ÖZGEÇMİŞ 1. GENEL

DÜZENLEME TARİHİ : 17/08/2017

T.C. KİMLİK NO : 29692531906

ÜNVANI ADI SOYADI : Prof. Dr. Asuman Sunguroğlu

YAZIŞMA ADRESİ : Ankara Üniversitesi Tıp Fakültesi Tıbbi Biyoloji Anabilim Dalı Başkanlığı Dekanlık Binası 2.Kat Sıhhiye-ANKARA 06100 Ankara/Türkiye

DOĞUM TARİHİ ve YERİ : 1963

TEL : 0312-3103010/388 GSM: 05333717653

E-POSTA : asungur@medicine.ankara.edu.tr

FAKS : 0312-5958188

2. EĞİTİM (Son aldığınız dereceden / diplomadan başlayarak yazınız)

ÖĞRENİM DÖNEMİ

DERECE (*) ÜNİVERSİTE ÖĞRENİM ALANI

1989-1992 Doktora Ankara Üniversitesi Tıbbi Biyoloji (Genetik)

-1989 Yüksek Lisans Hacettepe Üniversitesi Temel Onkoloji - Tümör İmmünolojisi

-1985 Lisans Hacettepe Üniversitesi Biyoloji

(*) Diploma Türü (Lisans, Y.Lisans, vb.) 3. AKADEMİK ve MESLEKİ DENEYİM

GÖREV DÖNEMİ

ÜNVAN ÜNİVERSİTE BÖLÜM

1992-1997 Yard. Doç. Dr. Ankara Üniversitesi Tıp F. Tıbbi Biyoloji Anabilim Dalı

1997-2003 Doç. Dr. Ankara Üniversitesi Tıp F. Tıbbi Biyoloji Anabilim Dalı

2003- Prof. Dr. Ankara Üniversitesi Tıp F. Tıbbi Biyoloji Anabilim Dalı

Başkanlığı

4. PROJELER

No

Proje Türü Proje Adı Başlama-Bitiş Tarihi

1

BAP

Kronik Miyeloid Lösemi’de Gelişen Dirençte Hücrelerin Yeniden Programlanmasında Mitokondrilerin Etkisinin Araştırılması

2016-

2

BAP

Adli DNA Fenotiplemede Göz Rengini Belirleyen Beş Tek Nükleotid Polimorfizm (Snp) Bölgesinin Kullanılabilirliğinin Araştırılması

2015-

3

1003

Glioblastoma Multiforme (GBM) İlaç Direncinde Rol Oynayan CD133+ Glioblastoma Kök Hücrelerini (GKH) Hedefleyen Terapötik Monoklonal Antikor Geliştirilmesi

2014-

4

BAP

Hipoksi/Re-oksijenasyona Maruz KalanKardiyomiyositlerde Metilprednizolon’un Endoplazmik Retikulum StresiÜzerindeki Etkisinin Araştırılması

2015-2016

5 1001 İnsan Kardiyomiyosit Hücrelerinin Mezenkimal Kök Hücreler Ile Füzyonu ve Yeniden Programlanması

2012-2015

6 BAP Pankreatik β Hücrelerinin Endoplazmik Retikulum Stres Yanıtında ATF6’nın Rolü

2012-2015

7 BAP

KML Etyolojisinde ve İlaç Direncinde Etkili Olan Genlerin Analizi

2015-

8

BAP

İnfertil erkeklerde, sperm nükleer proteinlerini kodlayan genlerin genetik ve epigenetik analizi ile fertilite üzerine etkisinin araştırılması

2010-2015

9

BAP

Non-obstruktif azoospermide, seminal moleküler belirteçlerle non-invaziv olarak spermatogenezi saptamak mümkün mü? Prospektif bir çalışma.

2015-2017

10 1001 Akut Myeloid Lösemide Beta katenin proteininin düzenlediği genlerin genom ebadında incelenmesi ve olası ilaç hedeflerinin belirlenmesi

2009-2011

11 1001 Beta-katenin, Nükleer faktör kappa B ve Akirin proteinlerinin birliktelikleri ve kronik myeloid lösemide imatinib direncindeki rolleri

2011-2013

12 1002 Imatinib mesilat Dirençli K-562/Ima-1 ve Dirençsiz K-562 Kronik Myeloid Lösemi Hücre Hatlarında Bim ve Bid Proapoptotik Genlerinin Polikomb Grup Proteinleri tarafından Epigenetik Regulasyonu

2009-2010

13 1001 Çocukluk çağı Akut Myeloid Lösemi hastalarının tedavisinde kullanılan metilprednizolonun DNA metilasyonu

2011-2013

üzerindeki etkinliği

14 BAP AML’de Wnt sinyal yolağındaki genlerin DNA mikrodizin analizi ile tanımlanması

2008-2011

15 BAP Kalsifiye Meme Tümörü Dokusunda Nanobakter Varlığının Araştırılması

2007-0809052HPD

16 BAP P53 +/+ ve P53 -/- Kolon Kanser Hücre Serilerinin İyonize Radyasyona Karşı Verdikleri Hücresel Cevabın Telomeraz Aktivitesi ile İlişkisi Ankara Üniversitesi Bilimsel Araştırma Projeleri

2007-0809052HPD 2007-2008

17 BAP MDR1 geninde gözlenen yaygın tek nükleotid değişimlerinin(C3435T, G2677T ve C1236T) Türkiye popülasyonunda haplotip temelli analizi

2007-2008

18 BAP

Kemik metastaz tanısı nedeniyle rhenium ile palyatif tedavi uygulanan hastalarda rheniumun olası genotoksik etkileri: MN ve FISH analizi ile değerlendirme

2006-2008

19 Klinik Vasküler Biyoloji Derneği

Koroner arter hastalarında myeloperoksidaz (MPO) gen polimorfizmi ve enzim aktiviteleri

2006-2007

20 BAP Türkiye’de D1S80, ApoB, D4S95, D17S30 ve TP53 VNTR lokuslarının polimorfizmleri

2002-2003

21 Ankara Üniversitesi Biyoteknoloji Enstitüsü

Bcr-Abl Füzyon Geni İçeren Hücre Serilerinin Apoptotik Tedavi Altındaki Davranışı

