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    Electrolytes

    Imbalances

    Prepared By: Mr. Charlie C. Falguera, RN

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    Sodium ImbalancesHyponatremia

    - A plasma sodium level below 135 mEq/L.

    Types:

    1. Hypovolemic hyponatremia

    - When sodium loss is greater than water loss.

    2. Euvolemic hyponatremia

    - When the total body water is moderately increased and the total body

    sodium remains at a normal level.

    3. Hypervolemic hyponatremia

    - When a greater increase occurs in TBW than in total body sodium.

    4. Redistributive hyponatremia

    - No change occur in TBW or total body sodium; water merely shifts

    between the intracellular & extracellular compartments relative to

    the sodium concentration.

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    Etiology:

    1. Hypovolemia hyponatremia

    - Renal loss of sodium from diuretic use, diabetic glycosuria,

    aldosterone deficiency, intrinsic renal disease

    - Extrarenal loss of sodium from vomiting, diarrhea, increased

    sweating, burns, high-volume ileostomy.

    2. Euvolemic hyponatremia

    - Sodium deficit resulting from SIADH or the continuous

    secretion of ADH due to pain, emotion, medications,

    cancers, CNS disorders

    3. Hypervolemic hyponatremia

    - Edematous disorder resulting in sodium deficit, CHF, livercirrhosis, nephrotic syndrome, acute & chronic renal

    failure

    4. Redistributive hyponatremia

    - Pseudohyponatremia, hyperglycemia, hyperlipidemia

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    Pathophysiology:

    1. Decreased excitability of the membranes.

    2. ECF becomes hypo-osmolar.

    Clinical Manifestations:

    1. Headache 11. Tachypnea, dyspnea

    2. Apprehension 12. Cheyne-stokes respi,3. Confusion neurogenic hyperventilation

    4. Hallucinations apneustic breathing

    5. Behavioral changes ataxic breathing

    6. Seizures 13. Nausea & vomiting

    7. Hypotension 14. Hyperactive bowel sounds

    8. Weak thready pulse 15. Abdominal cramping

    9. Tachycardia 16. Diarrhea

    10. Crackles 17. Dryness of skin & mucous

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    Diagnostic Findings;

    1. Plasma sodium level below 135 mEq/L

    2. Plasma chloride level below 98 mEq/L.

    3. Plasma osmolality less than 275 mOsm/kg.

    Management:

    1. Treat the underlying cause.

    2. Restrict fluid intake.3. Dietary supplementation.

    4. IV infusionPNSS or LR solution, 3% NaCl

    5. Meds: Diuretics, Demeclocycline

    6. Safety precautions.

    Complications:

    1. Brain herniation, coma, death

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    Hypernatremia

    - A plasma sodium level above 145 mEq/L.

    Types:

    1. Hypovolemic hypernatremia

    - When TBW is greatly decreased relative to sodium.

    2. Euvolemic hypernatremia

    - When the total body water is decreased relative to the normal total

    body sodium.

    3. Hypervolemic hypernatremia

    - When TBW is increased but the sodium gain exceeds the water gain.

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    Etiology:

    1. Hypovolemia hypernatremia

    - Renal loss of, osmotic diuresis, diuretics, severe

    hyperglycemia

    - Extrarenal loss: profuse diaphoresis, decreased thirst,

    diarrhea occuring with inadequate volume replacement or

    fluid replacement with hyperosmolar solutions, burns.

    2. Euvolemic hypernatremia

    - Excess fluid loss from the skin & lungs, hypodipsia in

    the elderly & infants, DI

    3. Hypervolemic hyponatremia

    - Administration of concentrated saline solutions,hypertonic feedings, excess mineralocorticoids, accidental

    or intentional salt ingestion, commercially preapred soups

    & canned vegetables.

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    Pathophysiology:

    1. Water shift from ICF to ECF.

    2. Na competes with Ca in the Ca channels for cardiac musclecontraction..

    Clinical Manifestations:

    1. Polyuria, oliguria 13. Weight gain

    2. Anorexia, N & V, weakness 14. Edema

    3. Restlessness, agitation, irritability 15. Dysrhythmia4. Dry, flushed skin 16. Crackles

    5. Dry, sticky mucous mem 17. Dyspnea

    6. Tongue furrows 18. Pleural effusion

    7. Increase thirst

    8. Fever

    9. Orthostatic hypotension/HPN

    10. Tachycardia

    11. Jugular vein distention

    12. S3 gallop

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    Diagnostic Findings;

    1. Plasma sodium level above 145 mEq/L

    2. Plasma chloride level above 106 mEq/L.

    3. Plasma osmolality more than 295 mOsm/kg.

    Management:

