bianca moses fall 2013
DESCRIPTION
Bianca Moses Fall 2013. -LOL. -LOL. β -Blockers. -LOL. β -Blockers. For the treatment of the symptoms of attack by ostriches…and other ailments; including those of the cardio-pulmonary tract. -LOL. β -Blockers. - PowerPoint PPT PresentationTRANSCRIPT
![Page 1: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/1.jpg)
Bianca Moses Fall 2013
![Page 2: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/2.jpg)
-LOL
![Page 3: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/3.jpg)
-LOLβ-Blockers
![Page 4: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/4.jpg)
For the treatment of the symptoms of attack by ostriches…and other ailments; including
those of the cardio-pulmonary tract
-LOLβ-Blockers
![Page 5: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/5.jpg)
For the treatment of the symptoms of attack by ostriches…and other ailments; including
those of the cardio-pulmonary tract
-LOLβ-Blockers
![Page 6: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/6.jpg)
For the treatment of the symptoms of attack by ostriches…and other ailments; including
those of the cardio-pulmonary tract
-LOLβ-Blockers
![Page 7: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/7.jpg)
For the treatment of the symptoms of attack by ostriches…and other ailments; including
those of the cardio-pulmonary tract
-LOLβ-Blockers
![Page 8: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/8.jpg)
For the treatment of the symptoms of attack by ostriches…and other ailments; including
those of the cardio-pulmonary tract
-LOLβ-Blockers
![Page 9: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/9.jpg)
-LOLβ-Blockers
Ateno
For the treatment of the symptoms of attack by ostriches…and other ailments; including
those of the cardio-pulmonary tract
![Page 10: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/10.jpg)
-LOLβ-Blockers
Atenolol
For the treatment of the symptoms of attack by ostriches…and other ailments; including
those of the cardio-pulmonary tract
![Page 11: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/11.jpg)
-LOLβ-Blockers
Atenolol
Carvedi
For the treatment of the symptoms of attack by ostriches…and other ailments; including
those of the cardio-pulmonary tract
![Page 12: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/12.jpg)
-LOLβ-Blockers
Atenolol
Carvedilol
For the treatment of the symptoms of attack by ostriches…and other ailments; including
those of the cardio-pulmonary tract
![Page 13: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/13.jpg)
-LOLβ-Blockers
Atenolol
Carvedilol
Timo
For the treatment of the symptoms of attack by ostriches…and other ailments; including
those of the cardio-pulmonary tract
![Page 14: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/14.jpg)
-LOLβ-Blockers
Atenolol
Carvedilol
Timolol
For the treatment of the symptoms of attack by ostriches…and other ailments; including
those of the cardio-pulmonary tract
![Page 15: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/15.jpg)
-LOLβ-Blockers
Atenolol
Carvedilol
Timolol
Metopra
For the treatment of the symptoms of attack by ostriches…and other ailments; including
those of the cardio-pulmonary tract
![Page 16: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/16.jpg)
-LOLβ-Blockers
Atenolol
Carvedilol
Timolol
Metopralol
For the treatment of the symptoms of attack by ostriches…and other ailments; including
those of the cardio-pulmonary tract
![Page 17: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/17.jpg)
-LOLβ-Blockers
Atenolol
Carvedilol
Timolol
Metopralol
Proprano
For the treatment of the symptoms of attack by ostriches…and other ailments; including
those of the cardio-pulmonary tract
![Page 18: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/18.jpg)
-LOLβ-Blockers
Atenolol
Carvedilol
Timolol
Metopralol
Propranolol
For the treatment of the symptoms of attack by ostriches…and other ailments; including
those of the cardio-pulmonary tract
![Page 19: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/19.jpg)
-LOLβ-Blockers
Atenolol
Carvedilol
Timolol
Metopralol
Propranolol
and more…
For the treatment of the symptoms of attack by ostriches…and other ailments; including
those of the cardio-pulmonary tract
![Page 20: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/20.jpg)
-LOLβ-Blockers
Atenolol
Carvedilol
Timolol
Metopralol
Propranolol
and more…
-LOL
For the treatment of the symptoms of attack by ostriches…and other ailments; including
those of the cardio-pulmonary tract
![Page 21: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/21.jpg)
symptoms of attack by ostriches
![Page 22: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/22.jpg)
symptoms of attack by ostriches
![Page 23: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/23.jpg)
symptoms of attack by ostriches
![Page 24: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/24.jpg)
symptoms of attack by ostriches
![Page 25: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/25.jpg)
symptoms of attack by ostriches
![Page 26: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/26.jpg)
symptoms of attack by ostriches
Medulla Oblongata
![Page 27: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/27.jpg)
symptoms of attack by ostriches
Medulla Oblongata
Fight or Flight Response
![Page 28: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/28.jpg)
symptoms of attack by ostriches
Medulla Oblongata
Fight or Flight Response
![Page 29: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/29.jpg)
symptoms of attack by ostriches
Medulla Oblongata
Adrenal Glands
Fight or Flight Response
![Page 30: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/30.jpg)
symptoms of attack by ostriches
Medulla Oblongata
Adrenal Glands
Fight or Flight Response
![Page 31: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/31.jpg)
symptoms of attack by ostriches
Medulla Oblongata
Adrenal Glands
Fight or Flight Response
Epinephrine
![Page 32: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/32.jpg)
symptoms of attack by ostriches
Medulla Oblongata
Adrenal Glands
Fight or Flight Response
Epinephrine
![Page 33: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/33.jpg)
symptoms of attack by ostriches
Medulla Oblongata
Adrenal Glands
Fight or Flight Response
Epinephrine
![Page 34: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/34.jpg)
symptoms of attack by ostriches
Medulla Oblongata
Adrenal Glands
Fight or Flight Response
Epinephrine
Sympathetic Neurons
![Page 35: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/35.jpg)
symptoms of attack by ostriches
Medulla Oblongata
Adrenal Glands
Fight or Flight Response
Epinephrine
Sympathetic Neurons
![Page 36: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/36.jpg)
symptoms of attack by ostriches
Medulla Oblongata
Adrenal Glands
Fight or Flight Response
Epinephrine
Sympathetic Neurons
Norepinephrine
![Page 37: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/37.jpg)
symptoms of attack by ostriches
Medulla Oblongata
Adrenal Glands
Fight or Flight Response
Epinephrine
Sympathetic Neurons
Norepinephrine
![Page 38: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/38.jpg)
symptoms of attack by ostriches
Medulla Oblongata
Adrenal Glands
Fight or Flight Response
Epinephrine
Sympathetic Neurons
Norepinephrine
![Page 39: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/39.jpg)
symptoms of attack by ostriches
Medulla Oblongata
Adrenal Glands
Fight or Flight Response
Epinephrine
Sympathetic Neurons
Norepinephrine
β1
![Page 40: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/40.jpg)
symptoms of attack by ostriches
Medulla Oblongata
Adrenal Glands
Fight or Flight Response
Epinephrine
Sympathetic Neurons
Norepinephrine
β1 β2
![Page 41: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/41.jpg)
symptoms of attack by ostriches
Medulla Oblongata
Adrenal Glands
Fight or Flight Response
Epinephrine
Sympathetic Neurons
Norepinephrine
β1 β2 β3
![Page 42: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/42.jpg)
β1 β2 β3Ep
inep
hrin
e
Nore
pine
phrin
e
Epin
ephr
ine
Nore
pine
phrin
e
Epin
ephr
ine
Nore
pine
phrin
e
![Page 43: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/43.jpg)
β1 β2 β3Ep
inep
hrin
e
Nore
pine
phrin
e
Epin
ephr
ine
Nore
pine
phrin
e
Epin
ephr
ine
Nore
pine
phrin
e
![Page 44: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/44.jpg)
β1 β2 β3Ep
inep
hrin
e
Nore
pine
phrin
e
Epin
ephr
ine
Nore
pine
phrin
e
Epin
ephr
ine
Nore
pine
phrin
eFight or Flight
Response Initiated
![Page 45: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/45.jpg)
β-Blockers
![Page 46: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/46.jpg)
β1 β2 β3
β-Blockers
![Page 47: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/47.jpg)
β1 β2 β3
β-Blockers
![Page 48: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/48.jpg)
β1 β2 β3
β-Blockers
Epin
ephr
ine
Nore
pine
phrin
e
![Page 49: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/49.jpg)
β1 β2 β3
↑ ♥ Rate (Chronotropic)
↑ ♥ Force (Inotropic)
↑ ♥ Automaticity (How well ♥ cells initiate their own impulse)
↑ ♥ Output (Cardiac Output)
PUMP THAT BLOOD!!! MOVE THAT O2 NOW!!!
