWMKIQP--L-NVP--GRR--A---MPQFHLSEGQVDDLAEFLKWSSKIDTNQWPPNKEG------------------ 1220524 ------------GEEGFNTFLQAWMNIQP--L-NVP--GRR--A---MPQFHLSEGQVDDLAEFLKWSSKIDTNQWPPNKEG------------------ 1220519 ------------GEEGFNTFLQAWMKIQP--L-NVP--GRR--A---MPQFHLSEGQVDDLAEFLKWSSKIDTNQWPPNKEG------------------ 1220521 ------------GEEGFNTFLQAWMKIQP--L-NVP--GRR--A---MPQFHLSEGQVDDLAEFLKWSSKIDTNQWPPNKEG------------------ 1220523 ------------GEEGFNTFLQAWMKIQP--L-NVP--GRR--A---MPQFHLSEGQVDDLAEFLKWSSKIDTNQWPPNKEG------------------ 1220525 ------------GEEGFNTFLQAWMKIQP--L-NVP--GRR--A---MPQFHLSEGQVDDLAEFLKWSSKIDTNQWPPNKEG------------------ 1211162 ------------GDQDFHSFLRAWMSAQP--L-GVP--GRR--A---MPQFHLSDRQVDDLAEFLKWTSKINNYNWPPNREG------------------ 1222643 ------------GEEQFSSFLHAWMAAQP--L-GVP--GRR--A---MPQFNLSDKEVDDLAEFLKWTSKIDTNDWPPNREG------------------ 1220965 ------------GEEAFKPFLHAWMKAQP--L-GAP--GRR--A---MPQFNLTEQQVDDMAEFLKWTSKIDTNNWPPNKEG------------------ 122X012 ------------GEETFKPFLHAWMKAQP--L-GAP--GRR--A---MPQFNLSEQQVDDMAEFLKWTSKIDTNDWPPNKEG------------------ 122X011 ------------GDEAFKPFLQAWMKMQP--L-NVP--GRR--A---MPQFNLSEQEVDDIAEFLKWSSKINTNGWPPNKEG------------------ 1222648 ------------GDEAFKPFLQAWMKMQP--L-NVP--GRR--A---MPQFNLSEQEVDDIAEFLKWSSKINTNGWPPNKEG------------------ 1222644 ------------GEAGFKPFLHAWMKMQP--L-RVP--GRR--A---MPQFNLSDQEVDDIAEFLKWSSKINTNGWPPNKEG------------------ 1222647 ------------GEEGFKPFLHAWMKMQP--L-GVP--GRR--A---MPQFNLSDQEVDDMAEFLKWSSKIDTNNWPPNKEG------------------ 1220624 ---------GAGNEAAFKSYLRAWMNAQP--L-AIP--HRR--K---MPQFNLTDAEIDNLAEFLIWTSRIDDNNWPPNIEG------------------ 1220385 ---------GGDT-EVFKAYMKAWMNAMP--T-NIP--GRR--Q---MPNFNLSDSEIEDLAAFLEWTSKIDDNGWPPNIEG------------------ 1220839 ----------AGNSDVFKAYMNAWMNAMP--T-NAP--GRR--Q---MPQFNLTDQEIEDLASFLEWTSKIDDNGWPPNIEG------------------ 1220203 ---------GGGNEVAFKAFLNGWMNAQP--L-NIP--GRR--Q---MPNFHLNDQEIDDLAEFLIWTSKLDANNWPPNIEG------------------ 1220490 ---------GGGNLTAFKGFMQGWMKIQP--L-GVP--GRR--Q---MPQFNLTVQQVDDLAEFLKFTAEMDVNSWPPNIEG------------------ 1220491 ---------GGGNLAAFKGFMQGWMRIQP--L-GVP--GRR--Q---MPQFNLTGQQVDDLAEFLKFTAEMDVNSWPPNIEG------------------ ^

310 320 330 340 350 360 370 380 390 400 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....| 1141613 ---------------------------------------------------------------------------------------------------- 1142558 ---------------------------------------------------------------------------------------------------- 1142557 ---------------------------------------------------------------------------------------------------- 1140225 ---------------------------------------------------------------------------------------------------- 1140226 ---------------------------------------------------------------------------------------------------- 1142559 ---------------------------------------------------------------------------------------------------- 1142556 ---------------------------------------------------------------------------------------------------- 1142560 ---------------------------------------------------------------------------------------------------- 1142732 ---------------------------------------------------------------------------------------------------- 1222482 LQLAHGIAPVAQANAAAASPAPAAAAPDPVAHGAQLVKDTGCLACHATDEKRLVGPGWGGLYNSKVSLADGSTVTADDAYLKESIRQ---------PNAK

1112544 ---------------------------------------------------------------------------------------------------- 1112653 ---------------------------------------------------------------------------------------------------- 1112654 ---------------------------------------------------------------------------------------------------- 1281324 ---------------------------------------------------------------------------------------------------- 1030986 ---------------------------------------------------------------------------------------------------- 1032043 ---------------------------------------------------------------------------------------------------- 1241031 ---------------------------------------------------------------------------------------------------- 1240766 ---------------------------------------------------------------------------------------------------- 1242289 ---------------------------------------------------------------------------------------------------- 1241030 ---------------------------------------------------------------------------------------------------- 1241223 ---------------------------------------------------------------------------------------------------- 1211829 ---------------------------------------------------------------------------------------------------- 1220409 ---------------------------------------------------------------------------------------------------- 1222655 ---------------------------------------------------------------------------------------------------- 1222652 ---------------------------------------------------------------------------------------------------- 1222541 ---------------------------------------------------------------------------------------------------- 1222748 ---------------------------------------------------------------------------------------------------- 1230031 ----------DSERAWKRSTERLLAGGLLSPGAALLKQESCLQCHALGAEGERIGPRLEWIGGRR--DAAYVAEFLEDPQRQQPGTTMPAYGHLSKGQRQ 1222638 VASSEQAPPAAAAAGEQLFS---------------DAATGCSGCHSIAPGVDLAGPSLAGVGERARRTVTDDGYTGSADTAAGYLRESIVAPSAHLVGGD 1210461 HASVSTDPVAQGEALFR------------------SSPPACNACHSIASGVNLAGPSLAGLATRAAAIIASPEYKGEAKTPTDYIRESITHPSAYLVPGA 1210008 ADDAKIERGGIAAPPGARPLSGNEDPIALGERVFRTATPACTACHSTAPGVNMAGPSLAGVKGRTEALLGSSDYKGQAKDVAAYLHESIVSPSAHLVPGP 1211479 ADDAKIERGGIAAPPGARPLSGNEDPIALGERVFRTATPACTACHSTAPGVNMAGPSLAGVKGRTEALLGSADYKGQAKDVAAYLHESIVSPSAHLVPGP 1040279 ---------------------------------------------------------------------------------------------------- 1041884 ---------------------------------------------------------------------------------------------------- 1042313 ---------------------------------------------------------------------------------------------------- 1042464 ---------------------------------------------------------------------------------------------------- 1230080 ---------------PDLAQPVSAAAVQATVAQPQIYGQVCVACHTMNGTGGNTGPTLDGIGSRRDGEYLTHWLKDPAAVKADSKMPKLPLTDEQIQELV 1250766 --------PNIPVDSIATAVPSQTTANVVKVAQPEKFSQLCVACHAVGGKGGNVGPALDHVGSKFDADYLNRWLIDPQAIKPGTNMPKLPLSDTERKDIV 1251518 --------PNIPVDSIATAVPSQTTANVVKVAQPEKFSQLCVACHAVGGKGGNVGPALDHVGSKFDADYLNRWLIDPQAIKPGTNMPKLPLSDTERKDIV 1252508 --------------PTIKVAQAEQATAQNSAAEPAVFQSLCKSCHALGGKGGTVGPALDGVGKKYDTAYLTKWLSDPQSVKPGTAMPKLPLSPEQLTELS 1200380 ---------------------------------------------------------------------------------------------------- 1201239 ---------------------------------------------------------------------------------------------------- 1201278 ---------------------------------------------------------------------------------------------------- 1200560 ---------------------------------------------------------------------------------------------------- 1200559 ---------------------------------------------------------------------------------------------------- 1200561 ---------------------------------------------------------------------------------------------------- 1200562 ---------------------------------------------------------------------------------------------------- 1202538 ---------------------------------------------------------------------------------------------------- 1200590 ---------------------------------------------------------------------------------------------------- 1200985 ---------------------------------------------------------------------------------------------------- 1201169 ----------------------------------------------------------------------------------------------------

1200838 ---------------------------------------------------------------------------------------------------- 1201222 ---------------------------------------------------------------------------------------------------- 1201843 ---------------------------------------------------------------------------------------------------- 1200477 ---------------------------------------------------------------------------------------------------- 1200238 ---------------------------------------------------------------------------------------------------- 1202651 ---------------------------------------------------------------------------------------------------- 1200589 ---------------------------------------------------------------------------------------------------- 1200983 ---------------------------------------------------------------------------------------------------- 1200641 ---------------------------------------------------------------------------------------------------- 1200666 ---------------------------------------------------------------------------------------------------- 1201844 ---------------------------------------------------------------------------------------------------- 1202650 ---------------------------------------------------------------------------------------------------- 1201266 ---------------------------------------------------------------------------------------------------- 1220025 ---------------------------------------------------------------------------------------------------- 122X009 ---------------------------------------------------------------------------------------------------- 1222498 ---------------------------------------------------------------------------------------------------- 1202231 ---------------------------------------------------------------------------------------------------- 1202317 ---------------------------------------------------------------------------------------------------- 1201839 ---------------------------------------------------------------------------------------------------- 1202563 ---------------------------------------------------------------------------------------------------- 1211833 ---------------------------------------------------------------------------------------------------- 1222407 ---------------------------------------------------------------------------------------------------- 1222409 ---------------------------------------------------------------------------------------------------- 1220458 ---------------------------------------------------------------------------------------------------- 1221136 ---------------------------------------------------------------------------------------------------- 1210459 ---------------------------------------------------------------------------------------------------- 1210460 ---------------------------------------------------------------------------------------------------- 1202251 ---------------------------------------------------------------------------------------------------- 1200095 ---------------------------------------------------------------------------------------------------- 1200094 ---------------------------------------------------------------------------------------------------- 1200962 ---------------------------------------------------------------------------------------------------- 1200556 ---------------------------------------------------------------------------------------------------- 122X013 ---------------------------------------------------------------------------------------------------- 1200022 ---------------------------------------------------------------------------------------------------- 1200097 ---------------------------------------------------------------------------------------------------- 1200098 ---------------------------------------------------------------------------------------------------- 1200099 ---------------------------------------------------------------------------------------------------- 1200100 ---------------------------------------------------------------------------------------------------- 1200101 ---------------------------------------------------------------------------------------------------- 1201159 ---------------------------------------------------------------------------------------------------- 1201161 ----------------------------------------------------------------------------------------------------

121X007 ---------------------------------------------------------------------------------------------------- 121X008 ---------------------------------------------------------------------------------------------------- 1200644 ---------------------------------------------------------------------------------------------------- 1201814 ---------------------------------------------------------------------------------------------------- 1200571 ---------------------------------------------------------------------------------------------------- 1201236 ---------------------------------------------------------------------------------------------------- 1200568 ---------------------------------------------------------------------------------------------------- 1242219 ---------------------------------------------------------------------------------------------------- 1241897 ---------------------------------------------------------------------------------------------------- 1242165 ---------------------------------------------------------------------------------------------------- 1222646 ---------------------------------------------------------------------------------------------------- 1200379 ---------------------------------------------------------------------------------------------------- 1211822 ---------------------------------------------------------------------------------------------------- 1211216 ---------------------------------------------------------------------------------------------------- 1212639 ---------------------------------------------------------------------------------------------------- 1210218 ---------------------------------------------------------------------------------------------------- 1222533 ---------------------------------------------------------------------------------------------------- 1210764 ---------------------------------------------------------------------------------------------------- 1210042 ---------------------------------------------------------------------------------------------------- 1211830 ---------------------------------------------------------------------------------------------------- 1211226 ---------------------------------------------------------------------------------------------------- 1212642 ---------------------------------------------------------------------------------------------------- 1211877 ---------------------------------------------------------------------------------------------------- 1211614 ---------------------------------------------------------------------------------------------------- 1212641 ---------------------------------------------------------------------------------------------------- 1210041 ---------------------------------------------------------------------------------------------------- 1212645 ---------------------------------------------------------------------------------------------------- 1222649 ---------------------------------------------------------------------------------------------------- 1220318 ---------------------------------------------------------------------------------------------------- 1220520 ---------------------------------------------------------------------------------------------------- 1220524 ---------------------------------------------------------------------------------------------------- 1220519 ---------------------------------------------------------------------------------------------------- 1220521 ---------------------------------------------------------------------------------------------------- 1220523 ---------------------------------------------------------------------------------------------------- 1220525 ---------------------------------------------------------------------------------------------------- 1211162 ---------------------------------------------------------------------------------------------------- 1222643 ---------------------------------------------------------------------------------------------------- 1220965 ---------------------------------------------------------------------------------------------------- 122X012 ---------------------------------------------------------------------------------------------------- 122X011 ---------------------------------------------------------------------------------------------------- 1222648 ----------------------------------------------------------------------------------------------------

1222644 ---------------------------------------------------------------------------------------------------- 1222647 ---------------------------------------------------------------------------------------------------- 1220624 ---------------------------------------------------------------------------------------------------- 1220385 ---------------------------------------------------------------------------------------------------- 1220839 ---------------------------------------------------------------------------------------------------- 1220203 ---------------------------------------------------------------------------------------------------- 1220490 ---------------------------------------------------------------------------------------------------- 1220491 ----------------------------------------------------------------------------------------------------

410 420 430 ....|....|....|....|....|....|....|...1141613 ------------------------------------- 1142558 ------------------------------------- 1142557 ------------------------------------- 1140225 ------------------------------------- 1140226 ------------------------------------- 1142559 ------------------------------------- 1142556 ------------------------------------- 1142560 ------------------------------------- 1142732 ------------------------------------- 1222482 VVAGYPASVMPVYETLLKDDEVNAIVAYLHSLEKQ-- 1112544 ------------------------------------- 1112653 ------------------------------------- 1112654 ------------------------------------- 1281324 ------------------------------------- 1030986 ------------------------------------- 1032043 ------------------------------------- 1241031 ------------------------------------- 1240766 ------------------------------------- 1242289 ------------------------------------- 1241030 ------------------------------------- 1241223 ------------------------------------- 1211829 ------------------------------------- 1220409 ------------------------------------- 1222655 ------------------------------------- 1222652 ------------------------------------- 1222541 ------------------------------------- 1222748 ------------------------------------- 1230031 MIGELVVSLAARGRVP--------------------- 1222638 RFSANGTSFMPTNYGTDLDADQIDALVDYLSTLK--- 1210461 MYSANSQSFMPDNFAVDLEPQQIDSLVAYLETLK---

1210008 MYSADGTSFMPTTYAKDLTAEQIDQLVAYLMSMK--- 1211479 MYSADGTSFMPTTYAKDLTAEQIDQLVAYLMSMK--- 1040279 ------------------------------------- 1041884 ------------------------------------- 1042313 ------------------------------------- 1042464 ------------------------------------- 1230080 TYLSQIK------------------------------ 1250766 TYLSALK------------------------------ 1251518 TYLSALK------------------------------ 1252508 EFLSALK------------------------------ 1200380 ------------------------------------- 1201239 ------------------------------------- 1201278 ------------------------------------- 1200560 ------------------------------------- 1200559 ------------------------------------- 1200561 ------------------------------------- 1200562 ------------------------------------- 1202538 ------------------------------------- 1200590 ------------------------------------- 1200985 ------------------------------------- 1201169 ------------------------------------- 1200838 ------------------------------------- 1201222 ------------------------------------- 1201843 ------------------------------------- 1200477 ------------------------------------- 1200238 ------------------------------------- 1202651 ------------------------------------- 1200589 ------------------------------------- 1200983 ------------------------------------- 1200641 ------------------------------------- 1200666 ------------------------------------- 1201844 ------------------------------------- 1202650 ------------------------------------- 1201266 ------------------------------------- 1220025 ------------------------------------- 122X009 ------------------------------------- 1222498 ------------------------------------- 1202231 ------------------------------------- 1202317 ------------------------------------- 1201839 ------------------------------------- 1202563 -------------------------------------

1211833 ------------------------------------- 1222407 ------------------------------------- 1222409 ------------------------------------- 1220458 ------------------------------------- 1221136 ------------------------------------- 1210459 ------------------------------------- 1210460 ------------------------------------- 1202251 ------------------------------------- 1200095 ------------------------------------- 1200094 ------------------------------------- 1200962 ------------------------------------- 1200556 ------------------------------------- 122X013 ------------------------------------- 1200022 ------------------------------------- 1200097 ------------------------------------- 1200098 ------------------------------------- 1200099 ------------------------------------- 1200100 ------------------------------------- 1200101 ------------------------------------- 1201159 ------------------------------------- 1201161 ------------------------------------- 121X007 ------------------------------------- 121X008 ------------------------------------- 1200644 ------------------------------------- 1201814 ------------------------------------- 1200571 ------------------------------------- 1201236 ------------------------------------- 1200568 ------------------------------------- 1242219 ------------------------------------- 1241897 ------------------------------------- 1242165 ------------------------------------- 1222646 ------------------------------------- 1200379 ------------------------------------- 1211822 ------------------------------------- 1211216 ------------------------------------- 1212639 ------------------------------------- 1210218 ------------------------------------- 1222533 ------------------------------------- 1210764 ------------------------------------- 1210042 ------------------------------------- 1211830 -------------------------------------

1211226 ------------------------------------- 1212642 ------------------------------------- 1211877 ------------------------------------- 1211614 ------------------------------------- 1212641 ------------------------------------- 1210041 ------------------------------------- 1212645 ------------------------------------- 1222649 ------------------------------------- 1220318 ------------------------------------- 1220520 ------------------------------------- 1220524 ------------------------------------- 1220519 ------------------------------------- 1220521 ------------------------------------- 1220523 ------------------------------------- 1220525 ------------------------------------- 1211162 ------------------------------------- 1222643 ------------------------------------- 1220965 ------------------------------------- 122X012 ------------------------------------- 122X011 ------------------------------------- 1222648 ------------------------------------- 1222644 ------------------------------------- 1222647 ------------------------------------- 1220624 ------------------------------------- 1220385 ------------------------------------- 1220839 ------------------------------------- 1220203 ------------------------------------- 1220490 ------------------------------------- 1220491 -------------------------------------

NorB subunit

10 20 30 40 50 60 70 80 90 100 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|

c1112653 ------------------------------MTQAMPQGKLYESQKLALWYFWVALALFGAQVLFGLLAAWQYLDPNFLYGK---LNFMTNRMLHVNAMIV c1112544 ------------------------------MTQALPQGKLYESQKLALWYFWVALALFGAQVLFGLLAAWQYLDPNFLYGK---LNFMTNRMLHVNAMIV c1112654 ------------------------------MTQALPQGKLYESQKLALWYFWVALALFGAQVLFGLLAAWQYLDPGFLYGK---LNFMTNRMLHVNAMIV c1032043 ------------------------------------MERLYESQRLAIWYFWTAIALFGAQLLFGLLAAYQFINPDFLYGT---LNFMTNRMLHINAMVI c1030986 ------------------------------------MSKLYESQKIALLYFSVAIVLFGAQLLFGLIAAYQFVNPEFLHNV---LPFSITRMLHINAMVV c1281324 ------------------------------MLSMKNPGILYESQKLALWYWALAVVLFGFQLIFGLIISYQYLQPEFLHKI---FNFSVGRLLHLNAMIL c1211829 ----------------------------MAMLGMLDSANLNGGQKLAVKYFIVAIVLFGAQVLFGLLSGLQYLYPDFLYGV---LDFSVNRMVHINALVV c1220409 -----------------------------MRTGIIDGANLNGGQQLAVKYFSVALVLFLVQMLFGLLAAIQFVRPDFLYNV---LDFNVNRMVHIDAMVV c1222655 -----------------------------MSVGVLDSRNLNGGQKLAVKYFIVAMVLFVAQVLFGLLAAIQFIVPSFLFET---LDFSVNRMLHINAMVV c1222652 ----------MAIQAYQDKAAALYAGLRSRYSVFMANPHLTGGQKLAVHYFTAAVVLFMAQLLFGLLAGLQFIWPGFLYEV---LDFNVNRMVHINAMIV c1222541 ------------MNVTELIEKATTRIKDFKAWVALDSGNLSNGQQLAVKYFSVAVILFVAQILFGLLAAAQFIWPGFLYEF---LDFNVNRMVHINAMVV c1222748 --MKSGGLAGVIENAGVLVDRSRGYWQDFQNWVQLDSSTLSPGRQLAVKYFIVAVILFCAQILFGLLAALQFIFPGFLYEI---LDFSVNRMVHINAMIV c1241031 ------------------------MEKSKERSMQGNNGQLYEGQKLALKYFTVAIVLFGAQLLFGLIAAIQFLYPGFLFNT---LDFSIARIVHINALVV c1240766 ---------------------------------MANSYLKSESKKLATWYFTVAATLFGAQLLFGLVAAIQYVMPGFLFEI---LDFSVARMLHINALVV c1241223 ------------------------------MASNHLTGIGSESKQLATWYFTFAAIIFGAQLLFGLVAAIQYVMPGFLFEL---LDFSVARMLHINALVV c1241030 ----------------------------MLTSIKTNEFAGDKGKELGMMYFRVAIILFGAQLLMGLIAAIQFLVPGFLFEL---FDFNVARMVHINALVV c1242289 -----------------------------MLSSIKSNVLQSESKKLAMMYFRVAIILFGAQLLFGLLAGLQFLFPGFLYGI---LDFSVNRMVHINALVV c1242165 --------------------------------------MKYSSQMVAKPYFIFALILLAGEILFGLLMATQYIFGDFLFPL---IPFNVLRMVHTNLLIV c1242219 --------------------------------------MKYSSQMVAKPYFIFALILLAGEIVFGLSMGVQYLYGDFLFPA---IPFNVLRMVHTNLLIV c1241897 --------------------------------------MKYTSQAVAKPYFIFALTLLAGEILFGILMGIQYVWGDFLFPL---IPFNVLRMVHTNLLIV c1230031 --------------------------------------VNYQSQRVAYPYFVVALLLFVAQVLLGLFLAFSYFFTLPQGFVDV-FPFSTARAIHTNLLVL c1042464 --------------------------------------MKYKSQQVAYWFFALCMLLFALQIVYGFIMGFARIGMDGLHDW---IPFNTARAVHTNLLVV c1042313 --------------------------------------MKYKSQQVAYWFFALCMLLFSLQIIYGFIMGFARIGMDGFHDW---IPFNTARAVHTNLLVV c1041884 --------------------------------------MKYKSQKVAYWFFALCMLLFTLQIVYGFVMGFARIGFDVLHDF---VPFNTARAVHTNLLVV c1040279 --------------------------------------MKYKSQKVAYWFFALSMLLLVLQLVYGFVMGFARIGFDNLHEF--GIPFNTARAVHTNLLVV c1251518 --------------------------------------MRFQSQKVAYWFFATCMLLLSLQIVYGFIMGFARIGMDGLHDY---IPFNTARATHTNLLVV c1250766 --------------------------------------MRFQSQKVAYWFFATCMLLLSLQIVYGFIMGFARIGMDGLHDY---IPFNTARATHTNLLVV c1252508 --------------------------------------MKFRSQKLAYWFFATCMLLFALQLVYGFVMGFARIGMDGLHEF---IPFNTARATHTNLLVV c1230080 --------------------------------------MKYQTQKIAYWFFATCMLLFSLQLVYGFIMGFAHMGFDGLHNI---IPFNAARATHTNLLVV c1222638 --------------------------------------MRFRTQRVAYWYFAVALSLFGLQLVMGLLMAAKYLGPDPLIDL---LPFDVAKAMHTNLLIV c1210461 --------------------------------------MRYRSQSIAYWYFAVAMCLFGLQLVFGLLTASKYLGPDPLLDF---LPFDKTKAIHTNLLIV c1211479 --------------------------------------MRYKSQSVAYWYFAVAVALFGLQLVFGLLSATKYLGPDPLLYI---LPFDVTKMIHTNILIV c1210008 --------------------------------------MRYKSQSVAYWYFAVAVALFGLQLVFGLLSATKYLGPDPLLYI---LPFDVTKMIHTNILIV c1211833 --------------------------------------MKYHTQALAFPYFIAALALFLIQVLAGVLAGTVYVFPNFLSES---VPFHIIRMIHTNALLV c1222407 --------------------------------------MKYQTQKLAYPYFIAALALFLVQVMAGVLAGSVYVFPNFLSES---VPFHIIRMIHTNALLV c1222409 --------------------------------------MKYQTQQLAYPYFVAALALFLVQLVAGVLAGTIYVFPHFLSEA---APFNIIRMIHTSALLV c1220458 --------------------------------------MKYQTQQLAYPYFVAALALFLVQLVAGVLAGTIYVFPHFLSEA---APFNIIRMIHTSALLV c1221136 --------------------------------------MKYQTQQLAYPYFVAALALFLVQLVAGVLAGTIYVFPHFLSEA---APFNIIRMIHTSALLV c1200568 --------------------------------------MKYQTQKVALLYFYGALTLFIAQVTFGVLAGTIYVLPNTLSEL---VPFNIVRMIHTNALIV c1200571 -------------------------------------MMKYQTQKVALLYFYGALTLFLAQVSFGVLAGTIYVLPNTLSEL---LPFNIVRMIHTNALIV c1201236 --------------------------------------MKYQTQKVALLYFYGALTLFLAQVSFGVLAGTIYVLPNTLSEL---LPFNIVRMIHTNALIV

