opthalmic dyes

OPTHALMIC DYES INDOCYANINE GREEN,SODIUM FLOURESCEIN

Jahan zeb khattakPirs isra universty isra universty islamabad

CONTENTS Introduction.(dyes,iCG,flourescence

sodium) Flourescein sodium:

Action. Indication. Contraindication. Warning. Adverse reaction. Patient information. Administration and dosage.

ACTIONo Yellow water soluble dibasic acid of

xanthine series.o Demonstrate defects of corneal

epthelium.o Does not stain tissue but useful

indicater dye.o Intact corneal epithethlium resist

flourescein penetration and is not colored.Any break in the epitheliul berrier permits rapid penetration.

INDICATION topical;

Fitting contact lenses Applanation tonometry Abrasion. Ulceration. Foreign bodies detection. Seidel testInjection;examination of fundus. Evalution of the iris vasculature. Abservation of aqous flow. Differntial diagnosis of malignant and non malignant

tumors.

CONTRAINDICATION Do not use with soft contact lenses. Hyper sensitivity to flourescein or any

other component of the product. Do not use in intra ocular surgery

WARNINGS Hyper sensitivity. Pregnancy. Lactation. Children. Do not touch dropper tip toa any

surface my contaminate the solution.

ADVERSE REACTION Injection:

o Gi distress.o Cardiac distress.o Skin discoloration.o Urine discoloration.

PATIENT INFORMATION May cause strong test with use. May cause temporary yellowish

discoloration. Soft contact lenses my become stained. Do not wear contact lenses while

flourescein is being used.

ADMINISTRATION AND DOSAGE Topical:detection of foreign bodies and

corneal abrasion instill 1 or 2 drops of solution allow for few seconds.

Injection:inject the contents of the ampule or prefilled syringe rapidely into the anticubital vein after taking precautions to avoid extravasation.

Strips. Applanation tonometry strips.

INDOCYANINE GREEN A water soluble dye with a peak

spectral absption at 8100- 810nm. ICG is used to acquire an angiogram of

the choraid. ICG was first used in 1969 but was not

brought into the practical clinical setting until 1992.

INDICATION Angiography:for opthalmic angiography.

WARNINGS Pregnancy:it is not known wether indocyanine green can cause fetal harm or not. Give to pregnant woman only if clearly indicated. Lactation:it is not known wether this drug is excreted in breast milk.

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DRUG INTERACTIONS Heparin preparations containing

sodium bisulfate reduce the absorption peak of absorption peak of indocyanine green in blood.

ADVERSE REACTION Anaphylactic or urticarial reaction have

also accurred an patients with history of allergy to iodides.

ADMINISTRATION AND DOSAGE Use 40 mg dye in 2 ml of aqueous

solvent.in some patient,half the volume has been found to produce angiograms of comparable resolution .

Use only the aqeuous solvent provided which specially prepared sterile water for injection

ICG is unstable in aqueous solution and must be used within 10 hours

ANY QUESTION”…???