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Dr Jian Zhou's Brilliant Mind-Part 2b

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80 2008 1 31

Nai Heng Zhang in Bei Jiang, 2008

9 i 1985 1978 1982 1982 1985 1984

1978 50 Toxicology and Applied Pharmacology 1985 1999 3 117 82

1984 Ying Han Xu (front middle), Jian Zhou(back right) and Hong Fu Zhang (back left)

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Dr Jian Zhou: Our PrideYinghan Xui

It has been nine years since Dr Jian Zhou left us. We are proud of his medical breakthrough on cervical cancer vaccine which has the huge potential to win a future Nobel Prize in Medicine as claimed by Time Magazine. It is even more significant as Dr Zhou is the first PhD educated in Mainland China to achieve such a hardearned glory. Dr Zhou has always been very proud of his Chinese heritage even though most of his world class medical research was done overseas. As Dr Zhous Master Degree supervisor, I have always been impressed by his hard work and diligence. Dr Zhous Master Degree thesis was awarded the best research achievement in 1985 by the Scientific Academy of Zhejiang Province. Dr Zhous early success in medical research was reported by China Daily before he started his research at Cambridge in 1989. The best student I have supervised 14 post-graduate students for Masters Degree in my academic life since 1978. I prefer quality to quantity therefore I only take in one post-graduate student per-year based only on their merit. They have all achieved success in their field and two of them are current university Chancellors. Dr Zhou was my fifth student but he is unarguably the best in academic achievement. Dr Zhous early departure is my biggest regret. Dr Zhou studied medicine at Wenzhou Medical School, graduating in 1982. He came to me the same year to enquire about post-graduate study under my supervision. He was a young energetic man with tall slim build accompanied by his wife Dr Sun. I took him under my wing after he passed the national entry exam with high distinction in both general and academic subjects. He had showed huge potential in medical research in the way he has analysed and solved the academic questions designed by me in the exam. The brilliant young researcher A good scientific researcher requires the virtue of honesty, diligence and excellent observation skills. One of the most important aspects is the ability to write and summarize the laboratory records daily. Dr Zhou had a brilliant eye for scientific detail. He has showed the excellent ability to design and conduct experiments as well as to record and analyse laboratory data. Dr Zhou was one of my best post-graduate students. From 1982 to 1985, Dr Zhou had worked very hard in my laboratory. Sometimes he had worked day and night in order to conduct a series of experiments which require continuous observation involving cell cultures. He has sacrificed many weekends and holidays for his research. Dr Zhou has also showed his extraordinary ability to modify and convert discarded domestic equipments such as refrigerators, centrifuges and incubators into laboratory use in order to conduct experiments with limited budget and meeting the high demands of the national research training work-shop. The key member of macrophage research In 1980s my laboratory played a leading role in the research of the morphology and function of alveolar macrophage nationally. The research has found a close relationship between the level of environmental pollution and the changes in macrophage cells in the lungs, which has national significance. In order to advance the research into this field, we have conducted an extensive training course nationally in 1984. More than 100 experts in pathophysiology, public health and general medicine attended the course. Dr Zhou was the key lecturer as well as the key organizer. The friendship We have forged a very good relationship as mentor and apprentice because we both shared a passion for medical research. We devoted our effort to plan and work efficiently with excellent work ethics. I have set strict laboratory rules and appeared stern while at work. Dr Zhou has enjoyed working in my laboratory because of our mutual understanding. We have also enjoyed a good relationship as friends. We have visited each others house on the weekends and shared laughs together.

