ภาวะแทรกซ้อนทางอายุรกรรมและศัลยกรรม...
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ภาวะแทรกซ้อนทางอายุรกรรมและศัลยกรรม Medical and surgical complications. พญ.ฐิติมา ชัยศรีสวัสดิ์สุข กลุ่มงานสูติศาสตร์และนรีเวชกรรม รพ.สรรพสิทธิประสงค์ อุบลราชธานี. Cardiac disease. Incidence. Complicate 1% of pregnancy But contribute significant maternal morbidity and mortality rate - PowerPoint PPT PresentationTRANSCRIPT
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Medical and surgical Medical and surgical complicationscomplications
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Cardiac diseaseCardiac disease
IncidenceIncidence
Complicate 1% of pregnancy
But contribute significant maternal morbidity and mortality rate
Mortality rate is about 2.7 : 1000 pregnancy
Why we take cardiac Why we take cardiac dz in pregnancy so dz in pregnancy so
serious?serious?
Pregnancy induce worsen cardiac diseases during antepartum, intrapartum and postpartum period
Physiologic change in hemodinamic of pregnancy mimics clinical finding of cardiac dz.
Antepartum period
Cardiac output is increase by 30-50%
Total blood volume is increase about 50%
Increase heart rate by 10-20 beats/min
Decrease in peripheral vascular resistant
Effect of pregnancy on Effect of pregnancy on cardiac diseasecardiac disease
Effect of pregnancy on Effect of pregnancy on cardiac diseasecardiac disease
Intrapartum and delivery
Consumption of energy and oxygen is increase
Pain increases sympathetic tone
Uterine contractions induce wide swings in the systemic venous return
Effect of pregnancy on Effect of pregnancy on cardiac diseasecardiac disease
Postpartum
Autotransfusion of at least 500 ml occur wiht placental separation
During first 2 days of postpartum period, great amount of fluid from interstitial tissue return into the systemic circulation
Physiologic change in Physiologic change in pregnancy mimics pregnancy mimics
cardiac dzcardiac dz
Functional systolic heart murmur
Respiratory effort
Edema in the lower extremities
Various heart sounds may suggest cardiac dz.
Clinical indicators of Clinical indicators of cardiac dz. in cardiac dz. in
pregnancypregnancyProgressive dyspnea or orthopnea
Nocturnal cough
Hemoptysis
Syncope
Chest pain
Cyanosis
Clubbing of fingers
Persistent neck vein distension
Systolic murmur > gr.3
Diastolic murmur
persistent split 2nd sound
Symptoms Clinical finding
Diagnostic studyDiagnostic study
EKG (15 degree left axis deviation, mild ST changes in inferior leads, atrial and ventricular premature contractions)
CXR
Echocardiography
Clinical classification Clinical classification of cardiac dz.of cardiac dz.(New York Heart (New York Heart
Association; NYHA)Association; NYHA)Class 1: Uncompromised -- no limitation of physical activity
Class 11: Slight limitation of physical activity
Class 111: Marked limitation of physical activity
Class 1v: Severely compromised -- inability to perform any physical activity without discomfort
Predictors of cardiac Predictors of cardiac complicationscomplications
Prior heart failure, transient ischemic attack, arrhythmia, or stroke
Baseline NYHA class 111 or 1v or cyanosis
Left-sided obstruction: mitral valve area <2cm2, aortic valve area less than 1.5 cm2, or peak left ventricular out flow tract gradient above 30 mm Hg
Ejection fraction less than 40%
PrognosisPrognosis
The likelihood of a favorable outcome for the mother with heart disease depends upon
1. Functional cardiac capacity
2. Other complications that further increase cardiac load
3. Quality of medical care provided
Valvular Heart Lesions Associated with High Maternal and/or Fetal Risk During Pregnancy
Severe AS with or without symptoms
AR with NYHA functional class III-IV symptoms
MS with NYHA functional class II-IV symptoms
MR with NYHA functional class III-IV symptoms
Aortic and/or mitral valve disease resulting in severe pulmonary hypertension
Aortic and/or mitral valve disease with significant LV disfunction (EF < 40%)
Mechanical prosthetic valve requiring anticoagulation
Marfan syndrome with or without AR
High-Risk Maternal Cardiovascular Disorders
• Aortic valve stenosis 10-20 • Coarctation of the aorta 5• Marfan syndrome 10-20• Peripartum cardiomyopathy 15-60• Severe pulmonary hypertension 50• Tetralogy of Fallot 10
DisorderEstimated MaternalMortality Rate (%)
Management in Management in cardiac diseasescardiac diseases
Preconceptional Preconceptional counselingcounseling
Maternal mortality rates vary directly with functional classification BUT may change as pregnancy progresses.
