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    Muscular System

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    Types of Muscle

    Skeletal

    striated & voluntarySmooth involuntary

    Cardiac - heart

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    Muscles and Muscle Fibers

    Muscles are composed of many fibers that

    are arranged in bundles called FASCICLES

    Individual muscles are separated by FASCIA,which also forms tendons and aponeuroses

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    Muscle Layers

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    ENERGY

    Fibers contain multiple

    mitochondria for energy

    Most fibers have multiplenuclei

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    SARCOLEMMA

    Sarcolemma = muscle fiber membrane

    Sarcoplasm = inner material surrounding

    fibers (like cytoplasm)

    Myofibrils = individual muscle fibers --

    > made of myofilaments

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    Myofibril

    Contains protein filaments

    ACTIN (thin) and MYOSIN (thick)

    These filaments overlap to form dark and

    light bands on the muscle fiber

    A band = dA

    rk thick

    (myosin) I band = lIght thIn (actin)

    In the middle of each I band are Z lines.

    A sarcomere is on Z line to the other

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    It is important to remember the

    heirarchy

    fasicles

    myofibrils

    myofilaments

    actin

    myosin

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    It is important to remember the

    heirarchy

    fasicles

    myofibrils

    myofilaments

    actin myosin

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    muscleepimysium

    myofibrilsmyofilament

    sarcomere

    muscle fiber

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    muscle

    epimysium

    myofibrils

    sarcomere

    muscle fiber

    myofilament

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    http://youtube.com/v/XoP1diaXVCI
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    Muscles & Nervous System

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    1. Neuron 2. Sarcolemma (or motor end plate)

    3. Vesicle 4. Synapse 5. Mitochondria

    Motor Unit or Neuromuscular

    Junction

    The neurotransmitter that crosses the gap is ACETYLCHOLINE

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    The neurotransmitter that crosses the gap is ACETYLCHOLINE.

    This is what activates the muscle.

    Acetylcholine is

    stored in vesicles

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    Motor Unit

    The musclefiber and the

    motor neuron

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    http://youtube.com/v/ZscXOvDgCmQ
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    SLIDING FILAMENT THEORY

    (MODEL)

    The theory of how muscle contracts is the sliding filament

    theory. The contraction of a muscle occurs as the thin

    filament slide past the thick filaments. The sliding filament

    theory involves five different molecules plus calcium ions.

    The five molecules are:

    myosin

    actintropomyosin

    troponin

    ATP

    Sliding Filament Handout

    https://docs.google.com/leaf?id=0Bx72aSXCBO09YTFhOGFlNTktNTE3Zi00YjJjLTgxYTMtMTY2MDA1ZTVhYmU0&hl=en_UShttps://docs.google.com/leaf?id=0Bx72aSXCBO09YTFhOGFlNTktNTE3Zi00YjJjLTgxYTMtMTY2MDA1ZTVhYmU0&hl=en_UShttps://docs.google.com/leaf?id=0Bx72aSXCBO09YTFhOGFlNTktNTE3Zi00YjJjLTgxYTMtMTY2MDA1ZTVhYmU0&hl=en_US
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    Sliding Filament Handout

    Sliding Filament Handout

    https://docs.google.com/leaf?id=0Bx72aSXCBO09YTFhOGFlNTktNTE3Zi00YjJjLTgxYTMtMTY2MDA1ZTVhYmU0&hl=en_UShttps://docs.google.com/leaf?id=0Bx72aSXCBO09YTFhOGFlNTktNTE3Zi00YjJjLTgxYTMtMTY2MDA1ZTVhYmU0&hl=en_UShttps://docs.google.com/leaf?id=0Bx72aSXCBO09YTFhOGFlNTktNTE3Zi00YjJjLTgxYTMtMTY2MDA1ZTVhYmU0&hl=en_UShttps://docs.google.com/leaf?id=0Bx72aSXCBO09YTFhOGFlNTktNTE3Zi00YjJjLTgxYTMtMTY2MDA1ZTVhYmU0&hl=en_UShttps://docs.google.com/leaf?id=0Bx72aSXCBO09YTFhOGFlNTktNTE3Zi00YjJjLTgxYTMtMTY2MDA1ZTVhYmU0&hl=en_UShttps://docs.google.com/leaf?id=0Bx72aSXCBO09YTFhOGFlNTktNTE3Zi00YjJjLTgxYTMtMTY2MDA1ZTVhYmU0&hl=en_US
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    g