2002-2004

5- YÖNETSEL GÖREVLER

Yönetsel Görevler Başlangıç Tarihi Bitiş Tarihi

Ankara Üniversitesi Tıp Fakültesi Tıbbi Biyoloji Anabilim Dalı Başkanlığı

2003-

Öğrenci Akademik ve Sosyal Danışma Kurulu Başkanlığı

2012-

Ankara Üniversitesi Proje Değerlendirme Grubu Üyeliği

2012-

Ankara Üniversitesi Burs Komisyon Başkanlığı

2013-

Ankara Üniversitesi Tıp 2009-

Fakültesi DI MI Kurul Başkanlığı

TUBİTAK KBAG Danışma Kurul Üyeliği

2017-

6- EDİTÖRLÜK/HAKEMLİK YAPILAN DERGİLER 1-DNA and Cell Biology 3-Türkiye Klinikleri(Editör) 7. SCI-YAYINLAR 1.Incomplete Antibodies May Reduce ABO Cross-match Incompatibility. A Pilot Study. Özen M, Yılmaz S, Özkan T, Özer Y, Pekel AA, Sunguroğlu A, Gürman G, Arslan Ö. Turk J Haematol. 2017 May 23. doi: 10.4274/tjh.2016.0504. [Epub ahead of print] 2. Apoptotic effects of some tetrahydronaphthalene derivatives on K562 human chronic myelogenous leukemia cell line. Koç A, Ozkan T, Karabay AZ, Hekmatshoar Y, Gurkan-Alp AS, Aktan F, Buyukbingol Z, Sunguroglu A, Buyukbingol E. Anticancer Agents Med Chem. 2017 Apr 12. doi: 10.2174/1871521409666170412122811. [Epub ahead of print] 3. A differential cytokine expression profile before and after rFSH treatment in Sertoli cell cultures of men with nonobstructive azoospermia By: Heidargholizadeh, S.; Aydos, S. E.; Yukselten, Y.; et al. ANDROLOGIA Volume: 49 Issue: 4 Article Number: e12647 Published: MAY 2017 4. Lomeguatrib, a O-6-Methylguanine-DNA-Methyltransferase (MGMT) Inhibitor, Induces DNA Damage Induced Apoptosis By Targeting Double-Strand DNA Repair in Multiple Myeloma By: Yildiz, Dilara Akcora; Ozkan, Tulin; Yukselten, Yunus; et al. Conference: 58th Annual Meeting and Exposition of the American-Society-of-ematology Location: San Diego, CADate: DEC 03-06, 2016 Sponsor(s): Amer Soc Hematol BLOOD Volume: 128 Issue: 22 Meeting Abstract: 2103 Published: DEC 2 2016 5. Role of ADAMTS1 and ADAMTS5 in male infertility By: Aydos, S. E.; Yukselten, Y.; Sunguroglu, A.; et al. ANDROLOGIA Volume: 48 Issue: 10 Pages: 1113-1119 Published: DEC 2016 6. Impact of rFSH treatment on Sertoli cell cytokine expression By: Aydos, S. Erdogan; Heidargholizadeh, S.; Yukselten, Y.; et al. Conference: 41st FEBS Congress on Molecular and Systems Biology for a Better Life Location: Kusadasi, TURKEYDate: SEP 03-08, 2016 Sponsor(s): FEBS JOURNAL Volume: 283 Special Issue: SI Supplement: 1 Pages: 80-80 Meeting Abstract: ST04044003 Published: SEP 2016 7. Gene expression profile of protamines in male infertility By: Aydos, S.; Altinok, B.; Ozkan, T.; et al. Conference: 41st FEBS Congress on Molecular and Systems Biology for a Better Life Location: Kusadasi, TURKEYDate: SEP 03-08, 2016 Sponsor(s): FEBS JOURNAL Volume: 283 Special Issue: SI Supplement: 1 Pages: 135-136 Meeting Abstract: P02091-018 Published: SEP 2016 8. Comparative genome wide gene expression analyses of primary MSC and MSC lines By: Akpinar, A. E.; Karadag, A.; Cubukcuoglu, G. Deniz; et al.