c122X013 --------------------------------------MKYQTQKVAMLYFYGAIGLFLAQVLFGVLAGTIYVMPNTLSEL---LPFNIVRMIHTNALIV c1201814 --------------------------------------MKYQTQKVAMLYFYGALGLFLAQVLFGVLAGTIYVLPNTLSEL---LPFNIVRMVHTNALIV c1200644 --------------------------------------MKYQTQKVAMLYFYGALGLFLAQILFGVLAGTIYVLPNTLSEL---LPFNIVRMVHTNALIV c121X007 --------------------------------------MKYQTQKVAMLYFYGALGLFLAQVLFGVLAGTIYVLPNTLSEL---LPFNIVRMVHTNALIV c1200022 --------------------------------------MKYQTQKVAMLYFYGAIGLFVAQILFGVVAATIYVLPNTLSEL---LPFNIVRMIHTNALVV c121X008 --------------------------------------MKYESQKVAMLYFYGALVLFIAQVAFGVLAGTIYVLPNTLSEL---LPFNIVRMIHTNALVV c1200100 ------------------------------------------------------------------------------MEL---LPFNIVRMIHTNALIV c1200101 --------------------------------------MKYQSQKVAMLYFYGALALFVAQVLFGVVAGTIYVLPNTLSVL---LPFNIVRMIHTNALIV c1201161 --------------------------------------MKYQSQKVAMLYFYGALALFVAQVLFGVVAGTIYVLPNTLSVL---LPFNIVRMIHTNALIV c1201159 --------------------------------------MKYQSQKVAMLYFYGALALFVAQVLFGVVAGTIYVLPNTLSVL---LPFNIVRMIHTNALIV c1200097 --------------------------------------MKYQSQKVAMLYFYGALALFVAQVLFGVVAGTIYVLPNTLSVL---LPFNIVRMIHTNALIV c1200098 --------------------------------------MKYQSQKVAMLYFYGALALFVAQVLFGVVAGTIYVLPNTLSVL---LPFNIVRMIHTNALIV c1200099 --------------------------------------MKYQSQKVAMLYFYGALALFVAQVLFGVVAGTIYVLPNTLSVL---LPFNIVRMIHTNALIV c1200556 --------------------------------------MKYKTQSVAMLYFYGALGLFMAQLLFGVLAGTIYVLPNTLPVE---LPFNIVRMIHTNALIV c1200095 --------------------------------------MKYQTQKVAMLYFYGALTLFLAQVLFGLLAGTIYVLPNTLSTL---LPFNIVRMIHTNALIV c1200094 --------------------------------------MRYETQKVAMLYFYGALTLFLAQVLFGLLAGTIYVLPNTLSVL---LPFNIVRMIHTNALIV c1200962 --------------------------------------MRYETQKVAMLYFYGALTLFLAQVLFGLLAGTIYVLPNTLSVL---LPFNIVRMIHTNALIV c1200380 --------------------------------------MKYESQKVALYFFAGALGLFVAQILFGLVIGTIVVMPNTLSEL---LPFNIARMIHTNALIV c1202251 --------------------------------------MKYASQRVAYWYFTCAMVLFGVQILAGVLAGTVYVLPNVLSEL---LPFNIIRMIHTNALIV c1202563 --------------------------------------MKYPTQRVALAYFTCAMILFGVQIIVGTLAGTVYVFPNFLSET---LPFNVLRMIHTNALIV c1202317 --------------------------------------MKYPTQRVALAYFTCAMILFGVQIIFGTLAGTVYVFPNFLANI---IPFNVLRMIHTNALIV c1201839 --------------------------------------MKYPTQRVALAYFVCAMVLFGVQIIVGVVAGTVYVLPNFLSDV---VPFNILRMIHTNALIV c1202231 --------------------------------------MKYESQKVALYYFAAAMGLFGVQILVGLLAGTVYVLPNTLSEL---LPFNIIRMIHTNALIV c122X009 --------------------------------------MKYETQKVALPFFMVAMALFALQIVFGLLAAAVYVWPNFMAEA---MPFNIMRASHTNLLIV c1220025 --------------------------------------MKYETQRVAYPFFLVAMALFALQITFGILAGTVYVLPNFLAEA---MPFHIIRTSHTNLLIV c1222498 --------------------------------------MKYQTQRVAYPFFVMAMVLFAAQVLFGVMAGLVYVMPEFLSEA---MPFHIMRMSHTNLLIV c1210459 --------------------------------------MKYSTQKLAYPYFIAALLLFMVQVLAGVLAGSVYAMPNFLSES---LPFHIIRMIHTNALLV c1210460 --------------------------------------MKYSTQKLAYPYFIAALALFLVQVLAGVLAGSVYTLPNLLAES---LPFHIIRMIHTNALLI c1201239 --------------------------------------MKYQSQKVALYYFAGALALFVAQVLFGTLLGTVVVAPNFLADL---VPFNILRMIHTNALIV c1201266 --------------------------------------MRYETQSIAKVYWYGAMLIFAVQVCFGLLGGLIYIMPNVLSEL---LPFNIIRMVHTNALIV c1202651 --------------------------------------MKYETQKIALAYFVVAMALFAVQVTMGLVLGYIYVQPNFLSEL---LPFNIARMLHSNSLVV c1202650 --------------------------------------MKYESQKIAYAYFAVAMALFAIQVIGGLLAGFIYVFPNFLSEL---LPFNIVRMLHTNSLIV c1200238 --------------------------------------MKYESQKIAYAYFATALGLFAIQVIGGLLAGWVYVSPNTLSEL---VPFNTIRMLHTNSLIV c1200641 --------------------------------------MKYESQKIALVYFAVAMGLFAIQVLGGLLAGWIYVAPNTLSEL---LPFNIVRMLHTNSLIV c1201844 --------------------------------------MKYESQKVAYAYFAFAMGLFAIQVIGGLLAGWIYVSPNFLSEL---LPFNIVRMLHTNALIV c1200666 --------------------------------------MKYQSQKVALAYFAVALGLFAVQVLGGLLAGYIYVAPNFLSEL---LPFNIVRMLHTNSLIV c1200983 --------------------------------------MKYQSQSIALVYFAVALGLFAIQVSGGLLLGWIYVSPNFLSEI---LPFNIVRMLHTNSLIV c1200589 --------------------------------------MKYQSQSIALVYFAVALGLFAIQVSGGLLLGWIYVSPNFLSEI---LPFNIVRMLHTNSLIV c1200838 --------------------------------------MKYQSQKVAYAYFIVAMALFAIQVLGGLLAGWIYVSPNFLSEL---LPFNIVRMLHTNALIV c1201843 --------------------------------------MKYQSQKVAYAYFLVAMALFAIQVLGGLLAGWIYISPNTLSEL---LPFNVIRMLHTNALIV c1201222 --------------------------------------MKYQSQKVAYAYFMVAMGLFAIQVLGGLLAGWIYVWPNTLSEL---LPFNIVRMLHTNALIV

c1202538 --------------------------------------MKYQSQSVAKYYFFAALALFAIQVLGGLLAGWIYVSPNTLSEL---LPFNIVRMIHTNALIV c1200562 --------------------------------------MKYQSQSVAKYYFFAALALFAIQVLGGLLAGWIYVSPNTLSEL---LPFNIVRMIHTNALIV c1200477 --------------------------------------MRYHSQRIAYAYFLVAMVLFAVQVTIGLIMGWIYVSPNFLSEL---LPFNIARMLHTNSLVV c1201278 --------------------------------------MKYSSQKVAYAYFVAALGLFAIQVLVGLIGGWIYVSPNFLSEL---LPFNIVRMLHTNALVV c1200560 --------------------------------------MKYQSQKVALAYFSVAMGLFAIQVLGGLLAGWIYVSPNTLSEI---LPFNVVRMIHTNALIV c1200561 --------------------------------------MKYQSQKVALAYFSVAMALFAIQVFGGLLAGWIYVSPNTLSEV---LPFNVVRMIHTNALIV c1200559 --------------------------------------MKYQSQKVALAYFSVAMALFAIQVLGGLLAGWIYVSPNTLSEV---LPFNVVRMIHTNALIV c1200590 --------------------------------------MKYQSQHVAFYYFVAAMALFGIQVLGGLLAGWVYVSPNFLAEI---LPFNIIRMIHTNALIV c1200985 --------------------------------------MKYQSQKVAQAYFICAMALFAIQVLGGLLAGWVYVSPNFLSEL---LPFNIIRMLHTNALIV c1201169 --------------------------------------MKYQSQKVAQAYFICAMALFAIQVLGGLLAGWVYVSPNFLSEL---LPFNIIRMLHTNALIV c1211822 ----------------------------------MPTTLKYQSQSVAKLYFIAALGLFTGQILFGLTLGLQYVIGDLMFPA---IPFNIARMVHTNLLIV c1211216 ---------------------------------MTNTILKYQSQSVSKLYFIAALGLFTAQIVFGLGLGLQYVIGDFLFPY---IPFNQARMVHTNLLIV c1212639 ---------------------------------MHIPTLKYQSQSVSKLYFIAAMALFAGQIIFGITLGLQYVVGDLFFPY---VPFNVARMVHTNLLIV c1222649 --------------------------------------MKFSSQAVAKPYFIFAMILFAGQLTFGAILGLQYVIGDFLFPY---LPFNVARMVHTNLLLV c1220624 --------------------------------------MKYESQLIAKPYFIFAMILFAGQVIFGLLMGLQYLNGDAGFPY---IPFNAARMVHTNLLIV c1220318 --------------------------------------MKYQSQAVAKPYFVFALILFAGQILFGLILGLQYVIGDFLFPE---IPFNVARMVHTNLLIV c1211162 -------------------------------MNAANPHLKFASQAVAKPYFVFALILFVGQILFGLVMGLQYVVGDFLFPV---IPFNVARMVHTNLLIV c1222643 -------------------------------MTTANPHLKFASQAVAKPYFVFALMLFVGQILFGLIMGLQYVVGDFLFPL---IPFNVARMVHTNLLIV c1222647 -------------------------------MRSANPYLKFQSQAVAKPYFVFALMLFVGQVLFGLIMGLQYVVGDFLFPL---IPFNVARMVHTNLLIV c1222648 -------------------------------MSMANPHLKFASQAVAKPYFVFALMLFLGQVLFGLIMGLQYVVGDFLFPL---IPFNVARMVHTNLLIV c122X011 -------------------------------MSMANPHLKFASQAVAKPYFVFALMLFLGQVLFGLIMGLQYVVGDFLFPL---IPFNVARMVHTNLLIV c122X012 -------------------------------MSSFNPHLKFQSQAVAKPYFVFALILFVGQVLFGLIMGLQYVVGDFLFPL---LPFNVARMVHTNLLIV c1220965 -------------------------------MGIINPHLKFQSQAVAKPYFVFALILFVGQILFGLIMGLQYVVGDFLFPL---LPFNVARMVHTNLLIV c1222644 -------------------------------MSVTNPHLKFASQAVAKPYFVFALMLFLGQVVFGLIMGLQYVVGDFLFPA---IPFNVSRMVHTNLLII c1220521 -------------------------------MMSPNGSLKFASQAVAKPYFVFALILFVGQILFGLIMGLQYVVGDFLFPA---IPFNVARMVHTNLLIV c1220524 -------------------------------MMSPNGSLKFASQAVAKPYFVFALILFVGQILFGLIMGLQYVVGDFLFPA---IPFNVARMVHTNLLIV c1220519 -------------------------------MMSPNGSLKFASQAVAKPYFVFALILFVGQILFGLIMGLQYVVGDFLFPA---IPFNVARMVHTNLLIV c1220523 -------------------------------MMSPNGSLKFASQAVAKPYFVFALILFVGQILFGLIMGLQYVVGDFLFPA---IPFNVARMVHTNLLIV c1220520 -------------------------------MMSPNGSLKFASQAVAKPYFVFALILFVGQILFGLIMGLQYVVGDFLFPA---IPFNVARMVHTNLLIV c1220525 -------------------------------MMSPNGSLKFASQAVAKPYFVFALILFVGQILFGLIMGLQYVVGDFLFPA---IPFNVARMVHTNLLIV c1220385 --------------------------------------MKYESQRVAMPYFIFALILFAGQIVFGLILGLQYVVGDFLFPE---IPFNVARMVHTNLLIV c1220839 --------------------------------------MKYESQRVAMPYFIFALILFAGQIVFGLILGLQYVVGDFLFPE---IPFNVARMVHTNLLIV c1220203 -----------------------------------MNTLKYQSQAVAKPYFIFAMILFVGQILFGLIMGLQYVVGDFLGGI---IPFNVARMVHTNLLIV c1220491 -----------------------------------MSTLKFQSQSVATPYFIFALILFTGQIIFGLVMGLQYVVGDFLAGT---IPFNVARMVHTNLLIV c1220490 -----------------------------------MSTLKFQSQSVATPYFIFALFLFTGQIIFGLVMGLQYVVGDFLAGA---IPFNVARMVHTNLLIV c1222646 --------------------------------------MKYQSQSVAKLYFIAAIALFAAQILFGLIMGLQYVVGDFLFPE---IPFNVARMVHTNALIV c1210042 --------------------------------------MKYTSQSVALPYFIAAIGLFVGQIVFGLAMGLQYVVGDFLFPE---IPFNVARMVHTNLLIV c1211226 --------------------------------------MQYKSQAVAMPYFIAAIGLFVGQIIFGLILGLQYVVGDFLFPE---IPFNVARMVHTNLLIV c1212642 --------------------------------------MQYKSQAVAMPYFIAAIGLFVGQIIFGLILGLQYVVGDFLFPE---IPFNVARMVHTNLLIV c1210218 --------------------------------------MQFKSQAVAKPYFIAAIGLFVGQILFGLILGLQYVLGDFLFPA---IPFNVARMVHTNLLIV c1200379 --------------------------------------MTYQSQSVARLYFIGALGLFVGQILFGLVLGTQYVIGDFLFPE---IPFNVARMVHSNLLIV

c1211614 ----------------MSTSTTAVLDTPRGVEEHAATRLKYRSQAVAKPYFIAAIGLFFGQIVFGLIMGLQYVIGDFLFPE---IPFNVARMVHTNLLIV c1212641 ----------------MSTSTTAVLDTPRGVEEHAATRLKYRSQAVAKPYFIAAIGLFFGQIVFGLIMGLQYVIGDFLFPE---IPFNVARMVHTNLLIV c1222533 --------------------------------------MKYQSQSVSKPYFIAAIGLFFGQIIFGLIMGLQYIIGDFLFPE---IPFNIARMVHTNLLIV c1211830 --------------------------------------MQFKSQSVAKPYFIAAIALFVGQILFGLIMGYQYVVGDFLFPL---IPFNVARMVHTNLLIV c1210764 --------------------------------------MKYQSQAVAKPYFIAAIGLFLGQILFGLIMGLQYVVGDFLFPA---IPFNVARMVHTNLLIV c1212645 --------------------------------------MQYKSQAVATPYFIAAIGLFVGQIIFGLIMGLQYVIGDFLFPM---IPFNVARMVHTNLLIV c1210041 --------------------------------------MQYTSQAVAKPYFVAAIGLFVGQILFGLIMGLQYVVGDFLFPA---LPFNVARMVHTNLLIV c1211877 --------------------------------------MQYQSQAVAKPYFIAAIALFLGQIIFGLIMGMQYVVGDFLFPA---IPFNVARMVHTNLLIV c1142560 ------------------MKLFKRFSFTGKVDKSLGRKQQFMAQKISRRYCLTAASLFALQSIVALLGASDLLIPDFPSP----IPFEYGRAIHLSLAVL c1142556 ------------------MKLLNFLPFAGKTHKSVNRKQQFLAQKISRRYCLTAVSLFALQSVVAVAGALDLVMPDLPSP----IPFEFGRAIHLGLADL c1142732 ------------------MKLLKWFSFRGKGDKSIARKQQFIAQKISRRYCFSAVSFFALQSVVALLGSLDLVIPDLPSP----IPFEFGRAIHLGLADL c1142559 ---MKLNQTVLGFIISKILKKTRQNDEDQKARVEKENGKKRGGQALSRRFAFLACALFVVQGFVAILGATSLVVPDLPSP----VPYEYGRSVHLGLATC c1142558 -------------------------------------LKALSGKQVARRYTLYAVFLFGVQGIVALLGATSLVIPDLPSP----VSGEYGRAVHLALATF c1142557 -------------------------------------LKGFLGKQIARRYVLYAVFLFGIQGLVALLGATSLIVPDFPSP----ISYEYGRAVHLALATF c1140225 -------------------------------------LKTFSGKQIARRYVLYGVFLFAIQGIVALLGATSLIFPDLPSP----VSYAYGRAVHLALATF c1140226 -------------------------------------MKTFSGKQIARRYVLYGVFLFAIQGIVALLGATSLIFPDLPSP----VSYAYGRAVHLALATF c1141613 -------------MFKALRQIGDFFFHRHKPAAKKVKEPEYVSQAVAIPYALVTLLLLAFQGVAATFGATEAVFPNLPSP----VRAEVGRAVHLNIAVF c1222482 ------------------------------------MQIEFQTQRLSMRFFMLMLVLFVLQVGYGLLLSVQQTDPTVLAGV---MNFNVARAEHLNLGIL 99% *

110 120 130 140 150 160 170 180 190 200 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|c1112653 WLLLGFMGGVYWFLPLELEREVVGIRLARLAFFTLIAAVGVVVLVYLLVQ--YGPGNAFTLWFITEGREYIEAPRWADIGIVAVMAIFLYNVVATALKAK c1112544 WLLLGFMGGVYWFLPMELGREVVGIRLARFAFFTLIAAVGIVVLVYLLVQ--YGPGNAFTLWFITEGREYIEAPRWADFGIVAVMAIFLYNVVATALKAQ c1112654 WLLLGFMGGVYWFLPMELGREVVGIRLAKAAFFTLVGAVAVVVLVYLLVQ--YGPGNAFTLWFITEGREYIEAPRWADIGIVAVMAIFLYNVVATALKAQ c1032043 WLLMGFIGGIYWFLPLETQREIVGIKLGKLAYFAFVITVAIVVLVFLIKQ--FGKGDFFTLWFITEGREYVEAPRWADIGVVAVALIVAYNVVATVLASR c1030986 WLIMGFIGGIYWLLPSETGRDVVGAKLGKLAWFLLTAAVGVVVLVYIFKQ--FGKGDFFTLWFITEGREYIEAPRWADIGIVAVMLIIYFNVAATVIKAG c1281324 WLLFGFIGGIYWFLPLETQREIVGLFLGKMAFVLIAVAVGIVVGVFLLVQ--IGKADWVTLWFITEGREYIEAPRWADIGIVAVFSIIFFNVLATIWKAQ c1211829 WLLYGFLGSVYWLLEEESQHEVVGLKLGNLIYWVLTAAVTVVVLVYLFVQ--IGPGKESTIWLINEGREYIEAPRWADIGIVVSVLVVFYNVAATFSKGR c1220409 WMLYGFVGAVYWLLEEESGTRVVGLAVGNLAFWVLTVAVAVVVVVYLWVQ--TGPGNDLTRWFVNEGREYLEAPRWADLGIVAMLGVFFYNVAATFSRGR c1222655 WMLYGFIGAVYWFLEEESGVEIVGLKLGEFAFWVLTAAVGVVVLVYLFLQ--TGAGNDTTRWLINEGREYIEAPRWADISIVAVLLVFFYNVAGTFSKGR c1222652 WMLYGFIGSVYWFLEDESGVPVVGLKWGQLAFWVLTGAVALVVLVYLLVQ--VGSGNDTSLWFINEGREYIEAPRWADIGIVAVMLVFFYNVAATFAQGK c1222541 WMLYGFIGSIYWLLEDESQTEIVGLKLGNLAFWVLTAAVTLVVLVYLLVQ--IGPGKDSSLWLINEGREYIEAPRWADIGIVVVMLIFFYNVVATFSKGK c1222748 WMLYGFFGCIYWLLEDESGTEIVGLKYGNIAFWVLTGAVTIVVLVYLLVQ--IGPGKDSSLWFINEGREYIEAPRWADIGIVAVVLTFFYNVVATFSKGK c1241031 WLLYAMIGAVYWLLPDEAGREVVGVKLGNLAFYVLTAAVAVVVLVYLFIQ--VGPGNEMTTWLITEGREYIEAPRWADIGIVAVVLIFLYNVYATVISGK c1240766 WMVFAMFGSVYWLLPDETGIETVGIGMGKLLFWVFTAAVTVVVLVYLFIQ--VGPADETSIWFIHEGREYIEAPRWADLGITVVALGFVANLFMTGMKGN c1241223 WMVFAMFGSVYWLLPDETGIETIGIKIGKLLYWVFVAAIVVVILVYLFIQ--VGPADETSIWFIHEGREYIEAPRWADFGIVVVALGFVANLWLTGFKGK c1241030 WMLYAMIGSVYFMLSDETGEQLVHAGIGKLAFWVLTAAVTVVVLVYIFIQ--VGPGTEATIWLINEGREYIEAPRWADIGIVVVVLIFYWNVFATFMKGK c1242289 WMLYAMIGSVYLMLPDETGIETVGIGLGKLAFWVLTAAVTVVVLVYLLVQ--VGPGKESTIWLINEGREYLEAPRWADIGIVVVVLIFYWNVFATYMKGK c1242165 LILFGFMGATYYLVPEESERELWSPWLAKVTFWVFAAAGVATILGYLLVPYAKLAEITFNNLLPTMGREFLEQPTITKIGIVIVVLSYILNVTMTVIKGR