    ANIMATION OF SLIDING FILAMENT

    https://docs.google.com/leaf?id=0Bx72aSXCBO09YTFhOGFlNTktNTE3Zi00YjJjLTgxYTMtMTY2MDA1ZTVhYmU0&hl=en_UShttps://docs.google.com/leaf?id=0Bx72aSXCBO09YTFhOGFlNTktNTE3Zi00YjJjLTgxYTMtMTY2MDA1ZTVhYmU0&hl=en_UShttps://docs.google.com/leaf?id=0Bx72aSXCBO09YTFhOGFlNTktNTE3Zi00YjJjLTgxYTMtMTY2MDA1ZTVhYmU0&hl=en_US
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    ANIMATION OF SLIDING FILAMENT

    http://www.blackwellpublishing.com/matthews/myosin.html

    http://www.blackwellpublishing.com/matthews/myosin.htmlhttp://youtube.com/v/pWP1u7rRJS8http://www.blackwellpublishing.com/matthews/myosin.htmlhttp://www.blackwellpublishing.com/matthews/myosin.html
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    Energy Source

    Provided by ATP from cellular

    respiration (mitochondria)

    Creatine phosphate increasesregeneration of ATP

    Much of the energy forms heat, which

    keeps our bodies warm

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    Other Terms

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    Other Terms1. Threshold Stimulus

    2. All-or-None Response3. Motor Unit

    5. Recruitment

    6. Muscle Tone

    7. Muscular Hypertrophy

    8. Muscular Atrophy

    9. Muscle Fatigue

    10. Muscle Cramp

    11. Oxygen Debt

    Th h ld Sti l

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    Threshold Stimulus

    Minimal strength required to cause a contraction

    Motor neuron releases enough acetylcholine to

    reach threshold

    All-or-None Response

    Fibers do not contract partially, they either do or

    don't

    Motor Unit

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    Motor Unit

    The muscle fiber + the motor

    neuron

    Recruitment

    more and more fibers contract asthe intensity of the stimulus

    increases

    Muscle Tone

    Sustained contraction of

    individual fibers, even when

    muscle is at rest

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    H t h

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    Hypertrophy - muscles enlarge (working out or certaindisorders)

    Atrophy - muscles become small and weak due to disuse

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    Muscle Fatigue- muscle loses ability to contractafter prolonged exercise or strain

    Muscle Cramp - a sustained involuntarycontraction

    Oxygen Debt - oxygen is used to create ATP,during exercise you may not have enough oxygen -

    -> this causes Lactic Acid to accumulate in the

    muscles

    *See Magic School Bus

    Origin and Insertion

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    Origin and Insertion

    Origin = the immovableend of the muscle

    Insertion = the movable

    end of the muscle

    **when a muscle

    contracts the insertion is

    moved toward the origin

    The biceps brachii has two origins

    (or two heads).

    What is rigor mortis? A few hours after a person or animal dies,

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    What is rigor mortis?the joints of the body stiffen and become

    locked in place. This stiffening is called

    rigor mortis. Depending on temperature

    and other conditions, rigor mortis lastsapproximately 72 hours. The

    phenomenon is caused by the skeletal

    muscles partially contracting. The muscles

    are unable to relax, so the joints become

    fixed in place.

    What is tetanus?

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    What is tetanus?

    Tetanus causes cholinosterase to not break down the

    acetylcholine in the synapse. This results in a person'smuscles contracting and not relaxing.

    A tetanus shot

    must be

    administered

    shortly after

    exposure to

    the bacteria.

    Once you

    develop

    tetanus, there

    is no cure.

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    http://youtube.com/v/2YZJt_Bw3eo
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    http://youtube.com/v/2YZJt_Bw3eo