Conference: 41st FEBS Congress on Molecular and Systems Biology for a Better Life Location: Kusadasi, TURKEYDate: SEP 03-08, 2016 FEBS JOURNAL Volume: 283 Special Issue: SI Supplement: 1 Pages: 142-142 Meeting Abstract: P03011-014 Published: SEP 2016 9. Effects of MLH1 and MSH2 expression on imatinib resistance in CML By: Hekmatshoar, Y.; Ozkan, T.; Altinok, B.; et al. Conference: 41st FEBS Congress on Molecular and Systems Biology for a Better Life Location: Kusadasi, TURKEYDate: SEP 03-08, 2016 FEBS JOURNAL Volume: 283 Special Issue: SI Supplement: 1 Pages: 162-162 Meeting Abstract: P05011-036 Published: SEP 2016 10. A benzamide derivative XT5 and imatinib combination induced apoptosis in Imatinib resistant K562 cell line By: Ozkan, T.; Hekmatshoar, Y.; Bolelli, T. Ertan; et al. Conference: 41st FEBS Congress on Molecular and Systems Biology for a Better Life Location: Kusadasi, TURKEYDate: SEP 03-08, 2016 FEBS JOURNAL Volume: 283 Special Issue: SI Supplement: 1 Pages: 162-162 Meeting Abstract: P05011-035 Published: SEP 2016 11. Role of apoptotic markers for determination of postmortem interval (PMI) By: Yildirim, E. F.; Yukselten, Y.; Sunguroglu, A.; et al. Conference: 41st FEBS Congress on Molecular and Systems Biology for a Better Life Location: Kusadasi, TURKEYDate: SEP 03-08, 2016 FEBS JOURNAL Volume: 283 Special Issue: SI Supplement: 1 Pages: 220-220 Meeting Abstract: P02022-045 Published: SEP 2016 12. Role of extracellular matrix proteases for determination of post mortem interval By: Parlakgorur, M.; Avci, A.; Sunguroglu, A.; et al. Conference: 41st FEBS Congress on Molecular and Systems Biology for a Better Life Location: Kusadasi, TURKEYDate: SEP 03-08, 2016 FEBS JOURNAL Volume: 283 Special Issue: SI Supplement: 1 Pages: 285-285 Meeting Abstract: P02075-005 Published: SEP 2016 13. TNFRSF21 and TNFSF7 are possible markers to target CD133+GBM stem cells By: Ozkanca, S.; Yukselten, Y.; Bal, M. G.; et al. Conference: 41st FEBS Congress on Molecular and Systems Biology for a Better Life Location: Kusadasi, TURKEYDate: SEP 03-08, 2016 FEBS JOURNAL Volume: 283 Special Issue: SI Supplement: 1 Pages: 303-303 Meeting Abstract: P05033-019 Published: SEP 2016 14. Tie2/TEK: a potential biomarker for targeting glioblastoma stem cells By: Yukselten, Y.; Bal, M. G.; Ozkanca, S.; et al. Conference: 41st FEBS Congress on Molecular and Systems Biology for a Better Life Location: Kusadasi, TURKEYDate: SEP 03-08, 2016 FEBS JOURNAL Volume: 283 Special Issue: SI Supplement: 1 Pages: 304-305 Meeting Abstract: P05033-023 Published: SEP 2016 15. Genome-wide analysis of hypoxic stress response in human cardiomyocytes By: Karadag, A.; Ozkan, T.; Akpinar, A. E.; et al. Conference: 41st FEBS Congress on Molecular and Systems Biology for a Better Life Location: Kusadasi, TURKEYDate: SEP 03-08, 2016 FEBS JOURNAL Volume: 283 Special Issue: SI Supplement: 1 Pages: 310-311 Meeting Abstract: P06025-004 Published: SEP 2016

16. Methylsulfonylmethane Induces p53 Independent Apoptosis in HCT-116 Colon Cancer Cells By: Karabay, Arzu Zeynep; Koc, Asli; Ozkan, Tulin; et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Volume: 17 Issue: 7 Article Number: 1123 Published: JUL 2016 17. The role of the collagen type 1 alpha 1 gene polymorphism in the prediction of osteoporosis and fracture risk in Turkish postmenopausal women By: Saban, Ilknur; Gok, Haydar; Aydos, Sena; et al. TURKIYE FIZIKSEL TIP VE REHABILITASYON DERGISI-TURKISH JOURNAL OF PHYSICAL MEDICINE AND REHABILITATION Volume: 62 Issue: 1 Pages: 1-8 Published: MAR 2016 18. Analysis of the correlation between sperm DNA integrity and conventional semen parameters in infertile men By: Aydos, Oya Sena; Yukselten, Yunus; Kaplan, Fuat; et al. TURKISH JOURNAL OF UROLOGY Volume: 41 Issue: 4 Pages: 191-197 Published: DEC 2015 19. Impact of follicle-stimulating hormone receptor variants in female infertility By: Ilgaz, Nermin Seda; Aydos, Oya Sena Erdogan; Karadag, Aynur; et al. JOURNAL OF ASSISTED REPRODUCTION AND GENETICS Volume: 32 Issue: 11 Pages: 1659-1668 Published: NOV 2015 20. The investigation of genetic analysis of genes encoding sperm nuclear proteins with the effects on fertility in infertile men By: Aydos, O. S.; Altinok, B.; Ozkan, T.; et al. Conference: 40th Congress of the Federation-of-European-Biochemical-Societies (FEBS) - The Biochemical Basis of Life Location: Berlin, GERMANY Date: JUL 04-09, 2015 FEBS JOURNAL Volume: 282 Special Issue: SI Supplement: 1 Pages: 64-65 Meeting Abstract: P02-036 Published: JUL 2015 21. Association of Contrin (YBX2) 187T > C and 1095+16A > G single nucleotide polymorphisms with male factor infertility By: Hekmatshoar, Y.; Aydos, O. S.; Kaplan, F.; et al. Conference: 40th Congress of the Federation-of-European-Biochemical-Societies (FEBS) - The Biochemical Basis of Life Location: Berlin, GERMANY Date: JUL 04-09, 2015 FEBS JOURNAL Volume: 282 Special Issue: SI Supplement: 1 Pages: 65-65 Meeting Abstract: P02-038 Published: JUL 2015 22. Hydrogen peroxide-induced oxidative damage in human mononuclear leukocyte: the anti-genotoxic effects of H. Perforatum extract on DNA damage By: Aktepe, N.; Keskin, C.; Yukselten, Y.; et al. Conference: 40th Congress of the Federation-of-European-Biochemical-Societies (FEBS) - The Biochemical Basis of Life Location: Berlin, GERMANY Date: JUL 04-09, 2015 FEBS JOURNAL Volume: 282 Special Issue: SI Supplement: 1 Pages: 128-128 Meeting Abstract: P10-065 Published: JUL 2015 23. Synthesis and anticancer effects of some novel 2-(4-phenoxyphenyl)-1H-benzimidazole derivatives on K562 cell line By: Gurkan-Alp, A. Selen; Goker, Hakan; Alp, Mehmet; et al. ARCHIVES OF PHARMACAL RESEARCH Volume: 38 Issue: 5 Pages: 650-658 Published: MAY 2015 24. The Role of IL33 in Glioblastoma Multiforme By: Demircan, Kadir; Yukselten, Yunus; Bal, Merve; et al.