![Page 50: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/50.jpg)
β1 β2 β3
↑ ♥ Rate (Chronotropic)
↑ ♥ Force (Inotropic)
↑ ♥ Automaticity (How well ♥ cells initiate their own impulse)
↑ ♥ Output (Cardiac Output)
PUMP THAT BLOOD!!! MOVE THAT O2 NOW!!!
![Page 51: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/51.jpg)
β1 β2 β3
↑ ♥ Rate (Chronotropic)
↑ ♥ Force (Inotropic)
↑ ♥ Automaticity (How well ♥ cells initiate their own impulse)
↑ ♥ Output (Cardiac Output)
![Page 52: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/52.jpg)
β1 β2 β3
↑ ♥ Rate (Chronotropic)
↑ ♥ Force (Inotropic)
↑ ♥ Automaticity (How well ♥ cells initiate their own impulse)
↑ ♥ Output (Cardiac Output)
![Page 53: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/53.jpg)
β1 β2 β3
Not as much effect as β1 stimulation however
↑ ♥ Rate (Chronotropic)
↑ ♥ Force (Inotropic)
↑ ♥ Automaticity (How well ♥ cells initiate their own impulse)
↑ ♥ Output (Cardiac Output)
![Page 54: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/54.jpg)
β1 β2 β3
Not as much effect as β1 stimulation however
↑ ♥ Rate (Chronotropic)
↑ ♥ Force (Inotropic)
↑ ♥ Automaticity (How well ♥ cells initiate their own impulse)
↑ ♥ Output (Cardiac Output)
![Page 55: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/55.jpg)
β1 β2 β3
↑ ♥ Rate (Chronotropic)
↑ ♥ Force (Inotropic)
↑ ♥ Automaticity (How well ♥ cells initiate their own impulse)
↑ ♥ Output (Cardiac Output)
![Page 56: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/56.jpg)
β1 β2 β3
Smooth Muscle Constriction
![Page 57: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/57.jpg)
β1 β2 β3
Central Arterial Constriction
=↑ Blood Pressure
=↑ Blood + O2 to essential
organs
Smooth Muscle Constriction
![Page 58: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/58.jpg)
β1 β2 β3
Central Arterial Constriction
=↑ Blood Pressure
=↑ Blood + O2 to essential
organs
Smooth Muscle Constriction
Constriction of Vessels of non essential organs(ie. Less blood to gut)
=Less digesting
![Page 59: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/59.jpg)
β1 β2 β3
Smooth Muscle Relaxation
Central Arterial Constriction
=↑ Blood Pressure
=↑ Blood + O2 to essential
organs
Smooth Muscle Constriction
Constriction of Vessels of non essential organs(ie. Less blood to gut)
=Less digesting
![Page 60: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/60.jpg)
β1 β2 β3
Smooth Muscle Relaxation
Airways Relax=
More air with each breath=
↑ oxygenation
Central Arterial Constriction
=↑ Blood Pressure
=↑ Blood + O2 to essential
organs
Smooth Muscle Constriction
Constriction of Vessels of non essential organs(ie. Less blood to gut)
=Less digesting
![Page 61: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/61.jpg)
β1 β2 β3
Smooth Muscle Relaxation
Airways Relax=
More air with each breath=
↑ oxygenation
Central Arterial Constriction
=↑ Blood Pressure
=↑ Blood + O2 to essential
organs
Smooth Muscle Constriction
Sweat =
Dissipate Heat
= Cools off
body
Constriction of Vessels of non essential organs(ie. Less blood to gut)
=Less digesting
![Page 62: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/62.jpg)
β1 β2 β3
Smooth Muscle Relaxation
Airways Relax=
More air with each breath=
↑ oxygenation
Central Arterial Constriction
=↑ Blood Pressure
=↑ Blood + O2 to essential
organs
Smooth Muscle Constriction
Eyes Dilate =
More Light In=
See Threat Better
Sweat =
Dissipate Heat
= Cools off
body
Constriction of Vessels of non essential organs(ie. Less blood to gut)
=Less digesting
![Page 63: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/63.jpg)
β1 β2 β3
Smooth Muscle Relaxation
Airways Relax=
More air with each breath=
↑ oxygenation
Central Arterial Constriction
=↑ Blood Pressure
=↑ Blood + O2 to essential
organs
Smooth Muscle Constriction
Eyes Dilate =
More Light In=
See Threat Better
Sweat =
Dissipate Heat
= Cools off
body
Constriction of Vessels of non essential organs(ie. Less blood to gut)
=Less digesting
![Page 64: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/64.jpg)
β1 β2 β3
Smooth Muscle Relaxation
Constriction of Vessels of non essential organs(ie. Less blood to gut)
=Less digesting
Airways Relax=
More air with each breath=
↑ oxygenation
Central Arterial Constriction
=↑ Blood Pressure
=↑ Blood + O2 to essential
organs
Smooth Muscle Constriction
Eyes Dilate =
More Light In=
See Threat Better
Sweat =
Dissipate Heat
= Cools off
body
![Page 65: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/65.jpg)
β1 β2 β3
Brown Fat
![Page 66: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/66.jpg)
β1 β2 β3
β-Blockers
Anxiety SymptomsEssential TremorGlaucomaTheophylline OverdoseMigraine ProphylaxisAngina PectorisDysrhythmiasCongestive Heart FailureMitral Valve ProlapseMyocardial InfarctionAcute Aortic DissectionTachycardia Marfan Syndrome
![Page 67: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/67.jpg)
β1 β2 β3
β-Blockers
Anxiety SymptomsEssential TremorGlaucomaTheophylline OverdoseMigraine ProphylaxisAngina PectorisDysrhythmiasCongestive Heart FailureMitral Valve ProlapseMyocardial InfarctionAcute Aortic DissectionTachycardia Marfan Syndrome
![Page 68: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/68.jpg)
β1 β2 β3
β-Blockers
Use With Caution In
![Page 69: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/69.jpg)
β1 β2 β3
β-Blockers
Use With Caution InRenal ImpairmentHepatic Impairment
![Page 70: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/70.jpg)
β1 β2 β3
β-Blockers
Use With Caution InRenal ImpairmentHepatic Impairment Metabolized by liver and excreted by kidneys
![Page 71: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/71.jpg)
β1 β2 β3
