anatomy unit 4 notes: the sliding filament theory
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Anatomy Unit 4 Notes: The Sliding Filament TheoryTRANSCRIPT
ANATOMY
Unit 4 Notes:Sliding Filament
Theory
(1) Muscle Contraction
• Sliding Filaments = Muscle Contraction
• The Basic Steps:
1- Message sent
2- Neurotransmitter
3- Depolarization
4- Calcium + Troponin = Actin Exposed
5- Actin + Myosin (Contraction)
(2) Neuron to Muscle
• Cause:– Conscious decision to move– Homeostatic response
• Nervous System Sends a Message to the Effector Organ:– Neurotransmitter released (ACh, acetylcholine)– ACh binds to sarcolemma of muscle fiber– ACh initiates opening of sodium-potassium
channels
(3) Depolarization of the Muscle
• Cause: – Binding of ACh to sodium-potassium channels– Opening of channels + Movement of Na-K+
across sarcolemma
• Involves the Movement of Charges:– More Na+ moves in, Than K+ moves out– Imbalance of charges electrical current
(action potential)
(4) The Release of Calcium
• Cause: Depolarization
• Action Potential across the Sarcoplasmic Reticulum causes the release of Calcium:– Ca+ released from membrane of sarcoplasmic
reticulum.– Ca+ binds with troponin:
• Troponin-Tropomyosion conformation changes
• Troponin & Tropomyosin no longer cover Actin• Actin is exposed
(5) Myosin interacts with Actin:
• Cause:– Troponin & Tropomyosin unveils Actin– Actin exposed
• Myosin releases Inorganic Phosphate + ADP– Pi + ADP = ATP– Myosin changes conformation– Myosin binds to Actin– Myosin and Actin slide towards each other – WE HAVE A CONTRACTION! WOO WOO!
(6) Relaxation
• ATP binds back with myosin…–Myosin detaches and moves away from
Actin
–Troponin & Tropomyosin cover up Actin
–Ca+ moves back into Sarcoplasmic Reticulum
–Repolarization Sarcolemma stable again
(7) Why is it called the Sliding Filament Theory?
• Movement of myofilaments causes contraction
• Myosin grabs actin & SLIDES them towards the center
(1-2) Depolarization of Sarcolemma & Generation of Action Potential
(3) Calcium Ions released from Sarcoplasmic Reticulum
(4-6) Calcium binds to troponin, tropomyosin moves, actin exposed
(7-8) Myosin attaches to actin, Myosin moves actin, ATP released
(9) Calcium removed by active transport
(10) Everything moves back & contraction done!