FASEB JOURNAL Volume: 29 Supplement: 1 Meeting Abstract: LB142 Published: APR 2015 25. Isolation of Human Glioblastoma Multiforme Primary Cells and analysis of CD133(+) By: Yukselten, Yunus; Yildiz, Dilara Akcora; Demircan, Kadir; et al. FASEB JOURNAL Volume: 29 Supplement: 1 Meeting Abstract: LB135 Published: APR 2015 26. Synthesis and antiproliferative evaluation of novel 5-(4-methylpiperazin-1-yl)-2-phenyl-1H-benzimidazole derivatives By: Alp, Mehmet; Gurkan-Alp, A. Selen; Ozkan, Tulin; et al. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES Volume: 70 Issue: 3-4 Pages: 79-85 Published: MAR 2015 27.Association of MDR1 C3435T and C1236T single nucleotide polymorphisms with male factor infertility By: Aydos, S. E.; Karadag, A.; Ozkan, T.; et al. GENETICS AND MOLECULAR RESEARCH Volume: 14 Issue: 2 Pages: 6330-6339 Published: 2015 28. Methylation analysis of the DAPK1 gene in imatinib-resistant chronic myeloid leukemia patients By: Celik, Selcen; Akcora, Dilara; Ozkan, Tulin; et al. ONCOLOGY LETTERS Volume: 9 Issue: 1 Pages: 399-404 Published: JAN 2015 29. Methylsulfonylmethane modulates apoptosis of LPS/IFN-gamma-activated RAW 264.7 macrophage-like cells by targeting p53, Bax, Bcl-2, cytochrome c and PARP proteins By: Karabay, Arzu Z.; Aktan, Fugen; Sunguroglu, Asuman; et al. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY Volume: 36 Issue: 6 Pages: 379-389 Published: DEC 2014 30. Cell fusion following cardiomyocyte and mesenchymal stem cell co-culture and functional evaluation of cellular changes By: Karadag, A.; Deniz, G. Cubukcuoglu; Dastouri, M.; et al. Conference: FEBS EMBO 2014 Conference Location: Paris, FRANCE Date: AUG 30-SEP 04, 2014 EMBO FEBS JOURNAL Volume: 281 Special Issue: SI Supplement: 1 Pages: 220-220 Meeting Abstract: SUN-452 Published: SEP 2014 31. Effects of OCT4, SOX2 and NANOG expression on imatinib resistance in CML By: Hekmatshoar, Y.; Ozkan, T.; Zaim, B. Altinok; et al. Conference: FEBS EMBO 2014 Conference Location: Paris, FRANCE Date: AUG 30-SEP 04, 2014 EMBO FEBS JOURNAL Volume: 281 Special Issue: SI Supplement: 1 Pages: 224-224 Meeting Abstract: SUN-465 Published: SEP 2014 32. Genome wide investigation of genes regulated by Beta-catenin in AML By: Ozkan, T.; Zaim, B. Altinok; Karadag, A.; et al. Conference: FEBS EMBO 2014 Conference Location: Paris, FRANCE Date: AUG 30-SEP 04, 2014 EMBO FEBS JOURNAL Volume: 281 Special Issue: SI Supplement: 1 Pages: 468-468 Meeting Abstract: TUE-110 Published: SEP 2014 33. Identification of genes in Wnt signaling pathway with DNA microarray analysis in acute myeloid leukemia By: Zaim, B. Altinok; Ozkan, T.; Karadag, A.; et al. Conference: FEBS EMBO 2014 Conference Location: Paris, FRANCE Date: AUG 30-SEP 04, 2014 EMBO FEBS JOURNAL Volume: 281 Special Issue: SI Supplement: 1 Pages: 474-474 Meeting Abstract: TUE-126 Published: SEP 2014

34. Investigation of the Taspine's antiproliferative, antiangiogenic and apoptotic effects on U118 and U87 glioblastoma multiforme cell lines By: Sharifi, S. S.; Aydos, S.; Ozkan, T.; et al. Conference: FEBS EMBO 2014 Conference Location: Paris, FRANCE Date: AUG 30-SEP 04, 2014 EMBO FEBS JOURNAL Volume: 281 Special Issue: SI Supplement: 1 Pages: 480-481 Meeting Abstract: TUE-145 Published: SEP 2014 35. Synthesis and cytotoxic evaluation of novel N-substituted amidino-1-hydroxybenzimidazole derivatives By: Alp, Mehmet; Goker, Hakan; Ozkan, Tulin; et al. ARCHIVES OF PHARMACAL RESEARCH Volume: 37 Issue: 5 Pages: 580-587 Published: MAY 2014 36. Chemotherapeutic resistance in anaplastic astrocytoma cell lines treated with a temozolomide-lomeguatrib combination By: Ugur, Hasan Caglar; Taspinar, Mehmet; Ilgaz, Seda; et al. MOLECULAR BIOLOGY REPORTS Volume: 41 Issue: 2 Pages: 697-703 Published: FEB 2014 37. A Preliminary Investigation on the Presence of Calcifying Nanoparticles in the Breast Tumor By: Ozkal-Baydin, Pinar; Gocmen, Sedef J.; Erdemli, Esra; et al. UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI Volume: 24 Issue: 1 Pages: 17-22 Published: 2014 38. Effects of gamma irradiation on cell cycle, apoptosis and telomerase activity in p53 wild-type and deficient HCT116 colon cancer cell lines By: Halacli, Sevil Oskay; Canpinar, Hande; Cimen, Eren; et al. ONCOLOGY LETTERS Volume: 6 Issue: 3 Pages: 807-810 Published: SEP 2013 39. Peripheral blood mononuclear cell microchimerism in Turkish female patients with systemic sclerosis By: Sahin, Ali; Ozkan, Tulin; Turkcapar, Nuran; et al. MODERN RHEUMATOLOGY Volume: 24 Issue: 1 Pages: 97-105 Published: JAN 2014 40. The roles of epigenetic modifications of proapoptotic BID and BIM genes in imatinib-resistant chronic myeloid leukemia cells By: Bozkurt, Sureyya; Ozkan, Tulin; Ozmen, Fusun; et al. HEMATOLOGY Volume: 18 Issue: 4 Pages: 217-223 Published: JUL 2013 41. Effect of lomeguatrib-temozolomide combination on MGMT promoter methylation and expression in primary glioblastoma tumor cells By: Taspinar, Mehmet; Ilgaz, Seda; Ozdemir, Mevci; et al. TUMOR BIOLOGY Volume: 34 Issue: 3 Pages: 1935-1947 Published: JUN 2013 42. The effect of CYP1A1, GSTT1 and GSTM1 polymorphisms on the risk of lung cancer: A case-control study By: Atinkaya, Cansel; Taspinar, Mehmet; Sakiragaoglu, Onur; et al. HUMAN & EXPERIMENTAL TOXICOLOGY Volume: 31 Issue: 10 Pages: 1074-1080 Published: OCT 2012 43. Variations in glutathione-S-transferase genes influence risk of chronic myeloid leukemia By: Oezten, Nur; Sunguroglu, Asuman; Bosland, Maarten C. HEMATOLOGICAL ONCOLOGY Volume: 30 Issue: 3 Pages: 150-155 Published: SEP 2012 44. Effects of methylsulfonylmethane on viability of HCT-116 cell line By: Karabay, A. Z.; Ozkan, T.; Koc, A.; et al.