β-Blockers
Use With Caution InRenal ImpairmentHepatic ImpairmentDiabetes Mellitus
![Page 72: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/72.jpg)
β1 β2 β3
β-Blockers
Use With Caution InRenal ImpairmentHepatic ImpairmentDiabetes Mellitus
β-blockers mask hypoglycemia symptoms
![Page 73: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/73.jpg)
β1 β2 β3
β-Blockers
Use With Caution InRenal ImpairmentHepatic ImpairmentDiabetes Mellitus Geriatrics
![Page 74: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/74.jpg)
β1 β2 β3
β-Blockers
Use With Caution InRenal ImpairmentHepatic ImpairmentDiabetes Mellitus Geriatrics
Enhanced effects
![Page 75: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/75.jpg)
β1 β2 β3
β-Blockers
Use With Caution InRenal ImpairmentHepatic ImpairmentDiabetes MellitusGeriatricsAsthma Patients
![Page 76: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/76.jpg)
β1 β2 β3
β-Blockers
Use With Caution InRenal ImpairmentHepatic ImpairmentDiabetes MellitusGeriatricsAsthma Patients
Constricts airways
![Page 77: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/77.jpg)
β1 β2 β3
β-Blockers
Contraindications
Use With Caution InRenal ImpairmentHepatic ImpairmentDiabetes MellitusGeriatricsAsthma Patients
![Page 78: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/78.jpg)
β1 β2 β3
β-Blockers
ContraindicationsUncompensated CHFPulmonary edemaCardiogenic shockBradycardiaHeart Block
Use With Caution InRenal ImpairmentHepatic ImpairmentDiabetes MellitusGeriatricsAsthma Patients
![Page 79: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/79.jpg)
β1 β2 β3
β-Blockers
ContraindicationsUncompensated CHFPulmonary edemaCardiogenic shockBradycardiaHeart Block
May ↑ these labs
Use With Caution InRenal ImpairmentHepatic ImpairmentDiabetes MellitusGeriatricsAsthma Patients
![Page 80: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/80.jpg)
β1 β2 β3
β-Blockers
ContraindicationsUncompensated CHFPulmonary edemaCardiogenic shockBradycardiaHeart Block
May ↑ these labsBUNSerum LipoproteinK+TriglyceridesUric Acid LevelsANA titersBlood Glucose Levels
Use With Caution InRenal ImpairmentHepatic ImpairmentDiabetes MellitusGeriatricsAsthma Patients
![Page 81: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/81.jpg)
β1 β2 β3
β-Blockers
ContraindicationsUncompensated CHFPulmonary edemaCardiogenic shockBradycardiaHeart Block
May ↑ these labsBUNSerum LipoproteinK+TriglyceridesUric Acid LevelsANA titersBlood Glucose Levels
Use With Caution InRenal ImpairmentHepatic ImpairmentDiabetes MellitusGeriatricsAsthma Patients
Primarily labs monitoring liver function
![Page 82: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/82.jpg)
β1 β2 β3
β-Blockers
ContraindicationsUncompensated CHFPulmonary edemaCardiogenic shockBradycardiaHeart Block
↑ myocardial depression
May ↑ these labsBUNSerum LipoproteinK+TriglyceridesUric Acid LevelsANA titersBlood Glucose Levels
Use With Caution InRenal ImpairmentHepatic ImpairmentDiabetes MellitusGeriatricsAsthma Patients
![Page 83: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/83.jpg)
β1 β2 β3
β-Blockers
ContraindicationsUncompensated CHFPulmonary edemaCardiogenic shockBradycardiaHeart Block
↑ myocardial depressionGeneral anesthesia
IV PhenytoinVerapamil
May ↑ these labsBUNSerum LipoproteinK+TriglyceridesUric Acid LevelsANA titersBlood Glucose Levels
Use With Caution InRenal ImpairmentHepatic ImpairmentDiabetes MellitusGeriatricsAsthma Patients
![Page 84: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/84.jpg)
β1 β2 β3
β-Blockers
ContraindicationsUncompensated CHFPulmonary edemaCardiogenic shockBradycardiaHeart Block
↑ myocardial depressionGeneral anesthesia
IV PhenytoinVerapamil
↑ Bradycardia
May ↑ these labsBUNSerum LipoproteinK+TriglyceridesUric Acid LevelsANA titersBlood Glucose Levels
Use With Caution InRenal ImpairmentHepatic ImpairmentDiabetes MellitusGeriatricsAsthma Patients
![Page 85: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/85.jpg)
β1 β2 β3
β-Blockers
ContraindicationsUncompensated CHFPulmonary edemaCardiogenic shockBradycardiaHeart Block
↑ myocardial depressionGeneral anesthesia
IV PhenytoinVerapamil
↑ BradycardiaDigoxin
May ↑ these labsBUNSerum LipoproteinK+TriglyceridesUric Acid LevelsANA titersBlood Glucose Levels
Use With Caution InRenal ImpairmentHepatic ImpairmentDiabetes MellitusGeriatricsAsthma Patients
![Page 86: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/86.jpg)
β1 β2 β3
β-Blockers
ContraindicationsUncompensated CHFPulmonary edemaCardiogenic shockBradycardiaHeart Block
↑ myocardial depressionGeneral anesthesia
IV PhenytoinVerapamil
↑ BradycardiaDigoxin
↑ HTN
May ↑ these labsBUNSerum LipoproteinK+TriglyceridesUric Acid LevelsANA titersBlood Glucose Levels
Use With Caution InRenal ImpairmentHepatic ImpairmentDiabetes MellitusGeriatricsAsthma Patients
![Page 87: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/87.jpg)
β1 β2 β3
β-Blockers
ContraindicationsUncompensated CHFPulmonary edemaCardiogenic shockBradycardiaHeart Block
↑ myocardial depressionGeneral anesthesia
IV PhenytoinVerapamil
↑ BradycardiaDigoxin
↑ HTNOther antihypertensives
Acute –OH ingestionnitrates
May ↑ these labsBUNSerum LipoproteinK+TriglyceridesUric Acid LevelsANA titersBlood Glucose Levels
Use With Caution InRenal ImpairmentHepatic ImpairmentDiabetes MellitusGeriatricsAsthma Patients
![Page 88: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/88.jpg)
β1 β2 β3
β-Blockers
ContraindicationsUncompensated CHFPulmonary edemaCardiogenic shockBradycardiaHeart Block
↑ myocardial depressionGeneral anesthesia
IV PhenytoinVerapamil
↑ BradycardiaDigoxin
↑ HTNOther antihypertensives
Acute –OH ingestionnitrates