By corrective surgery, subsequent pregnancy is less dangerous. If mechanical valves taking warfarin, fetal risk should be consider.
Congenital heart lesions could be inherited.
Congenital heart disease risks in fetus with affected family members
Congenital heart disease risks in fetus with affected family members
Management of NYHA Management of NYHA Class I and II DiseaseClass I and II DiseaseMostly deliver without morbidity
Prevention and early detection of heart failure
Prevent infection and sepsis syndrome
Prevention of bacterial endocarditis
Pneumococcal and influenza vaccination
Avoid smoking, intravenous drug use
Signs of congestive heart Signs of congestive heart failurefailure
Persistent basilar rales
Nocturnal cough
Sudden limitation of normal activities
Dyspnea on exertion
Smothering with cough
Hemoptysis, Progressive edema, tachycardia
Warning signsSerious signs
Vaginal delivery with short second stage unless obstetrical indication is obtained for C/S
Labor and delivery
Rout of delivery
MonitoryV/S : if PR > 100 bpm or RR > 24 tpm with dyspnea, may suggest impending ventricular failure
Analgesia and AnesthesiaEpidural analgesia is recommended in most
case
General anesthesia is preferable in case of intracardiac shunts, pulmonary hypertension and aortic stenosis
Proper therapeutic approach depends on the specific hemodynamic status and the underlying cardiac lesion.
Labor and delivery
Intrapartum heart failure
Puerperium
Woman who have no evidence of cardiac distress during pregnancy, labor, or delivery may still decompensate postpartum
Avoid : Postpartum hemorrhage, anemia, infection, and thromboembolism ( cause much more serious complication in heart disease)
Sterilization : should delay until hemodynamically near normal, afebrile, not anemic and ambulates normally
Oral combine pills: should avoid because they can induce thrombosis
DMPA: can use safely, but hematoma should be monitors
Implant: safely use, less hematoma complication
IUDs: safely use, but ATB should be given for endocarditis prevention
Contraception
Pregnancy interruption is preferable
If the pregnancy is continued, prolonged hospitalization or bed rest is often necessary
Epidural analgesia usually recommended
vaginal delivery is preferred in most cases, and labor induction can usually be done safely
C/S is limited to obstetrical indications
Need ICU care, experienced obstetrician and anesthesiologist
Management of NYHA Management of NYHA Class III and IV Class III and IV
DiseaseDisease
Valve replacement Valve replacement before pregnancybefore pregnancy
Mechanical valve itself doesn’t effect on pregnancy.
Thromboembolism involving the prosthesis and hemorrhage from anticoagulation are of extreme concern
Overall; maternal mortality rate = 3-4% with mechanical valves, and fetal loss is common
Effects on pregnancy
Management
The critical issue for mechanical prosthetic valves is anticoagulation: thromboembolic issue VS bleeding , teratogenic issue
Most effective to prevent mechanical valve thrombosis
Cause teratogenic and miscarriage, still birth and fetal malformation
Highest risk is when mean daily dose exceeded 5 mg
Anticoagulation agent
Warfarin
No teratogenic issue
Is definitely inadequate control of thromboembolism
Anticoagulation agent
Low dose unfractionated heparin
Unfractionated heparin or low-molecular-weight heparins
Report of valvular thrombosis
ACOG(2002) advised against use of LMWH during pregnancy.