c1242219 LLLFGFMGATYYLIPEESERELWSPMLAKITFWVFAAAGVATILGYLLVPYATLAELTYNNLLPTMGREFLEQPTITKIGIVLVVLSYILNVTMTVIKGR c1241897 TLLFGFMGATYYLIPEETESELWSPKLAIITFWIFAAAGVATILGYLFVPYATLTEWTFNNLLPTMGREFLEQPLPTKVGIVIVVLSYILNTAMTILKGR c1230031 WLLLGFMGATYYMVPEETGRELASPKLAIAQLVVLTGTGVVAIVGFLFGW--------------TQGRPLLEIPRPLDLLVVAGALMFLGNVGATMLLAR c1042464 WLLTGFMGAAYYIIPEEAQRELVSVKLAYVQLISLAVVGVAAITGYHFNI--------------WEGRKFLEIPRELDYLVVVNVLLFLGIILATLFKGK c1042313 WLLTGFMGAAYYIIPEEAQRELVSVKLAYVQLISLAVVGVVAITGYHFNI--------------WEGRKFLEIPRELDYLVVVNVLLFLGIILATLFKGK c1041884 WLLSGFMGAAYYIIPEEAQRELVSVKWAYVQLISLAVVGVVAITGYHFNI--------------WEGRKFLEIPRELDYLVVVNVLLFLGIIIATLYKGK c1040279 WLLSGFMGAAYYIIPEEAQRELVNVKLAYVQLISLALVGVAAVVGYHFNY--------------WEGRKFLEIPRPLDFLVVVNVLLFLGLILVTLFKGK c1251518 WLLTGFMGAAYYIIPEESDRELYSVKLAYIQLISWVVVGVVAIVGFHFNW--------------WEGRKFLEIPRPLDYLVVVNVLTFLFNIAMTIWEAK c1250766 WLLTGFMGAAYYIIPEESDRELYSVKLAYIQLISWVVVGVVAIVGFHFNW--------------WEGRKFLEIPRPLDYLVVVNVLTFLFNIAMTIWEAK c1252508 WLLTGFMGAAYFIIPEESDREIYSEKLGWIQLISLVVVGVVAIAGFHLNW--------------WEGRKFLEIPRPLDFLVVVNVLAFLFNIGMTVWKGN c1230080 WLLTGFMGAAYYIIPEEADRELIHPKLAYVQLGALVAVGVVAIIGFHMNW--------------WEGRKFLEIPRPLDYLVVADVLLFIYLIGGTIWKGK c1222638 WVLAGFMGGTYYVVAEESRTELYSERLAYIQLVAWTLMGATAIVGYMLGW--------------TAGIKMLEQPYPLKLVIVAVMLLFFFNIFMTIRQAG c1210461 WVLTGFMGATYYVVPEESRSEIYSVKLAYIQLIAWTLMGVTAIVGYVFGW--------------TAGNKMLEQPFPLKIVIVIVMLMFLYNILMTIKRAG c1211479 WVLCGFMGATYWMVPDESRTELHSTRLAYIQLVLWTVMGVATVVGYLFRW--------------GTGNKLLEQPLPSKIVIVIVMLMFLYNVGMTIRKSG c1210008 WVLCGFMGATYWMVPDESRTELHSTRLAYIQLVLWTVMGVATVVGYLFRW--------------GTGNKLLEQPLPSKIVIVIVMLMFLYNVGMTIRKSG c1211833 WLLLGYFGASYFLIPEESEREIHSPKLAWLQLGIFVFAALAAVGSYLSGV--------------HEGREFLEQPFWVKILMAIAFLIFIYNVTMTVLKGR c1222407 WLLLGYFGASYFLIPEESEHEIHSPKVAWLQLGIFVFAALAAVVGYLFRI--------------HEGREFLEQPLWIKILLVVAFLLFLYNVTLTVLKGR c1222409 WLLLGYFGASYFLIPEECEREVYSPKLAWWQLGIFVFAALGAVISYLFGV--------------HEGREFLEQPLWVKILLAVAFVIFLYNITMTVLKGR c1220458 WLLLGYFGASYFLIPEECEREIYSSRLAWWQLGIFVFAALGAVISYLFGV--------------HEGREFLEQPLWVKILLAVAFVIFLYNVTMTVLKGR c1221136 WLLLGYFGASYFLIPEECEREIYSSRLAWWQLGIFVFAALGAVISYLFGV--------------HEGREFLEQPLWVKILLAVAFVIFLYNVTMTVLKGR c1200568 WLLMGFMGCTYYLIPEETETELYSPLIAKIQFWSFFVAAGVAVVGYLFRY--------------HEGREFLEQPYIIKIAIVVVCLLFLFNITMTVLKGR c1200571 WLLMGFMGCAYYLVPEEAENELFSPLLAKLQFWLFFGAAGAAVVGYLFHY--------------HEGREFLEQPFVIKIGIVVVCLIFLFNITMTVLKGR c1201236 WLLMGFMGCAYYLVPEEAENELFSPLLAKLQFWLFFGAAGVAVVGYLLHY--------------HEGREFLEQPFVIKVGIVVVCLIFLFNITMTVLKGR c122X013 WLLIGFMGATYYLLPEEAETELYSPKLAIAQFWIFLIAAAIAVVGYMFKI--------------HEGREFLEQPFIIKIGIVIVCLMFLFNVTMTSLKGR c1201814 WLLMGFMGATYYLLPEEAETELYSPKIAIAQFWIFLIAAAVAVVGYLFHI--------------HEGREFLEQPFAIKVGIVVVALMFLFNITLTVLKGR c1200644 WLLMGFMGATYYLLPEEAETELYSPKIAIAQFWIFLIAAAVAVVGYLLHI--------------HEGREFLEQPFAIKVGIVVVALMFLFNITLTVLKGR c121X007 WLLMGFMGATYYLLPEEAETELYSTKIAIAQFWIFLIAAAIAVVGYLMHI--------------HEGREFLEQPFAIKVGIVIVALMFLYNITLTVLKGR c1200022 WLLMGFMGSTFYLLPEETETELYSPKLAIAQFWIFLVAAAVAVVGYMFRI--------------HEGREFLEQPFAIKVGIVLVVLMFLFNITMTALKGR c121X008 WLLMGFMGSTYYLLPEETETELYSTKLAVIQFWLFFVAAGVAVVGYLFHI--------------HEGREFLEQPFIIKVGIVVVCLIFLFNITLTALKGR c1200100 WLLMGFMGSTYYLLPEETETELYSTKLAVIQFWLFFVAAGVAVAGYLFHI--------------HEGREFLEQPFFIKVGIVVVCLIFLFNITLTVLKGR c1200101 WLLMGFMGSTYYLLPEETETELYSTKLAVIQFWLFFVAAGVAVAGYLFHI--------------HEGREFLEQPFFIKVGIVVVCLIFLFNITLTALKGR c1201161 WLLMGFMGSTYYLLPEETETELYSTKLAVIQFWLFFVAAGVAVAGYLFHI--------------HEGREFLEQPFFIKVGIVVVCLIFLFNITLTALKGR c1201159 WLLMGFMGSTYYLLPEETETELYSTKLAVIQFWLFFVAAGVAVAGYLFHI--------------HEGREFLEQPFFIKVGIVVVCLIFLFNITLTALKGR c1200097 WLLMGFMGSTYYLLPEETETELYSTKLAVIQFWLFFVAAGVAVAGYLFHI--------------HEGREFLEQPFFIKVGIVVVCLIFLFNITLTALKGR c1200098 WLLMGFMGSTYYLLPEETETELYSTKLAVIQFWLFFVAAGVAVAGYLFHI--------------HEGREFLEQPFFIKVGIVVVCLIFLFNITLTALKGR c1200099 WLLMGFMGSTYYLLPEETETELYSTKLAVIQFWLFFVAAGVAVAGYLFHI--------------HEGREFLEQPFFIKVGIVVVCLIFLFNITLTALKGR c1200556 WLLMGFMGTTYFLLPEECETELYSPKLAIAQFWIFLIAAAVAVIGYLFHI--------------HEGREFLEQPFAIKVGIVVVALMFLFNVTMTALKGR c1200095 WSLIGFMGATYFLLPEETETELYSPLLAKIQFWMFFGAAGVAVVGYLFHY--------------HEGREFLEQPFIIKVGIVVVCLMFLFNVTMTALKGR c1200094 WSLIGFMGATYFLLPEETETELYSPLLAKIQFWMFFGAAGAAVVGYLFHY--------------HEGREFLEQPFIIKVGIVVVCLMFLFNVTMTALKGR c1200962 WSLIGFMGATYFLLPEETETELYSPLLAKIQFWMFFGAAAAAVVGYLFHY--------------HEGREFLEQPFIIKVGIVVVCLMFLFNVTMTALKGR c1200380 WLLMGFFGASYYLIPEEAETELYSTKLAIVQFWLFLIGAAAAVVGYLFHI--------------HEGREFLEQPLWIKLAIVVVALMFLFNITMTVLKGR

c1202251 WLLMGFFGCAYYLVPEEAERDIESPLLAYIQLGLLMFGALSAVAGYTLGV--------------HEGREFLEQPLWIKVAIVVVALIFLYNVSMTVLKGR c1202563 WLLMGFFGCGYYLVPEEAERDIESPFLAYVQLGLLMFGALAAVIGYVFGI--------------HGGREFLEQPLWIKAAIVVVALIYLYNISMTILKGR c1202317 WLLMGFFGCGYYLIPEEAERDIESPFLAYVQLGLLMFGALAAVAGYLLGV--------------HEGREFLEQPLWIKGAIVVVALIYLYNVSMTILKGR c1201839 WLLMGFFGCGYYLVPEEAERDIESPMLAYVQLGLLMFGALAAVVGYLFGI--------------HEGREFLEQPLWIKGAIVVVALIYLYNISMTIMKGR c1202231 WLLIGFFGAAYYLVPEEAETELHSPKLALVQLGLFVFGALAAVVGYVFRI--------------HEGREFLEQPLWIKAAIVVVALMFLYNITLTVLKGR c122X009 WLLIGFMGSTYYLMPEEAEREIHSPTIAYIQLAIFAFAGAAALVGYQFGI--------------HEGREFLEQPFWVKLLITISFLMFLFNTSMTLLKGR c1220025 WLLIGFFGCTYYLIPEETEHELYSPKLAYIQLGIFAFAGAAALVGYQFGI--------------HEGRHYLEQPFWVKSLLTLSFLMFLFNTTMTLIKGR c1222498 WLLIGFFGATYYLLPEETENEIHNPTLAYIQLGIFVFAGAAALIGYQFGI--------------HEGRHYLEQPVWVKVLLTVSFLMFLYNASFTVLKGR c1210459 WLLLGYFGAAYFLIPEESERDIHSPKVAWLQLFIFVFAALAAVVSYLAGV--------------HEGREFLEQPLWIKILLVVAFLLFLYNVSMTVLKGR c1210460 WLLLGYFGAAYFLIPEESERDIHSPKIAWLQLFIFVFAALAAVVSYLMGI--------------HEGREFLEQPLWVKVLLVVAFLLFLYNVSMTVLKGR c1201239 WLLMGFFGCAYYLIPEEAETELHSPKLAVIQFWLFLFGAAAAVVGYLFKI--------------HEGREFLEQPLWIKLAIVVVALMFLYNVTMTVLKGR c1201266 WLLLGFFGATYYLVPEESEREIYSTKLAYIQFAIFFFGALAAVVGYLFHV------------NANEARSYLEQPLWVKLGIIVAALIFLFNISMTVLQGR c1202651 WLLTGFFGAAYFLVPEEAEREIHSPKLAYLQLAILVLGTAGVVVTYLFNL------FEGNFLLGKEGREFLEQPKWVKVGIVVAALIFLYNVTLTVLKGK c1202650 WLILGFFGAAYFLIPEEAEREIHSPKLAYLQLIILVVGTLGVVVTYVFNL------FEGNWLLGKEGREFLEQPKWVKMGIVVAALIFLYNVSMTVLKGK c1200238 WLLLGFFGAAYFLIPEEAEREIHSPMLAYVQLAILVVGTLGVVVTYLFNP------FEGHWLLGKEGREFIEQPKWVKAGIVVAALIFLYNVSMTSLKGR c1200641 WLILGFFGAAYFLIPEEAEREIHSTKLAYIQLAILVLGTLGVVVTYVFNL------FEGHWLLGKEGREFIEQPKWVKAGIVVAALIFLYNVSMTVLKGK c1201844 WLITGFFGAAYFLIPEEAEREIHSTKLAYIQLAILILGTLGVVLTYVFNL------FEGNWLLGKEGREFLEQPKWVKAGIVVAALIFLYNVSLTVLKGK c1200666 WLLLGFMGSAYFLIPEEAEREIHSTKLAYLQLIILVVGTLGVVLTYVFNL------FEGNWLLGKEGREFIEQPKWVKVGIVVAALIFLFNITMTVLKGK c1200983 WLLLGFMGAAYFVIPEESEREIHSPLLAYIQLAIMVLGTLGVVVTYLFNL------FEGNWLLGKEGREFLEQPVWVKMGIVVAALIFMYNITMTVLQGR c1200589 WLLLGFMGAAYFVIPEESEREIHSPLLAYLQLAIMVLGTLGVVVTYLFNL------FEGNWLLGKEGREFLEQPVWVKMGIVVAALIFMYNISMTVLQGR c1200838 WLLLGFFGAAYFLVPEESERELFSTKLAYIQLAILVVGTLGAVGSYLVGI--------------HGGREFLEQPLWVKFGILVAAVIFLINITLTVLAGR c1201843 WLLLGFFGAAYYLVPEESERELFSAKLAYIQLAILVVGTLGAVVSYLVGI--------------HGGREFLEQPLWVKFGILVAAVIFLVNISLTVLAGR c1201222 WLLLGFFGAAYYLVPEESERELFSVKLAYIQLAILVVGTLGAVVSYLAGI--------------HGGREFLEQPLWVKFGILVAAVIFLVNISLTVLAGR c1202538 WLLLGFFGAAYYLVPEEAERELFSTKLAYIQLIILLVGTLGAVGSYLVGI--------------HGGREFLEQPLWVKFGILVAAVIFLVNISLTALAGR c1200562 WLLLGFFGAAYYLVPEEAERELFSTKLAYIQLIILLVGTLGAVGSYLVGI--------------HGGREFLEQPLWVKFGILVAAVIFLVNISLTALAGR c1200477 WLLLGFFGATYYILPEEAEREIHSPLLAWIQLGIFVLGTAGVVVTYLFDL------FHGHWLLGKEGREFLEQPKWVKLGIAVAAVIFMYNVSMTALKGR c1201278 WLLLGFFGAAYFIIPEESEREIHSVKLAYIQLLILVVGTLGAVVSYIFGI--------------HEGREFLEQPLWVKVGILVAALIFLFNISMTVLKGR c1200560 WLLLGFFGAAYFLVPEEAERELFSVKLAYLQLAILVIGTLGAVVSYLVGI--------------HGGREFLEQPLWVKFGILVAAVIFLVNISLTALAGR c1200561 WLLLGFFGAAYFLVPEEAERELFSTKLAYLQLGILVIGTLGAVVSYLVGI--------------HGGREFLEQPLWVKFGILVAAVIFLVNISLTVLAGR c1200559 WLLLGFFGAAYFLVPEEAERELFSTKLAYLQLGILVIGTLGAVVSYLVGI--------------HGGREFLEQPLWVKFGILVAAVIFLVNISLTVLAGR c1200590 WLLLGFFGAAYYLVPEESEREIWSPKLAYLQLIILVVGTLGAVGSYLVGI--------------HGGREFLEQPLWVKFGILVAALIFLLNISMTVLAGK c1200985 WLLLGFFGAAYFLIPEESEREIYSVKLAYLQLAILMIGTLGAVGSYLVGI--------------HGGREFLEQPLWVKFGILVAALIFLFNVSMTVLAGK c1201169 WLLLGFFGAAYFLIPEESEREIYSVKLAYLQLAILMIGTLGAVGSYLVGI--------------HGGREFLEQPLWVKFGILVAALIFLFNVSMTVLAGK c1211822 WLLFGFMGAAYFMVPEESETELYSPLLAKVLFWIFLAAGALTILGYLLVPYAKLAEMTGNDLLATMGREFLEQPLPTKVGIVVVALGFLFNISMTVLKGR c1211216 WLLFGFMGAAYYMVPEESETELHSPLLAKILFWVFLVAGALTIVGYLAVPYAKLAELTGNDVLQTMGREFLEQPLPTKLGIVVVALGFLYNITMTVLKGR c1212639 WLLFGFMGAAYYMVPEESETELHSVLLAKVLFWVFLTAGALTIVGYLTVPYAKLAELTGNDLLQTMGREFLEQPLPTKVGIVVVALGFLYNISMTVLKGR c1222649 WLLFGFMGATYYLVPEESDTELCSPLLAKLLFWIFAAAGVATILGYLFVPYARLTELTFNELWPTMGREFLEQPTITKIGIVIVALGFVFNVAMTVLKGL c1220624 WMLFGFMGASYYLVPEEAETELYSPVLAKITFWVFVVAGVATILGYLLVPYAELARITKNELFPTMGREFLEQPTITKIGIVLVCLSFVFNIAMTILKGR c1220318 WLLFGFMGATYFLVPEECETELHSPKLALILFWVFASAGVLTILGYLMVPYATLAEITGNKFFPTMGREFLEQPTLTKVGIVIVCLGFLYNVGMTLLKGR c1211162 WLLFGFMGAAYYLIPEEADRELHSPKLALALFWIFAVAGVLTILGYLLLPYAGLAALTGNDVLPTMGREFLEQPTITKAGIVVVALGFLYNIGMTLLKGR c1222643 WLLFGFMGAAYYLIPEEADRELHSPKLAIILFWVFAIAGVLTILGYLAVPYATLARITGNELLPTMGREFLEQPTITKAGIVVVALGFLYNIGMTLLKGR

c1222647 WLLFGFMGAAYYLVPEEADRELHSPKLAILLFWVFAVAGVLTILGYLLVPYAALAKLTHNELLPTMGREFLEQPTITKMGIVVVCLGFLYNIGMTLLKGR c1222648 WLLFGFMGAAYYLIPEEADRELHSPKLALVLFWVFAAAGVATILGYLSVPYATLAKFTGNDLLPTMGREFLEQPTITKMGIVVVCLGFLYNIGMTLLKGR c122X011 WLLFGFMGAAYYLIPEEADRELHSPKLALLLFWVFAAAGVATILGYLSVPYATLAKFTGNDLLPTMGREFLEQPTITKMGIVVVCLGFLYNIGMTLLKGR c122X012 WLLFGFMGAAYYLIPEESDCELHSPKLAIILFWVFAAAGVLTILGYLFVPYAALAEMTRNDLLPTMGREFLEQPTITKIGIVVVALGFLYNIGMTMLKGR c1220965 WLLFGFMGAAYYLIPEEADRELHSPKLAIILFWVFAAAGVLTILGYLFVPYAGLAEMTKNELLPTMGREFLEQPTITKIGIVIVALGFLYNIGMTMLKGR c1222644 WLLFGFMGAAYYLIPEEADRELHSPKLALILFWVFAATGVLTILGYLLVPYAGLARLTHNELLPTMGRVYLEQPTITKMGIVLVCLGFLYNIGMTLLKGR c1220521 WLLFGFMGAAYYLVPEESDCELYSPKLAWILFWVFAAAGVLTILGYLLVPYAGLARLTGNELWPTMGREFLEQPTISKAGIVIVALGFLFNVGMTMLRGR c1220524 WLLFGFMGAAYYLVPEESDCELYSPKLAWILFWVFAAAGVLTILGYLLVPYAGLARLTGNELWPTMGREFLEQPTISKAGIVIVALGFLFNVGMTVLRGR c1220519 WLLFGFMGAAYYLVPEESDCELYSPKLAWILFWVFAAAGVLTILGYLLVPYAGLARLTGNELWPTMGREFLEQPTISKAGIVIVALGFLFNVGMTVLRGR c1220523 WLLFGFMGAAYYLVPEESDCELYSPKLAWILFWVFAAAGVLTILGYLLVPYAGLARLTGNELWPTMGREFLEQPTISKAGIVIVALGFLFNVGMTVLRGR c1220520 WLLFGFMGAAYYLVPEESDCELYSPKLAWILFWVFAAAGVLTILGYLLVPYAGLARLTGNELWPTMGREFLEQPTISKAGIVIVALGFLFNVGMTVLRGR c1220525 WLLFGFMGAAYYLVPEESDCELYSPKLAWILFWVFAAAGVLTILGYLLVPYAGLARLTGNELWPTMGREFLEQPTISKAGIVIVALGFLFNVGMTVLRGR c1220385 WLLFGFMGATYYMVPEEAQTELHSPLLAWILFWVFAAAGTLTILGYLFVDYATLAEVTMNKLLPTMGREFLEQPTITKIGIAVVVVAFLYNIAMTALKGR c1220839 WLLFGFMGATYYLVPEEAQTELYSPLLARILFWVFAVAGTLTILGYLFVDYATLADITMNKLWPTMGREFLEQPTITKMGLALVFIGFLFNILMTALKGR c1220203 WLLFGFMGAAYYLVPEEAETELYSPKLAIILFWVFAAAGVLTILGYLLVPYSTLADITFNELWPTMGREFLEQPTITKFGIVIVCLGFLFNLGMTILKGR c1220491 WLLFGFMGAAYFLVPEESETELYSPKLAIVLFWVFAAAGTLTILGYLLVPYSTLAQITGNEYFPTMGREFLEQPTITKIGIVIVCLGFLFNIGMTILRGR c1220490 WLLFGFMGAAYFLVPEESETELYSPKLAILLFWVFAAAGTLTILGYLLVPYSTLAQITGNEYFPTMGREFLEQPTITKIGIVIVCLGFLFNIGMTILRGR c1222646 WMLMAFMGAAYYLVPEEAETELFAPWLATLMFWIFLVAAGLTVAGYLLVPYSTLADLTMNELLPTMGREFLEQPTITKIGIVIVALAFLFNIGMTILKGR c1210042 WLLFGFMGAAYYLIPEEAETELYSPKLALLMFWIFLVAGAATILGYLFVDYATLAEMTGNNILATMGREFLEQPLLTKIGIVIVALAFLFNISMTMLKGR c1211226 WLLFGFMGAAYYLIPEETETELFSPKLALAMFWIFLVAGALTIVGYLLVPYSTLASMTGNDILATMGREFLEQPLLTKIGIVIVALAFLFNITMTVLKGR c1212642 WLLFGFMGAAYYLIPEETETELFSPKLALLMFWIFLVAGALTIVGYLLVPYSTLASMTGNDILATMGREFLEQPLLTKVGIVIVALAFLFNITMTVLKGR c1210218 WLLFGFMGGAYYMIPEEAETELFSPKLALLMFWIFLVAGALTIVGYLAVPYATLAELTGNNILETMGREFLEQPLPTKLGIVVVALVFLFNITMTVLKGK c1200379 WLLFGFMGASYYLVPEESETELWSPLLAKLLFWVFLVAGALTILGYLLVPYAKLAELTHNDLLPTMGREFLEQPTITKIGIVIVVLGFILNIGMTMLKGR c1211614 WLLFGFMGAGYYLIPEESERELHSPKLAIITFWVFLVAGALTIVGYLSVPYATLAKLTHNEILPTMGREFLEQPTITKVGIVLVALSFLYNLSMTVLSGR c1212641 WLLFGFMGAGYYMIPEESERELHSPKLAIITFWVFLVAGALTIVGYLSVPYATLAQLTHNEILPTMGREFLEQPTITKVGIVLVALSFLYNLSMTVLSGR c1222533 WLLFGFMGAGYYLIPEESERELHSPKLAIALFWIFLIAGALTIVGYLSLPYARLAELTGNNLLSTMGREFLEQPLITKVGIVIVALGFLYNLSMTILGGR c1211830 WILFGFMGAAYYLIPEESETELFSPKLAIVMFWVFLTAGVLTIVGYLAVPYATLAQMTGNDILATMGREFLEQPLPTKIGIVIVALAFLFNISMTVLKGR c1210764 WLLFGFMGAAYYLIPEESERELHSPKLALAMFWIFLVAGAATILGYLFVPYASLAEMTGNNLLATMGREFLEQPLPTKVGIVIVALAMLYNLSMTVLRGR c1212645 WLLFGFMGAAYYMIPEESETELFSPKLALAMFWIFLVAGALTIVGYLAVPYATLAELTGNDLLETMGREFLEQPLITKVGIVIVALAFLFNISMTVLKGR c1210041 WLLFGFMGAAYYMVPEESETELWSPRLALVLFWVFLAAGALTILGYLFVPYARLAEMTGNDILATMGREFLEQPLITKIGIVVVALAFLFNITMTMLRGR c1211877 WLLFGFMGATYYLIPEESETELFSPKLALITFWVFLAAGAATVLGYLLVPYATLAKLTGNDLLATMGREFLEQPLPTKVGIVIVVLSFLFNVVMTMLKGR c1142560 WPLIGTLGMVYFFITAELNREIYSPRLVRWQFGLVMFFSLSIFGTLALGI--------------GNGREYLEGLPVFYVGISSALALVSYNLIRTLLMDK c1142556 WPLIGTMGMVYFFITAELNREIYSPPLARWQYWIVVVFSLAIFASLSLKI--------------GNGREFLEGLPVLYLGICISLAIASYNLVRTLLIDK c1142732 WPLIGTMGMVFFFTTAELNREIYSPRLARWQYWIVMLFSVSIFGTLALRI--------------GNGREFLEGMPIFYVGICLALALASYNLIRTLLTDK c1142559 WPLIGAMGMVYFFTVDELKADLYSLKIVRWQFWIVVLSTAGLLGTLTFRI--------------GNGREFLDGLPMFYAGISLAILLCAYNLIQTLKKSK c1142558 WPVIGMLGMVYYFTAEQLKTDIHSPKLARWQFAILLVTSLGLLGSLALGI--------------GNGREYLDGLPIFYAGISLGILIGAYNLVRTLWENR c1142557 WPVIGMMGMVYYFTVDQLKADIYSPRLARWQFVILLIASGGLLGTLALGI--------------GNGREYLDGLPVFYMGISLGLLLGTYNLIRTLWKNR c1140225 WPVIGMMGMVYYYTVEQLKADIYSPKLARWQFLILLMASAGLLGTLALGI--------------GNGREYLDGLPVFYLGISLGLLLGAYNLIRTLWQNK c1140226 WPVIGMMGMVYYYTVEQLKADIYSPKLARWQFLILLMASAGLLGTLALGI--------------GNGREYLDGLPVFYLGISLGLLLGAYNLIRTLWQNK c1141613 WPLLGSMGMVYYFFIQEAEKELYSLRLAWLQFFVLIASGLGAITFLAFGL--------------MRGMEYREAALVFDLGIAVGLAIFVYNLTRTYFLSA c1222482 WILCGFIGAILFVGPLLAKREMVSPWLIKLLFYALIVIAVWNFFTLRLAQFGIAGWWHGQPWL-QQGLEYLEAGRIAGVLVLIGFAILAYVVLRTFPPVR

