who am i? what can i do? how do i live? · structural effect of dendrimers upon gelation. h n n ome...
TRANSCRIPT
![Page 1: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/1.jpg)
Who am I? What can I do? How do I live?
1. Why did you take a doctorate in foreign nation ? 2. Why did you select not America and Europe but Japan as destination to
study abroad ?
![Page 2: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/2.jpg)
Who am I? The Answer is variable.
Who am I?
![Page 3: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/3.jpg)
Kyoungpook National University
Excellent Student
What can I do? No Answer
![Page 4: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/4.jpg)
What can I do? No Answer1 year after, I entered army without dream.
What can I do?
I can do anythingor nothing!
![Page 5: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/5.jpg)
What can I do? What should I do?
I likes Chemistry. But….
![Page 6: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/6.jpg)
What did I do?
I registered 6:40 AM class of language school of the University for 2 years to learn Japanese.
What happens?6:40 AM is too early to take a class.
Most students disappear within one month.
1:1 lesson from Japanese teacher.
![Page 7: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/7.jpg)
How do I live?
Working?
Recruiting of LG Semiconductor
Application form
Yes
Recommendation
Prof. Inn-Kyu Kangin KPNU
Studying
No
LG Semicon. Ltd.was disappeared 1 year later
by the crisis of Korean Economy.
![Page 8: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/8.jpg)
To study advanced field.
Going to abroadJapan or America?
I am already good at Japanese
Pass the Japanese Government Scholarship Exam.
![Page 9: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/9.jpg)
Physical Gelation of Dendrimer in Organic Solvents
Jang, W. –D.; Jiang, D. –L; Aida, T. J. Am. Chem. Soc. 2000, 122, 3232.
O
O
O
O
O
O
O
CO2Me
CO2MeCO2Me
MeO2C
Dipeptide
What did I do in Ph.D. program?
![Page 10: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/10.jpg)
Structural Effect of Dendrimers upon Gelation
H NN
O Me
H
OH
H
MeH
O
N-Dendronized
H NN
O H
H
OH
H
MeH
O
tertBuO2C NN
O Me
H
OH
H
MeH
O
O-Dendronized
O-Methylated N-Deprotected
Change of Dendron
tertBuO2C NOH
H
OHNN
OH
O H
MeH
H
N-Deprotected O-Methylated/N-Deprotected
Cyclized Mono-peptide
O-Methylated
tertBuO2C NN
H
OH
H
MeH
O O
O
O
O
CH2
O
O
O
MeO2C
CO2Me
CO2Me
MeO2C
tertBuO2C NN
O H
H
OH
H
MeH
O
O OO
O
CH2
O
O
O
MeO2C
MeO2C CO2Me
CO2Me
tertBuO2C NN
O H
H
OH
H
MeH
O
O OO
O
CH2
O
O
O
MeO
MeO
MeO OMe MeO OMe
OMe
OMe
H NN
H
OH
H
MeH
O O
O
O
O
CH2
O
O
O
MeO2C
CO2Me
CO2Me
MeO2C
NN
O Me
H
OH
H
MeH
O
O
O
O
O
O
O
CO2Me
MeO2C
MeO2C
O
CO2Me
NN
O H
H
OH
H
MeH
O
O
O
O
O
O
O
CO2Me
MeO2C
MeO2C
O
CO2Me
W.-D. Jang, T. Aida,
Macromolecules, 2003.
![Page 11: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/11.jpg)
Nanofiber Formation of Self-Assembled Dendrimer
Regular Thickness (6 nm) Fibrou s Assembly Formation!!
8.2 nm
5.4 nm
2.7 nm
0.0 nm
1.3 nm
4.0 nm
6.7 nm
O
OHN
O
O
ON
NHH
NHO
O
ON
NHH
OO
OO
O
O
O
O
O
O
O
OOMe
OMe
OMeMeO
OMeMeO
MeO
OMeOMe
MeO
MeOOMe
OMeMeO
OMe
OMe
O
O
OO
OO
O
O
O
O
O
O
O
OMeO
MeO
MeOOMe
MeOOMe
OMe
MeOMeO
OMe
OMeMeO
MeOOMe
MeO
MeO
W.–D. Jang, T. Aida Macromolecules 2004, 37, 7325–7330.
![Page 12: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/12.jpg)
NNN
NZn
O
O
O
NNN
NZn
O
O
O
NH
HN
N
N
NN N
NZn
O
O
O
NN N
NZn
O
O
O
N
N
NNZn
OO
O
N
N
NNZn
OO
O
N
N
NNZn
OO
O
N
N
NNZn
OO
O
N
N N
NZn
OO
NN
NN
Zn
O
O
NN
NNZn
O
O
N N
NNZn
O
O
OO
O
O
O
O
N N
NNZn O
O
NN
NN Zn
O
ONN
NN Zn
OO
N
NN
NZn
OO
O
O
OO
O
O
N
NN
NZn
OO
N
NN
NZn
O
O
NN
NN
Zn
O
O
NN
N NZn
O
O
OO
O
O
O
O
NN
N NZnO
O
NN
NNZn
O
O NN
NNZn
OO
N
N N
NZn
O O
O
O
OO
O
O
NHNHN
N
9mer9mer 17mer17mer
MeO
MeO
NH
HN
N
N
NN N
NZn
O
O
O
NN N
NZn
O
O
O
OMeMeO
OMeMeO
NN
NNZn
O
O
N N
NNZn
O
O
N N
NN Zn O
O
NN
NN Zn
O
O
O
O
O
O
O
O
OMeMeO
OMeMeO
MeO
MeO
NH N
HNN
3mer3mer 5mer5mer
Artificial Light Harvesting System
![Page 13: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/13.jpg)
Physical Gelation of Dendrimer in Organic Solvents
O
O
O
O
O
O
O
CO2Me
CO2MeCO2Me
MeO2C
Dipeptide
How can I find physical gel?