Unopposed α adrenergic stimulation
May ↑ these labsBUNSerum LipoproteinK+TriglyceridesUric Acid LevelsANA titersBlood Glucose Levels
Use With Caution InRenal ImpairmentHepatic ImpairmentDiabetes MellitusGeriatricsAsthma Patients
![Page 89: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/89.jpg)
β1 β2 β3
β-Blockers
ContraindicationsUncompensated CHFPulmonary edemaCardiogenic shockBradycardiaHeart Block
↑ myocardial depressionGeneral anesthesia
IV PhenytoinVerapamil
↑ BradycardiaDigoxin
↑ HTNOther antihypertensives
Acute –OH ingestionnitrates
Unopposed α adrenergic stimulationAmphetamines
CocaineEphedrine
EpinephrinePhenylephrine
pseudophedrine
May ↑ these labsBUNSerum LipoproteinK+TriglyceridesUric Acid LevelsANA titersBlood Glucose Levels
Use With Caution InRenal ImpairmentHepatic ImpairmentDiabetes MellitusGeriatricsAsthma Patients
![Page 90: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/90.jpg)
β1 β2 β3
β-Blockers
Side Effects/Adverse Rxns
![Page 91: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/91.jpg)
β1 β2 β3
β-Blockers
Extension of therapeutic effect
Side Effects/Adverse Rxns
![Page 92: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/92.jpg)
β1 β2 β3
β-Blockers
Side Effects/Adverse Rxns FatigueWeaknessArrhythmiasBradycardiaCHFPulmonary EdemaErectile dysfunctionAnaphylaxis (rare)Nasal StuffinessBronchospasm/wheezingOrthostatic hypotension
Extension of therapeutic effect
![Page 93: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/93.jpg)
β1 β2 β3
β-BlockersSymptoms of Toxicity
Side Effects/Adverse Rxns FatigueWeaknessArrhythmiasBradycardiaCHFPulmonary EdemaErectile dysfunctionAnaphylaxis (rare)Nasal StuffinessBronchospasm/wheezingOrthostatic hypotension
![Page 94: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/94.jpg)
β1 β2 β3
β-BlockersSymptoms of ToxicityBradycardiaSevere DizzinessFaintingSevere DrowsinessDyspneaBluish FingernailsSeizures
Side Effects/Adverse RxnsFatigueWeaknessArrhythmiasBradycardiaCHFPulmonary EdemaErectile dysfunctionAnaphylaxis (rare)Nasal StuffinessBronchospasm/wheezingOrthostatic hypotension
![Page 95: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/95.jpg)
β1 β2 β3
β-BlockersSymptoms of ToxicityBradycardiaSevere DizzinessFaintingSevere DrowsinessDyspneaBluish FingernailsSeizures
AssessmentSide Effects/Adverse Rxns FatigueWeaknessArrhythmiasBradycardiaCHFPulmonary EdemaErectile dysfunctionAnaphylaxis (rare)Nasal StuffinessBronchospasm/wheezingOrthostatic hypotension
![Page 96: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/96.jpg)
β1 β2 β3
β-BlockersSymptoms of ToxicityBradycardiaSevere DizzinessFaintingSevere DrowsinessDyspneaBluish FingernailsSeizures
Side Effects/Adverse Rxns FatigueWeaknessArrhythmiasBradycardiaCHFPulmonary EdemaErectile dysfunctionAnaphylaxis (rare)Nasal StuffinessBronchospasm/wheezingOrthostatic hypotension
AssessmentMonitor BP and HR
![Page 97: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/97.jpg)
β1 β2 β3
β-BlockersSymptoms of ToxicityBradycardiaSevere DizzinessFaintingSevere DrowsinessDyspneaBluish FingernailsSeizures
AssessmentMonitor BP and HR hold med, call MD, if apical pulse is <50bpm
Side Effects/Adverse Rxns FatigueWeaknessArrhythmiasBradycardiaCHFPulmonary EdemaErectile dysfunctionAnaphylaxis (rare)Nasal StuffinessBronchospasm/wheezingOrthostatic hypotension
![Page 98: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/98.jpg)
β1 β2 β3
β-BlockersSymptoms of ToxicityBradycardiaSevere DizzinessFaintingSevere DrowsinessDyspneaBluish FingernailsSeizures
AssessmentMonitor BP and HR hold med, call MD, if apical pulse is <50bpm
Assess for orthostatic hypotension
Side Effects/Adverse Rxns FatigueWeaknessArrhythmiasBradycardiaCHFPulmonary EdemaErectile dysfunctionAnaphylaxis (rare)Nasal StuffinessBronchospasm/wheezingOrthostatic hypotension
![Page 99: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/99.jpg)
β1 β2 β3
β-BlockersSymptoms of ToxicityBradycardiaSevere DizzinessFaintingSevere DrowsinessDyspneaBluish FingernailsSeizures
AssessmentMonitor BP and HR hold med, call MD, if apical pulse is <50bpm
Assess for orthostatic hypotension teach pt to stand up slowly
Side Effects/Adverse Rxns FatigueWeaknessArrhythmiasBradycardiaCHFPulmonary EdemaErectile dysfunctionAnaphylaxis (rare)Nasal StuffinessBronchospasm/wheezingOrthostatic hypotension
![Page 100: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/100.jpg)
β1 β2 β3
β-BlockersSymptoms of ToxicityBradycardiaSevere DizzinessFaintingSevere DrowsinessDyspneaBluish FingernailsSeizures
AssessmentMonitor BP and HR hold med, call MD, if apical pulse is <50bpm
Assess for orthostatic hypotension teach pt to stand up slowlyMonitor I/O and daily weights
Side Effects/Adverse Rxns FatigueWeaknessArrhythmiasBradycardiaCHFPulmonary EdemaErectile dysfunctionAnaphylaxis (rare)Nasal StuffinessBronchospasm/wheezingOrthostatic hypotension
![Page 101: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/101.jpg)
β1 β2 β3
β-BlockersSymptoms of ToxicityBradycardiaSevere DizzinessFaintingSevere DrowsinessDyspneaBluish FingernailsSeizures
AssessmentMonitor BP and HR hold med, call MD, if apical pulse is <50bpm
Assess for orthostatic hypotension teach pt to stand up slowlyMonitor I/O and daily weights assess chest sounds and for edema
Side Effects/Adverse Rxns FatigueWeaknessArrhythmiasBradycardiaCHFPulmonary EdemaErectile dysfunctionAnaphylaxis (rare)Nasal StuffinessBronchospasm/wheezingOrthostatic hypotension
![Page 102: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/102.jpg)
β1 β2 β3
β-BlockersSymptoms of ToxicityBradycardiaSevere DizzinessFaintingSevere DrowsinessDyspneaBluish FingernailsSeizures