American College of Chest Physicians has recommended us of UFH or LMWH given throughout pregnancy
American College of Chest Physicians Guidelines for Anticoagulation of pregnant women with mechanical
prosthetic valves
American College of Chest Physicians Guidelines for Anticoagulation of pregnant women with mechanical
prosthetic valves
Bacterial endocarditis Bacterial endocarditis prophylaxisprophylaxis
Estimate incidence of transient bacteremia at delivery is 1-5%
ATB prophylaxis is optional for uncomplicated delivery
Ampicillin 2 g. or cefazolin/ceftriaxone 1 g. IV 30-60 minutes before the procedure
For penicillin-sensitive pt. : Cefazolin/ceftriaxone 1 g., or if anaphylaxis, Clindamycin 600 mg IV 30-60 minutes before the procedure
Regimen recommended
American Heart Association Guidelines for Endocarditis Prophylaxis with Dental Procedures
American Heart Association Guidelines for Endocarditis Prophylaxis with Dental Procedures
Thyroid DisordersThyroid Disorders
Thyroid physiology Thyroid physiology and pregnancyand pregnancy
Thyroid binding globulin
TSH in early pregnancy
Thyroxine cross placenta and is important for normal fetal brain development and fetal thyroid gland function
90
HyperthyroidismHyperthyroidism
1:1000 - 2000 pregnancies
Mild thyrotoxicosis may be difficult to Dx during pregnancy
Most common cause : Graves disease
Molar pregnancy should be considered
Prior Hx of thyrotoxicosis/autoimmune thyroid dz in pt or in her family
Presence of typical symptoms of thyrotoxicosis : weight loss ( or failure to wt gain), palpitations, proximal muscle weakness
Symptoms suggestive of Graves disease like opthalmopathy, pretibial myxedema
Thyroid enlargement
occurrence of hyperemesis gravidarum leading to wt loss
Clinical features suggestive of possibility of hyperthyroidism
Historical
Pulse > 100 bpm
Widened pulse pressure
Eye signs of Graves disease or pretibial myxedema
Thyroid enlargement esp. in iodine sufficient geographical area
Onycholysis
Clinical features suggestive of possibility of hyperthyroidism
Physical examination
confirmed by laboratory tests
Serum TSH <0.1 mIU/L
Elevated Serum FT4 & FT3 levels
Thyroid autoantibodies
Diagnosis
Women with active Graves dz Dx pregnancy
Women who are in remission and considered cured after primary treatment
Women who is in diagnosis of Graves dz has not been established before the onset of pregnancy but have TSHR Ab
Graves disease in pregnancy
Both maternal & fetal outcome is directly related to adequate control of hyperthyroidism
Obstetric complication : Preeclampsia, fetal malformations, premature delivery, low birth weight
The risk of fetal and neonatal hyperthyroidism is negligible in euthyroid women not currently receiving ATD, but had received ATD previously for graves dz
For euthyroid women who has previously received radioiodine therapy or undergone thyroid surgery for graves dz, the risk of fetal & neonatal hyperthyroidism depends on level of TSHR Ab in mother
So these antibodies had to be measured early in pregnancy to evaluate the risk
Graves disease in pregnancy
For pregnant woman who takes ATDs for active graves dz, TSHR Ab should be checked again in 3rd trimestter
If the Ab titers have not decreased during the 2nd trimester, the possibility of fetal hyperthyroidism is to be considered
Graves disease in pregnancy
Hyperthyroidism due to graves tends to improve during pregnancy. ( Although exacerbations in early months of pregnancy)
Partial immunosuppression (due to pregnancy) with significant decrease in TSHR Ab titer
Marked increase serum TBG = reduce FT3 & FT4
Graves disease in pregnancy
Reasons
Monitor PR, wt gain, thyroid size, FT4, FT3, TSH monthly)
Use lowest dose of ATD (not > 300mg of PTU) : maintain euthyroid or mildly hyperthyroid state.