Conference: 22nd IUBMB Congress/37th FEBS Congress Location: Seville, SPAIN Date: SEP 04-09, 2012 IUBMB; FEBS JOURNAL Volume: 279 Special Issue: SI Supplement: 1 Pages: 55-55 Published: SEP 2012 45. Effects of methylprednisolone on DNA methylation in HL-60 AML cells By: Yukselen, I.; Altinok, B.; Karadag, A.; et al. Conference: 22nd IUBMB Congress/37th FEBS Congress Location: Seville, SPAIN Date: SEP 04-09, 2012 IUBMB; FEBS JOURNAL Volume: 279 Special Issue: SI Supplement: 1 Pages: 495-496 Published: SEP 2012 46. The role of MDR1 C3435T single nucleotide polymorphism in male infertility By: Karadag, A.; Aydos, S.; Ozkan, T.; et al. Conference: 22nd IUBMB Congress/37th FEBS Congress Location: Seville, SPAIN Date: SEP 04-09, 2012 IUBMB; FEBS JOURNAL Volume: 279 Special Issue: SI Supplement: 1 Pages: 560-561 Published: SEP 2012 47. Investigation of apoptotic and efflux-pump gene expressions in Imatinib resistant CML cell line By: Sunguroglu, A.; Ozkan, T.; Altinok, B.; et al. Conference: 22nd IUBMB Congress/37th FEBS Congress Location: Seville, SPAIN Date: SEP 04-09, 2012 IUBMB; FEBS JOURNAL Volume: 279 Special Issue: SI Supplement: 1 Pages: 574-574 Published: SEP 2012 48. Effect of methylsulfonylmethane on iNOS gene methylation in macrophages By: Buyukbingol, Z.; Karabay, A. Z.; Ozkan, T.; et al. Conference: 22nd IUBMB Congress/37th FEBS Congress Location: Seville, SPAIN Date: SEP 04-09, 2012 IUBMB; FEBS JOURNAL Volume: 279 Special Issue: SI Supplement: 1 Pages: 575-576 Published: SEP 2012 49. GSTP1 gene methylation analysis in prostate cancer By: Ozkan, T.; Gokce, I.; Altinok, B.; et al. Conference: 22nd IUBMB Congress/37th FEBS Congress Location: Seville, SPAIN Date: SEP 04-09, 2012 IUBMB; FEBS JOURNAL Volume: 279 Special Issue: SI Supplement: 1 Pages: 576-576 Published: SEP 2012 50. MDR1 gene polymorphisms may be associated with Behcet's disease and its colchicum treatment response. By: Rustemoglu, Aydin; Gul, Ulker; Gumus-Akay, Guvem; et al. GENE Volume: 505 Issue: 2 Pages: 333-339 Published: SEP 1 2012 51. Potential genotoxic effect of Re-186-HEDP on human lymphocyte cells: in-vitro evaluation with micronucleus-FISH analysis By: Ozkal-Baydin, Pinar; Gumus-Akay, Guvem; Varol, Nuray; et al. NUCLEAR MEDICINE COMMUNICATIONS Volume: 33 Issue: 4 Pages: 415-421 Published: APR 2012 52. Impact of Genetic Variations of the CYP1A1, GSTT1, and GSTM1 Genes on the Risk of Coronary Artery Disease. By: Taspinar, Mehmet; Aydos, Sena; Sakiragaoglu, Onur; et al. DNA AND CELL BIOLOGY Volume: 31 Issue: 2 Pages: 211-218 Published: FEB 2012 53. Effect of L-carnitine on the synthesis of nitric oxide in RAW 264 center dot 7 murine macrophage cell line By: Koc, A.; Ozkan, T.; Karabay, A. Z.; et al. CELL BIOCHEMISTRY AND FUNCTION Volume: 29 Issue: 8 Pages: 679-685 Published: DEC 2011 54. Effect of Urtica dioica on proliferation of HCT-116 colon cancer cell line By: Aydos, S.; Avci, A.; Durak, I; et al.