AssessmentMonitor BP and HR hold med, call MD, if apical pulse is <50bpm
Assess for orthostatic hypotension teach pt to stand up slowlyMonitor I/O and daily weights assess chest sounds and for edema
Vitals q5-15 post parenteral administration
Side Effects/Adverse Rxns FatigueWeaknessArrhythmiasBradycardiaCHFPulmonary EdemaErectile dysfunctionAnaphylaxis (rare)Nasal StuffinessBronchospasm/wheezingOrthostatic hypotension
![Page 103: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/103.jpg)
β1 β2 β3
β-BlockersSymptoms of ToxicityBradycardiaSevere DizzinessFaintingSevere DrowsinessDyspneaBluish FingernailsSeizures
AssessmentMonitor BP and HR hold med, call MD, if apical pulse is <50bpm
Assess for orthostatic hypotension teach pt to stand up slowlyMonitor I/O and daily weights assess chest sounds and for edema
Vitals q5-15 post parenteral administrationadminister atropine if needed
Side Effects/Adverse Rxns FatigueWeaknessArrhythmiasBradycardiaCHFPulmonary EdemaErectile dysfunctionAnaphylaxis (rare)Nasal StuffinessBronchospasm/wheezingOrthostatic hypotension
![Page 104: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/104.jpg)
β1 β2 β3
β-BlockersSymptoms of ToxicityBradycardiaSevere DizzinessFaintingSevere DrowsinessDyspneaBluish FingernailsSeizures
AssessmentMonitor BP and HR hold med, call MD, if apical pulse is <50bpm
Assess for orthostatic hypotension teach pt to stand up slowlyMonitor I/O and daily weights assess chest sounds and for edema
Vitals q5-15 post parenteral administrationadminister atropine if needed
Side Effects/Adverse Rxns FatigueWeaknessArrhythmiasBradycardiaCHFPulmonary EdemaErectile dysfunctionAnaphylaxis (rare)Nasal StuffinessBronchospasm/wheezingOrthostatic hypotension For pulse <40bpm, ↓CO = atropine 0.25-0.5 mg IV
![Page 105: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/105.jpg)
β1 β2 β3
β-BlockersSymptoms of ToxicityBradycardiaSevere DizzinessFaintingSevere DrowsinessDyspneaBluish FingernailsSeizures
AssessmentMonitor BP and HR hold med, call MD, if apical pulse is <50bpm
Assess for orthostatic hypotension teach pt to stand up slowlyMonitor I/O and daily weights assess chest sounds and for edema
Vitals q5-15 post parenteral administrationadminister atropine if needed
Patient and Family Teaching
Side Effects/Adverse Rxns FatigueWeaknessArrhythmiasBradycardiaCHFPulmonary EdemaErectile dysfunctionAnaphylaxis (rare)Nasal StuffinessBronchospasm/wheezingOrthostatic hypotension
![Page 106: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/106.jpg)
β1 β2 β3
β-BlockersSymptoms of ToxicityBradycardiaSevere DizzinessFaintingSevere DrowsinessDyspneaBluish FingernailsSeizures
AssessmentMonitor BP and HR hold med, call MD, if apical pulse is <50bpm
Assess for orthostatic hypotension teach pt to stand up slowlyMonitor I/O and daily weights assess chest sounds and for edema
Vitals q5-15 post parenteral administrationadminister atropine if needed
Patient and Family TeachingAbrupt withdrawal can cause life
threatening arrhythmias, HTN or MI
Side Effects/Adverse Rxns FatigueWeaknessArrhythmiasBradycardiaCHFPulmonary EdemaErectile dysfunctionAnaphylaxis (rare)Nasal StuffinessBronchospasm/wheezingOrthostatic hypotension
![Page 107: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/107.jpg)
β1 β2 β3
β-BlockersSymptoms of ToxicityBradycardiaSevere DizzinessFaintingSevere DrowsinessDyspneaBluish FingernailsSeizures
AssessmentMonitor BP and HR hold med, call MD, if apical pulse is <50bpm
Assess for orthostatic hypotension teach pt to stand up slowlyMonitor I/O and daily weights assess chest sounds and for edema
Vitals q5-15 post parenteral administrationadminister atropine if needed
Patient and Family TeachingAbrupt withdrawal can cause life
threatening arrhythmias, HTN or MI
Check pulse and BP 2x/wkIf HR <50bpm, hold dose and call MD
Side Effects/Adverse Rxns FatigueWeaknessArrhythmiasBradycardiaCHFPulmonary EdemaErectile dysfunctionAnaphylaxis (rare)Nasal StuffinessBronchospasm/wheezingOrthostatic hypotension
![Page 108: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/108.jpg)
β1 β2 β3
β-BlockersSymptoms of ToxicityBradycardiaSevere DizzinessFaintingSevere DrowsinessDyspneaBluish FingernailsSeizures
AssessmentMonitor BP and HR hold med, call MD, if apical pulse is <50bpm
Assess for orthostatic hypotension teach pt to stand up slowlyMonitor I/O and daily weights assess chest sounds and for edema
Vitals q5-15 post parenteral administrationadminister atropine if needed
Patient and Family TeachingAbrupt withdrawal can cause life
threatening arrhythmias, HTN or MI
Check pulse and BP 2x/wkIf HR <50bpm, hold dose and call MD
Notify if having difficulty breathing, wheezing, coldHands/feet, confusion, dizzy
Side Effects/Adverse Rxns FatigueWeaknessArrhythmiasBradycardiaCHFPulmonary EdemaErectile dysfunctionAnaphylaxis (rare)Nasal StuffinessBronchospasm/wheezingOrthostatic hypotension
![Page 109: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/109.jpg)
β1 β2 β3
β-BlockersSymptoms of ToxicityBradycardiaSevere DizzinessFaintingSevere DrowsinessDyspneaBluish FingernailsSeizures
AssessmentMonitor BP and HR hold med, call MD, if apical pulse is <50bpm
Assess for orthostatic hypotension teach pt to stand up slowlyMonitor I/O and daily weights assess chest sounds and for edema
Vitals q5-15 post parenteral administrationadminister atropine if needed
Patient and Family TeachingAbrupt withdrawal can cause life
threatening arrhythmias, HTN or MI
Check pulse and BP 2x/wkIf HR <50bpm, hold dose and call MD
Notify if having difficulty breathing, wheezing, coldHands/feet, confusion, dizzy
Change positions slowly