Follow fetal pulse & growth
Should Not attemp full normalization of serum TSH (Keep TSH 0.1-0.4 mU/L ) lower levels are acceptable if pt is doing well clinically
Management of hyperthyroidism
Propylthiouracil (PTU) is preferred to methimazole, but both can be used
Methimazole could cause embryopathy (esophageal or choanal atresia or aplasia cutis)
Iodides should not used during pregnancy unless for preparing the patient for surgery
Management of hyperthyroidism
Requirement for high doses of PTU/MMI with inadequate control of clinical hyperthyroidism
Poor compliance with resulting clinical hyperthyroidism
Appearance of fetal hypothyroidism at dose required to control disease in mother
Management of hyperthyroidism
Indication for surgery
Usually the dose of ATD can be adjusted downward after 1st trimester & discontinued during 3rd trimester
ATDs often need to be reconstituted/increased after delivery
Management of hyperthyroidism
Pulmonary hypertension and heart failure from cardiomyopathy caused by thyroxine is common in pregnant women
High-output state dilated cardiomyophthy
Cardiac decompensation is usually precipitated by preeclampsia, anemia, sepsis, or combination
Fortunately, thyroxine-induced cardiomyopathy and pulmonary hypertension are frequently reversible
Thyroid storm and heart failure
ICU is needed
1000mg of PTU orally the 200mg every 6 hr
An hour after initial PTU, iodide is given to inhibit thyroidal release of T3 & T4
Sodium iodide 500-10000mg of sodium iodide IV every 8 hrs.
Supersaturated solution of potassium iodide (SSKI) 5 drops or Lugol solution 10 drops orally every 8 hr
Thyroid storm and heart failure
Management
Dexamethasone 2 mg IV every 6 hrs. for IV dose for blocking peripheral conversion of T4 to T3
Beta-blocker drug is given to control tachycardia
Coexisting severe preeclampsia, infection, or anemia should be aggressively managed
Thyroid storm and heart failure
Management
Cannot be diagnosed based on clinical features
Usually diagnosed using biochemical tests
Characterised by raised TSH level
Affects 2.5% of all pregnancies
In iodine sufficient areas, most common cause is Hashimoto’s thyroiditis
Diagnosis of maternal hypothyroidism is important as has implication on both maternal and fetal outcomes
HypothyroidismHypothyroidism
Adverse outcomes of maternal hypothyroidism
Abortion
Gestational hypertension
Increased C/S
Anemia
Placental abruption
Preterm labour
Postpartum hemorrhage
Preterm birth
Fetal and perinatal death
Disorders of brain development
Low IQ scores
Fetal respiratory distress
Low birth weight
Cretinism
Maternal disorders
Fetal disorders
Difficult to detect hypothyroidism during pregnancy base on symptoms & signs alone
Diagnosis is made by Serum TSH
Serum TSH that is more than upper limit of normal should alert the clinician to diagnosis
Total or FT4 must be checked during screening
As low T4 even with normal TSH is considered abnormal (especially in iodine deficient zone)
Diagnosis
Levothyroxine is treatment of choice
Dosage: 2ug/kg/day
Subclinical hypothyroid OR TSH < 10 mU/L starting dose is 50-100 ug/day
Pregestational hypothyroidism require a 25-47% increase in dosage
Hypothyroid woman taking levothyroxine becomes pregnant, the dose is increased by 25-50 ug as soon as pregnancy is diagnosed
Management
Iron and calcium tablets should not take simultaneously with levothyroxine, may be taken 4 hrs after taking levothyroxine
First half of pregnancy - monitor Ft4, TSH every 4 wks
Later on every 6 wk
Target TSH in 1st trimester <2.5 mU/L
Target TSH in 2nd 3rd trimester <3 mU/L
Management
Monitor
Post delivery dose should reduced to pre-pregnancy dose
Thyroid function should be re-checked 6 wks after delivery
Management
Surgical complication Surgical complication in pregnancyin pregnancy