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210 220 230 240 250 260 270 280 290 300 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|c1112653 K--ITGVAAVLMFDLVALAGLYTAGMHYTPNISMDQYFWWWVVHLWVEATWEVLVGSIMAMALMHLLGTPR--RIVETWLYLEVALVFGTGILGLGHHYF c1112544 R--ITGVVAVLMFDLVALAGLYMAGMHYTPNISMDQYFWWWVVHLWVEATWEVLVGSIMAMALMHLLGTPR--RIVETWLYLEVALVFGTGILGLGHHYF c1112654 R--ITGVVAVLMFDLVALAGLYTAGMHYTPNISMDQYFWWWVVHLWVEATWEVLTGAIMAMALMHLLGTPR--RIVETWLYLEVALVFGTGILGLGHHYF c1032043 R--LTGILGVLIVDLAALFGLYLAGMFFTPNITVDQFWWWWVVHLWVEATWEVLVGVLMGWLLMHLLGTPR--KIIEAWLYIEVMLVFGTGILGLGHHYY c1030986 R--LTGLMGVLLIDLLALAGLYVAGMFFTPNITHDQFWWWWVVHLWVEATWEVLVGVLMGYALMTVLGTPR--RIIEGWLYLEVLLVFGTGILGLGHHYY c1281324 K--LKGILWVLTLDLLAIIGFYIAGMFFTPNISVDQFWWWWVVHLWVEATWEVLVGVLVAWVLMAVLDTPR--KILEGWLYLEVFLVFGTGILGLGHHYF c1211829 Y---TGIAGVLVLDMLALFGIYLAGMFYTTNISIDQYWWWWVIHLWVEATWEVMVACIMAYGLMKVLGVSR--KIVETWLYIEVALMFGSGILGLGHHYF c1220409 W---SGIAGVLTLDLVALAGLYCAGMFYLTNITADQYWWWWVIHLWVEATWEVLVGCIMAWGLMHVLGVRR--RIVETWLYIEVALMFGSGILGLGHHYF c1222655 W---SGISGVLTLDLVALVGLYLTGMFYTTNVTVDHYWWWWVVHLWVEATWEVLVGCIMAWSLMKLLGARR--RIVQTWLYIEVALMFGSGILGLGHHYF c1222652 W---SGIAGVLTLDLVALAGLYLAGMFYATNISVDQYWWWWVIHLWVEATWEVLVGCIMAWSLMKLLGVRR--QIVQTWLYIEVALMFGSGILGLGHHYF c1222541 W---SGIAGVLTLDLVALAGLYVAGMFYMTNITHEQYWWWWVIHLWVEATWEVLVGVIMAWSLMKLLGVRR--KIVQTWLYIEVALMFGSGILGLGHHYF c1222748 W---SGIAGVLTLDLVALAGLYVAGMFYMTNITHEQYWWWWVIHLWVEATWEVLVGVIMAWSLMKLLGVRR--KIVETWLYIEVALMFGSGILGLGHHYF c1241031 R---SGILTVLMADLIALAGLYLAGMFYTDNIAVDQYWWWWVVHLWVEATWEVYVAAVGGYILIKTLNANR--KVVEMWLWIEVAMMFGSGILGLGHHYF c1240766 R---SGIVTVLMADMIAFAGLYLTGMFYTDNISVDQFWWWWVIHLWVEATWEVFVGAIAAYGLITMIGAHR--KVVEMWLWIEVSMLFGSGILGLGHHYF c1241223 N---SGIVTVLMADMIAFAGLYLAGMFFTDNITVDQYWWWWVIHLWVEATWEVFVGAIAAYGLITMIGAHR--KVVEMWLWIEVAMLFGSGILGIGHHYF c1241030 K---TGIMTVMVADLLALAGLYVAGMFFTDNISMDQFWWWWVIHLWVEATWEVFVGVLAAYSLIKIIGAKR--EIVEMWLWIEVLMLFGSGILGMGHHYF c1242289 R---TGIMTVMVANLMALAGLYLAGMFFTDNISVDQYWWWWVIHLWVEATWEVFVGTLAAYALIKVIDAKR--EIVEMWLWIEVLMLFGSGILGLGHHYF c1242165 K---TVITTVLLTGLFGLAFFFLFAFYVPENLVMDKFFWWFVVHLWVEATWELILGALLAFVIIKTTGIDR--EHIDKWLYLIIAMTLVSGLVGTGHHFY c1242219 K---TTISVILLTGLFGLAFFFLFAFYVPENLVMDKFFWWFVVHLWVEATWELILGALLAFVLIKTTGVDR--EHIDKWLYLIIAMTLISGLAGTGHHFF c1241897 R---TVITTVLLTGLLGLAVFFLFAFYVPDNLIQDKFFWWFTVHLWVEATWELILGAILAFVLIKVTGVDR--EHIDKWLYLIIAMTMVSGILGTGHHFF c1230031 R--FTVTQGSLLAGLVFLAVLYLFGIPFYRNLATDWYYWWWVIHLWVEGAWELVTAALVAFMLIHLTGVER--RVVEKWLYVELGLFLFTGIAGTGHHYY c1042464 R--QTTTALVMTMGLVFAALLYLPGMIWFDSQVTDSFFRWWVVHLWVEGVWELIMGGILAFLLIKLTGVDR--EVIEKWLYVIVGLTFLSGILGTGHHYY c1042313 R--QTTTALVMTMGLVFAALLYLPGMIWFDSQVTDSFFRWWVVHLWVEGVWELIMGGILAFLLIKLTGVDR--EVIEKWLYVIVGLTFLSGVLGTGHHYY c1041884 R--KTTTSIVLVMGLFFAALLYLPGMIWFDSQVTDSFFRWWVVHLWVEGVWELIMGGILAFLLIKLTGVDR--EVIEKWLYVIVGLTFLSGILGTGHHYY c1040279 R--RTTTALVLSMGLLFAALLYLPGMLPFDSQVTDSFFRWWVVHLWVEGVWELIMGGILSFLLIKLTGVDR--EVIEKWLYVIVGLTFLSGVLGTGHHYY c1251518 K--RSTTQLVLFFGLLCAALLYLPGMIYFDNQTLDSYFRWWVVHLWVEGVWELIMGGILAFLLIKLTGVDR--EVIEKWLYVVVGLTFLSGILGTGHHYY c1250766 K--RSTTQLVLFFGLLCAALLYLPGMIYFDNQTLDSYFRWWVVHLWVEGVWELIMGGILAFLLIKLTGVDR--EVIEKWLYVVVGLTFLSGILGTGHHYY c1252508 R--YTTTSLVLFFGLFSAALLYLPGMIYFHNQTLDSYFRWWVVHLWVEGVWELIMGSLLAYLLIKLTGVDR--EVIEKWLYVIVGLTFLSGILGTGHHYY c1230080 R--YTTTSMVLFLGLLMAALLYLPGMINTDHQTLDSYWRWWVVHLWVEGVWELIMGAIMSFLLIKMTGVDR--EVIEKWLYIIVGFTFLSGILGTGHHYY c1222638 R--WTLTEGVLIAGLVLAALLYLPALLPYDNYTVETFYRWWTIHLWVEGVWEMIQGSMLAFLLVRLSGADR--EVMEKWLYVIVGLVFMAGILGTAHHYY c1210461 R--WTVTEGVLVAGLAFAAILYLPALIEYENYTVSIFYRWWTIHLWVEGVWEMIQGGLLAYLLIRLSGADR--EVMEKWLYVIVGLVFMAGILGTAHHYY c1211479 R--FTTPEGVLLGGLGLAAVLYLPALLEFHNYTVAIFYRWWTIHLWVEGVWEMIQGGFLAYLLIRLSGADR--EVMEKWLYVIVGLVFIAGILGTAHHYY c1210008 R--FTTPEGVLLGGLGLAAVLYLPALLEFHNYTVAIFYRWWTIHLWVEGVWEMIQGGFLAYLLIRLSGADR--EVMEKWLYVIVGLVFIAGILGTAHHYY c1211833 K---TVVSIVLLLGLWGAAIFFMFAFYNPDNLAVDKLYWWWVVHVWVEGVWELIMAAMLAFLLIKLTGVDR--EVIEKWLYVIVGFSLFSGLLGTGHHYY c1222407 K---TVVSTVLLIGLWGAALFFLFAFYNPSNLALDKMYWWWVVHVWVEGVWELIMASMLAFLLIKLTGVDR--EVIEKWLYVIVGLSIVSGLLGTGHHYY

c1222409 K---TVVSIVLLVGLWGAALFYLFAFYNPSNLALDKLYWWWVVHVWVEGVWELIMAAMLAFLLIKLTGVDR--EIIEKWLYVIVGLSLVSGLLGTGHHYY c1220458 K---TVVSIVLLVGLWGAALFYLFAFYNPSNLALDKLYWWWVVHVWVEGVWELIMAAMLAFLLIKLTGVDR--EVIEKWLYVIVGLSLVSGLLGTGHHYY c1221136 K---TVVSIVLLVGLWGAALFYLFAFYNPSNLALDKLYWWWVVHVWVEGVWELIMAAMLAFLLIKLTGVDR--EVIEKWLYVIVGLSLVSGLLGTGHHYY c1200568 K---TTVVNILLFGLWGVAIFFLFSFYNPVNLALDKMYWWYVVHLWVEGVWELIMASVLAFLMIKLNGIDR--EVVEKWLYVIMGLALFSGILGTGHHYY c1200571 K---TTITNILLFGLWGVAIFFLFAFYNPANLALDKMYWWYVVHLWVEGVWELIMASVLAFLMIKLNGIDR--EVVEKWLYVIIGLALFSGILGTGHHYY c1201236 K---TTITNILLFGLWGVAIFFLFAFYNPANLALDKMYWWYVVHLWVEGVWELIMASVLAFLMIKLNGIDR--EVVEKWLYVIIGLALFSGILGTGHHYY c122X013 K---TVVTNILIFGLWGIAIFFLFSFYNPANLALDKMYWWYVVHLWVEGVWELIMASVLAFLMIKLNGIDR--EVVEKWLYVIVGLALFSGILGTGHHYY c1201814 K---TTVTNILIFGLWGVAIFFLFAFYNPINLALDKMYWWYVVHLWVEGVWELIMASVLAFLMIKLNGIDR--EVVEKWLYVIVGLALFSGILGTGHHYY c1200644 K---TTVTNILIFGLWGVAIFFLFAFYNPVNLALDKMYWWYVVHLWVEGVWELIMASVLAFLMIKLNGIDR--EVVEKWLYVIVGLALFSGILGTGHHYY c121X007 K---TTVTNILIFGLWGVAIFFLFAFYNPINLALDKMYWWYVVHLWVEGVWELIMASVLAFLMIKLNGIDR--EVVEKWLYVIVGLALFSGILGTGHHYY c1200022 K---TTVINILLFGLWGLAIFFLFAFYNPINLALDKMYWWYVIHLWVEGVWELIMASILAFLMIKLNGIDR--EVVEKWLYVIVGLALFSGILGTGHHYY c121X008 K---TTVTNILLFGLWGLALFFLFAFYNPINLALDKLYWWYVIHLWVEGVWELIMASILAFLMIKLNGIDR--EVVEKWLYVIVGLALFSGILGTGHHYY c1200100 K---TTVTNILLFGLWGLALFFLFAFYNPINLALDKLYWWYVIHLWVEGVWELIMASILAFLMIKLNGIDR--EVVEKWLYVIVGLALFSGILGTGHHYY c1200101 K---TTVQHSLLFGLWGLALFFLFAFYNPINLALDKLYWWYVIHLWVEGVWELIMASILAFLMIKLNGIDR--EVVEKWLYVIVGLALFSGILGTGHHYY c1201161 K---TTVQHSLLFGLWGLALFFLFAFYNPINLALDKLYWWYVIHLWVEGVWELIMASILAFLMIKLNGIDR--EVVEKWLYVIVGLALFSGILGTGHHYY c1201159 K---TTVQHSLLFGLWGLALFFLFAFYNPINLALDKLYWWYVIHLWVEGVWELIMASILAFLMIKLNGIDR--EVVEKWLYVIVGLALFSGILGTGHHYY c1200097 K---TTVTNILLFGLWGLALFFLFAFYNPINLALDKLYWWYVIHLWVEGVWELIMASILAFLMIKLNGIDR--EVVEKWLYVIVGLALFSGILGTGHHYY c1200098 K---TTVTNILLFGLWGLALFFLFAFYNPINLALDKLYWWYVIHLWVEGVWELIMASILAFLMIKLNGIDR--EVVEKWLYVIVGLALFSGILGTGHHYY c1200099 K---TTVTNILLFGLWGLALFFLFAFYNPINLALDKLYWWYVIHLWVEGVWELIMASILAFLMIKLNGIDR--EVVEKWLYVIVGLALFSGILGTGHHYY c1200556 K---TTITNILLFGLWGVAIFFLFAFYNPVNLSLDKMYWWYVVHLWVEGVWELIMASVLAFLMIRLNGIDR--EVIEKWLYVIIGLALFSGILGTGHHYY c1200095 K---TTVTNILLFGLWGVAIFFLFAFYNPANLAVDKMYWWYVVHLWVEGVWELIMASVLAYLMIKLNGIDR--EVVEKWLYVIIGLALFSGILGTGHHFY c1200094 K---TTVTNILLFGLWGVAIFFLFAFYNPANLAVDKMYWWYIVHLWVEGVWELIMASILAFLMIKLNGIDR--EVVEKWLYVIIGLALFSGILGTGHHFY c1200962 K---TTVTNILLFGMWGVAIFFLFAFYNPANLAVDKMYWWYIVHLWVEGVWELIMASILAFLMIKLNGIDR--EVVEKWLYVIIGLALFSGILGTGHHFY c1200380 K---TAITNVLLLGLWGIAVFFLFSLYNPANLIMDKIFWWWVVHLWVEGVWELVMASILAFLMIKLTGVDR--EVVEKWLYVIIGLALFSGILGTGHHYY c1202251 R---TAVTSVLLLGLWGIALFWLFAFYAPANLSLDKLYWWYIVHLWVEGVWELVMASVLAFLMIKTTGVDR--EVVEKWLYSIVGLALFSGLLGTGHHYY c1202563 K---TAIGNVLLLGMWGIAVFWLFAFYNPGNIALDKVYWWYVVHLWVEGVWELVMASVLAFLMIKMTGVDR--EVIEKWLYAIVGLALFSGVLGTGHHYY c1202317 K---TAIGNVLLLGMWGIAVFWLFAFYNPGNIALDKVYWWYVVHLWVEGVWELVMASVLAFLMIKMTGVDR--EVIEKWLYAIVGLALFSGLLGTGHHYY c1201839 K---TAIGNVLLLGMWGIAVFWLFAFYNPGNIALDKVYWWYIVHLWVEGVWELVMASILAFLLIKMTGVDR--EVIEKWLYAIVGLALFSGVLGTGHHYY c1202231 R---TVITNILLVGMWGIALFFLFSFYNPANLSLDKMYWWYVVHLWVEGVWELVLASILAFLMIKMTGVDR--EVVEKWLYAMVGLALFSGILGTGHHYY c122X009 K---TAINMVLMLGLWLAAVFWLFAFYNPSNLAVDKLYWWWVVHLWVEGVWELIMASLLGYLLIKMTGVDR--EVIEKWLYVIVGLALFSGLLGTGHHYY c1220025 R---TAVSLVLMLGLWLAAIFWMFAFYNPSNLALDKLYWWWIVHIWVEGVWELIMAALLGYLLIKLTGVDR--EIIEKWLYVIVGLSLFSGLLGTGHHYY c1222498 K---TAISLVLLLGLWLAAIFWLFAFYTPDNMSLDKMYWWYIVHIWVEGVWELIIASLLGFLLIKMTGVDR--EVIEKWLYVIVGLALFTGLLGTGHHYY c1210459 K---TVVTTILLLGMWGAALMFLFAFYNPGNLALDKMYWWYVVHIWVEGVWELIMASMLAFLLIKMTGVDR--EVIEKWLYVIVGLALFSGLLGTGHHYY c1210460 K---TVVSTVLLLGMWGAALLFLFAFYNPDNLALDKMYWWYVVHLWVEGIWELIMASMLAFLLIKMTGVDR--EVIEKWLYVIVGLALFSGLLGTGHHYY c1201239 K---TAITNILLLGLWGIAIFFLFSLYNPNNLVLDKMFWWWVVHLWVEGVWELVMASVLAFLMIKLTGVDR--EIVEKWLYVIVAMSLFTGILGTGHHYY c1201266 K---TAITNVLLLGLWGIAIFFLFSLYNPGNLSEDKMFWWYVVHLWVEGVWELVMASVLAFIMLKITGVDR--EVIEKWLYVIVATALFSGVLGTGHHYY c1202651 K---TAISNILLLGLWGLALLFLFAFYNPSNLALDKQYWWYVIHLWVEGVWELIMASILAYLMLKLTGVDR--EVVEKWLYVIVATALFSGILGTGHHYY c1202650 K---TAITNILLLGLWGLALLFLFAFYNPGNLSLDKQYWWYVVHLWVEGVWELIMASILAYLMLKLTGVDR--EVVEKWLYVIVAAALFSGILGTGHHYY c1200238 K---TAITNILLLGLWGLALLFLFSFYNPHNLSLDKMYWWYVVHLWVEGVWELIMASILAYLMLKLTGVDR--EVVEKWLYVIVAAALFSGILGTGHHYY c1200641 K---TAITNILLLGLWGLALLFLFSFYNPSNLALDKQYWWYIVHLWVEGVWELIMASILAYLMLKLTGVDR--EVVEKWLYVIVAAALFSGILGTGHHYY c1201844 K---TAITNILLLGLWGLALLFLFAFYNPGNLSLDKQYWWYVVHLWVEGVWELIMASILAYLMLKLTGVDR--EVVEKWLYVIVAAALFSGILGTGHHYY

c1200666 K---TAITNILLLGLWGLALLFLFSFYNPSNLSLDKQYWWNVVHLWVEGVWELIMASVLAYLMLKLTGVDR--EVIEKWLYVIVAAALFSGILGTGHHYY c1200983 K---TAITNVLLLGLWGLTLLFLFAFYNPSNLALDKMYWWYVVHLWVEGTWELIMASVLAFLMLKLTGVDR--EIIEKWLYLIVATALFSGILGTGHHYF c1200589 K---TAITNVLLLGLWGLTLLFLFAFYNPSNLALDKMYWWYVVHLWVEGTWELVMASVLAFLMLKLTGVDR--EIIEKWLYLIVATALFSGILGTGHHYF c1200838 K---TAITNILLMGLWLLCLLWVFAFINPDNLSLDKMYWWFVVHLWVEATWELVMAAILGYLMLKLTGVDR--EVVEKWLYIIVATALFSGILGTGHHFY c1201843 K---TAITNILLMGLWLLCLLWIFAFINPDNLSLDKMYWWFVVHLWVEATWELVMAAILGYLMLKMTGVDR--EVVEKWLYVIVATALFSGILGTGHHFF c1201222 K---TAITNILLMGLWLLSLLWIFAFINPDNLSLDKMYWWFVVHLWVEATWELVMAAILGYLMLKLTGVDR--EVVEKWLYVIVALALFSGILGTGHHFF c1202538 K---TAITNILLMGLWLLCLLWVFAFINPDNLSLDKMYWWMVVHLWVEATWELVMAATLGFLMLKLTGVDR--EVIEKWLYVIVALALFSGILGTGHHFY c1200562 K---TAITNILLMGLWLLCLLWVFAFINPDNLSLDKMYWWMVVHLWVEATWELVMAATLGFLMLKLTGVDR--EVIEKWLYVIVALALFSGILGTGHHFY c1200477 R---TAVTNVLLMGLWGLVLLWLFAFYNPANLVLDKQYWWWVIHLWVEGVWELIMAAILAFLMLKLTGVDR--EVVEKWLYVIVATALFSGILGTGHHYY c1201278 K---TAITNILVIGLWALSLLWLFAFYNPANLSLDKMYWWYVVHLWVEGTWELVMASILGFLMLKLTGVDR--EVIEKWLYIIVATALFSGILGTGHHYY c1200560 K---TAITNILLAGLWLLCLLWVFAFINPDNLGLDKMYWWYIVHLWVEGTWELVMAAILGYLMLKLTGVDR--EVIEKWLYVIVATALFSGILGTGHHFY c1200561 R---TAITNILLMGLWLLSLLWIFAFINPDNLGLDKMYWWFIVHLWVEGTWELVMAAILGYLMLKLTGVDR--EVVEKWLYVIVATALFSGILGTGHHFY c1200559 R---TAITNILLMGLWLLSLLWIFAFINPDNLGLDKMYWWFIVHLWVEGTWELVMAAILGYLMLKLTGVDR--EVVEKWLYVIVATALFSGILGTGHHFY c1200590 K---TAITNVLLMGLWLLSLLWVFAFINPDNLSLDKMYWWFVVHLWVEATWELVMAAILAFLLLKLTGVDR--EVVEKWLYVIVATALFSGILGTGHHFY c1200985 K---TAITNVLLMGLWLLSLLWIFAFINPENLSLDKMYWWFVVHLWVEATWELVMAAILAFLLLKLTGVDR--EVVEKWLYVIVATALFSGILGTGHHFY c1201169 K---TAITNVLLMGLWLLSLLWIFAFINPENLSLDKMYWWFVVHLWVEATWELVMAAILAFLLLKLTGVDR--EVVEKWLYVIVATALFSGILGTGHHFY c1211822 K---TAISLVLLMGLWGLALMFLFSFVNPSNLVRDKMYWWFVVHLWVEGTWELIMASLLAFVLIKTTGVDR--EVIDKWMYMIIAFALISGILGTGHHFY c1211216 K---TSISLVLLVGLWGLAIFFLFSFVNPHNLVRDKMYWWFVVHLWVEGVWELILGALLAYVLVKTTGVDR--EIIDKWLYVIIAFALMTGILGTGHHFY c1212639 K---TAISLVLLMGLWGLALMFLFSFVNPHNLVRDKMYWWFVVHLWVEGVWELILGSLLAYVLVKTTGVDR--EVIDKWLYVIIAFALMTGILGTGHHFY c1222649 K---PVINMVLLTGLVGLAVFFLFSFYNPSNLVLDKYFWWWTVHLWVEGVWELILGAILAFTLIKVTGVDR--EVIEKWLYVIIGMALISGLIGMGHHYF c1220624 K---TVINMVLITGLAGLALFYLFSFYNPDSLTMDKYFWWFVVHLWVEGVWELILGALLAFVLIKVTGVDR--EHIEKWLYVIIAMALISGLIGMGHHYF c1220318 K---TVINVVLMTGLVGLAVMFLFSFYNPSNLALDKYFWWWVVHLWVEGVWELIMGSILAFVLIRVTGVDR--EVIEKWLYVIIGMALITGIIGTGHHYY c1211162 K---TAISMVMMTGLIGLAVLFLFSFYNPENLARDKYYWWWVVHLWVEGVWELIMGSMLAFVLIKITGVDR--EVVEKWLYVIIGMALITGIIGTGHHYF c1222643 K---TTVSVVMMTGLIGLAVMFLFSFFNPENLARDKYYWWWVVHLWVEGVWELIMGSMLAFVLIKITGVDR--EVIEKWLYVIIAMALITGIIGTGHHYF c1222647 K---TTVSMVMMTGLIGLAVFFLFSFYNPGNLARDKFYWWWVVHLWVEGVWELIMGSMLAFVLIKVTGVDR--EVVEKWLYVIIAMALITGIIGTGHHFF c1222648 K---TTVSMVMMTGLIGLAVFFLFSFYNPSNLARDKFYWWWVVHLWVEGVWELIMGSMLAFVLIKITGVDR--EVVEKWLYVIIAMALITGIIGTGHHFF c122X011 K---TTVSMVMMTGLIGLAVFFLFSFYNPENLARDKFYWWWVVHLWVEGVWELIMGSMLAFVLIKITGVDR--EVVEKWLYVIIAMALITGIIGTGHHFF c122X012 K---TVVSTVMMTGLIGLAVFFLFAFYNPENLSRDKFYWWFVVHLWVEGVWELIMGAMLAFVLIKVTGVDR--EVIEKWLYVIIAMALITGIIGTGHHFF c1220965 K---TVVSTVMMTGLIGLAVFFLFSFYNPENLARDKYYWWFVVHLWVEGVWELIMGSMLAFVLIKITGVDR--EVVEKWLYVIIAMALITGIIGTGHHFF c1222644 K---TTVSVVMMTGLILLAVFFLFSFYNPGNLVRDKFYWWWVVHLWVEGVWELIMGSMLAFVLIKITGVDR--EVVEKWLYVIIAMALITGIIGTGHHYF c1220521 K---TAISMVLMTGLIGLALLFLFSFYNPENLTRDKFYWWWVVHLWVEGVWELIMGAILAFVLVKITGVDR--EVIEKWLYVIIAMALISGIIGTGHHYF c1220524 K---TAISMVLMTGLIGLALLFLFSFYNPENLTRDKFYWWWVVHLWVEGVWELIMGAILAFVLVKITGVDR--EVIEKWLYVIIAMALISGIIGTGHHYF c1220519 K---TAISMVLMTGLIGLALLFLFSFYNPENLTRDKFYWWWVVHLWVEGVWELIMGAILAFVLVKITGVDR--EVIEKWLYVIIAMALISGIIGTGHHYF c1220523 K---TAISMVLMTGLIGLALLFLFSFYNPENLTRDKFYWWWVVHLWVEGVWELIMGAILAFVLVKITGVDR--EVIEKWLYVIIAMALISGIIGTGHHYF c1220520 K---TAISMVLMTGLIGLALLFLFSFYNPENLTRDKFYWWWVVHLWVEGVWELIMGAILAFVLVKITGVDR--EVIEKWLYVIIAMALISGIIGTGHHYF c1220525 K---TAISMVLMTGLIGLALLFLFSFYNPENLTRDKFYWWWVVHLWVEGVWELIMGAILAFVLVKVTGVDR--EVIEKWLYVIIAMALISGIIGTGHHYF c1220385 K---TVVNIVLITGLVGLAVLWLFSFYNPGNLATDKYFWWFVVHLWVEGVWELIMGAILAYVLIKLTGVDR--EVIEKWLYVIIAMALITGIIGTGHHFF c1220839 K---TVVNIILITGLIGLTVLWMFSFYNPENLTTDKYYWWFVIHLWVEGVWELIMGAILAFVLIKITGVDR--EVIEKWLYVIIAMALITGIIGTGHHFF c1220203 K---TAINMVMMTGLIGLAVFFLFAFYNPTNLALDKYFWWFVVHLWVEGVWELIMGAILAYVLIKVTGVDR--EVIEKWLYVIIAMALISGILGTGHHFY c1220491 K---TVINIVLITGLIGLAVFFLFSFYNPDNIAMDKLFWWFVVHLWVEGVWELIMGAILAFILIKITGVDR--EIIEKWLYVIIAMALISGLLGTGHHFF c1220490 K---TVINMVLITGLIGLAVFFLFSFYNPENIAMDKLFWWFVVHLWVEGVWELIMGAILAFILIKITGVDR--EIIEKWLYVIIAMALISGLLGTGHHFF