Side Effects/Adverse Rxns FatigueWeaknessArrhythmiasBradycardiaCHFPulmonary EdemaErectile dysfunctionAnaphylaxis (rare)Nasal StuffinessBronchospasm/wheezingOrthostatic hypotension
![Page 110: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/110.jpg)
β1 β2 β3
β-BlockersSymptoms of ToxicityBradycardiaSevere DizzinessFaintingSevere DrowsinessDyspneaBluish FingernailsSeizures
AssessmentMonitor BP and HR hold med, call MD, if apical pulse is <50bpm
Assess for orthostatic hypotension teach pt to stand up slowlyMonitor I/O and daily weights assess chest sounds and for edema
Vitals q5-15 post parenteral administrationadminister atropine if needed
Patient and Family TeachingAbrupt withdrawal can cause life
threatening arrhythmias, HTN or MI
Check pulse and BP 2x/wkIf HR <50bpm, hold dose and call MD
Notify if having difficulty breathing, wheezing, coldHands/feet, confusion, dizzy
Change positions slowly
Don’t double dose if you miss one Take ASAP or up to 4 hours before the next dose
Side Effects/Adverse Rxns FatigueWeaknessArrhythmiasBradycardiaCHFPulmonary EdemaErectile dysfunctionAnaphylaxis (rare)Nasal StuffinessBronchospasm/wheezingOrthostatic hypotension
![Page 111: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/111.jpg)
β1 β2 β3
β-BlockersSymptoms of ToxicityBradycardiaSevere DizzinessFaintingSevere DrowsinessDyspneaBluish FingernailsSeizures
AssessmentMonitor BP and HR hold med, call MD, if apical pulse is <50bpm
Assess for orthostatic hypotension teach pt to stand up slowlyMonitor I/O and daily weights assess chest sounds and for edema
Vitals q5-15 post parenteral administrationadminister atropine if needed
Patient and Family TeachingAbrupt withdrawal can cause life
threatening arrhythmias, HTN or MI
Check pulse and BP 2x/wkIf HR <50bpm, hold dose and call MD
Notify if having difficulty breathing, wheezing, coldHands/feet, confusion, dizzy
Change positions slowly
Don’t double dose if you miss one Take ASAP or up to 4 hours before the next dose
Take as directed, even if you feel well
Side Effects/Adverse Rxns FatigueWeaknessArrhythmiasBradycardiaCHFPulmonary EdemaErectile dysfunctionAnaphylaxis (rare)Nasal StuffinessBronchospasm/wheezingOrthostatic hypotension
![Page 112: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/112.jpg)
β1 β2 β3
β-BlockersSymptoms of ToxicityBradycardiaSevere DizzinessFaintingSevere DrowsinessDyspneaBluish FingernailsSeizures
AssessmentMonitor BP and HR hold med, call MD, if apical pulse is <50bpm
Assess for orthostatic hypotension teach pt to stand up slowlyMonitor I/O and daily weights assess chest sounds and for edema
Vitals q5-15 post parenteral administrationadminister atropine if needed
Patient and Family TeachingAbrupt withdrawal can cause life
threatening arrhythmias, HTN or MI
Check pulse and BP 2x/wkIf HR <50bpm, hold dose and call MD
Notify if having difficulty breathing, wheezing, coldHands/feet, confusion, dizzy
Change positions slowly
Don’t double dose if you miss one Take ASAP or up to 4 hours before the next dose
Take as directed, even if you feel well
Monitor glucose closely. ↓ glucose symptoms may be masked
Side Effects/Adverse Rxns FatigueWeaknessArrhythmiasBradycardiaCHFPulmonary EdemaErectile dysfunctionAnaphylaxis (rare)Nasal StuffinessBronchospasm/wheezingOrthostatic hypotension
![Page 113: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/113.jpg)
β1 β2 β3
AcebutololAtenololBetaxololBisprolol
CeliprololEsmololMetoprololNebivolol
![Page 114: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/114.jpg)
β1 β2 β3
AlprenololBucindololCarteololCarvedilolLabetalolNadololOxprenololPenbutololPindololPropranololSotalolTimolol
AcebutololAtenololBetaxololBisprolol
CeliprololEsmololMetoprololNebivolol
![Page 115: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/115.jpg)
β1 β2 β3
AlprenololBucindololCarteololCarvedilolLabetalolNadololOxprenololPenbutololPindololPropranololSotalolTimolol
AcebutololAtenololBetaxololBisprolol
CeliprololEsmololMetoprololNebivolol
![Page 116: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/116.jpg)
β1 β2 β3
β-BlockersMetoprolol PO
Beloc, Beloc-ZOK, betaloc Durules, Betaloc-Zok, lopresor, Lopresor SR, Lopressor, Metoprol, Novo-metoprol, Seloken-ZOK, Toprol
![Page 117: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/117.jpg)
β1 β2 β3
β-BlockersMetoprolol PO
![Page 118: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/118.jpg)
β1 β2 β3
β-BlockersMetoprolol PO
…effects of ↓♥rate, ↓BP, suppression of arrhythmias
![Page 119: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/119.jpg)
β1 β2 β3
β-BlockersMetoprolol PO
Labeled Uses
…effects of ↓♥rate, ↓BP, suppression of arrhythmias
![Page 120: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/120.jpg)
β1 β2 β3
β-BlockersMetoprolol PO
Labeled UsesManagement of HTNPrevention and mgmt of MIMgmt of stable, symptomatic Class 1, 3 ♥ failureAngina
…effects of ↓♥rate, ↓BP, suppression of arrhythmias
![Page 121: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/121.jpg)
β1 β2 β3
β-BlockersMetoprolol PO
Labeled UsesManagement of HTNPrevention and mgmt of MIMgmt of stable, symptomatic Class 1, 3 ♥ failureAngina
Off Label Uses
…effects of ↓♥rate, ↓BP, suppression of arrhythmias
![Page 122: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/122.jpg)
β1 β2 β3
β-BlockersMetoprolol PO
Labeled UsesManagement of HTNPrevention and mgmt of MIMgmt of stable, symptomatic Class 1, 3 ♥ failureAngina
Off Label UsesVentricular arrhythmiasVentricular tachycardia
Migraine prophylaxisDrug induced akathisia
Aggressive behaviorTremorsanxiety…effects of ↓♥rate, ↓BP, suppression of arrhythmias
![Page 123: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/123.jpg)
