高血压综合危险因素防控

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高血压综合危险因素防控. 北京同仁医院心脏中心 王吉云. 目录. 最新高血压指南推荐高血压患者进行综合防治 综合防治是降低心血管事件风险的重要手段 阿司匹林是综合防治的重要部分 规范使用阿司匹林. 2010 中国高血压防治指南发布. 2010 年高血压指南于 2011 年 5 月 15 日发布. 发表机构: 卫生部疾病预防控制局 中国高血压联盟 国家心血管病中心. 中国高血压指南 2010 年版是 自 05 年的再次修订. 新指南、新亮点 —— 综合防治是高血压管理的重要手段. 美国指南更新也将强调综合防治. - PowerPoint PPT Presentation

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  • ()Ann N Y Acad Sci. 2001 Dec;947:271-92Common approaches to therapy in atherosclerosis and cancer

    Reduce oxidative stress by eliminating cigarette smoking, reducing dietary fat intake, and administering antioxidant therapeutics Use anti-inflammatory agents to reduce chemokine, cytokine, and growth factor signaling Employ anti-proliferative drugs targeting growth factor receptors to reduce cell proliferation (i.e., postangioplasty restenosis in coronary and carotid atherosclerosis) Reduce excess matrix digestion caused by metalloprotease hyperactivity Reduce NFB signaling with proteasome inhibitors Use antiangiogenesis strategies to delay plaque expansion in therosclerosis and cancer invasion and metastasis Use radiation treatment (not proven to date) to prevent restenosis after angioplasty and stent placement

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  • Professor Peter Rothwell, John Radcliffe Hospital, Oxford, and University of Oxford, UK, noted that previous guidelines have rightly cautioned that in healthy middle aged people the small risk of bleeding on aspirin partly offsets the benefit from prevention of strokes and heart attacks, but the reductions in deaths due to several common cancers will now alter this balance for many people.Peter RothwellLancet.Published Online December 7, 2010 Peter Rothwell

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  • ****ATP IVJNC8obesity2,Trends in vascular and non-vascular mortality rates in UK populationThe figure shows the age standardised annual UK mortality rates for vascular and non-vascular causes ofdeath at ages 35-69 between 1950 and 2005. Throughout this period, vascular mortality rates in middle age in men were about twice those in women, peaking in 1970 and declining linearly by about 2% a year in both sexes (or by almost 70% between 1970 and 2005). The proportion of deaths attributed to vascular disease in middle age also declined between 1970 and 2005, from about 50% to 30% in men and from 40% to 20% in women. The figure also shows age standardised mortality rates from vascular and non-vascular causes for men and women aged 70-79. For both sexes, the absolute mortality rates in old age were about fivefold greater than those in middle age. In old age, vascular mortality rates declined by about two thirds between 1950 and 2005 in both men and women, but non-vascular mortality rates declined to a much lesser extent in this age group. The proportion of deaths attributed to vascular disease in old age declined from about 60% in 1950 to less than 40% in 2005 for both men and women.**68647-55681025737.4%199229.2%RR1.695%CL1.4-2.127.6% vs.14.2%

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    **123()45NFB67 Reduce oxidative stress by eliminating cigarette smoking, reducing dietary fat intake, and administering antioxidant therapeutics Use anti-inflammatory agents to reduce chemokine, cytokine, and growth factor signaling Employ anti-proliferative drugs targeting growth factor receptors to reduce cell proliferation (i.e., post angioplasty restenosis in coronary and carotid atherosclerosis) Reduce excess matrix digestion caused by metalloprotease hyperactivity Reduce NFB signaling with proteasome inhibitors Use antiangiogenesis strategies to delay plaque expansion in therosclerosis and cancer invasion and metastasis Use radiation treatment (not proven to date) to prevent restenosis after angioplasty and stent placement

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