c1222646 K---TVVNLVLMMGLTGLAVFFLFAFYNPVNLVLDKFFWWWVVHLWVEGVWELILGSILAFVLIKTTGVDR--EVIEKWLYIIIAMVLITGIIGTGHHFY c1210042 K---TVISIVMLLGLWGLAIFFLFSFYNPGNLVKDKFYWWWVVHLWVEGVWELIMAAMLAFVLIKVTGVDR--EVIEKWLYVIITLALVSGLIGTGHHYF c1211226 K---TVISIVLLLGLWGLAIFFLFSFYNPVNLVRDKFYWWWVVHLWVEGVWELIMAAMLAFVLIKVTGVDR--EVIEKWLYVIITLALVTGIIGTGHHYF c1212642 K---TVISIVLLLGLWGLAIFFLFSFYNPVNLVRDKFYWWWVVHLWVEGVWELIMAAMLAFVLIKVTGVDR--EVIEKWLYVIITLALVTGIIGTGHHYF c1210218 K---TAISIVLLLGLWGLAVFFLFSFYNPTNVVLDKFFWWWTVHLWVEGVWELILGSFLAFVLIKTTGVDR--EVIEKWLYVIVTLTLISGIIGTGHHYF c1200379 K---TSISIVLLTGLIGLAVMFLFSFYNPSNLVLDKFYWWWVVHLWVEGVWELILGAILAFVLIKVTGVDR--EVIEKWLYLIIAMTLITGILGTGHHYY c1211614 K---TSVSLVMMLGLWGLAIFFLFSFYNPTNLVLDKYFWWYVVHLWVEGVWELIMGAMLAFVLIKVTGVDR--EVVEKWLYVIIAMTLISGIIGTGHHYY c1212641 K---TSVSLVMMLGLWGLAIFFLFSFYNPTNLVLDKYFWWYVVHLWVEGVWELIMGAMLAFVLIKVTGVDR--EVVEKWLYVIIAMTLISGIIGTGHHYY c1222533 K---TSISLVMMIGLWGLAIFFLFSFYNPTNIVLDKYFWWWVVHLWVEGVWELIMGAMLAFVLIKVTGVDR--EVIEKWLYLIVAFTLITGLIGTGHHYF c1211830 K---TSISLVMLLGLWGLAIFFLFSFYNPSNLVLDKYFWWWTVHLWVEGVWELILGAMLAFVLIKITGVDR--EVIEKWLYIIIAMTLITGIIGTGHHYF c1210764 K---TAINLVMLVGLWGLAIFFLFSFYNPGNLVKDKYYWWWVVHLWVEGVWELIMGAMLAFVLIKVTGVDR--EVIEKWLYVIIAMALITGIIGTGHHYY c1212645 K---TSISLVMLLGLWGLAVFFLFSFYNPTNLVLDKFFWWWTVHLWVEGVWELILGAMLAFVLIKVTGVDR--EVIEKWLYVIITLTLVTGIIGTGHHYF c1210041 K---TAISMVLLLGLWGLAIFFLFSFVNPHNLVRDKFYWWWVVHLWVEGVWELILGALLAFVLIKVTGVDR--EVIEKWLYVIITLTLVTGIIGTGHHYY c1211877 K---TAISLVLVLGLVGLAVFFLFSFYNPHNLVKDKYYWWWVVHLWVEGVWELILGAILAFVLIKVTGVDR--EVVEKWLYVIITMTLITGIIGTGHHYY c1142560 K-NITPAAAIMTVGVIFLLLLLLPNAITFSNPIADEATKFWVVHLWEEMAFELTTAGFIAAYYSVSGLASR--KQIEKWLYLEAALAVVGGLYSTGHHYY c1142556 R-NVTPAAAVMTVGIVFLLLLMLPNTITYHNPITDEATKFWIVHLWEEMAFELTSAGFIAGFYVVSGLADR--NKVEQWLYLEASLAVVGGLYGTGHHYY c1142732 R-NITPASATMTVGIIFLFLLLLPNTITYRNPITDEVTKFWVVHLWEEMAFELTSAGFIATFYVVSGLAPR--AQVEKWLYLEASMAVVGGFYGTGHHYY c1142559 Q-HITPASAIMTGGMVFLGLLLIPNVLNYTNPIVDEAVKYWVVHLWEEMAFELITSGFIASFFIASGLVEK--KDMEKWLYLEASLAVSGGLFGTGHHYY c1142558 Q-RLTPATGIMTVGVVLLCVLLIPNILHYSNPVADEAVKFWVVHLWEEMAFELTTSGFIASFFVSTGIADK--KDIEKWLYLEATLSVTGGLFGTGHHYF c1142557 R-KITPAAGIMTVGVVFLSVLLIPNVLRFNNPVADEAVKFWVVHLWEEMAFELTTSGFIASFFVTAGIAAK--KDIEKWLYLEATLSVIGGLFGTGHHYF c1140225 Q-KITPAAGIMAVGAVFLCVLIIPNVLRFTNPVADEAVKFWVVHLWEEMAFELTTSGFIASFFVTAGIAEK--RDIEKWLYLEATLSVIGGLFGTGHHYF c1140226 Q-KITPAAGIMAVGAVFLCVLIIPNVLRFTNPVADEAVKFWVVHLWEEMAFELTTSGFIASFFVTAGIAEK--RDIEKWLYLEATLSVIGGLFGTGHHYF c1141613 V-RGRVTMLGMLSGAISLIVLFIPNLIEYVHPTIDEIIRFWVVHMWEELSKELLLIGALVAFLLTVGKARR--KTLEKLLFLQLALLIVGATFATGHHYY c1222482 Q--WNEIHWGLGLGVSALMAVWVFGLFYVARLDLQEYFRWFVVHYWVEGVWEVIHITLVGFLLVLMFKVDV--KSVGFAVFWGVALVWLSGLIGNAHHYF 99% * * * ** ^ ^ ^ ^ ^

310 320 330 340 350 360 370 380 390 400 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|c1112653 WIGTPEYWLGLGGFFSALEPIPLVAMVVHAVYDAG-VHRMQT---------------VNQPALFWAIAQAFGNFVGAGVWGFMQTLPQINLYSHGTQLAP c1112544 WIGTPEYWLGLGGFFSALEPIPLVAMVVHAVYDAG-MHRMQT---------------VNQPALFWAIAQAFGNFIGAGVWGFMQTLPQINLYSHGTQLAA c1112654 WIGTPEYWLGLGGFFSALEPIPLVAMVVHAVYDAG-VHRMQT---------------VNQPALFWAIAQAFGNFIGAGVWGFMQTLPQINLYSHGTQLAP c1032043 WIGTPPYWLGIGGFFSSLEPLPLVAMVIHAVYDAG-VHRLQT---------------VNRPALFWAFAQAFGNLFGAGVWGFMHTLPQINLFSHGTQLAA c1030986 WIGTPEYWLGIGGFFSSLEPLPLVAMIVHAVYDAG-VHKLQT---------------VNRPALFWIFLQAFGNFFGAGVWGFMHTLPQINLYSHGTQMAA c1281324 WIGAPEYWLGIGGFFSALEPLPLVAMVVHAVYDAG-MHRLTT---------------TNKPAFFWIVFQSFGNFLGAGVWGFMHTLPQINLYSHGTQITA c1211829 WIGTPEYWFSIGGFFSALEPIPLVAMVVHAVFDAG-ARHAKN---------------SNHPAMAWLIAHAFGNFFGAGVWGFMHTLPQINLYTHGTQWSA c1220409 WIGTPDYWFSIGGFFSALEPIPLVAMVVHSVYDAG-VRKLRN---------------GNHPALAWIIAHTFGNFLGAGVWGFMHTLPQINLYTHGTQWTA c1222655 WIGTPEYWFPIGGFFSALEPIPLVAMVVHSIYDAG-VHKLRS---------------TNHPALAWVIAHTFGNFLGAGVWGFMHTLPQINLYTHGTQWTA c1222652 WIGTPEYWFTIGGFFSALEPIPLVAMVVHSVYDSG-VHNFKN---------------GNHPALAWIIAHTFGNFLGAGVWGFMHTLPQINLYTHGTQWSA c1222541 WIGTPEYWLTIGGFFSALEPIPLVAMVVHAVYDSG-THAFKN---------------GNHPALAWIIAHAFGNFFGAGVWGFMHTLPQINLYTHGTQWSA

c1222748 WIGTPEYWLTIGGFFSALEPIPLVAMVVHAVYDAG-AHSFKT---------------GNHPALAWIIAQAFGNFFGAGVWGFMHTLPQINLYTHGTQWSA c1241031 WIGTPEYWWEIGALFSALEPVPLVGLFVHVLYDWG-KERGKG------------NTIKNVPAFAWLTVETFGNFLGAGVWGFMHTLPQINLYTHGTQWPA c1240766 WIGTPEYWWEIGALFSALEPLPLVAMFIHVLYDWG-KMQGEEDAKG-----QEISVITNKPAFTWFVLNAFGNFLGAGIWGFFHTLPQVNLYTHGTQFTS c1241223 WIGTPEYWWEIGALFSALEPLPLVAMFIHVLYDWG-KTQGAQDATG-----QEVSVINNKPAFTWFVLNAFGNFLGAGIWGFFHTLPQVNLYTHGTQFTS c1241030 WIGTPEYWWEIGALFSALEPVPLVAMFVHVLYDWG-KEQGAAKAEG-----HKGAVANNGPAIAWIVTNAFGNFLGAGVWGFFHTLPQVNIYTHGTQFTA c1242289 WIGTPEYWWEIGALFSALEPVPLVAMFVHVLYDWG-KEQGHTEAKG------EKSAIKNGPAMAWITTNAFGNFLGAGIWGFFHTLPQVNIYTHGSQFTA c1242165 YIGTPEYWLWLGSIASAIEPLPFFLMILFVYSATK-DRAIMH---------------DNKIALTWAKGTAVMGFLGAGVWGFIHTLAPVNYYTHGTQLTA c1242219 FIGTPGYWLWIGSIASAAEPIPFFLMILFAYNMAK-NRRIQH---------------DNKIALTWAKGTAVVGFLGAGVWGFLHTLAPINYYTHGTQLTA c1241897 YMGAPEYWLWIGSISSAVEPLPFLLMILFAFTMAR-ERKIEH---------------KNKMALTWAKGTAVMAFLGAGVWGFFHTLAPVNMYTHGTQLTA c1230031 WLGTPRYWLWVGGVFSALEPLPILLMLWDTFRAER-EGGRKL---------------EPRLTWTLLIGMAVLHFVGAGLFGLAHTLPQINYYTHGSQVTV c1042464 YIGVNKIWLVVGGVFSALEPLAFLAMALFAVYMYR-KGEKNH---------------PNKIALFWTIGAAIVSFIGAGLLGFAHTLPQTNLYTHGTLVTA c1042313 YIGVNKIWLVVGGVFSALEPLAFLAMALFAVYMYR-KGEKNH---------------PNKIALFWTIGAAIVSFIGAGLLGFAHTLPQTNLYTHGTLVTA c1041884 YIGVNKIWIIVGGIFSALEPLAFLAMALFAVYMYR-KGEKNH---------------PNKIALFWTIGASIVSFIGAGLLGFAHTLPQTNIYTHGTLVTA c1040279 YIGVNKIWLIVGGIFSALEPLAFLAMALFAVNMYR-KGEKKH---------------PNKLALYWTLGAAIVSFVGAGLLGFAHTLPQTNLYTHGTLVTA c1251518 WIGTPKYWLMVGGIFSALEPLAFLGMAIWALNMYR-KKGKDH---------------PNKIALYWTLGSAMMSFIGAGFLGFAHTWPAVNQWTHGTLVTA c1250766 WIGTPKYWLMVGGIFSALEPLAFLGMAIWALNMYR-KKGKDH---------------PNKIALYWTLGSAMMSFIGAGFLGFAHTWPAVNQWTHGTLVTA c1252508 YIGTPSYWLWIGGIFSALEPLAFLGMALFAIAMYR-RAGRSH---------------PNKVALYWTIGCAIMSFVGAGFLGFAHTLPQVNLYTHGTLVTA c1230080 YIGTPRYWLLVGGLFGALEPLAFLGFAIYAVAMAR-KGGKNP---------------DNKMAMAWTMATAILSFVGAGFLGFAHTLPQVNLYTHGTLVTA c1222638 WTGVPGYWLPIGGFFSALEPVALVGMAIYAYAAIR-RSGAAH---------------PNTLAVHWTIGSAVFTLFGAGLLGLAHTWPAINKWTHGTLITA c1210461 WVGVPHYWLPIGGFFSALEPVALLGMAMYAYFAMR-RAGLSH---------------PNSLAVHWTIGSTVFTVFGAGLLGFAHTWPSVNKWTHGTLITA c1211479 WVGVPQYWLPIGGFFSALEPVALVGMAMYAYFAMR-RSGMAH---------------PNKLALHWTVGSAVFTLFGAGLLGLAHTFPSVNKWTHGTLITA c1210008 WVGVPQYWLPIGGFFSALEPVALVGMAMYAYFAMR-RSGMAH---------------PNKLALHWTVGSAVFTLFGAGLLGLAHTFPSVNKWTHGTLITA c1211833 WIGAPEYWHWIGIIFSFLEVVPFFAMMLWAFYLVK-KSGRDH---------------PNKAAILWSLGCPVMAFIGAGLLGLMHSFPSINFYTHGTQLTA c1222407 WIGTPSYWLWIGGLFSVLEVLPFFAMVLWAFYLVY-RSGRDH---------------PNKAAMLWSLGCPVMAFFGAGVWGLMHSFSPVNFYSHGTQVTA c1222409 WIGTPGYWHWIGGVFSVLEVLPFFAMVLWAFYLVH-ESGRDH---------------PNRAAMLWSLGCPVMAFFGAGVWGLMHSFSQVNFYSHGTQVTA c1220458 WIGTPSYWHWIGGVFSVLEVLPFFAMVLWAFYLVH-ESGRDH---------------PNRAAMLWSLGCPVMAFFGAGVWGLMHSFSQVNFYSHGTQVTA c1221136 WIGTPSYWHWIGGVFSVLEVLPFFAMVLWAFYLVH-ESGRDH---------------PNRAAMLWSLGCPVMAFFGAGVWGLMHSFSQVNFYSHGTQVTA c1200568 WIGAPGYWQWIGSVFSTLEVAPFFTMVLFTIQMTW-KAGRKH---------------ENRAALLWAVGCSVMAFFGAGVWGFLHTLSSVNFYTHGTQVTA c1200571 WIGAPGYWQWIGSLFSTLEVAPFFTMVVFTVQMTW-KAGRKH---------------ENRAALLWSVGCSVMAFFGAGVWGFLHTLSSVNYYTHGTQVTA c1201236 WIGAPGYWQWIGSLFSTLEVAPFFTMVVFTVQMTW-KAGRKH---------------ENRAALLWSVGCSVMAFFGAGVWGFLHTLSSVNYYTHGTQVTA c122X013 WIGAPGYWQWIGSLFSTLEVAPFFTMVIFTFVMTW-KAGRKH---------------PNRAALLWSIGCSVMAFFGAGVWGFLHTLSSVNYYTHGTQVTA c1201814 WIGAPGYWQWIGSLFSTLEVAPFFTMVVFTFVMTW-KAGRKH---------------PNKAALLWSIGCSVMAFFGAGVWGFLHTLSSVNYYTHGTQVTA c1200644 WIGAPGYWQWIGSLFSTLEVAPFFTMVVFTFVMTW-KAGRKH---------------PNKAALLWSIGCSVMAFFGAGVWGFLHTLSSVNYYTHGTQVTA c121X007 WIGAPGYWQWIGSLFSTLEVAPFFTMVVFTFVMTW-KAGRKH---------------PNRAALLWSIGCSVMAFFGAGVWGFLHTLSSVNYYTHGTQVTA c1200022 WIGAPGYWQWIGSLFSTLEVAPFFTMVIFTFVMTW-KAGRKH---------------ENRAALLWSIGCSVMAFFGAGVWGFLHTLSSVNYYTHGTQLTA c121X008 WIGAPGYWQWIGSLFSTLEVAPFFTMVIFTFVMTW-KAGRKH---------------PNRAALLWSIGCSVMAFFGAGVWGFLHTLSSVNYYTHGTQLTA c1200100 WIGAPGYWQWIGSLFSTLEVAPFFTMVMFTFVMTW-RAGRKH---------------PNRAALLWSIGCSVMAFFGAGVWGFLHTLSSVNYYTHGTQLTA c1200101 WIGAPGYWQWIGSLFSTLEVAPFFTMVMFTFVMTW-RAGRKH---------------PNRAALLWSIGCSVMAFFGAGVWGFLHTLSSVNYYTHGTQLTA c1201161 WIGAPGYWQWIGSLFSTLEVAPFFTMVMFTFVMTW-RAGRKH---------------PNRAALLWSIGCSVMAFFGAGVWGFLHTLSSVNYYTHGTQLTA c1201159 WIGAPGYWQWIGSLFSTLEVAPFFTMVMFTFVMTW-RAGRKH---------------PNRAALLWSIGCSVMAFFGAGVWGFLHTLSSVNYYTHGTQLTA c1200097 WIGAPGYWQWIGSLFSTLEVAPFFTMVMFTFVMTW-RAGREH---------------PNRAALLWSIGCSVMAFFGAGVWGFLHTLSSVNYYTHGTQLTA

c1200098 WIGAPGYWQWIGSLFSTLEVAPFFTMVMFTFVMTW-RAGREH---------------PNRAALLWSIGCSVMAFFGAGVWGFLHTLSSVNYYTHGTQLTA c1200099 WIGAPGYWQWIGSLFSTLEVAPFFTMVMFTFVMTW-RAGRKH---------------PNRAALLWSIGCSVMAFFGAGVWGFLHTLSSVNYYTHGTQLTA c1200556 WIGAPGYWQWIGSLFSTLEVAPFFTMVIFTFVMTW-KAGRKH---------------ENKAALLWSIGCSVMAFFGAGVWGFLHTLSSVNYYTHGTQVTA c1200095 WIGAPGYWQWIGSLFSTLEVAPFFTMVIFTVQMTW-KAGRKH---------------PNRAALLWSVGCSVMAFLGAGVWGFLHTLSSVNYYTHGTQVTA c1200094 WIGAPGYWQWIGSLFSTLEVAPFFTMVIFTVQMTL-KAGRSH---------------PNRAALLWSVGCSVMAFLGAGVWGFLHTLSSVNYYTHGTQVTA c1200962 WIGAPGYWQWIGSLFSTLEVAPFFTMVIFTVQMTL-KAGRKH---------------PNRAALLWSVGCSVMAFLGAGVWGFLHTLSSVNYYTHGTQVTA c1200380 WIGTPGYWQWIGSVFSTLEVAPFFAMVVFAFMMVW-KGGRNH---------------PNKAALLWSLGCSVFAFFGAGVWGFLHTLAPVNYITHGTQVTA c1202251 WIGAPGYWQWVGSVFSALEIAPFFAMVIFAFRMVF-KGRKDH---------------PNRAAVLWSLGCTVGAFFGAGVWGFLHTLSFVNYYTHGTQLTA c1202563 WIGAPGYWQWIGSIFSTFEVAPFFAMVIFAFTTVW-KGRRDH---------------PNKAAMLWSLGCTVGAFFGAGVWGFMHTLSFVNYYSHGTQVTA c1202317 WIGAPGYWQWIGSIFSTFEVAPFFAMVIFAFNMVW-KGRRDH---------------PNKAAMLWSLGCTVGAFFGAGVWGFMHTLSFINYYSHGTQVTA c1201839 WIGAPGYWQWIGSIFSTFEVAPFFAMVIFAFTMVW-KGRRDH---------------PNKAAMLWSLGCTVGAFFGAGVWGFMHTLSFVNYYSHGTQVTA c1202231 WIGTPGYWQWIGSLFSTLEVAPFFTMVVFAFMMVW-KSGRRH---------------PNRAAMLWSLGCAVFAFFGAGLWGFLHTLAPINYYTHGTQVTA c122X009 WIGAPSYWQPIGSIFSTLEVLPFFAMVIFAFTMFW-KGSRNH---------------PNKAAMLWALGCPTMAFFGAGVWGFMHTLHWVNYYSHGTQVTA c1220025 WIGTPGYWQPIGSIFSTLEVIPFFAMVVFAFYMFW-KGSRNH---------------PNKAAMLWTLGCAVIAFFGAGVWGFMHTLSFINYYTHGTQITA c1222498 WIGTPGYWQPIGGFFSALEVLPFFAMVVFAFYMFW-RGQRNH---------------PNRAAILWTLGCAVMAFFGAGVWGFMHTLSFINYYTHGTQITA c1210459 WIGTPGYWQWIGSIFSVLEVLPFFAMVLWCFHMVY-RSGRNH---------------PNKAAMLWSLGCPVMAFFGAGVWGLLHSFSQVNFYSHGTQITA c1210460 WIGTPGYWQWIGSLFSILEVLPFFAMVLWCFHMVY-RSGRNH---------------PNKAAMLWTLGCPVMAFFGAGVWGLMHSFSFINFYSHGTQITA c1201239 WIGTPAYWQWIGSIFSTLEVLPFFAMVVFTFYMVW-KGGRTH---------------PNKAALLWALGCSAFAFFGAGVWGFLHTLAPINYYTHGTQVTA c1201266 WIGAPGYWQWIGSIFSSLEVVPFFGMVLFTFTMVW-KGRRDH---------------PNKAALLWSLGCSVLAFFGAGVWGFLHTLHGVNFYTHGTQVTA c1202651 WIGTPPYWQWIGSIFSSLEVIPFFAMMAFAFVMVW-KGRRDH---------------PNKAALLWSLGCATLAFFGAGVWGFLHTLHGVNYYTHGTQITA c1202650 WIGTPAYWQWIGSIFSSLEVIPFFAMMAFAFVMVW-KGRRDH---------------PNKAALLWSLGCATLAFFGAGVWGFLHTLHGVNYYTHGTQITA c1200238 WIGTPGYWQWIGSIFSSLEVIPFFAMMAFAFVMVW-KGRRDH---------------PNKAALLWSLGTATLAFFGAGVWGFLHTLHGVNYYTHGTQITA c1200641 WIGTPGYWQWIGSIFSSLEVIPFFAMMAFAFVMVW-KGRRDH---------------PNKAALLWSLGCATLAFFGAGVWGFLHTLHGVNYYTHGTQITA c1201844 WIGTPGYWQWIGSIFSSLEVIPFFAMMAFAFVMVW-KGRRDH---------------PNKAALLWSLGCATLAFFGAGVWGFLHTLHGVNYYTHGTQITA c1200666 WIGTPGYWQWIGSIFSSLEVIPFFAMMAFAFVMVW-KGRRDH---------------PNKAALLWSLGCATLAFFGAGVWGFLHTLHGVNYYTHGTQITA c1200983 WIGTPGYWQWIGSVFSALEVVPFFGMMAFAFVMVW-KGRKDH---------------PNKAALLWSLGCATLAFFGAGVWGFLHTLHGINYYTHGTQITA c1200589 WIGTPGYWQWIGSIFSALEVVPFFGMMAFAFVMVW-KGRKDH---------------PNKAALLWSLGCATLAFFGAGVWGFLHTLHGINYYTHGTQITA c1200838 WIGTPGYWQWIGSIFSTFEVAPFFAMMCFAFVMVW-KGRKNH---------------PNKAALLWSLGASTVAFFGAGVWGFLHTLHGVNYYTHGTQITA c1201843 WIGTPGYWQWIGSIFSVFEVVPFFTMMSFAFVMVW-KGRKNH---------------PNKAALLWSLGASTVAFFGAGVWGFLHTLHGVNFYTHGTQITA c1201222 WIGTPGYWQWIGSIFSTLEVIPFFAMMSFAFIMVW-KGRKNH---------------PNKAALLWSLGASTVAFFGAGVWGFLHTLHGVNYYTHGTQITA c1202538 WIGTPGYWQWVGSIFSTLEVIPFFAMMTFAFVMVW-KGRRNH---------------PNKAALLWSLGSSTVAFFGAGVWGFLHTLHGVNYYTHGTQITA c1200562 WIGTPGYWQWVGSIFSTLEVIPFFAMMTFAFVMVW-KGRRNH---------------PNKAALLWSLGSSTVAFFGAGVWGFLHTLHGVNYYTHGTQITA c1200477 WIGLPAYWQWIGSIFSSFEIVPFFAMMSFAFVMVW-KGRRDH---------------PNKAALVWSLGCTVLAFFGAGVWGFLHTLHGVNYYTHGTQITA c1201278 WIGLPGYWQWIGSIFSTLEVIPFFLMMTFSFVMVW-KGRKNH---------------PNKAALLWSLGSATVAFFGAGVWGFLHTLHGVNFYSHGTQITA c1200560 WIGLPGYWQWIGSIFSTMEVIPFFAMMSFAFVMVW-KGRRNH---------------PNKAALLWSLGASTVAFFGAGVWGFLHTLHGVNYFTHGTQITA c1200561 WIGLPAYWQWIGSIFSTMEVVPFFAMMSFAFVMVW-KGRKNH---------------PNKAALLWSLGASTVAFFGAGVWGFLHTLHGVNYYTHGTQITA c1200559 WIGLPAYWQWIGSIFSTMEVVPFFAMMSFAFVMVW-KGRKNH---------------PNKAALLWSLGASTVAFFGAGVWGFLHTLHGVNYYTHGTQITA c1200590 WIGLPGYWQWVGSIFSTFEVIPFFLMMSFAFVMVW-KGRKNH---------------PNKAALLWSLGSSTVAFFGAGVWGFLHTLHGVNFYSHGTQITA c1200985 WIGLPGYWQWVGSIFSTFEVIPFFLMMSFAFVMVW-KGRKNH---------------PNNAALLWSLGSSTVAFFGAGVWGFLHTLHGVNFYSHGTQITA c1201169 WIGLPGYWQWVGSIFSTFEVIPFFLMMSFAFVMVW-KGRKNH---------------PNKAALLWSLGSSTVAFFGAGVWGFLHTLHGVNFYSHGTQITA c1211822 FIGLPGYWHWVGGVFSALEPIPFFMMTLFAFNMVQ-RRRREH---------------PNQAAVLWAVGTAVIGFLGAGVWGFIHTLSPVNYYTHGSQVTA