β1 β2 β3
β-BlockersMetoprolol PO
Labeled UsesManagement of HTNPrevention and mgmt of MIMgmt of stable, symptomatic Class 1, 3 ♥ failureAngina
…effects of ↓♥rate, ↓BP, suppression of arrhythmias
25mg, 50mg, 100mg
Off Label UsesVentricular arrhythmiasVentricular tachycardia
Migraine prophylaxisDrug induced akathisia
Aggressive behaviorTremorsanxiety
![Page 124: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/124.jpg)
β1 β2 β3
β-BlockersMetoprolol PO
Labeled UsesManagement of HTNPrevention and mgmt of MIMgmt of stable, symptomatic Class 1, 3 ♥ failureAngina
…effects of ↓♥rate, ↓BP, suppression of arrhythmias
25mg, 50mg, 100mg 15 min onsetUnknown peak5-8 hr duration3-7 hr ½ life
Off Label UsesVentricular arrhythmiasVentricular tachycardia
Migraine prophylaxisDrug induced akathisia
Aggressive behaviorTremorsanxiety
![Page 125: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/125.jpg)
β1 β2 β3
β-BlockersMetoprolol PO
Labeled UsesManagement of HTNPrevention and mgmt of MIMgmt of stable, symptomatic Class 1, 3 ♥ failureAngina
…effects of ↓♥rate, ↓BP, suppression of arrhythmias
25mg, 50mg, 100mg 15 min onsetUnknown peak5-8 hr duration3-7 hr ½ lifeFull effect not seen for 3-4 weeksMostly metabolized by liverAdminister with meals
Off Label UsesVentricular arrhythmiasVentricular tachycardia
Migraine prophylaxisDrug induced akathisia
Aggressive behaviorTremorsanxiety
![Page 126: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/126.jpg)
β1 β2 β3
β-BlockersMetoprolol PO
Labeled UsesManagement of HTNPrevention and mgmt of MIMgmt of stable, symptomatic Class 1, 3 ♥ failureAngina
Off Label UsesVentricular arrhythmiasVentricular tachycardia
Migraine prophylaxisDrug induced akathisia
Aggressive behaviorTremorsanxiety…effects of ↓♥rate, ↓BP, suppression of arrhythmias
25mg, 50mg, 100mg 15 min onsetUnknown peak5-8 hr duration3-7 hr ½ lifeFull effect not seen for 3-4 weeksMostly metabolized by liverAdminister with meals
Anti-Anginal/HTN25mg/day → 100mg/day
May ↑ After 1 week
![Page 127: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/127.jpg)
β1 β2 β3
β-BlockersMetoprolol PO
Labeled UsesManagement of HTNPrevention and mgmt of MIMgmt of stable, symptomatic Class 1, 3 ♥ failureAngina
Off Label UsesVentricular arrhythmiasVentricular tachycardia
Migraine prophylaxisDrug induced akathisia
Aggressive behaviorTremorsanxiety…effects of ↓♥rate, ↓BP, suppression of arrhythmias
25mg, 50mg, 100mg 15 min onsetUnknown peak5-8 hr duration3-7 hr ½ lifeFull effect not seen for 3-4 weeksMostly metabolized by liverAdminister with meals
Anti-Anginal/HTN25mg/day → 100mg/day
May ↑ After 1 week
Heart Failure12.5mg → 25mg/day
Can be doubled q2 weeksMax 200mg
![Page 128: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/128.jpg)
β1 β2 β3
β-BlockersMetoprolol PO
Labeled UsesManagement of HTNPrevention and mgmt of MIMgmt of stable, symptomatic Class 1, 3 ♥ failureAngina
Off Label UsesVentricular arrhythmiasVentricular tachycardia
Migraine prophylaxisDrug induced akathisia
Aggressive behaviorTremorsanxiety…effects of ↓♥rate, ↓BP, suppression of arrhythmias
25mg, 50mg, 100mg 15 min onsetUnknown peak5-8 hr duration3-7 hr ½ lifeFull effect not seen for 3-4 weeksMostly metabolized by liverAdminister with meals
Anti-Anginal/HTN25mg/day → 100mg/day
May ↑ After 1 week
Heart Failure12.5mg → 25mg/day
Can be doubled q2 weeksMax 200mg
MI Treatment25mg → 50mg 15 min after last IV dose
Every 6 hrs for 48 hrsThen 100mg 2x daily for 3mo min.
![Page 129: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/129.jpg)
β1 β2 β3
β-BlockersMetoprolol PO
Labeled UsesManagement of HTNPrevention and mgmt of MIMgmt of stable, symptomatic Class 1, 3 ♥ failureAngina
Off Label UsesVentricular arrhythmiasVentricular tachycardia
Migraine prophylaxisDrug induced akathisia
Aggressive behaviorTremorsanxiety…effects of ↓♥rate, ↓BP, suppression of arrhythmias
25mg, 50mg, 100mg 15 min onsetUnknown peak5-8 hr duration3-7 hr ½ lifeFull effect not seen for 3-4 weeksMostly metabolized by liverAdminister with meals
Anti-Anginal/HTN25mg/day → 100mg/day
May ↑ After 1 week
Heart Failure12.5mg → 25mg/day
Can be doubled q2 weeksMax 200mg
MI Treatment25mg → 50mg 15 min after last IV dose
Every 6 hrs for 48 hrsThen 100mg 2x daily for 3mo min.
Migraine Prevention50-100mg, 2-4x/day
![Page 130: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/130.jpg)
β1 β2 β3
β-BlockersMetoprolol IV
![Page 131: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/131.jpg)
β1 β2 β3
β-BlockersMetoprolol IV
…effects of ↓♥rate, ↓BP, suppression of arrhythmias
![Page 132: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/132.jpg)
β1 β2 β3
β-BlockersMetoprolol IV
Labeled UsePrevention and mgmt of MI
…effects of ↓♥rate, ↓BP, suppression of arrhythmias
![Page 133: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/133.jpg)
β1 β2 β3
β-BlockersMetoprolol IV
Labeled UsePrevention and mgmt of MI
…effects of ↓♥rate, ↓BP, suppression of arrhythmias
1mg/mL
![Page 134: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/134.jpg)
β1 β2 β3
β-BlockersMetoprolol IV
Labeled UsePrevention and mgmt of MI
…effects of ↓♥rate, ↓BP, suppression of arrhythmias
1mg/mL
For MI, suggested dose is 5mg q2 min for 3 doses, followed by oral dosing.
Following this order, how many total mLs of metoprolol would be administered?
![Page 135: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/135.jpg)
β1 β2 β3
β-BlockersMetoprolol IV
Labeled UsePrevention and mgmt of MI
…effects of ↓♥rate, ↓BP, suppression of arrhythmias
1mg/mL
For MI, suggested dose is 5mg q2 min for 3 doses, followed by oral dosing.
Following this order, how many total mLs of metoprolol would be administered?