Conference: 59th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research Location: Antalya, TURKEY Date: SEP 04-09, 2011 Sponsor(s): Soc Med Plant & Nat Prod Res PLANTA MEDICA Volume: 77 Issue: 12 Pages: 1372-1373 Published: AUG 2011 55. Antiproliferative, apoptotic and antioxidant activities of wheatgrass (Triticum aestivum L.) extract on CML (K562) cell line By: Aydos, Oya Sena; Avci, Aslihan; Ozkan, Tulin; et al. TURKISH JOURNAL OF MEDICAL SCIENCES Volume: 41 Issue: 4 Pages: 657-663 Published: AUG 2011 56. Epigenetic regulation of bim and bid proapoptotic genes by polycomb group proteins in imatinib mesylate resistant and non-resistant chronic myeloid leukemia cell lines By: Bozkurt, S.; Ozkan, T.; Kansu, E.; et al. Conference: 36th FEBS Congress of the Biochemistry for Tomorrows Medicine Location: Torino, ITALY Date: JUN 25-30, 2011 Federat Soc Biochem & Mol Biol FEBS JOURNAL Volume: 278 Special Issue: SI Supplement: 1 Pages: 81-81 Published: JUN 2011 57. Expression of nucleostemin in glioblastoma multiforme tumor cells and its effect on the diagnosis and prognosis By: Caliskan, E.; Altinok, B.; Ozkan, T.; et al. Conference: 36th FEBS Congress of the Biochemistry for Tomorrows Medicine Location: Torino, ITALY Date: JUN 25-30, 2011 Federat Soc Biochem & Mol Biol FEBS JOURNAL Volume: 278 Special Issue: SI Supplement: 1 Pages: 193-194 Published: JUN 2011 58. Detection of NPM1 gene mutations in AML patients in Turkish population By: Ozturk, G.; Altinok, B.; Ozkan, T.; et al. Conference: 36th FEBS Congress of the Biochemistry for Tomorrows Medicine Location: Torino, ITALY Date: JUN 25-30, 2011 Federat Soc Biochem & Mol Biol FEBS JOURNAL Volume: 278 Special Issue: SI Supplement: 1 Pages: 212-212 Published: JUN 2011 59. A STUDY OF PARAOXONASE I GENE POLYMORPHISMS WITH THE RISK AND SEVERITY OF NON-SMALL CELL LUNG CANCER (NSCLC) IN TURKISH PATIENTS By: Ahsan, Fadhil; Sunguroglu, Asuman JOURNAL OF THORACIC ONCOLOGY Volume: 6 Issue: 6 Supplement: 2 Pages: S755-S755 Published: JUN 2011 60. Effects of aqueous garlic extract on oxidant/antioxidant status in 32D and 32Dp210 cell lines By: Avci, Aslihan; Sunguroglu, Asuman; Erguder, Imge B.; et al. TURKISH JOURNAL OF MEDICAL SCIENCES Volume: 40 Issue: 6 Pages: 881-888 Published: DEC 2010 61. Effects of antioxidants on post-thawed bovine sperm and oxidative stress parameters: Antioxidants protect DNA integrity against cryodamage By: Bucak, Mustafa Numan; Tuncer, Purhan Barbaros; Sariozkan, Serpil; et al. CRYOBIOLOGY Volume: 61 Issue: 3 Pages: 248-253 Published: DEC 2010 62. Effect of methylsulfonylmethane on LPS-IFN-gamma induced RAW 264.7 macrophage apoptosis By: Karabay, A. Z.; Ozkan, T.; Koc, A.; et al. Conference: 35th Congress of the Federation-of-European-Biochemical-Societies Location: Gothenburg, SWEDENDate: JUN 26-JUL 01, 2010

FEBS JOURNAL Volume: 277 Supplement: 1 Pages: 57-57 Published: JUN 2010 63. Effect of L-carnitine on NF-kB activity in lipopolysaccharide stimulated RAW 264.7 macrophage cell By: Koe, A.; Ozkan, T.; Karabay A., Z.; et al. Conference: 35th Congress of the Federation-of-European-Biochemical-Societies Location: Gothenburg, SWEDENDate: JUN 26-JUL 01, 2010 FEBS JOURNAL Volume: 277 Supplement: 1 Pages: 146-147 Published: JUN 2010 64. Effect of wnt3a or lithium chloride preconditioning on nitric oxide production in RAW264.7 macrophages and K562 leukemic cell line By: Karabay, A. Z.; Ozkan, T.; Koc, A.; et al. Conference: 35th Congress of the Federation-of-European-Biochemical-Societies Location: Gothenburg, SWEDENDate: JUN 26-JUL 01, 2010 FEBS JOURNAL Volume: 277 Supplement: 1 Pages: 147-148 Published: JUN 2010 65. NF-kappaB activation and complex control of NOS2 gene promoter in K562 imatinib mesylate resistant CML cell line By: Ozkan, T.; Karadag, A.; Altinok, B.; et al. Conference: 35th Congress of the Federation-of-European-Biochemical-Societies Location: Gothenburg, SWEDENDate: JUN 26-JUL 01, 2010 FEBS JOURNAL Volume: 277 Supplement: 1 Pages: 147-147 Published: JUN 2010 66. Haplotype-Based Analysis of MDR1/ABCB1 Gene Polymorphisms in a Turkish Population By: Gumus-Akay, Guevem; Rustemoglu, Aydin; Karadag, Aynur; et al. DNA AND CELL BIOLOGY Volume: 29 Issue: 2 Pages: 83-90 Published: FEB 2010 67. DNA Copy Number Changes in Gastric Adenocarcinomas: High Resolution-Comparative Genomic Hybridization Study in Turkey By: Gumus-Akay, Guvem; Unal, Ali Ekrem; Elhan, Atilla Halil; et al. ARCHIVES OF MEDICAL RESEARCH Volume: 40 Issue: 7 Pages: 551-560 Published: OCT 2009 68. Acute myeloid leukemia in Turkish children with Fanconi anemia. One center experience in the period between 1964-1995 By: Gozdasoglu, Sevgi; Ertem, Mehmet; Uysal, Zuemruet; et al. TURKISH JOURNAL OF HEMATOLOGY Volume: 26 Issue: 3 Pages: 118-122 Published: SEP 2009 69. Association of CYP1A1 and glutathione S-transferase polymorphisms with male factor infertility By: Aydos, Sena Erdogan; Taspinar, Mehmet; Sunguroglu, Asuman; et al. Conference: 6th Annual Meeting of the Mediterranean-Society-for-Reproductive-Medicine Location: Antalya, TURKEY Date: APR 20-23, 2007 Sponsor(s): Mediterranean Soc Reproduct Med FERTILITY AND STERILITY Volume: 92 Issue: 2 Pages: 541-547 Published: AUG 2009 70. The effect of LPS incubation periods on nitric oxide levels in RAW 264.7 macrophage cell line By: Akinci, A.; Karabay, A.; Oezkan, T.; et al. Conference: 34th Congress of the Federation-of-European-Biochemical-Societies Location: Prague, CZECH REPUBLIC Date: JUL 04-09, 2009 Sponsor(s): Federat European Biochem Soc FEBS JOURNAL Volume: 276 Pages: 297-297 Published: JUL 2009 71. Effect of methylsulfonylmethane on proliferation and nitric oxide production in LPS activated RAW 264.7 cells By: Karabay, A. Z.; Akinci, A.; Ozkan, T.; et al. Conference: 34th Congress of the Federation-of-European-Biochemical-Societies Location: Prague, CZECH REPUBLIC Date: JUL 04-09, 2009 Sponsor(s): Federat European Biochem Soc FEBS JOURNAL Volume: 276 Pages: 316-316 Published: JUL 2009 72. Wheatgrass extract affects lipid peroxidation levels in human promyelocytic leukemia cell line HL-60 By: Ozkan, T.; Bakar, F.; Karabay, A. Z.; et al. Conference: 34th Congress of the