c1211216 FIGLPGYWQWIGSIFSAMEPIPFFMMTVFAFNMVQ-RRRREH---------------PNQAAVLWAVGTSVMGFLGAGLWGFIHTLSPVNYYTHGTQVTA c1212639 FIGLPGYWHWIGSIFSALEPVPFFMMTVFAFNMVQ-RRRRDH---------------PNQAAVLWAVGTAVLGFLGAGLWGFIHTLSAVNYYTHGSQITA c1222649 WIGPGEYWLWLGSIFSAIEPIPFFMMVMFAFKMVR-ERRHGH---------------GNSIAVTWALGTAVMGFLGAGVWGFIHTLAPVNYFTHGSQITA c1220624 WVGPPRYWLWMGSFFSALEPVPFFMMVLFAFKMVK-ERRREH---------------GNKIATTWAQGTAVMAFLGAGVWGFLHTLAPVNYYTHGTQLTA c1220318 WIGPEPYWHWLGGVFSALEPLPFFAMTIFAFNMVN-RRRRVH---------------PNKAATLWAMGTAVMAFLGAGVWGFLHTLAPVNYYTHGSQITA c1211162 WIGAPGVWLWLGSIFSALEPLPFFAMVLFAWNMMN-RRRRQH---------------PNRAASYWAIGTTVTAFLGAGVWGFLHTLAPVNYYTHGTQITA c1222643 WIGAPGVWLWLGSIFSALEPLPFFAMVLFAFNMVR-RRRRQH---------------PNRAAGLWALGTTVTAFFGAGVWGFLHTLAPVNYYTHGTQLTA c1222647 WIGAPQVWLWVGSIFSALEPLPFLAMVMFAFTMVK-RRRRQH---------------PNRAATLWAKGTTVTAFFGAGVWGFLHTLAPVNFYTHGTQLTA c1222648 WIGAPEVWLWVGSIFSAMEPLPFLAMVVFAFSMVK-NRRRQH---------------PNRAATLWAKGTTVTAFFGAGVWGFLHTLAPVNYYTHGSQLTA c122X011 WIGAPEVWLWVGSIFSAMEPLPFLAMVVFAFSMVK-NRRRHH---------------PNRAATLWAKGTTVTAFFGAGVWGFLHTLAPVNYYTHGSQLTA c122X012 WIGAPTVWLWVGSIFSALEPLPFFAMVLFALNMVN-RRRREH---------------PNKAASLWAIGTTVTAFLGAGVWGFMHTLAPVNYYTHGSQLTA c1220965 WIGAPTVWLWLGSIFSALEPLPFFAMVLFALNMVN-RRRREH---------------PNKAASLWAIGTTVTAFLGAGVWGFLHTLAPVNYYTHGSQLTA c1222644 WIGGPEVWLWVGSIFSALEPLPFLAMVIFAFSMVK-SRRRQH---------------PNRAATLWAKGTTVTAFFGAGVWGFLHTLAPVNYYTHGTQLTN c1220521 WIGVPGYWLWLGSVFSALEPLPFFAMVLFAFNTIN-RRRRDY---------------PNRAVALWAMGTTVMAFLGAGVWGFMHTLAPVNYYTHGTQLTA c1220524 WIGVPGYWLWLGSVFSALEPLPFFAMVLFAFNTINRRRRRDY---------------PNRAVALWAMGTTVMAFLGAGVWGFMHTLAPVNYYTHGTQLTA c1220519 WIGVPGYWLWLGSVFSALEPLPFFAMVLFAFNTIN-RRRRDY---------------PNRAVALWAMGTTVMAFLGAGVWGFMHTLAPVNYYTHGTQLTA c1220523 WIGVPGYWLWLGSVFSALEPLPFFAMVLFAFNTIN-RRRRDY---------------PNRAVALWAMGTTVMAFLGAGVWGFMHTLAPVNYYTHGTQLTA c1220520 WIGVPGYWLWLGSVFSALEPLPFFAMVLFAFNTIN-RRRRDY---------------PNRAVALWAMGTTVMAFLGAGVWGFMHTLAPVNYYTHGTQLTA c1220525 WIGVPGYWLWLGSVFSALEPLPFFAMVLFAFNTIN-RRRRDY---------------PNRAVALWAMGTTVMAFLGAGVWGFMHTLAPVNYYTHGTQLTA c1220385 WIGPPEYWLWLGSVFSALEPLPFFMMVVFAFNMIN-RRRRNH---------------PNKAAMLWAMGTTVMAFLGAGVWGFLHTLAPVNWYTHGSQITA c1220839 WIGPSEYWLWLGSVFGALEPIPFFMMVLFAFTMIN-RRKRNH---------------PNKAATLWAMGTAVMAFLGAGVWGFLHTLAPINYYTHGSQITA c1220203 WLMTPEYWQWVGSIFSALEPLPFFAMVLYAFNMVN-RRRREH---------------PNKAATLWALGTAVMAFLGAGVWGFLHTLSFVNYYTHGSQITA c1220491 WLATPGYWQWIGSVFSALEPLPFFAMVLYAFNMVN-NRRREH---------------PNKAATLWALGTAVMAFLGAGVWGFLHTLAPVNFYTHGTQITA c1220490 WLATPGYWQWVGSVFSALEPLPFFAMVLYAFNMVN-NRRREH---------------PNKAATLWALGTAVMAFLGAGVWGFLHTLAPVNFYTHGTQITA c1222646 WIGTPEYWQWWGSIFSAMEPIPFFMMTVFAFNMVN-KRRREH---------------PNKAAVLWALGTAVMAFLGAGVWGFLHTLSPVNYYTHGTQITA c1210042 WIGTPGYWQWWGSIFSALEPIPFFAMTVFAFNMVN-RRRREH---------------PNKAAVLWALGTGVMAFLGAGVWGFLHTLAPVNFYTHGSQITA c1211226 WIGTPEYWQWWGSIFSALEPIPFFAMTVFAFNMVN-RRRREH---------------PNKAAVLWALGTGVMAFLGAGVWGFLHTLAPVNYFTHGSQITA c1212642 WIGTPEYWQWWGSIFSALEPIPFFAMTVFAFNMVN-RRRREH---------------PNKAAVLWALGTGVMAFLGAGVWGFLHTLAPVNYFTHGSQITA c1210218 WIGTPEYWQWWGSIFSALEPIPFFGMTVFAFNMVN-RRRREH---------------PNKAAVLWALGTGVMAFLGAGVWGFLHTLAPVNYYTHGTQITA c1200379 WIGTQEYWQWVGSLFSALEPIPFFMMVLFAFNMIN-KRRRNH---------------PNKAATLWAMGTAVMAFLGAGVWGFLHTLAPVNYLTHGTQITA c1211614 WIGTPGYWQWWGSIFSAIEPIPFFMMTLFSFNMVN-RRRREH---------------PNKAAVLWALGTGVMAFLGAGVWGFLHTLAPVNYLTHGTQLTA c1212641 WIGTPGYWQWWGSIFSAIEPIPFFMMTLFAFNMVN-RRRREH---------------PNKAAVLWALGTGVMAFLGAGVWGFLHTLAPVNYLTHGTQLTA c1222533 WIGAPEYWQTLGSVFSAMEPIPFFMMTIFAFNMVN-RRRREH---------------PNRVATLWAMGTGVMAFLGAGVWGFLHTLSPVNYYTHGTQVTA c1211830 WIGAPEYWQWFGSVFSALEPIPFFMMTVFAFNMVN-RRRREH---------------PNKAATLWALGTGVMAFLGAGVWGFLHTLAPVNFYTHGTQITA c1210764 WIGAPEYWQWWGSVFSALEPIPFFMMTVFAFNMVN-RRRREH---------------PNKAAVLWALGTGVMAFLGAGVWGFLHTLAPVNFYTHGSQITA c1212645 WIGTPEYWQWWGSVFSALEPIPFFAMTVFAFNMVN-RRRREH---------------PNKAATLWALGTGVMAFLGAGVWGFLHTLAPVNYYTHGTQITA c1210041 WIGAPEYWQWWGSIFSALEPIPFFAMTVFAFNMVN-RRRREH---------------PNRAATLWALGTGVMAFLGAGVWGFLHTLAPVNFYTHGSQITA c1211877 WIGAPAYWQVWGSVFSALEPIPFFMLTIFAFNMVN-KRRREH---------------PNQAATLWALGTGVMSFLGAGVWGFMHTLAPVNYYTHGTQLTA c1142560 WIGFPAFWLVLGSLVSLVEIIPVGMLAHMTYKGLK-SVKIRS--------------NRQKLTLWLILSGVFHHITGASLLGLFMTLPWVNLYAHGTYFTS c1142556 WIGFPAIWLVLGSLVSIVEVIPVGLLVHMTYKGLK-SKNLRS--------------RREKLTLWLLLSSIFYHITGASLLGLFITIPWVNLYMHGTYVTS c1142732 WIGFPAVWLAVGSLVSVVEVIPVGMLAIMTYKGLK-SVKVRS--------------NREKLTLWLLLSSVFYHLTGASLLGLFITIPWVNLYMHGTYVTS

c1142559 WIGYPAIWLIIGVVFSLIQMIPVILLAHLTYKGLK-RHRPLK--------------RVEKLTLWMILSSLLYHLTGASMLGMLMTIPWVNLYTHGTYITS c1142558 WIGFPSIWLFLGSFFSVIQAIPVLLLAYMIYKGFK-NHKVLS--------------LKEKLAMWLILSSIFHHLTGATLLGLLMTIPWVNLYTHGTYITS c1142557 WIGFPPIWLFLGPVFSFIQVLPVFLLAYLIYKGFK-KHKPFS--------------LREKLAVWLILSSIFHHLTGATLLGILITIPWINLYTHGTYITS c1140225 WIGFPPVWLFLGTFFSLIQVLPVFLLAYLVYKGFK-KHKPFS--------------LREKLAVGLILSSIFHHLTGATLLGILITIPWINVYAHGTYITS c1140226 WIGFPPVWLFLGTFFSLIQVLPVFLLAYLVYKGFK-KHKPFS--------------LREKLAVGLILSSIFHHLTGATLLGILITIPWINVYAHGTYITS c1141613 WIGTPPMWLWIGGIFSVIQVAALFLLAYIFYLGIR-EVPWGS------------LNFGARLSLGFTFASVVYHVAGAAMLGMLLAVPHFNRYARATYLTS c1222482 WIGTPAFWQFWGSLFSALEPLPLVFCFWHIYLDAH-TNKRPL---------------ENAPAFYFILGSVVLEQIGAGILGFTMTFALTNVWSHGTWVTP 99% * * * * ^ ^ ^ ^ ^

410 420 430 440 450 460 470 480 490 500 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|c1112653 AHGHLAFFGAYVTAILTVIYMALHQVR-RPEL--PKF--DSKLWKWAFVLMVVGIFGMSAAMTVAGFTQTMVERAIGGSTWQAYIEAQTHPWFQNGMVWR c1112544 SHGHLAFFGAYVTAILTVIYMALHQVR-RPDL--PRF--DSRLWKWAFVLMIIGIFGMSAAMTIAGFTQTMVERAIGGSTWQAYIDAQQHPWFQNGMVWR c1112654 AHGHLAFFGAYVTAILTVIYMALHQVR-RPDL--PRF--DSRLWKWAFVLMVVGIFGMSAAMTVAGFTQTMVERAIGGSTWQAYIEAQMHPWFQNGMVWR c1032043 AHGHLAFFGAYVAANLAIFYYILGKTR-VKEG--YIM--NGAVWRIAYIGLIIGMFGMVASLTVAGFAQTMIERASLGSTWEAYIQAQMHPWMEHAYRWR c1030986 SHGHLAFFGAYVATNLALLYIILQHIR-APEG--PIL--DSRTWKVAYIGMIISMVGMVGALLVAGFAQTFFERAVGGATWQDFIVTQMHPWVSIPYMWR c1281324 AHGHLAFFGAYVATNIAMIYTALQKIR-LSKG--GNL--DGRLWRWTFVGFILSIFGITAPLTVAGFAQTFIERAVGGSTWQAYINGQLHPWVKEAMAWR c1211829 SHGHLAFFGAYATIIIAMFYLGIQRWL-GGVWMSGDLAGNGWRWKWALFLLNLGMVGMTVSMLVSGYVQSQIERAIEGSTWIGYFAAQIHPWFVQGMWWR c1220409 SHGHLAFFGAYATINIAFFYIAMQTWR-GNIWLGSGLAGEGWKWKGALALINLGVIGMTVALLIAGYEQSFIERAMEGSTWRGYFAGQMHPWFQQAMAWR c1222655 SHGHLSFFGAYATINIAFFYLAIQQWR-GNVWMGANLADNGWKWKWSIGLLSLGVVGMTVALLIAGYEQSFIERAIEGSTWSGYFAAQTHPWFTQAMFWR c1222652 SHGHLAFFGAYATINIAFFYLAAQQAR-GNCWMGGGLA-NGWRWKWSLALLNLGVMGMTVALLIAGYEQSFIERAIEGSTWTAYFDAQNHPWFVQAMVWR c1222541 SHGHLAFFGAYATINIAFFYLAIQHWR-GNVWMGAGIA-NAWRWKWALGLLNVGVLGMTIAMLVAGYEQSFIERAVEGSSWGGYFTAQNHPSFQSAMSWR c1222748 SHGHLAFFGAYATINIAFFYLAIQHWR-GDVWMAGGIK-HAWRWKWALGLLNAGVLGMTIALLIAGYEQSFIERAVEGSTWGGYFAAQSQPAFQSAMTWR c1241031 AHGHLAFFGAYVAIMIAAIYLAIQGKA-GLK---ELK--MTKAGWWAISLITVGVLFMTVALTLSAYVQTMVERGMYGGTWEGYFVAQANQWFVQGMGWR c1240766 AHGHLAFFGAYATILVGMMYLAVQGKN-GIK---VLN--NTKSTVWATSMIVGGVVGMTVALTIAGYSDVIISRAQMGATWAGYFDAQGTTWLVQGMVWR c1241223 AHGHLAFFGAYATILIGMMYIAVQGTN-GIK---IMK--NTRASLWAVSLIVGGVMGMTIALTIAGYVQVLVSRAQMGATWAGYFDGQSGMWFAQAMDWR c1241030 AHGHLAFFGAYATILIGMMYLGVQYAY-GIE---RLK--ATFKSKMGIFLIVFGVLGMTVALTIAGYEQVLVERAELGGGWNAFFQAQELPWYVQAMMWR c1242289 AHGHLAFFGAYATILIGMMYLGIQEAY-GIK---RMK--ATFKSKMAIFLITFGVLGMAVALTIAGYEQVLVERAELGAGWQAFFTAQNLPWYVQAQVWR c1242165 AHGHLSFYGAYIMIIFTLISYAMPILR-GRNNGNSPK--AQAVERTSFWMMNIGMLGLTLALTFAGVMQIIQQRT----GENPLGFMEVQESMSSVYFVR c1242219 AHGHLAFFGAYVMICFTLISYAMPILR-GRLHGNGPK--AQSVELTSFWMMVIGMIGLTLALTAAGIMQIEMQRL--RDVADALDFMSAQEAISTVYGVR c1241897 AHGHLSFYGAYVMIVFTVISYAMPILR-GRPYGNCAK--AQKVELASFWMMNIGMVGLTLALSIAGLVQIFDQRV----GTNLIGFMDSQESIAGIYMVR c1230031 SHGHLAFYGAYVLVNLTFFYFAIPRLR-ALPG--GRF--RERRGQVGFWAASFGLVGMSLAFSVAGVLQSYLERM------RGEPYIVSQEPIRFWMLLV c1042464 MHGHYAFWGAYVMIVLAIISYAMPNIT-GRK----RH--DKTNGHLAFWLSNIGMLGMVVALGVAGVVQVYLERR------LSMDFMVAQEEVKIHFVVM c1042313 MHGHYAFWGAYVMIVLAIISYAMPNLT-GRK----RH--DKTNGHLAFWLSNIGMLGMVVALGVAGVVQVYLERR------LNMDFMVAQEEVKIHFVVM c1041884 MHGHYAFWGAYAMIVLAIISYSMPNMT-GRK----RY--NNTNGHLAFWLSNIGMLGMVTAMGVAGVVQVYLERK------LKMEFMIVQEEVKIHFVVM c1040279 MHGHLAFWGAYGMIVLAIISYSLPNMT-GRK----LY--TSSTGRAAFWLSNIGMIGMTVAFGVAGVVQVYLERK------LGMEFMEVQNETKVHFVVL c1251518 MHGHLAFWGAYAMLVLAVISYAMPNMT-GRK----LF--TGMSGYLAFWASNIGMLGMTGALAVAGITQVYLERK------LGMDFLVVQKEIIFHFYGM c1250766 MHGHLAFWGAYAMLVLAVISYAMPNMT-GRK----LF--TGMSGYLAFWASNIGMLGMTGALAVAGITQVYLERK------LGMDFLVVQKEIIFHFYGM c1252508 MHGHLAFWGAYAMIVLAVISYAQPLMT-GRK----LW--NNMTGLLAFWTSNIGMTSMTGAFAVAGIAQVYLERR------LGMDFLAVQEEIEIHFVGL

c1230080 MHGHLAFWGAYACLVLALIAYAMPKLT-GRN----LQ--DSRMNVFAFWTSNIGMIAMTLAFGVAGIAQVYLERK------LGMDFLTVQKEVEVHFLGL c1222638 MHGHAAFYGAYAMIVLAMISYTRPYLT-SNR---PER--GQSLGYWAFWLQVAGMFGMTLSFATAGIGQVYLERV------MGLGYLDTQLKIQIHFVML c1210461 MHGHGAFYGAYAMTVLAMVSYTLPHLT-SDR---KVE--GSSIGYWAFWMQVMGMFGMTLSFGTAGIGQVYLERI------LGLGYLDTQLKLQVHFLML c1211479 MHGHAAFYGAYAMIVMAMISYAQPALT-RRP----EE--GTSMGYLSFWMQLAGMFGMTLSFATAGIGQVYLERI------MGMGYLDAQLKIQVHFVML c1210008 MHGHAAFYGAYAMIVMAMISYAQPALT-RRP----EE--GTAMGYLSFWMQLAGMFGMTLSFATAGIGQVYLERI------MGMGYLDAQLKIQVHFVML c1211833 AHGHLAFYGAYVMLNLAFFTYALPALR-KV----QPF--NQTLNIWSFWLMNAAMIGITFALIFAGVLQTHLQRV------LEMGYMQVQSQIELFYWLR c1222407 AHGHLAFYGAYVMLNLAFFTYALPALR-GL----QPF--NQILNMWSFWIMTGAMAFMTFTLTFAGVVQTHLQRV------LGMGFMEIQQQISLFYWLR c1222409 AHGHLAFYGAYVMLNLAFFTYALPALR-GV----QPF--NQILNMWSFWIMTGSMAFMTFTLTFAGVIQTHLQRV------LGMDFMEIQQQIALFYWLR c1220458 AHGHLAFYGAYVMLNLAFFTYALPALR-GL----QPF--NQILNMWSFWIMTGSMAFMTFTLTFAGVIQTHLQRV------LGMDFMEIQQQIDLFYWLR c1221136 AHGHLAFYGAYVMLNLAFFTYALPALR-GL----QPF--NQILNMWSFWIMTGSMAFMTFTLTFAGVIQTHLQRV------LGMDFMEIQQQIDLFYWLR c1200568 AHGHLAFFGAYVMLNLAMMAYAIPQLR-GR----APY--NQMLSIVSFWLMCGAMSVMTFALTFAGVIQVHLQRV------LGQGFMEVQDQLALFYWVR c1200571 AHGHLAFFGAYVMLNLAMMTYAIPQLC-GR----APY--NQALSIASFWLMCTAMSVMTFALTFAGIIQVHLQRV------LGQGYMEVQDQIALFYWVR c1201236 AHGHLAFFGAYVMLNLAMMTYAIPQLR-GR----APY--NQALSIASFWLMCTAMSVMTFALTFAGVIQVHLQRV------LGQGYMEVQDQIALFYWVR c122X013 AHGHLAFFGAYVMLNLAIMAYAVPEIC-GR----KPY--NQWLSMVSFWMMCTAMSVMTFALTFAGVLQVHLQRV------LGEGYMDVQDQLALFYWVR c1201814 AHGHLAFFGAYVMLNLAIMAYAIPEIR-GR----APY--NQWLSIVSFWAMCSAMSVMTFALTFAGVVQVHLQRV------LGESFMAVQDQLALFYWVR c1200644 AHGHLAFFGAYVMLNLAVMAYAIPEIR-GR----APY--NQWLSIASFWAMCSAMSVMTFALTFAGVVQVHLQRV------LGESFMAVQEQLALFYWIR c121X007 AHGHLAFFGAYVMLNLAVMAYAIPEIR-GR----APY--NQWLSMVSFWIMCTAMSAMTFALTFAGVLQAHLQRV------LGESYMDVQDQLALFYWIR c1200022 AHGHLAFFGAYVMLNLAMMAYAIPEMK-KR----APY--NQWLSMTSFWVMCTAMSVMTFALTFAGVVQIQLQRV------MGESFMDVQDQLAIFYWIR c121X008 AHGHLAFFGAYVMLNLAVMAYAIPELR-GR----APY--NQMLSMVSFWAMCTAMSVMTFALTFAGVVQTHLQRV------LGESFMVVQDQLALFYWIR c1200100 AHGHLAFFGAYVMLNLAVMAYAIPEIR-GR----APY--NQWLSMVSFWMMCTAMSAMTFALTFAGVVQVHLQRV------LGENFMEVQDQLALFYWIR c1200101 AHGHLAFFGAYVMLNLAVMAYAIPEIR-GR----APY--NQWLSMVSFWMMCTAMSVMTFALTFAGVVQVHLQRV------LGENFMEVQDQLALFYWIR c1201161 AHGHLAFFGAYVMLNLAVMAYAIPEIR-GR----APY--NQWLSMVSFWMMCTAMSVMTFALTFAGVVQVHLQRV------LGENFMEVQDQLALFYWIR c1201159 AHGHLAFFGAYVMLNLAVMAYAIPEIR-GR----APY--NQWLSMVSFWMMCTAMSVMTFALTFAGVVQVHLQRV------LGENFMEVQDQLALFYWIR c1200097 AHGHLAFFGAYVMLNLAAMAYAIPEIR-GR----TPY--NQWLSMVSFWMMCTAMSVMTFALTFAGVVQVHLQRV------LGENFMEVQDQLALFYWIR c1200098 AHGHLAFFGAYVMLNLAAMAYAIPEIR-GR----TPY--NQWLSMVSFWMMCTAMSVMTFALTFAGVVQVHLQRV------LGENFMEVQDQLALFYWIR c1200099 AHGHLAFFGAYVMLNLAVMAYAIPEIR-GR----APY--NQWLSMVSFWMMCTAMSVMTFALTFAGVVQVHLQRV------LGENFMEVQDQLALFYWIR c1200556 AHGHLAFFGAYVMLNLAAMAYAIPQIR-GR----APY--NQWLSITSFWIMCTAMSVMTFALTFAGIIQVHLQRI------LGEAYMDVQDQLGVFYWVR c1200095 AHGHLAFFGAYVMLNLSVMAYAIPQLK-GR----APY--NQWLSMTSFWIMCTAMMTMTFALTFAGVVQVHLQRV------LGQSYMDVQDQLAMFYWVR c1200094 AHGHLAFFGAYVMLNLAVMAYAVPQLR-QR----APY--NQWLSIASFWIMCTAMLVMTFALTFAGILQVHLQRV------LGQSYMDVQDQLAMFYWVR c1200962 AHGHLAFFGAYVMLNLAVMAYAVPQLR-QR----APY--NQWLSIASFWIMCTAMMVMTFALTFAGILQVHLQRV------LGQSYMDVQDQLAMFYWVR c1200380 AHGHLAFYGAYVMINIAIMTYAMPNIL-KR----EPY--NQLLNMWGFWITSSGVTFMTFALTFAGVVQSHLQRV------MGMGFMEVQDQLGLFYWMR c1202251 AHGHLAFFGAYVMLNLALITYAMPYLR-GK----APY--HQGLNILSFWLMTGAMTVMTFALTFAGVIQVHLQRV------LGMPYMEVQDQIAPFYWLR c1202563 AHGHLAFFGAYVMLNLAMITYAMPYLR-KR----KPY--NQVLNMWSFWIMTSAMAFMTFTLTFAGVVQVHLQRV------LGMSYMEVQDQLALFYWMR c1202317 AHGHLAFFGAYVMLNLAMISYAMPYLR-NR----KPY--NQVLNMWSFWIMTSAMAFMTFTLTFAGVVQVHLQRV------LGMSYMEVQDQLVLFYWMR c1201839 AHGHLAFFGAYVMLNLAMITYAMPYLR-KR----APY--NQVLNMWSFWIMTSAMAFMTFTLTFAGVVQVHLQRV------LGMNYMEVQDQLALFYWMR c1202231 AHGHLAFYGAYAMINLAIITYAMPYLR-GR----APY--NQTLNIWSFWLMSGGMAFMTFALTAAGIVQTHLQRV------MGMGYMEVQEQIAMFYWLR c122X009 AHGHLAFYGAYVMLLLGIISFAMPQLR-RV----QPY--NQVINMWGFWIMTGAMAFMTFTLTFAGVVQTHLQRV------LGMNFMEVQDQLVLFYGMR c1220025 AHGHLAFFGAYVMLVLALISYAMPQMR-RV----QPY--NQVMNMWSFWIMTSAMCFMTFTLTFAGVVQTHLQRV------LGMNFMEVQGQLDMFYVMR c1222498 AHGHLAFFGAYVMLNLAIISYAMPHLR-GQ----QPY--NQVLNMWSFWIMTSAMAFMTFALTFAGVVQTHLQRV------MGMNFMEVQEHLHLFYVFR c1210459 AHGHMAFYGAYVMLNLAFFTYALPQLR-NA----QPY--NQILNMWSFWVMTAAMAFMTFTLTFAGVLQTHLQRV------VGMGFMEIQQQLDLFYWMR c1210460 AHGHMAFYGAYVMLNLAFFTYALPQLR-SV----QPY--NQVLNMWGFWVMTASMAFMTFTLTFAGVLQTHLQRV------VGMGFMEIQQQLDLFYWMR

