3


4


MFS: Millar Fisher’s syndrome

CIDP: chronic inflammatory demyelinating polyneuropathy



GBS
GM1C. Jejuni Ref. Yuki, N. Proc. Jpn. Acad., Ser. B 2012, 88 299-326.
GBSAGBSB Ref. Yuki, N.; H.-P. Hartung, N. Eng. J. Med. 2012, 366, 2294-304.
6


SFNP 310 nm CdTe/CdS 150

f-mono linker or
f-mono-linker

10 mM NaBH4
13
GM1-Glc-
70 0 11 00 15 00 19 00 23 00 27 00 Mass (m/z)
0
14 42 .726 0
14 40 .727 0
14 44 .715 4
95 2.6 856 12 22 .712 0
12 80 .737 110 42 .685 3 14 08 .715 5
15 94 .654 512 52 .730 4 14 10 .751 910 44 .694 1 15 46 .640 492 2.6558 12 82 .741 071 6.5 981 81 7.7 258 13 94 .732 111 34 .691 7 17 05 .809 915 70 .975 492 0.6 988 10 28 .694 3 18 20 .873 9
70 0 1100 15 00 19 00 23 00 27 00 Mass (m/z)
0
12 90 .462 4
13 08 .386 3
12 01 .832 2 15 04.365 0
11 99 .871 7 14 68.401 510 11 .541 0 81 0.5 196 10 13.553 0 13 27 .421 7
11 41 .549 4 1480 .3935776.5361 13 22 .430 211 43 .524 397 0.5 697 14 99 .406 1783.5 720 11 83 .712 0 20 39 .562 51296 .375410 67.735 9 16 40 .263 9 2340 .480 318 58.933 614 26 .432 7 25 07.270 194 3.4937 15 34 .300 775 2.7 299 22 19.898 717 51.516 3 19 70 .112 584 8.4 575 21 08 .293 912 88.451 31093 .9382 1856 .9107 23 49.705 4 24 99 .745 215 53 .773 5
8.9 nm
GM1-Glc-SFNP MALDI-TOF MS analysis GM1-Glc-SFNP MALDI-TOF MS analysis
14
(14,000G, 15 sec)
RCA120 Gal
0.11 M
GM1:TEG=10:0
PNA GM1-Glc-SFNPPNA
6 5 4
3 2 1
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