Federation-of-European-Biochemical-Societies Location: Prague, CZECH REPUBLIC Date: JUL 04-09,2009 Federat European Biochem Soc FEBS JOURNAL Volume: 276 Pages: 334-334 Published: JUL 2009 73. Effects of MSM (methylsulfonylmethane) on SNP (sodium nitroprusside) and H2O2 (hydrogen peroxide) induced RAW 264.7 macrophages By: Karabay, Z. A.; Ozkan, T.; Koc, A.; et al. Conference: 57th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-Research-and-Natural-Product Research Location: Geneva, SWITZERLAND Date: AUG 16-20, 2009 Soc Medicinal Plant & Nat Prod Res PLANTA MEDICA Volume: 75 Issue: 9 Pages: 911-911 Published: JUL 2009 74. Wheatgrass extract increases proliferation of RAW 264.7 macrophages induced by hydrogen peroxide (H2O2) or lipopolysaccharide (LPS) By: Ozkan, T.; Karabay, Z. A.; Koc, A.; et al. Conference: 57th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-Research-and-Natural-Product-Research Location: Geneva, SWITZERLAND Date: AUG 16-20, 2009 Sponsor(s): Soc Medicinal Plant & Nat Prod Res PLANTA MEDICA Volume: 75 Issue: 9 Pages: 923-923 Published: JUL 2009 75. EFFECT OF L-CARNITINE ON NO PRODUCTION IN LIPOPOLYSACCHARIDE INDUCED RAW 264.7 CELLS By: Koc, Asli; Karabay, Arzu Z.; Ozka, Tulin; et al. IUBMB LIFE Volume: 61 Issue: 3 Pages: 327-327 Published: MAR 2009 76. PLASMA ADA AND PON1-ARYLESTERASE ENZYME ACTIVITIES IN LUNG CANCER PATIENTS By: Gurleyik, Ebru; Taspinar, Mehmet; Oztuna, Derya; et al. IUBMB LIFE Volume: 61 Issue: 3 Pages: 337-338 Published: MAR 2009 77. PLASMA NITRIC OXIDE LEVELS AND NITRIC OXIDE SYNTHASE ACTIVITY IN LUNG CANCER PATIENTS By: Korkmaz, Sebnem; Gurleyik, Ebru; Taspinar, Mehmet; et al. IUBMB LIFE Volume: 61 Issue: 3 Pages: 373-374 Published: MAR 2009 78. WHEATGRASS JUICE REDUCES NITRIC OXIDE PRODUCTION IN LPS INDUCED RAW 264.7 CELLS By: Aydos, Sena; Ozkan, Tulin; Karabay, Arzu Z.; et al. IUBMB LIFE Volume: 61 Issue: 3 Pages: 376-376 Published: MAR 2009 79. Effects of Genomic Imbalances on Telomerase Activity in Gastric Cancer: Clues to Telomerase Regulation By: Gumus-Akay, Guvem; Elhan, Atilla Halil; Unal, Ali Ekrem; et al. Conference: 12th World Congress on Advances in Oncology/10th International Symposium on Molecular MedicineLocation: Hersonissos, GREECE Date: OCT 11-13, 2007 ONCOLOGY RESEARCH Volume: 17 Issue: 10 Pages: 455-462 Published: 2009 80. Apoptotic effect of wheatgrass (Triticum aestivum L.) extract on Baf3p210 and Baf3p210-T3151 leukemia cell lines By: Altinok, B.; Ozkan, T.; Karadag, A.; et al. Conference: 7th Joint Meeting of the Association-Francophone-pour-l'Enselgnement-et-la-Recherche-en-Pharmacognosie/American-Society-of-Pharmacognosy/Society-for-Medicinal-Plant-Research/Phytochem-Society-of-Europe/Societa-Italiana-di-Fitochimica : Athens, GREECE Date: AUG03-08,2008 Assoc Francophone Enseignement Rech Pharmacognosie; Amer Soc Pharmacognosy; Soc Medicinal Plant Res; Phytochem Soc Europe; Soc Italiana Fitochim PLANTA MEDICA Volume: 74 Issue: 9 Pages: 970-970 Published: JUL 2008 81. Effect of wheatgrass (Triticum aestivum L.) on oxidant/antioxidant status in Baf 3p210 and T315i cell lines By: Avci, A.; Gurleyik, E.; Ozkan, T.; et al. Conference: 7th Joint Meeting of the Association-Francophone-pour-l'Enselgnement-et-la-Recherche-en-Pharmacognosie/American-Society-of-Pharmacognosy/Society-for-Medicinal-Plant-Research/Phytochem-Society-of-Europe/Societa-Italiana-di-Fitochimica Location: Athens,