![Page 14: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/14.jpg)
O
O
O
O
O
O
O
CO2Me
CO2MeMeO2C
MeO2C
O
O
O
O
O
O
O
CO2Me
CO2MeMeO2C
MeO2C
O
O
O
O
O
O
O
CO2Me
CO2MeMeO2C
MeO2C
O
O
O
O
O
O
O
CO2Me
CO2MeMeO2C
MeO2C
O
O
O
O
O
O
O
CO2Me
CO2MeMeO2C
MeO2C
OHN O
O
No Polymerization
![Page 15: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/15.jpg)
O
O
O
O
O
O
O
CO2Me
CO2MeMeO2C
MeO2C
NH
OHHNO
O
O O
Introducing Spacer
1 g of dendrimer gelled 500 mL of EA
Serendipity
![Page 16: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/16.jpg)
What did I do in Postdoc period?
Laser
Administration of Photosensitizer
Delivery
Treatment
Photodynamic Therapy
![Page 17: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/17.jpg)
π
Conjugation(Long Wavelength Absorption)
π Conjugation(Long Wavelength Absorption)
Hydrophobic Propertiesπ-Stacking
Hydrophobic Propertiesπ-Stacking
QuenchingQuenching
Limitation of Conventional Photosensitizers
PhotosensitizerPhotosensitizer
S0
S1
T1LightFL
PL
ISC
3O2
1O2
Type II ReactionEnergy
Transfer
OxygenOxygen
Type I ReactionElectron Transfer (Free Radical Process)
O2
O2- (Superoxide)
PhotosensitizerPhotosensitizer
S0
S1
T1LightFL
PL
ISC
3O2
1O2
Type II ReactionEnergy
Transfer3O2
1O2
Type II ReactionEnergy
Transfer3O2
1O2
Type II Reaction
3O2
1O2
Type II ReactionEnergy
Transfer
OxygenOxygen
Type I ReactionElectron Transfer (Free Radical Process)
O2
O2- (Superoxide)
OxygenOxygen
Type I ReactionElectron Transfer (Free Radical Process)
O2
O2- (Superoxide)
Type I ReactionElectron Transfer (Free Radical Process)
O2
O2- (Superoxide)
Encapsulation of Photosensitizers
No Self-Quenching Effect !!
![Page 18: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/18.jpg)
![Page 19: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/19.jpg)
Block Copolymer
(~60 nm)Dendrimer Porphyrin Micelle (DP/m)
Dendrimer Porphyrin (DP)
-
-
--
--
-
--
--
-
+
+ + + + +
+ + ++
Dendrimer Porphyrin Polyion Complex Micelle
![Page 20: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/20.jpg)
![Page 21: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/21.jpg)
EPR (Enhanced Permeability and Retention) Effect
![Page 22: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/22.jpg)
Photodynamic TherapyFormation of Polyion Complex Micelle
Enhanced Photodynamic Efficacy
in vivo PDT Effect (Cancer, wet AMD, Corneal Neovascularization)
What did I do in Postdoc period?
![Page 23: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/23.jpg)
What I am doing now
Real Time Therapy
Monitoring
Nano-Device for Real Time Treatment
Multifunctional Nano- Device for Therapeutic Application
![Page 24: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/24.jpg)
The First Chemistry Department in Korea22 Faculty MemberTop Level Education & Research in Korea
College of Science Department of Chemistry
![Page 25: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/25.jpg)
Who am I? How do I live?
The ‘I’ is variable.What you do now is able to change your
‘I’ in the future.
![Page 26: Who am I? What can I do? How do I live? · Structural Effect of Dendrimers upon Gelation. H N N OMe H H O H H Me O. N-Dendronized. H N N O H H H O H H Me O. tert. BuO. 2. CN N OMe](https://reader034.vdocuments.pub/reader034/viewer/2022042315/5f03a87b7e708231d40a2277/html5/thumbnails/26.jpg)
Chi-Hwa LeeJongsu KimJungmi HeoKwangmo ChoiSoohyun KimDongyong KimEunyoung Lee
Prof. Inn-Kyu KangKyungpook National UniversityProf. Takuzo AidaProf. Kazunori KataokaThe University of Tokyo
Fund: Center for Bioactive Molecular Hybrids, KOSEFKorea Research Fund
AcknowledgementAcknowledgement