c1201239 AHGHLAFYGAYVMLNIAMFTYAMPLIL-KR----EPY--NQLLNMWGFWITSGAVSFMTFALTFAGVVQTHLQRV------LGLSFMEVQDQLQLFYQFR c1201266 AHGHLAFYGAYVCLNLAMMTYAFPQLK-NR----APY--NQVLNMISFWVLSGGVVFMTVSLTFAGVLQTHLERV------MGLSYMEVQDQLGLFYLMR c1202651 AHGHLAFFGAYVALNLAIFTYAMPILK-GR----DPY--NQVLNMASFWLMSGGMVFMTFTLTFAGTVQTHLQRV------MGEGFMDVQDQLALFYWMR c1202650 AHGHLAFYGAYVCLNLAIFSYAMPILK-NR----DPY--NQVLNMGSFWLMTSGMVFMTFVLTFGGTVQTHMQRV------VGDYFMDVQDQIAIFYWMR c1200238 AHGHLAFFGAYVALNLAIISYAMPILK-GR----DPY--NQVLNMASFWMMAGGMTFMTFVLTFAGTVQTHLQRV------MGIDYMSVQDDITIFYWMR c1200641 AHGHLAFFGAYVSLNLAIFSYAMPILL-NR----DPY--NQVLNMASFWLMSSGMVFMTFVLTFAGTIQTHLQRV------LGEYFMDVQDQVAIFYWMR c1201844 AHGHLAFYGAYVCLNLAIFTYAMPILK-NR----DPY--NQVLNMASFWLMTGGMVFMTFVLTFAGTVQTHMQRV------VGDYYMDVQDQVAIFYWMR c1200666 AHGHLAFFGAYVSLNLAIITYAMPLLR-GR----DPY--NQVLNMASFWLMAGGMSFMTFVLTFAGTVQTHLQRV------MGEYYMDVQDQLAVFYWMR c1200983 AHGHLAFFGAYVSLNLAIFSYAFPILR-KR----DPY--NQVLNMASFWLMAGGMTFMTFVLTFAGTVQTHAQRV------QGDYFMDVQDAITIFYWMR c1200589 AHGHLAFFGAYVSLNLAIFSYAFPILR-KR----DPY--NQVLNMASFWLMAGGMTFMTFVLTFAGTVQTHAQRV------QGDYFMDVQDAITIFYWMR c1200838 AHGHLAFYGAYVAMNLAIFSYAMPILR-GR----DPY--NQVLNMASFWLMTGGMAFMTFVLTFAGTIQTHMQRI------VGDYYMDVQEQLGLFYLMR c1201843 AHGHLAFYGAYVALNLAMFTYAMPQLR-GR----APY--NQVLNMASFWLMTGGMCFMTFVLTFAGTIQTHMQRI------VGDYYMDVQDQLGLFYMMR c1201222 AHGHLAFYGAYVAMNLAMFTYAMPHLR-NR----DPY--NQVLNMASFWLMTGGMAFMTFVLTFAGTIQTHMQRI------VGDYFMDVQDQLGLFYLMR c1202538 AHGHLAFYGAYVALNLAMFTYAMPQLR-KR----APY--NQVLNMASFWLMTGGMAFMTFTLTFAGTIQTHMQRI------LGEYYMDVQDQLDLFYIMR c1200562 AHGHLAFYGAYVALNLAMFTYAMPQLR-KR----APY--NQVLNMASFWLMTGGMAFMTFTLTFAGTIQTHMQRI------LGEYYMDVQDQLDLFYIMR c1200477 AHGHLAFYGAYVCLVLALVTYCMPLMK-NR----DPY--NQVLNMASFWLMSSGMVFMTVTLTFAGTVQTHLQRV------EGGFFMDVQDGLALFYWMR c1201278 AHGHLAFFGAYVALNLAVFTYAMPMLK-GR----NPY--NQVINMGSFWLMTGGMSFMTFVLTFAGTIQTHMQRV------VGEDFMTVQDQLTVFYIMR c1200560 AHGHLAFYGAYVALNLAMFTYAMPMLL-GR----APY--NQWLNMTSFWLMTTGMAFMTFTLTFAGTVQVHMQRV------IGDYYMDVQDQLAMFYMIR c1200561 AHGHLAFYGAYVALNLAMFTYAMPMLR-GR----APY--NQWLNMTAFWLMTGGMSFMTFVLTFAGTIQVHLQRV------MGEYYMDVQDQLGLFYAMR c1200559 AHGHLAFYGAYVALNLAMFTYAMPMLR-GR----APY--NQWLNMTAFWLMTGGMSFMTFVLTFAGTIQVHLQRV------MGEYYMDVQDQLGLFYAMR c1200590 AHGHLAFYGAYVALNLAIFTYAMPILR-GR----APY--NQVLNMASFWLMTGGMAFMTFVLTFAGTIQTHMQRV------VGDYYMDVQDGLSLFYLMR c1200985 AHGHLSFYGAYVALNLAIFTYAMPMLR-GR----APY--NQVLNMASFWLMTGGMAFMTFVLTFAGTIQTHMQRV------IGDYYMDVQDSLSIFYLMR c1201169 AHGHLSFYGAYVALNLAIFTYAMPMLR-GR----APY--NQVLNMASFWLMTGGMAFMTFVLTFAGTIQTHMQRV------IGDYYMDVQDSLSIFYLMR c1211822 AHGHLAFYGAYVLVVLALISYSMPLLR-GR-EANPMR--AQRAEMWSFWIMSIGMAVMVLALSGAGILQVWLQRM---PTTGAMSFMATQDQLVFFYWVR c1211216 AHGHLAFYGAYVLVVITLISYAMPTLN-GR-IANSRK--SQAAEMWSFWIMTIGMAVMVLALTGAGILQVWLQRM---PTEGALGFMATQDQLSLFYWVR c1212639 AHGHLAFYGAYVLVVITLISYAMPTLR-GR-IANSPR--AQAAEMWSFWIMSIGMAVMVLALTGAGILQVWLQRI---PETNAMGFMATQEQLSIFYWVR c1222649 AHGHLAFFGAYVMIVLTIISYAMPIMR-GRPQGNSLA--AQSLERKAFWIMCLSMMGITLALTVAGAYQVALQRL--PGDAEALSFMATQDKLMPIYWVR c1220624 AHGHLAFFGAYAMVVMCMISYSMPVMN-GRPQGNSAQ--AQKVERWGFWLMCIGMLGITFALTAAGIWQVALQRI--PDAGEALSFMATQDAIAPFYVAR c1220318 AHGHMAFYGAYAMIVLTIISYAMPILG-GRTEGNSNR--SQVVEMWGFWLMTVAMVFITLFLTGAGILQVWLQRL--PEAAGALPFMVTQEKIAVFYWLR c1211162 AHGHLAFYGAYVMIVLTMISYAMPRLR-GVGEAPPAC--AQRMELWGFWLMTISMLAITLLLTAAGVVQVWLQRM--PADPAAMSFMNTMEQLALFFWLR c1222643 AHGHLAFYGAYAMIVMTMISYAMPRLR-GIGEAPQER--AQRVEIAGFWLMTISMVLITLLLTAAGAAQIWLQRW--PSDNEAMAFMATMDQLAPYFWAR c1222647 AHGHLAFFGAYAMIVMTLISYAMPRLR-GIGEAPDPR--SQALEIRGFWIMVLSMVMITLFLTAAGAVQVWLQRW--QVDGVALPFMATVEHLQGLFWAR c1222648 AHGHLAFYGAYAMIVMTLISYAMPRLR-GLGEAADER--SQRLEIWGFWLMTLSMVMITLFLTAAGVVQVWLQRW--MTDGSALPFMATMDHLKPLFWAR c122X011 AHGHLAFYGAYAMIVMTLISYAMPRLR-GLGEAADER--SQRLEIWGFWLMTLSMVMITLFLTAAGVVQVWLQRW--MEDGSALPFMATMDHLKPLFWAR c122X012 AHGHLAFYGAYAMIVMTMISYAMPRLR-GLGEAPDAR--AQRIEVWGFWLMTISMIAITLFLTAAGVVQIWLQRI--PADGAAMSFMNTADQLAIFFWLR c1220965 AHGHLAFYGAYAMIVMTMISYAMPRLR-GLGEAPDAR--AQRVEVWGFWLMTLSMVAITLFLTAAGVVQVWLQRI--PADGAAMSFMATADQLAIFFWLR c1222644 AHAHLSFYGAYAMIVMTLISYAMPRLR-GLGEAGDER--SQTLEIWGFWLMTLSMVMITLLLTAAGVVQIYLQRW--QADGIALPFMATVEHLQVLFWAR c1220521 AHGHMAFYGAYAMIVMTIISYAMPRLR-GIGEAMDNR--SQVLEMWGFWLMTVAMVFITLFLSAAGVLQVWLQRM--PADGAAMTFMATQDQLAIFYWLR c1220524 AHGHMAFYGAYAMIVMTIISYAMPRLR-GIGEAMDNR--SQVLEMWGFWLMTVAMVFITLFLSAAGVLQVWLQRM--PADGAAMTFMATQDQLAIFYWLR c1220519 AHGHMAFYGAYAMIVMTIISYAMPRLR-GIGEAMDNR--SQVLEMWGFWLMTVAMVFITLFLSAAGVLQVWLQRM--PADGAAMTFMATQDQLAIFYWLR c1220523 AHGHMAFYGAYAMIVMTIISYAMPRLR-GIGEAMDNR--SQVLEMWGFWLMTVAMVFITLFLSAAGVLQVWLQRM--PADGAAMTFMATQDQLAIFYWLR

c1220520 AHGHMAFYGAYAMIVMTIISYAMPRLR-GIGEAMDNR--SQVLEMWGFWLMTVAMVFITLFLSAAGVLQVWLQRM--PADGAAMTFMATQDQLAIFYWLR c1220525 AHGHMAFYGAYAMIVMTIISYAMPRLR-GIGEAMDNR--SQVLEMWGFWLMTVAMVFITLFLSAAGVLQVWLQRM--PADGAAMTFMATQDQLAIFYWLR c1220385 AHGHMAFYGAYVMIVLTIISYAMPIMR-GRPYGNSNT--AQIVEMWGFWLMTISMVFITLFLTAAGVLQVWLQRI--PESGEALSFMAGQDQIALFYWMR c1220839 AHGHMAFYGAYVMIVLTIISYAMPIMR-GRPYGNSNE--AQVVEMWGFWLMTISMVFITLFLTGAGILQIWLQRM--PESGEALSFMVTQDKIAVFYWAR c1220203 AHGHMAFYGAYAMIVMTIISYAMPKLR-GIGEANCNK--AQVVEMWGFWLMTVAMVFITLFLTGAGILQVWLQRL--PESGEALSFMATQDKLAIFYWLR c1220491 AHGHMAFYGAYVMIVLTIISYAMPKLR-GVGEASSNK--AQVIEMWGFWLMTVAMVFITLFLTGAGILQVWLQRL--PESGEALNFMATQDKLSIFYWAR c1220490 AHGHMAFYGAYVMIVLTIISYAMPKLR-GVGEASSNK--AQVIEMWGFWLMTVAMVFITLFLTGAGILQVWLQRL--PESGEALNFMATQDKLSIFYWAR c1222646 AHGHMAFYGAYVMINLTMISYAMPLLR-GRNAANPAK--SQILEMWSFWLMTISMVFITLFLTGAGILQAYLQRM----GDNPLPFMAVQDKIELFYWLR c1210042 AHGHMAFYGAYVMVVLTMISYAMPLMR-GR-AANSQR--AQVAEMWSFWLMTISMVFIVLFLTAAGILQVWLQRV----SDTPMPFMQVQDQIALFYWMR c1211226 AHGHMAFYGAYVMVVITMISYAMPILR-GR-AANSTK--AQVLEMWAFWLMTIAMVFITLFLTAAGILQVWLQRV----SDTPMSFMATQDQLMLFYWMR c1212642 AHGHMAFYGAYVMVVITMISYAMPILR-GR-AANPTK--AQVLEMWAFWLMTIAMVFITLFLTAAGILQVWLQRV----SDTPMSFMATQDQLMLFYWMR c1210218 AHGHMAFYGAYAMVNLMMISYAMPILR-GR-AANSNK--SQVLEMWSFWLMTVAIVFITLFLTAAGILQVWLQRV----SDAPLPFMVAQEKIALFYWMR c1200379 AHGHMAFYGAYVMIVLTIISYAMPYLR-GHGPTSGER--AQIWEMWGFWLMTIAMVFITLFLTGAGILQTYMQRM----GDDPGAFMDVQEKIAFFYWLR c1211614 AHGHMAFYGAYAMVVITMISYTMPKLR-GR-EANSRG--AQKLEMVSFWLMTLAMVAITLFLTAAGYVQVSLQRM----GTTPMPFMVAQDHAATYYWLR c1212641 AHGHMAFYGAYAMVVITMISYTMPKLR-GR-EANSRG--AQKLEMVSFWLMTLAMVAITLFLTAAGYVQVSLQRM----GTTPMPFMVAQDHAATYYWLR c1222533 AHGHMAFYGAYAMVVMTMISYTMPLMR-GR-EANSNL--SQVVEMWSFWLMTIAMVFITLFLTGAGILQIWLQRV----SETPMSFMATQDQLMIFYWLR c1211830 AHGHMAFYGAYVMVNLTMISYAMPLLR-GR-SSNPDS--AQTMEMWSFWLMTVSIVFITLFLTVAGVLQIWLQRM----GTSPLGFMDTQDQVRLFYWMR c1210764 AHGHMAFYGAYAMVVMTMISYTMPLLR-GR-VANSAT--AQVMEMWSFWLMTISMVFITLFLTAAGILQIWLQRI----SDTPMPFMAAQEQVALFYWMR c1212645 AHGHMAFYGAYVMVNLTMISYAMPILR-GR-AANSNK--SQVLEMWSFWLMTISIVFITLFLTAAGILQVWLQRV----SETPLSFMATQDKISLFYWMR c1210041 AHGHMAFYGAYVMVVLCIISYAMPILR-GR-AANSNK--AQVMEMWAFWLMTIAMVFITLFLTAAGILQVWLQRV----SDTPLSFMATQDQISLFYWMR c1211877 AHGHMAFYGAYAMVVLTIISYAMPILR-GR-AANGNK--AQVVEMWSFWLMTVAMVFITLFLTAAGVLQTWLQRI----ATVPMSFMATQDSVAIFYWMR c1142560 GHAHLALFGSLGFTVLAGCYYILSQGS-EPTL----K--GYRGGVIGVLLLNGGLITMGVALLIAGSIQTYLWRI------LGVDFMEVHSLLKPYLIIR c1142556 GHAHLALFGSLGFVVLSGCYYILSWGS-EPTN----K--GYKSGVLAVGLLNVGLVSMAVALLIAGSVETYLWRY------LGMNFEKVRMLLNPYLMIR c1142732 GHAHLALFGSLGFVVLAGCYYILSRGS-EPTL----K--GYKRGVLAVCLLNGGLITMASALLVAGFMETYFWRI------LGMDFMEVRLLINPYLIMR c1142559 GHAHLALFGVMGFLVLAGSHAILSRGT-VLSR----K--SYIWAVAGVLFLNLGVITMSSSLLVAGFLQSYLWRY------LGMDFTQVQGLISPYLLAR c1142558 GHAHLALFGTIGFLILAGAYTILSDRD-NPTP----K--TYRYGVMGIILLNFGLIGMSSCLLIAGFLQTYLWRV------LGLDFMAVSSILSPYLILR c1142557 GHAHLALFGTIGFLILAGAYAILIEED-ALNK----K--TYGYGVSGIILLNLGLIGMSLCLILAGFLQTYLWRV------MGIDFMVVSSVINPYLILR c1140225 GHAHLALFGTIGFLVLAGAYTILSEKE-PLDK----K--AYGYGLSGVILLNLGLIGMSSSLILAGFLQTYLWRV------MGIDFMAVNSVINPYLILR c1140226 GHAHLALFGTIGFLVLAGAYTILSEKE-PLDK----K--AYGYGLSGVILLNLGLIGMSSSLILAGFLQTYLWRV------MGIDFMAVNSVINPYLILR c1141613 SHAHLALFGAVGMLVLAGCTYILTRDS-HWPK----Q--QKNWAVWGFLLLNAGLIIMGGALAVAGLLQTYLVRI------VGMDYAVAHQLLHPYLLMR c1222482 GHAHLALFGTFGMLGIAAAYFAVPILR-KV----PNY--DQRLGKLSFWLVLTGVLGMAFSFSIGGTVQIYVYRI----LGLDWFGGDVARSMGVFKLML 99% * *

510 520 530 540 550 560 570 580 590 600 ....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|....|c1112653 FIFGVFFLVSYLVLLWDLLTIGKGQAHASKGVGAHD---------------------------------------------------------------- c1112544 FAFGVFFLVSYLVLLWDLVTIGKGEAKAAKGVGAHD---------------------------------------------------------------- c1112654 FVFGVFFFVSYLVLLWDLATIGRGRAAEAKGVGAHD---------------------------------------------------------------- c1032043 FFFGLIFALSYMALLYDLLTAGKRVEQVKEAELAR----------------------------------------------------------------- c1030986 LGFGVLFFLSYIVLVYDLLTIGKKATAVEVKPA-------------------------------------------------------------------

c1281324 FGFGIMFFICYLMLVIDLCTIGKQPVDKENTHCL------------------------------------------------------------------ c1211829 EVFGVMFLAGFILLVWDLLTIGRGESRKMIEASNAS---------------------------------------------------------------- c1220409 LVFGVVTLAGALLLVWDLLTIGVGETRRAPQFAAEAG--------------------------------------------------------------- c1222655 LIFGFVTAVGLVLLIWDLATIGARETRPALVIERPEEPGIKATVVETA---------------------------------------------------- c1222652 VIFGLMTIAGGGLLFWDLLAIGKAETRKAAVINLA----------------------------------------------------------------- c1222541 LLFGLVTAAGLGLLVWDLLTTGKGETRKAQEITQH----------------------------------------------------------------- c1222748 LFFGLITASGLVLLVWDLLTIGKGEERKAEMPQQA----------------------------------------------------------------- c1241031 LATGLMVIVGYVFLVYDLLTCAKKQPEEVYEASGAAAAA------------------------------------------------------------- c1240766 LLMGVVTFVGFLFLAKDLLSIGKATHHVR----------------------------------------------------------------------- c1241223 LFMGAITFLGFLFLVKDLLSTGKNPVHER----------------------------------------------------------------------- c1241030 AIMGVVTFVGFIYLVWDLLTIGKEQKAAQAV--------------------------------------------------------------------- c1242289 EIMGLVTFVGFVYLLIDLLTIGKKEAAQGA---------------------------------------------------------------------- c1242165 LGFGLLVFSGLITYLYSFFVKEEK---------------------------------------------------------------------------- c1242219 LAFGVMVLLGLLTYFYSFFVKEEKVNA------------------------------------------------------------------------- c1241897 LAFGFLVFTGLLTYFYSFFVKEPAVEPAKV---------------------------------------------------------------------- c1230031 FLHGLLVLAGAAIIAWDLLTLRSPPDEAARGAAPAA---------------------------------------------------------------- c1042464 LLCATMFATGIGIYIYEFIKYGRPTDEALTKNEEAVLVS------------------------------------------------------------- c1042313 LLNATLFSIGIGLYIYEFIKYGRPSDEALTKKEEAILVS------------------------------------------------------------- c1041884 LLCATLFTVGIGFYIYEFIKYGKPTDEALESENPFDEDNDKMSNQKNQAELVS----------------------------------------------- c1040279 ILCATLFTTGIIMYIVDFYKHGKPSDEALEINQ------------------------------------------------------------------- c1251518 LLAATLFTIGITYFIVDFIRHGLPSNEALGKNVGDLD--------------------------------------------------------------- c1250766 LLAATLFTIGITYFIVDFIRHGLPSNEALGKNVGDLD--------------------------------------------------------------- c1252508 ILAASLFSVGIILYIYNFIKFGLPSDEMIGVSDEKMTAGAGRE--------------------------------------------------------- c1230080 VLAASLFSVGIVAYVWNFIRFGKPAGEVK----------------------------------------------------------------------- c1222638 VATGSLFAVGVILYIVDFFRFAPLRVAAPHDEGAAPRHAPGTV--------------------------------------------------------- c1210461 IATASVFATGAALFIWNFFRTAPRSVAAIDSSTSAPDLAPAAHTNSAVSG-------------------------------------------------- c1211479 VITASIFAIGVALFIIDFFRHPLRLEVSASDPVDRPLDTHRAAAI------------------------------------------------------- c1210008 VITASIFAIGVALFIIDFFRHPLRLEVSASDPMDRPLDTHRAAAI------------------------------------------------------- c1211833 LGAGVFFIIGALMFIYSALGPVREHVVTA-KHAHFAAGYGILIWDLLTIGKRETRPAQVLLPH------------------------------------- c1222407 LGAGAFFVIGALLYVFAALGPVREQMMASLKAQPTAK--------------------------------------------------------------- c1222409 LGSGIFFVIGALLYIYAVLGPVRGQMAAPLGVQTATK--------------------------------------------------------------- c1220458 LGSGIFFVIGALLYIYAVLGPVRGQMVAPLGAQSATK--------------------------------------------------------------- c1221136 LGSGIFFVIGALLYIYAVLGPVRGQMVAPLGAQSATK--------------------------------------------------------------- c1200568 LGSGAVVLISALMFVWAILVPGREKQAAVGGLLQPAE--------------------------------------------------------------- c1200571 LGSGVAVLISALMFVWAILVAGRTKQATLTGALQPAE--------------------------------------------------------------- c1201236 LGSGVAVLISALMFVWAILVAGRTKQATLTGALQPAE--------------------------------------------------------------- c122X013 LGSGVFVLISALMFVWAILVPGKDRVPAASGIAERPSERFPARDPEAAGRDLSLHPQGNLR--------------------------------------- c1201814 LGSGVVVLISALMFIWAVLVPGRSRSPAPSQAVQPAE--------------------------------------------------------------- c1200644 LGSGVVVLISALMFFWAVLVPGKRASPALNQAVQPAE--------------------------------------------------------------- c121X007 LGSGAVVLISALMFIWAVLVPGRERSEKLAGVVQPAE--------------------------------------------------------------- c1200022 LGSGFAVLISAIMFIWAVLVPGKQKQGDVARLVQPAE---------------------------------------------------------------

