1 動物科技系 營養生技實驗室 研究室：生資大樓 302 室...
Post on 21-Dec-2015
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- 1 302 430
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- 4 inflammatory bowel disease (IBD) (Ulcerative colitis, UC) (Ulcerative colitis, UC) (Crohns disease, CD) (Crohns disease, CD) 7 / /
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- 5 (UC) 15-35
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- 6 (Crohn s disease, CD)
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- 7 Innate immune response Macrophage Macrophage IL-1 IL-1 IL-6 IL-6 IL-8 IL-8 IL-12 T T H 1 IL-12 T T H 1 TNF- TNF- Dendritic cell Dendritic cell IL-12 IL-12 Neutrophils Neutrophils
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- 8 IBD ( ) TNF- -Infliximab Mesalamine (Asacol, 5-ASA) Probiotic Steroid UC - DS -
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- 9 9 (a)17 (b)24 (Franklin et al., 2002)
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- 10
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- 11 (A) (B) Montagne et al., 2007 (C) (D) a cc c b a cc bb a a b bb a bbbb a b b bb a b b b b
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- 12 ( ) ( ) / ( ) 20082294146168547 20092301142065946
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- 13 ( ) ( ) (kg) 20086428731191.36 20096138751191.43
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- 14 ( ) 95000 613 613 5955 46980 9725
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- 15 IBD IBD
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- 16 ?
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- 17 - 3.
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- 18
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- 19 ( ) ( ) (MHC) (MHC)
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- 20 T B T B ( ) ( )
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- 21 5. (A) (B) (C)M (IEL) (ILP) (PP) (MLN) (Spleen)
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- 22
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- 23 - 70% 70%
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- 24 FIG. A schematic representation of the temporal nature of the host immune response to invasion by a pathogenic microorganism.
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- 25 (Klasing, 1998)
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- 27 2. G27 S93 Lane 1 MK Lane 2 hEGF Lane 3 GS115 Lane 4 G27 0 h Lane 5 G27 72 h Lane 6 SMD1168 Lane 7 S93 0 h Lane 8 S93 72 h 1 2 3 4 5 6 7 8 6 kDa (EGF)
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- 28 3. ( MeOH =0.028 h -1 ) pEG F
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- 29 (4) pEGF 1.5 mg/kg 14 32 14 (1) (2) pEGF 0.5 mg/kg (3) pEGF 1.0 mg/kg
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- 30 a cDNA EGF 0 0.5 1.0 1.5 Fig. 8. Effects of diets supplemented with recombinant pEGF on jejunal maltase in early-weaned piglets * * (c) Activity GAPDH Maltase
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- 31 0.6% OA ( ) 0.1% NT ( ) 0.6% 0.1%
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- 32 4. PWM a) 28 (b) 46 * * * 64 % 10 % 79 %
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- 33 (resistant starch, RS) 1992 -
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- 34 Wheat starch ItemCornDriedSteamed Autoclav ed- cooled Total starch (%) 58.8492.5287.7478.07 Resistant starch (%) 3.250.053.397.58
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- 35 11. 35 T P
- 53 DPPH > 100 umol trolox /g TEAC > 100~200 umol trolox /g > 10~30 mg/g > 50% Amylase > 400~1200 U/g (per min)
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- 54 a b mg/kg b bb nmol/mg, protein mg/kg bacdd 1 (A) (B) (MDA)
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- 55 2 (A) CuZn-SOD mg/kg b ab a a mg/kg a b b b b (B)
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- 56 3 mg/kg (A) a ab b b mg/kg (B) a ab a c bc
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- 57 2
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- 59 ( ) ( ) ( )
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- 62 : 40% : 40% : 60% : 60% 12 24
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