Thesis published on I have started research on the alveolar macrophage culture in vitro since 1978. All my post-graduate students research was involved in this area. As my fifth Masters student, Dr Zhous research was focused on lead and alveolar macrophage. Based on my research of lead poisoning on animal model in 1950s, Dr Zhou designed his Master research on the effects of lead ion on alveolar macrophages after intensive literature review. He was the first to conduct research on the effects of lead ion on the immune function of alveolar macrophages. The research was published on titled The effects of lead ion on immune function of rabbit alveolar macrophages: quantitation of immune pathagocytosis and Fc-rosette formation by 51Cr in vitro. Dr Zhou has also published two research articles on this topic in and respectively. Our research in this area has been awarded the best research achievement in 1985 by the Scientific Academy of Zhejiang Province. Successful career After Dr Zhou finished his Master research in my laboratory, I was really hoping that he could have stayed on to assist my research. His father also wished that he would continue his career in his hometown. Instead, Dr Zhou started his PhD study with Professor Sun at Henan Medical School to advance his career. I understood his move and his ambition in medical research. The worlds first cervical cancer vaccine was created after Dr Zhous life long hard work and research. Cervical cancer is one of the most common cancers which has killed many women. My grand mother and mother were both died from cervical cancer. Dr Zhous vaccine makes it possible for us to wipe it out in the future. I am really happy that Dr Zhou has made an incredible medical breakthrough and great contribution to human wellbeing. Early departure I received a unexpected phone call from Dr Zhous sister and learnt of his sudden death in March 1999. Dr Zhou died at the 117 Hospital, Hangzhou from septic shock. I wish I would have visited him at the hospital before his tragic departure. As a young man, Dr Zhou has achieved incredible success in medical research. He would have made even greater contribution to medical research and human wellbeing if his life had not been cut short. Dr Zhou, the world are a better place because of your great contribution to humanity, you can sleep peacefully. The Australian government has set up a fund in your name in honour of your contribution. I, am 82 years old chap and your Masters supervisor, I am really pride of you the best student ever!i

Professor Yinghan Xu, Medical School, Zhejiang University

, 20 1983 Hans Wolf DNA 61116 18 DNA EB 1986 DNA Hans Wolf Laboratory Manual Course on Molecular Virology19831985 Elu-tipd columns DNA Lionel Crawford 1990 Lionel Crawford Lionel Crawford EB Antibodies A Laboratory Manual. Molecular Biology of the Cell

1997 From left: Jian Zhou and Shu Yan Gu in Brisbane,1997.

A Letter to Xiaoyi Sun: Memories of Jian Zhou

Dear Xiao Yi As a friend of Dr Jian Zhou and his former supervisor, it is my great honor to write some words in memory of him. At the moment, all the memories regarding Jian Zhou are coming back to me. I would like to recall how we met and what I had learned from him when we worked together. I would also like to say something about his attitude towards his research work, his inter-personal relationship skills that had inspired me. Jian and I became to know each other due to a project of Human Papilloma Virus (HPV) about 20 years ago. I brought back several dozens of HPV DNA clones including 6, 11, 16 and 18 types which are related to the human tumors from the Prof. Hans Wolfs Lab in Germany examined the HPV DNA of papilloma wart and cervical cancer tissue using the methods of nucleic acid in situ hybridization and indirect nucleic acid hybridization. I then published the first research paper on this area in China. However as my major research project at that time was Epstein-Barr virus (EB virus). I did not continue the research on the HPV. In 1986, Jian intended to expand his PhD research project to study the relationship between the HPV and esophageal cancer. At that time, there were only a few biochemical labs in China, and only myself had many types of HPV DNA. He was in Beijing to wait for my coming back from Germany. I was persuaded by his envisagement, and our close personal relationship started from the HPV. During my stay in Germany, Prof. Hans Wolf and I co-authored a Laboratory Manual which was used widely as a teaching material in Molecular Virology in Beijing, Guangzhou, and some other places from 1983 to 1985. That was the major operating protocol applied by Dr. Jian Zhou. Worked very hard and diligently, Jian became familiar with the operation quickly and successfully completed his project in our laboratory. He was always the first one coming to the laboratory and the last one leaving. He even very bravely helped to extinguish an accidental fire in the laboratory. We usually learned something new from each other. We also exchanged ideas and discussed experimental work and the problems we faced in research. He was really good at problem solving. Elu-tipd columns are a tool to purify nucleic acid, and it could not be purchased in China at that time. However, Jian Zhou found a way to recycle them for re-use. Our friendship was formed and built up in the laboratory. Outwardly, he was a PhD student and I was a supervisor, but inwardly we were good friend. In the following years, no matter he was in Britain,