c121X008 LGSGVVVVISAFMFIWAVLVPGKERRENTSGFVQPAE--------------------------------------------------------------- c1200100 LGSGVVVVISALMFVWAVLVPGRQRSQKLSGFAQQPAE-------------------------------------------------------------- c1200101 LGSGVVVVISALMFVWAVLVPGRQRSQKLSGFAQQPAE-------------------------------------------------------------- c1201161 LGSGVVVVISALMFVWAVLVPGRQRSQKLSGFAQQPAE-------------------------------------------------------------- c1201159 LGSGVVVVISALMFVWAVLVPGRQRSQKLSGFAQQPAE-------------------------------------------------------------- c1200097 LGSGVVVVISALMFVWAVLVPGRQRSQKLSGFAQQPAE-------------------------------------------------------------- c1200098 LGSGVVVVISALMFVWAVLVPGRQRSQKLSGFAQQPAE-------------------------------------------------------------- c1200099 LGSGVVVVISALMFVWAVLVPGRQRSQKLSGFAQQPAE-------------------------------------------------------------- c1200556 LGSGVFVFISALMFIWSVLVPGRARLPDAIAQPAE----------------------------------------------------------------- c1200095 LGSGVFVAISALMFVWAVLVPGREKQATVSAALQPAE--------------------------------------------------------------- c1200094 LGSGVFVAISALMFVWAVLVPGRAKPAVIPGALQPAE--------------------------------------------------------------- c1200962 LGSGVFVAISALMFVWAVLVPGRAKQAVIPGALQPAE--------------------------------------------------------------- c1200380 LGAGVATFIGVVMIVWSLVVPGKAKPAQ------------------------------------------------------------------------ c1202251 LGSGVVVGISAILFLWSVFGPVRERKARPAKVAVQPAE-------------------------------------------------------------- c1202563 LGSGVFVLISCLLFLYSIFGPVKEEQLAHIDMSLQPAN-------------------------------------------------------------- c1202317 LGSGVFVLISCLLFLYSIFGPVKEEQPAHISMPLQAAK-------------------------------------------------------------- c1201839 LGAGAFVAIACVLFLYSIFGPVREEKPARIDMPLQPAN-------------------------------------------------------------- c1202231 LGGGVAVGIGVLLYLYAVFGPAREERPVSVAKGLQAAE-------------------------------------------------------------- c122X009 LASGVAVGIGACLLLYAFFGPAREQVPAGGTQLTSGTNRA------------------------------------------------------------ c1220025 LGAGVAVAVGLVLFLWSIYGRTREQVPQTANVPGTA---------------------------------------------------------------- c1222498 LGAGIAVVIGVILFLYAVFGPSRSQASASAAHAPASP--------------------------------------------------------------- c1210459 LLAGVAFLVGALMYLYATLGPTTKQVSSSPNMQPAAR--------------------------------------------------------------- c1210460 LLSGIVFVAGAILYIYAALGPTKNQVSSSPNLQP------------------------------------------------------------------ c1201239 LGAGLFTLLGVVLIVWSLVVPGKAKQAAGYQAAE------------------------------------------------------------------ c1201266 FGAGVVTVIGALMFIYALLVPRTAEVIAPANGLGAPAE-------------------------------------------------------------- c1202651 FGSGVAVVLGVILFIYAVLVPRREVIEPGPAQRVAAE--------------------------------------------------------------- c1202650 LGSGVVVVLGALLFIYSIWVPRKEVVEPGPIERDRLESDPDHVAAES----------------------------------------------------- c1200238 FGSGVVVVLGALLFIYAIFVPRKEIIEPNDRSVAAETPAE------------------------------------------------------------ c1200641 FGSGLVVVIGALLFIYAMWVPRREIIERGTAETPAE---------------------------------------------------------------- c1201844 FGAGLVVVIGALLFIYSIWVPRKEVIEPGVVETPAE---------------------------------------------------------------- c1200666 FGAGAAFVLGAILFIYAVAVPRREVIQPGEAAGVLAE--------------------------------------------------------------- c1200983 FGSGIAVVLGALLFIYAVAVPRKEIISPSDKQPVAAE--------------------------------------------------------------- c1200589 FGSGIAVVLGALLFIYAVAVPRKEII-------------------------------------------------------------------------- c1200838 LGSGAVFVIGALLFIYSQVVARREVVSPGSAAVPGE---------------------------------------------------------------- c1201843 FGAGVAVVLGALLFIYSQLVVRRELIAPGPVTAPGE---------------------------------------------------------------- c1201222 LGSGAVVVLGALLFIYATVVVRREVIKPGPVAVPGE---------------------------------------------------------------- c1202538 FGSGVAVVLGAILFIQSLVMVRRELIQPGPIVAQAGE--------------------------------------------------------------- c1200562 FGSGVAVVLGAILFIQSLVMVRRELIQPGPIVAQAGE--------------------------------------------------------------- c1200477 FGSGVAVVLGALLFIYAVLFPRREVVKAGPVQAHKDGHLEAAE--------------------------------------------------------- c1201278 FGAGAAVVLGAILFIYSVLVPRKELFTETSGSKPVTGSNPEAQAVLEGGR-------------------------------------------------- c1200560 FGSGAMVVLGALLFIYSLAAVRKTAPAAHAVGEAA-----------------------------------------------------------------

c1200561 FGAGAMVVAGALLFIYSLAVVRRGAPVGNGVGEAA----------------------------------------------------------------- c1200559 FGAGAMVVAGALLFIYSLAVVRRGAPVGKVAGEAA----------------------------------------------------------------- c1200590 FGAGAAVVIGALLYIYSLLVVRKSE--------------------------------------------------------------------------- c1200985 FGAGAAVVIGALLFIYALLVVRKDEVIAPGPSHKASTVAGE----------------------------------------------------------- c1201169 FGAGAAVVIGALLFIYALLVVRKDEVIAPGPSHKASTVAGE----------------------------------------------------------- c1211822 VSGGVMFLAGLLTYLSSFFIGPAANEQEVAAIPGGRTQRA------------------------------------------------------------ c1211216 VGGGVVFLLGLLTYLSSFFIGGEPVTEESVGNGATGGLLRAQPARRA----------------------------------------------------- c1212639 VGGGVVFLLGQLLFFYSFFIGGDPVTEEGRAGTPGRTALGTA---------------------------------------------------------- c1222649 MAFGVAFLSGVLMYFASFFVGGKLPEAVQAEA-------------------------------------------------------------------- c1220624 LLFGLLFAAGVITYFASFVVANRGAKQTSSEGLTEQTA-------------------------------------------------------------- c1220318 EGAGVVFLVGLICYFVSFFVKGPQAQSA------------------------------------------------------------------------ c1211162 LGAGVVFLAGLVCYLLSFRQRGSVVSQQAMAGA------------------------------------------------------------------- c1222643 LVAGIGFALGLVCYLLSFVQRKNVVIATA----------------------------------------------------------------------- c1222647 LAAGVLFMFGLLCYLFSFRQRARVAGAPVPIVY------------------------------------------------------------------- c1222648 LVSGVGFLAGLLCYLFSFRQRGRAALRAPAAVVPS----------------------------------------------------------------- c122X011 LVSGVGFLAGLLCYLFSFRQRGRAALRAPAAVVPS----------------------------------------------------------------- c122X012 FIAGVFFLIGLVCYLYSFRQRGRVPVVVAAPAAA------------------------------------------------------------------ c1220965 LVAGVFFLIGLVCYLYSFRQRGRVPVAAAAAAAA------------------------------------------------------------------ c1222644 LGAGVGFLAGLLCYLFSFKQRGRAALRAPAAVVPS----------------------------------------------------------------- c1220521 EGAGVVFLIGLVAYLLSFRRGKAAA--------------------------------------------------------------------------- c1220524 EGAGVVFLIGLVAYLLSFRRGKAAA--------------------------------------------------------------------------- c1220519 EGAGVVFLIGLVAYLLSFRRGKAAA--------------------------------------------------------------------------- c1220523 EGAGVVFLIGLVAYLLSFRRGKAAA--------------------------------------------------------------------------- c1220520 EGAGVVFLIGLVAYLLSFRRGKAAA--------------------------------------------------------------------------- c1220525 EGAGVVFLIGLVAYLLSFRRGKAAA--------------------------------------------------------------------------- c1220385 FVAGAFFMAGLVVYFGSFFIKGEASPAEEVRGPATADA-------------------------------------------------------------- c1220839 LIAGCFFSGGLVVYFCSFFIKGQASFDDEVRGPARQDA-------------------------------------------------------------- c1220203 EISGVIFLLGLISYITSFFITEKKAQA------------------------------------------------------------------------- c1220491 EAAGVVFLIGLITYLSNFLVDKKAVK-------------------------------------------------------------------------- c1220490 EAAGVIFLIGLITYLSNFFVDKKAVK-------------------------------------------------------------------------- c1222646 EVAGLVFLVGLVIYIASFFVGQDEPEAVVAD--------------------------------------------------------------------- c1210042 LWAGVVFAVGLVTYVASFFIKGESKPLITP---------------------------------------------------------------------- c1211226 EWAGVMFFIGLLAYLASFFVKGDAKGVVHG---------------------------------------------------------------------- c1212642 EWAGVMFFIGLLAYLASFFVKGDAKGVVHG---------------------------------------------------------------------- c1210218 EWAGVVFLIGLIVYITSFFVGGSEKEAA------------------------------------------------------------------------ c1200379 LAAGFVFMGGLVVYLMSFFKGKPGQTENA----------------------------------------------------------------------- c1211614 EASGVVFFIGLALYIISFFVKGKTDEAAH----------------------------------------------------------------------- c1212641 EASGVVFFIGLALYIISFFVKGKTDEAAH----------------------------------------------------------------------- c1222533 LASGLMFLAGLLLYIASFFINGEPATVESRNPVGARGAAA------------------------------------------------------------ c1211830 EFTGFIFLLGLVLYIWSFFKKGNGKNCCVAPLCIGGRSRPSFLICKNSL--------------------------------------------------- c1210764 EVAGLVFLVGILLYIGSFFVKGKEVTVSTTATAAAAA---------------------------------------------------------------

c1212645 EWTGVVFLIGLILYIASFFVKGEDKAAA------------------------------------------------------------------------ c1210041 EASGVIFLIGLLIYLASFFVKGDKKAVAA----------------------------------------------------------------------- c1211877 EVAGVVFLIGLIAYITSFFIKGETKAS------------------------------------------------------------------------- c1142560 LLGGVMFGLGDLLFSWRIYKAWQETRSYR----------------------------------------------------------------------- c1142556 ALGGGIFALGDLLLFWLFYKTWKQTKVKK----------------------------------------------------------------------- c1142732 VLGGAMFTLGNLLLSWRIFKAWQTTKYKK----------------------------------------------------------------------- c1142559 VAGGSFYTVGSILFGWRIVNVWWLTREDGKISEEVSKRI------------------------------------------------------------- c1142558 ALSGSLFTLGAMILCTIIIRTWWKTRPVRRKTAN------------------------------------------------------------------ c1142557 ALLGSLFTLGAAILSFLIIKTWWKTRKA------------------------------------------------------------------------ c1140225 VLWGSLFTLGAAILCSLIIRTWWKTRRA------------------------------------------------------------------------ c1140226 VLWGSLFTLGAAILCSLIIRTWWKTRRA------------------------------------------------------------------------ c1141613 ALGGGVFAVGGLLYAGAVLYVLWLRRHNLLQSLLQKRETNEKKVDDEA---------------------------------------------------- c1222482 PLFGVVFATGAGVLVYDLLTLGRRLAVPAGADTHGEPAEAHPVTRWSRPLSGFEAGIWLMMMWIFGTIITLGLLSFNLPRVRVAGDPTLPYLLAGVGYPG

610 620 630 ....|....|....|....|....|....|....|.c1112653 ------------------------------------ c1112544 ------------------------------------ c1112654 ------------------------------------ c1032043 ------------------------------------ c1030986 ------------------------------------ c1281324 ------------------------------------ c1211829 ------------------------------------ c1220409 ------------------------------------ c1222655 ------------------------------------ c1222652 ------------------------------------ c1222541 ------------------------------------ c1222748 ------------------------------------ c1241031 ------------------------------------ c1240766 ------------------------------------ c1241223 ------------------------------------ c1241030 ------------------------------------ c1242289 ------------------------------------ c1242165 ------------------------------------ c1242219 ------------------------------------ c1241897 ------------------------------------ c1230031 ------------------------------------ c1042464 ------------------------------------ c1042313 ------------------------------------ c1041884 ------------------------------------ c1040279 ------------------------------------

c1251518 ------------------------------------ c1250766 ------------------------------------ c1252508 ------------------------------------ c1230080 ------------------------------------ c1222638 ------------------------------------ c1210461 ------------------------------------ c1211479 ------------------------------------ c1210008 ------------------------------------ c1211833 ------------------------------------ c1222407 ------------------------------------ c1222409 ------------------------------------ c1220458 ------------------------------------ c1221136 ------------------------------------ c1200568 ------------------------------------ c1200571 ------------------------------------ c1201236 ------------------------------------ c122X013 ------------------------------------ c1201814 ------------------------------------ c1200644 ------------------------------------ c121X007 ------------------------------------ c1200022 ------------------------------------ c121X008 ------------------------------------ c1200100 ------------------------------------ c1200101 ------------------------------------ c1201161 ------------------------------------ c1201159 ------------------------------------ c1200097 ------------------------------------ c1200098 ------------------------------------ c1200099 ------------------------------------ c1200556 ------------------------------------ c1200095 ------------------------------------ c1200094 ------------------------------------ c1200962 ------------------------------------ c1200380 ------------------------------------ c1202251 ------------------------------------ c1202563 ------------------------------------ c1202317 ------------------------------------ c1201839 ------------------------------------ c1202231 ------------------------------------ c122X009 ------------------------------------ c1220025 ------------------------------------

c1222498 ------------------------------------ c1210459 ------------------------------------ c1210460 ------------------------------------ c1201266 ------------------------------------ c1202651 ------------------------------------ c1202650 ------------------------------------ c1200238 ------------------------------------ c1200641 ------------------------------------ c1201844 ------------------------------------ c1200666 ------------------------------------ c1200983 ------------------------------------ c1200589 ------------------------------------ c1200838 ------------------------------------ c1201843 ------------------------------------ c1201222 ------------------------------------ c1202538 ------------------------------------ c1200562 ------------------------------------ c1200477 ------------------------------------ c1201278 ------------------------------------ c1200560 ------------------------------------ c1200561 ------------------------------------ c1200559 ------------------------------------ c1200590 ------------------------------------ c1200985 ------------------------------------ c1201169 ------------------------------------ c1211822 ------------------------------------ c1211216 ------------------------------------ c1212639 ------------------------------------ c1222649 ------------------------------------ c1220624 ------------------------------------ c1220318 ------------------------------------ c1211162 ------------------------------------ c1222643 ------------------------------------ c1222647 ------------------------------------ c1222648 ------------------------------------ c122X011 ------------------------------------ c122X012 ------------------------------------ c1220965 ------------------------------------ c1222644 ------------------------------------ c1220521 ------------------------------------ c1220524 ------------------------------------

c1220519 ------------------------------------ c1220523 ------------------------------------ c1220520 ------------------------------------ c1220525 ------------------------------------ c1220385 ------------------------------------ c1220839 ------------------------------------ c1220203 ------------------------------------ c1220491 ------------------------------------ c1220490 ------------------------------------ c1222646 ------------------------------------ c1210042 ------------------------------------ c1211226 ------------------------------------ c1212642 ------------------------------------ c1210218 ------------------------------------ c1200379 ------------------------------------ c1211614 ------------------------------------ c1212641 ------------------------------------ c1222533 ------------------------------------ c1211830 ------------------------------------ c1210764 ------------------------------------ c1212645 ------------------------------------ c1210041 ------------------------------------ c1211877 ------------------------------------ c1142560 ------------------------------------ c1142556 ------------------------------------ c1142732 ------------------------------------ c1142559 ------------------------------------ c1142558 ------------------------------------ c1142557 ------------------------------------ c1140225 ------------------------------------ c1140226 ------------------------------------ c1141613 ------------------------------------ c1222482 LLLVTLLFVWRFLASMEARAKAVAAPSLLRVLPAQA

Genome ID Organism1030986 Hydrogenivirga (128-5-R1-1)1032043 Hydrogenobacter thermophilus (DSM 6534/TK-6)

1040279 Maribacter (HTCC2170)1041884 Marivirga tractuosa (DSM 4126)1042313 Aquiflexum balticum (BA160)1042464 Belliella baltica (DSM 15883)1112544 Thermus scotoductus (SA-01)1112653 Thermus oshimai (JL-2)1112654 Thermus thermophilus (JL-18)1140225 Desulfitobacterium hafniense (DCB-2)1140226 Desulfitobacterium hafniense (Y51)1141613 Dethiobacter alkaliphilus (AHT 1)1142556 Desulfosporosinus acidophilus (SJ4)1142557 Desulfitobacterium dehalogenans (ATTC 51507)1142558 Desulfitobacterium dichloroeliminans (LMG P-21439)1142559 Desulfitobacterium metallireducens (DSM 15288)1142560 Desulfosporosinus youngiae (DSM 17734)1142732 Desulfosporosinus (OT)1200022 Agrobacterium tumefaciens (C58/ATCC 33970)1200094 Bradyrhizobium (BTAi1)1200095 Bradyrhizobium japonicum (USDA 110)1200097 Brucella abortus (2308)1200098 Brucella abortus (9-941)1200099 Brucella melitensis (16M/ATCC 23456)1200100 Brucella ovis (ATCC 25840)1200101 Brucella suis (1330)1200238 Dinoroseobacter shibae (DF L12)1200379 Magnetococcus (MC-1)1200380 Magnetospirillum magneticum (AMB-1)1200477 Paracoccus denitrificans (PD1222)1200556 Rhizobium etli (CFN 42)1200559 Rhodobacter sphaeroides (2.4.1)1200560 Rhodobacter sphaeroides (ATCC 17025)

1200561 Rhodobacter sphaeroides (ATCC 17029)1200562 Rhodobacterales (HTCC2654)1200568 Rhodopseudomonas palustris (BisA53)1200571 Rhodopseudomonas palustris (CGA009/ATCC BAA-98)1200589 Roseobacter denitrificans (OCh 114)1200590 Roseovarius (217)1200641 Ruegeria pomeroyi (DSS-3)1200644 Sinorhizobium meliloti (1021)1200666 Labrenzia aggregata (IAM12614)1200838 Roseobacter (SK209-2-6)1200962 Bradyrhizobium (ORS278)1200983 Roseobacter litoralis (Och 149)1200985 Phaeobacter gallaeciensis (2.10)1201159 Brucella canis (ATCC 23365)1201161 Brucella suis (ATCC 23445)1201169 Phaeobacter gallaeciensis (BS107)1201222 Rhodobacterales (Y4I)1201236 Rhodopseudomonas palustris (TIE-1)1201239 Magnetospirillum gryphiswaldense (MSR-1)1201266 Methylocella silvestris (BL2)1201278 Pseudovibrio (JE062)1201814 Sinorhizobium fredii (NGR234)1201839 Hyphomicrobium denitrificans (ATCC 51888)1201843 Silicibacter (TrichCH4B)1201844 Silicibacter lacuscaerulensis (ITI-1157)1202231 Azospirillum (B510)1202251 Starkeya novella (DSM 506)1202317 Afipia (1NLS2)1202538 Maritimibacter alkaliphilus (HTCC2654)1202563 Hyphomicrobium denitrificans (1NES1)1202650 Ruegeria (TW15)

1202651 Polymorphum gilvum (SL003B-26A1)1210008 Acidovorax (JS42)1210041 Azoarcus (BH72)1210042 Aromatoleum aromaticum (EbN1)1210218 Dechloromonas aromatica (RCB)1210459 Nitrosomonas europaea (ATCC 19718/IFO 14298)1210460 Nitrosomonas eutropha (C71)1210461 Nitrosospira multiformis (Surinam/ATCC 25196)1210764 Thiobacillus denitrificans (ATCC 25259)1211162 Bordetella petrii (DSM 12804)1211216 Leptothrix cholodnii (SP-6)1211226 Thauera (MZ1T)1211479 Acidovorax ebreus (TPSY)1211614 Lutiella nitroferrum (2002)1211822 Acidovorax delafieldii (2AN)1211829 Gallionella ferruginea (capsiferriformans ES-2)1211830 Sideroxydans lithotrophicus (ES-1)1211833 Nitrosomonas (AL212)1211877 Methylotenera mobilis (JLW8)1212639 Acidovorax radicis (N35)1212641 Pseudogulbenkiania (NH8B)1212642 Thauera selenatis (AX)1212645 Dechlorosoma suillum (PS)1220025 Alkalilimnicola ehrlichei (MLHE-1)1220203 Colwellia psychrerythraea (34H)1220318 Hahella chejuensis (KCTC 2396)1220385 Marinobacter aquaeolei (VT8/ATCC 700491/DSM 11845)1220409 Methylococcus capsulatus (Bath/NCIMB 11132)1220458 Nitrosococcus oceani (ATCC 19707)1220490 Photobacterium profundum (3TCK)1220491 Photobacterium profundum (SS9)

1220519 Pseudomonas aeruginosa (2192)1220520 Pseudomonas aeruginosa (C3719)1220521 Pseudomonas aeruginosa (LESB58)1220523 Pseudomonas aeruginosa (PACS2)1220524 Pseudomonas aeruginosa (PAO1/ATCC 15692)1220525 Pseudomonas aeruginosa (UCBPP-PA14)1220624 Shewanella denitrificans (OS217)1220839 Marinobacter (ELB17)1220965 Pseudomonas stutzeri (A1501)1221136 Nitrosococcus oceani (AFC-27)1222407 Nitrosococcus halophilus (Nc4)1222409 Nitrosococcus watsoni (C-113)1222482 Rhodanobacter (2APBS1)1222498 Thioalkalivibrio thiocyanoxidans (ARh 4)1222533 gamma proteobacterium (HdN1)1222541 Methylomonas methanica (MC09)1222638 Salinisphaera shabanensis (E1L3A)1222643 Pseudomonas mendocina (NK-01)1222644 Pseudomonas fluorescens (HK44)1222646 endosymbiont of Tevnia jerichonana1222647 Pseudomonas fluorescens (WH6)1222648 Pseudomonas brassicacearum (NFM421)1222649 Gamma proteobacterium IMCC20471222652 Methylomicrobium album (BG8)1222655 Methylocaldum szegediense (O-12)1222748 Methylomicrobium alcaliphilum1230031 Anaeromyxobacter (Fw109-5)1230080 Bdellovibrio bacteriovorus (HD100/DSM 50701/ATCC 15356)1240766 Sulfurimonas denitrificans (ATCC 33889/DSM 1251)1241030 Sulfurovum (NBC37-1)1241031 Nitratiruptor (SB155-2)

1241223 Campylobacterales (GD 1)1241897 Sulfurimonas autotrophica (OK10)1242165 Sulfurospirillum (Am-N)1242219 Sulfuricurvum kujiense (DSM 16994)1242289 Nitratifractor salsuginis (DSM 1651)1250766 Leptospira biflexa (Patoc 1/ATCC 23582/Paris)1251518 Leptospira biflexa (Patoc 1/Ames)1252508 Leptonema illini (DSM 21528)1281324 Methylacidiphilum infernorum (V4)121X007 Achromobacter cycloclastes121X008 Alcaligenes faecalis122X009 Halomonas halodenitrificans122X011 Pseudomonas fluorescens122X012 Pseudomonas stutzeri122X013 Pseudomonas(G-179)