GREECE Date: AUG03-08,2008 ,Assoc Francophone Enseignement Rech Pharmacognosie; Amer Soc Pharmacognosy; Soc Medicinal Plant Res; Phytochem Soc Europe; Soc Italiana Fitochim PLANTA MEDICA Volume: 74 Issue: 9 Pages: 1010-1010 Published: JUL 2008 82. The importance of genetic polymorphisms of phase I and phase II enzymes in the development of atherosclerosis By: Taspinar, M.; Aydos, S.; Comez, O.; et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION Volume: 38 Issue: 5 Pages: 342-342 Meeting Abstract: KVBD6 Published: MAY 2008 83. By: Taspinar, M.; Comez, O.; Duzen, I. V.; et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION Volume: 38 Issue: 5 Pages: 355-355 Meeting Abstract: KVBD-45 Published: MAY 2008 84. CYP1A1 GST gene polymorphisms and risk of chronic myeloid leukaemia By: Taspinar, Mehmet; Aydos, Sena Erdogan; Comez, Omer; et al. SWISS MEDICAL WEEKLY Volume: 138 Issue: 1-2 Pages: 12-17 Published: JAN 12 2008 85. Genotype and allele frequencies of MDR1 gene C1236T polymorphism in a Turkish population By: Gumus-Akay, G.; Rustemoglu, A.; Karadag, A.; et al. GENETICS AND MOLECULAR RESEARCH Volume: 7 Issue: 4 Pages: 1193-1199 Published: 2008 86. Antiproliferative and apoptotic effects of wheatgrass (Triticum aestivum L.) extracts on chronic myeloid leukemia (CML) cell line By: Karadag, A.; Ozkan, T.; Altinok, B.; et al. Conference: 55th Annual Congress of the Society-for-Medicinal-Plant-Research Location: Karl Franzens Univ, Graz, AUSTRIA Date: SEP 02-06, 2007 Sponsor(s): Soc Med Plant Res PLANTA MEDICA Volume: 73 Issue: 9 Pages: 991-992 Meeting Abstract: P540 Published: AUG 86. 2007 87. Molecular pathogenesis of pancreatic cancer: Review By: Sahin, Fikret; Taspinar, Mehmet; Sunguroglu, Asuman TURKIYE KLINIKLERI TIP BILIMLERI DERGISI Volume: 27 Issue: 4 Pages: 560-566 Published: AUG 2007 88. Telomerase activity could be used as a marker for neoplastic transformation in gastric adenocarcinoma: but it does not have a prognostic significance By: Gumus-Akay, G.; Unal, A. E.; Bayar, S.; et al. GENETICS AND MOLECULAR RESEARCH Volume: 6 Issue: 1 Pages: 41-49 Published: 2007 89. Antiproliferative and apoptotic effects of garlic on chronic myeloid leukemia cell line By: Sunguroglu, A.; Akay, G. G.; Ozkal, P.; et al. Conference: 54th Annual Congress on Medicinal Plant Research Location: Helsinki, FINLAND Date: AUG 29-SEP 02, 2006 Soc Medicinal Plant Res; Univ Helsinki,Fac Pharm PLANTA MEDICA Volume: 72 Issue: 11 Pages: 1057-1057 Meeting Abstract: P252 Published: SEP 2006 90. Effects of aqueous garlic extract on oxidant/antioxidant status in 32 D and 32 Dp cell lines By: Durak, I; Sunguroglu, A.; Avci, A.; et al. Conference: 54th Annual Congress on Medicinal Plant Research Location: Helsinki, FINLAND Date: AUG 29-SEP 02, 2006 Sponsor(s): Soc Medicinal Plant Res; Univ Helsinki,Fac Pharm PLANTA MEDICA Volume: 72 Issue: 11 Pages: 1058-1058 Meeting Abstract: P256 Published: SEP 2006 91. D17S30 and TP53 VNTR loci polymorphisms in a Turkish population By: Gumus, G; Rustamov, A; Kadikiran, A; et al. HUMAN BIOLOGY Volume: 76 Issue: 5 Pages: 785-788 Published: OCT 2004 92. Transfer of BCR/ABL fusion gene to phagocyter cell by apoptotic bodies. By: Pekkurnaz, G; Tukun, A; Elhan, A; et al. Conference: AACR-NCI-EORTC International Conference on

Molecular Targets and Cancer Therapeutics Location: BOSTON, MASSACHUSETTS Date: NOV 17-21,2003 AACR; NCI; EORTC CLINICAL CANCER RESEARCH Volume: 9 Issue: 16 Supplement: S Pages: 6167S Part: 2 Published: DEC 1 2003 93. Common fragile sites associated with the breakpoints of chromosomal aberrations in hematologic neoplasms By: Gumus, G; Sunguroglu, A; Tukun, A; et al. CANCER GENETICS AND CYTOGENETICS Volume: 133 Issue: 2 Pages: 168-171 Article Number: PII S0165-4608(01)00569-6 Published: MAR 2002 94. Autoimmune hemolytic anemia in Philadelphia positive chronic myeloid leukemia with t(7;14) anomaly after 5 years of interferon alpha treatment By: Koksal, A; Ozatli, D; Haznedaroglu, IC; et al. HAEMATOLOGIA Volume: 32 Issue: 2 Pages: 163-167 Published: 2002 95. A sex-specific difference in homozygosity for HLA-DR53 in newborns By: Sunguroglu, A; Guc, D; Sipahi, TU; et al. TURKISH JOURNAL OF PEDIATRICS Volume: 40 Issue: 2 Pages: 211-216 Published: APR-JUN 1998 96. Donor leukocyte infusions for the treatment of leukemia relapse after allogeneic hematopoietic progenitor cell transplantation. By: Gurman, G; Arslan, O; Koc, H; et al. BLOOD Volume: 90 Issue: 10 Supplement: 1 Pages: 4452-4452 Part: 2 Published: NOV 15 1997 97. Donor mononuclear cells infusion and alfa interferon administration in relapsed chronic myeloid leukemia patients after allogeneic bone marrow transplantation By: Gurman, G; Koc, H; Akan, H; et al. BLOOD Volume: 88 Issue: 10 Supplement: 1 Pages: 3800-3800 Part: 2 Published: NOV 15 1996 98. ORBITO-OCULAR GRANULOCYTIC SARCOMA (OOGS) AND ACUTE MYELOBLASTIC-LEUKEMIA (AML) WITH DUPLICATION OF PHILADELPHIA-CHROMOSOME By: CAVDAR, AO; BOKESOY, I; SUNGUROGLU, A; et al. CANCER GENETICS AND CYTOGENETICS Volume: 69 Issue: 1 Pages: 38-40 Published: AUG 1993