Tablets

1.

2.

() 2005

1.(Compressed tablets)0.1g0.5gB1 (Coated tablets)(sugar coated tablets)(film coated tablets)(enteric coated tablets) (Multilayer tablets)(Tablets by dry coating) (Model tablets)

2.

(Buccal tablets, Toroches) (Buccal patch) (Chewable tablets)(Sublingual tablets)(Vaginal tabets)(Implant tabets)(Hypodermic tablets)

3.

(Immediate release tablets) (Sustained release tablets)(Controlled release tablets)(Dispersible tablets )(Effervescent tablets)#/CO2 (Solution tablets)

4.

AdjuvantsAdditivesExcipients() ()

()(Fillers)(Diluents)(Absorbents)5mm100mg (50mg)

(Starch)#200-980MW 104-105 20%1.

-Pregelatinized starch

(Lactose)# -

(Dextrin)MW 102-10480%

(Sugar)

MannitolSorbitol

2.

(Microcrystalline cellulose, MCC)# 101102

(Powdered cellulose)1500MW 2.43105,

(Calcium sulphate) 70C

()Moistening agents

(Distilled water)

(Ethanol)()

()Adhesives)

1.#hydroxypropylmethylcellulose,HPMC 2%5%550cPas hydroxypropylcellulose,HPC(MCC)methylcellulose,MC (carboxymethylcellulose ,CMC-Na ethylcellulose,EC

2polyvinylpyrrolidine,PVP#K15K30K90 10% PVP K30 3.(Starch slurry) 70C520% (Dextrin) (Sugar and Syrup) 1070g/g

4.(Mucilage)5101025

()(Disintegrants)

+>> >>

1. croscarmellose sodium,CCNa Ac-Di-Sol 0.5%5%

2. crospovidone, PVPP0.5%5% 3. carboxymethyl starch sodium, CMS-Na#2

4.L-HPC#500%700% 25

5. 5%20%

6. 80SDS

()(Lubricants)

1.(glidants)(anti-adherents)(lubricants)

()200

2. 60

3.(Magnesium stearate)0.3%1% (Talc) 5%(Hydronated plant oil)

PEG PEG4000600050um

Sodium dodecyl sulphate,SDS

Colloidal silicon dioxide, aerosil100-350m2/g 0.15%3% Aerosil

Talc

()

Color additives, Colorants, Coloring agents

Aromatizing agents,

Sweetening agents

wet granulation

2.12345 3.

()Granulation

1.# (Extrusion) (1).1) 801001202) 3)

(2). 12-20

2#(Wheeling)+2-3mm

3.#(Fluid bed) 30-80

4.#(Spray dry) 50%60%()

5.#(High-velocity shearing)

()()()

6.#(Compound device)++

7.Spherical crystallization in liquids

(Drying)

(Re-granulation)

()(Tableting) 1.

1() ()%+=100 mg /50%=200mg7.5%185-215mg

2.

# (Single punch tablet press)

12

123

123456

()

#(Rotary tablet press)()()(////) 161927335575

Dry granulation and press tablets 12.

31pressure roll process

2double compressionslugging method19mm5-20g

(press tablets directly)

1

C

212123(MCC)()

/

(Capping, Laminating)#/

(Cracking, Chipping)

Sticking, Binding

(Delay of disintegration)

5.(Variance of tablet weight beyond the limit)

6.(Color changes or spots)

7.(Disqualification of content uniformity)

8.

(Tablet coating)1.

2.

3.

1. 2. 3.

1.#(Pan coating)+3040 2040/min

( fluidized bed coating)

compression coating123

()(Film coating) 25

()(Solvents)30%E30D ()(Plasticizers) ()

(Sugar coating) 1 // 30-35%10-15%65%:

+40C-50C3-5 +40C 55C15-1840C15-1840C(Glassing)2%24

()(Apperance) 10075W60cm30cm30s

()(Hardness)#

()(Friability)#% 2000

Roche25r/min100(4min)1%()RH%40%

()(Variance of tablet weight)%

()(Content uniformity)

()(Limit for disintegration time)2mm

61000ml371C3032

()(Dissolution)#

?

()1000ml37C 0.5C50200

()(Limit for microbes)

1000/g100/g

()( ) ()+()

(Examples)

() [] 400g 800g HPMC3% 180200g 80g 3g 1000

[]+80HPMC141670C80C14

()

[] 268g 136g 33.4g (17%) 15g 266g 0.25g 1000

[]+1001/31470C12[]1. 100C105C2.

()

[] 5g 50% 60g 0.7g 18g 1.5g 1000[] 50%

[]+501655C16[] B2

[] 88.8g 38.0g 17% 10% (0.6g) 1.0g 1000(0.5mg/)

[]301040C50-60 []

[] 1 57.5g 10% 10g 3.6g 1000

Eudragit L100 28g 85% 560ml 80 5.6g 16.8g 5.6g 16.8g

[]1080-90C5g12Eudragit85%80

[]