AppendicitisAppendicitis
1:2000 to 1:6000 pregnancies
Difficult diagnosis
Intermediate intervention is a must
Some time difficult in pregnancy
Displacement
Distorted lab values
Mimic symptoms
Mimic other conditions
Diagnosis
Leukocytosis
N/V, Tachycardia
Cholecystitis
Preterm labor
Pyelonephritis
Renal colic
Placental abruption
Degenerative myoma
Diagnosis
Mimic conditions
1975 Study Parkland: 34 pts over 15 year
Direct abdominal tenderness is rarely absent
Rebound tenderness 55-75%
Rectal tenderness: especially 1st trimester
Anorexia is only 1/3-2/3 pts, VS almost 100% in non pregnancy
Symptoms & Signs
(Cunningham 1975)
Ultrasound
CT scan
MRI
Diagnostic test
Difficult: cecal displacement and uterine imposition
Ultrasound
Numerous report in surgical literature suggesting accuracy of > 97% in non-pregnant patient
2008 study reported
Negative appendectomy rate was 54% with clinical Dx alone
8% if U/S +CT scan
CT scan
CT scan
* NO evidence of any increased risk of teratogenicity with exposure of up to 5 Rads
CT scan and teratogenicity
Maximal risk at 1 rad is 0.003%
15% embryos naturally abort
2.7-3.0% have genetic malformations
4% IUGR
-8-10% late onset genetic abnormalities
(Brent RL. 1989)
Preterm contractions/ labor
Rupture leading to peritonitis
Sepsis
Fetal tachycardia
Maternal/fetal death
Risks if untreated
Increased GA = Increased complication
Uterine contraction - as high as 80% of pts > 24 wks GA
Appendiceal perforation
4-19% non- pregnant pts
57% pregnant pts (inability to isolate infection by omentum)
Incidence of perforation = 8, 12, 20 percent in successive trimesters
Risks if untreated
Am Sur 2000
“ The mortality of appendicitis complicating pregnancy is the
mortality of delay”
Babler 1908
Suspicion:
Immediate surgery (Laparotomy VS Laparoscopy)
Delay:
Generalized peritonitis
Antibiotics
Perioperative 2nd cephalosporin/ 3rd penicillin, may be discontinued post-op,
Management
Safe - esp. in first 20 wks
Risk
Low birth weight
Preterm labor
Fetal growth restriction (no diff. VS laparotomy)
Fetal acidemia (CO2 Pneumoperitoneum)
Laparoscopy
General anesthesia considered safe
May increase risk of neural tube defects and hydrocephaly when general anesthesia is used in first trimester
General anesthesia
Increased biliary sludge in pregnancy
Increase bile viscosity
Increased micelles
Gall bladder relaxation
Increased risk of gallstone formation
Cholelithiasis cause of 90% of cystitis
0.2-0.5/1000 pregnancies require surgery
Gall bladderGall bladder
May be asymptomatic
2.5-10% of pregnant patient
RUQ pain- most reliable symptom
pain may radiate to back
Vomiting approx 50%
Can mimic appendicitis in 3rd trimester
Symptoms
Ultrasound
Effective rate 90%
Liver enzymes
Amylase, Lipase
CBC
Workup
Several studies - Conservative vs. Surgical
Current management favour surgical management
Conservative treatment trend to be high recurrence rate during the same pregnancy and if in later gestation : Incidence of preterm labor is higher
Management
Laparoscopic approach is safe, generally to 3rd
trimester
Slight increase of low birth weight
Slight increase of infant death within 7 day
Increase in contractions esp. > 24 wk
Surgical Management
Est. 1:200 deliveries (adnexal masses)
Est.1:1300 adnexal mass require surgery
Ovarian cystOvarian cyst
1990 Study
Whitecar 1990
130 pregnancies
5% malignant rate: >1/2 serous carcinoma of LMP
30% cystic teratomas
28% serous/mucinous cystadenoma
13% corpus luteal
7% benign
Adnexal Masses
Ovarian torsion
Most common and serious sequelae
5% occurrence
most common at 10-14 wks GA and immediate postpartum
Rupture ovarian cyst
Most common in 1st trimester
Complications
Best approach:
<5 cm : expectant management
5-10 cm: watch unless complex on sonography
if > 6 cm after 16 wks GA : surgery is required
Managements