5mg x 3 = 15mg
15mg/1 x 1mL/1mg = 15mL
![Page 136: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/136.jpg)
β1 β2 β3
β-BlockersMetoprolol IV
Labeled UsePrevention and mgmt of MI
…effects of ↓♥rate, ↓BP, suppression of arrhythmias
1mg/mLImmediate onset20 min peak6-12 hr duration3-7 hr ½ life
![Page 137: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/137.jpg)
β1 β2 β3
β-BlockersMetoprolol IV
Labeled UsePrevention and mgmt of MI
…effects of ↓♥rate, ↓BP, suppression of arrhythmias
1mg/mLImmediate onset20 min peak6-12 hr duration3-7 hr ½ lifeAdminister undilutedAdminister over 1 minute
![Page 138: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/138.jpg)
β1 β2 β3
β-BlockersMetoprolol IV
Labeled UsePrevention and mgmt of MI
…effects of ↓♥rate, ↓BP, suppression of arrhythmias
1mg/mLImmediate onset20 min peak6-12 hr duration3-7 hr ½ lifeAdminister undilutedAdminister over 1 minute
MI Treatment5mg q2min for 3 doses
Followed by oral dosing
![Page 139: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/139.jpg)
β1 β2 β3
β-BlockersMetoprolol IV
Labeled UsePrevention and mgmt of MI
…effects of ↓♥rate, ↓BP, suppression of arrhythmias
1mg/mLImmediate onset20 min peak6-12 hr duration3-7 hr ½ lifeAdminister undilutedAdminister over 1 minute
MI Treatment5mg q2min for 3 doses
Followed by oral dosing
Get calculations VERIFIED
![Page 140: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/140.jpg)
β1 β2 β3
β-BlockersCarvedilol PO
![Page 141: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/141.jpg)
β1 β2 β3
β-BlockersCarvedilol PO
Coreg, Coreg CR
![Page 142: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/142.jpg)
β1 β2 β3
β-BlockersCarvedilol PO
β1 (myocardial) & β2 (pulmonary, vascular)
![Page 143: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/143.jpg)
β1 β2 β3
β-BlockersCarvedilol PO
Labeled Uses
β1 (myocardial) & β2 (pulmonary, vascular)
![Page 144: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/144.jpg)
β1 β2 β3
β-BlockersCarvedilol PO
Labeled UsesManagement of HTNCHF (ischemic cardiomyopathies)Left ventricular dysfunction after MI
β1 (myocardial) & β2 (pulmonary, vascular)
![Page 145: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/145.jpg)
β1 β2 β3
β-BlockersCarvedilol PO
Labeled UsesManagement of HTNCHF (ischemic cardiomyopathies)Left ventricular dysfunction after MI
β1 (myocardial) & β2 (pulmonary, vascular)
3.125mg, 6.25mg, 12.5mg, 25mg
![Page 146: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/146.jpg)
β1 β2 β3
β-BlockersCarvedilol PO
Labeled UsesManagement of HTNCHF (ischemic cardiomyopathies)Left ventricular dysfunction after MI
β1 (myocardial) & β2 (pulmonary, vascular)
3.125mg, 6.25mg, 12.5mg, 25mg Within 1 hr onset1-2 hr peak12 hr duration7-10 hr ½ life
![Page 147: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/147.jpg)
β1 β2 β3
β-BlockersCarvedilol PO
Labeled UsesManagement of HTNCHF (ischemic cardiomyopathies)Left ventricular dysfunction after MI
β1 (myocardial) & β2 (pulmonary, vascular)
3.125mg, 6.25mg, 12.5mg, 25mg Within 1 hr onset1-2 hr peak12 hr duration7-10 hr ½ life98% protein binding Excreted in feces and urine
![Page 148: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/148.jpg)
β1 β2 β3
β-BlockersCarvedilol PO
Labeled UsesManagement of HTNCHF (ischemic cardiomyopathies)Left ventricular dysfunction after MI
β1 (myocardial) & β2 (pulmonary, vascular)
3.125mg, 6.25mg, 12.5mg, 25mg Within 1 hr onset1-2 hr peak12 hr duration7-10 hr ½ life98% protein binding Excreted in feces and urineCYP2D6 metabolized
![Page 149: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/149.jpg)
β1 β2 β3
β-BlockersCarvedilol PO
Labeled UsesManagement of HTNCHF (ischemic cardiomyopathies)Left ventricular dysfunction after MI
β1 (myocardial) & β2 (pulmonary, vascular)
3.125mg, 6.25mg, 12.5mg, 25mg Within 1 hr onset1-2 hr peak12 hr duration7-10 hr ½ life98% protein binding Excreted in feces and urineCYP2D6 metabolizedFood decreases absorption
![Page 150: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/150.jpg)
β1 β2 β3
β-BlockersCarvedilol PO
Labeled UsesManagement of HTNCHF (ischemic cardiomyopathies)Left ventricular dysfunction after MI
β1 (myocardial) & β2 (pulmonary, vascular)
3.125mg, 6.25mg, 12.5mg, 25mg Within 1 hr onset1-2 hr peak12 hr duration7-10 hr ½ life98% protein binding Excreted in feces and urineCYP2D6 metabolizedFood decreases absorption
Anti-Anginal80mg/day → 320mg/day
In 2-4 divided doses
![Page 151: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/151.jpg)
β1 β2 β3
β-BlockersCarvedilol PO
Labeled UsesManagement of HTNCHF (ischemic cardiomyopathies)Left ventricular dysfunction after MI
β1 (myocardial) & β2 (pulmonary, vascular)
3.125mg, 6.25mg, 12.5mg, 25mg Within 1 hr onset1-2 hr peak12 hr duration7-10 hr ½ life98% protein binding Excreted in feces and urineCYP2D6 metabolizedFood decreases absorption
Anti-Anginal80mg/day → 320mg/day
In 2-4 divided doses
Anti-HTN120mg → 240mg
Twice daily
![Page 152: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/152.jpg)
β1 β2 β3
β-BlockersCarvedilol PO
Labeled UsesManagement of HTNCHF (ischemic cardiomyopathies)Left ventricular dysfunction after MI
β1 (myocardial) & β2 (pulmonary, vascular)
3.125mg, 6.25mg, 12.5mg, 25mg Within 1 hr onset1-2 hr peak12 hr duration7-10 hr ½ life98% protein binding Excreted in feces and urineCYP2D6 metabolizedFood decreases absorption
Anti-Anginal80mg/day → 320mg/day
In 2-4 divided doses
Anti-HTN120mg → 240mg
Twice daily
Anti-Arrhythmic10mg-30mg
3-4 times a day
![Page 153: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/153.jpg)
β1 β2 β3
β-BlockersCarvedilol PO
Labeled UsesManagement of HTNCHF (ischemic cardiomyopathies)Left ventricular dysfunction after MI
β1 (myocardial) & β2 (pulmonary, vascular)
3.125mg, 6.25mg, 12.5mg, 25mg Within 1 hr onset1-2 hr peak12 hr duration7-10 hr ½ life98% protein binding Excreted in feces and urineCYP2D6 metabolizedFood decreases absorption
Anti-Anginal80mg/day → 320mg/day
In 2-4 divided doses
Anti-HTN120mg → 240mg
Twice daily
Anti-Arrhythmic10mg-30mg
3-4 times a day
MI Prevention180mg-240mg
Divided doses daily
![Page 154: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/154.jpg)
β1 β2 β3
β-BlockersCarvedilol PO
Labeled UsesManagement of HTNCHF (ischemic cardiomyopathies)Left ventricular dysfunction after MI
β1 (myocardial) & β2 (pulmonary, vascular)
3.125mg, 6.25mg, 12.5mg, 25mg Within 1 hr onset1-2 hr peak12 hr duration7-10 hr ½ life98% protein binding Excreted in feces and urineCYP2D6 metabolizedFood decreases absorption
Anti-Anginal80mg/day → 320mg/day
In 2-4 divided doses
Anti-HTN120mg → 240mg
Twice daily
Anti-Arrhythmic10mg-30mg
3-4 times a day
MI Prevention180mg-240mg
Divided doses daily
Vascular HA Prev.1mg-3mg
May be repeated after 2 min and again in 4 hours
![Page 155: Bianca Moses Fall 2013](https://reader036.vdocuments.pub/reader036/viewer/2022081604/5681613c550346895dd09e22/html5/thumbnails/155.jpg)
References
Deglin, J., Vallerand, A., & Sanoski, C. (2011). Davis's drug guide for nurses. (12 ed., p. 1043). Philadelphia, Pennsylvania: F.A. Davis Company.
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