    1. Treat the underlying cause.

    2. Increase fluid intake.

    3. Restrict sodium.4. IV infusion0.3%, 0.45% NaCl, or D5W

    5. Meds: Diuretics, Desmopressin acetate

    6. Safety precautions.

    Complications:

    1. Coma, irreversible brain damage, death

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    Potassium Imbalances

    Hypokalemia

    - A plasma potassium level below 3.5 mEq/L. Etiology & Risk Factors:

    1. Inadequate K-intake.

    - Debilitated, confused, restrained, or lack access to dietary

    intake.- Malnourished, anorexic, bulimic, K-restricted diets, K-free IV

    solutions, older adults

    2. Excessive K-loss.

    - Vomiting & diarrhea, nasogastric suctioning, intestinal fistulae,

    ileostomy.

    - Osmotic diuresis, post-op clients, alcoholism,

    - Meds: K-wasting diuretics, cathartics, steroids,

    aminoglycosides, amphotericin B, digitalis preparations, beta-

    adrenergic drugs, cisplatin, bicarbonate, natural licorice

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    Etiology & Risk Factors:

    1. Redistribution of potassium

    - Increased levels of insulin, alkalosis, burns, sever tissue injury2. Others

    - Cushings syndrome, diuretic phase of renal failure,

    hyperaldosteronism, liver disease, cancer, wounds, Bartters

    syndrome

    Pathophysiology:

    1. Decreased gradient between ICF & plasma.

    2. Increase excitability.

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    Clinical Manifestations:

    1. Anorexia 16. Apnea

    2. Abdominal distention 17. Dysphasia

    3. Constipation 18. Areflexia4. Muscle weakness 19. Confusion

    5. Flabbiness 20. Vomiting

    6. Leg cramps 21. Ileus

    7. Fatigue 22. Polyuria8. Paresthesias 23. Nocturia

    9. Hyporeflexia

    10. Irritability

    11. Dysrhythmias

    12. Hypotension

    13. Slow, weakened pulse

    14. Shallo respirations

    15. SOB

    Di ti Fi di

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    Diagnostic Findings:

    1. ECG results:- Depressed & prolonged ST segment

    - Depressed & inverted T wave

    - Prominent U wave2. Lab test:- Plasma potassium level below 3.5 mEq/L

    Management:

    1. Treat the underlying cause.

    2. Foods high in K.

    3. K-supplementation.

    (eg. K-chloride, K-gluconateIV or PO)

    4. Safety precautions.

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    Hyperkalemia

    - A plasma potassium level above 5.0 mEq/L.

    Etiology & Risk Factors:

    1. Retention of K by body because of decreased or inadequate

    urine output.

    2. Excessive release of potassium from the cells during the first

    24-72 hours after traumatic injury or burns, or from cell lysis

    or acidosis

    3. Excessive infusion of IV solutions that contain K or

    excessive oral intake, especially in a person who has renal

    disaese.

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    Pathophysiology:

    1. Increase cell membranes excitation threshold.

    Clinical Manifestations:

    1. Paresthesia

    2. Tachycardia

    3. Intestinal colic

    4. Diarrhea

    5. Hypotension

    6. Convulsions

    7. Impaired cardiac conduction8. Muscle weakness

    9. Paralysis

    10. Flaccid muscles

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    Diagnostic Findings;

    1. Plasma potassium level above 5 mEq/L

    2. Plasma BUN above 20 mg/dL.

    3. Plasma creatinine more than 2.5 mg/dL.

    4. ECG reveals: Peak T-wave

    Management:

    1. Treat the underlying cause.

    2. Dietary restriction of foods high in K.3. Infusion of IV Calcium gluconate.

    4. Infusion of insulin & glucose.

    5. IV Beta-agonist albuterol.

    6. Na-polystyrene sulfonate (Kayexalate)PO or rectal

    7. Allopurinol & diuretics

    8. Safety precautions

    Complications:

    1. Cardiac arrest, respiratory muscle paralysis

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    Calcium Imbalances

    Hypocalcemia-A plasma calcium level below 4.5 mEq/L or

    8.5 mg/dL.

    Etiology & Risk Factors:

    1. Inadequate intake

    - Older adult, decreased Vit. D, lactose intolerance, GI disease, liverdisease, alcoholism, anorexia, bulimia, prolong NPO, prolong

    intsitutionalization

    2. Hypoparathyroidism, inadvertent removal of PT gland,

    Pancreatitis, open wounds, Cushings disease, alkalosis,

    multiple BT.3. Meds: Mg So4, colchicine, neomycin, aspirin,

    anticonvulsants, estrogen, phosphate preps, steroids, loop

    diuretics, antacids & laxatives

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    Pathophysiology:

    1. Decrease in threshold potential.

    Clinical Manifestations:

    1. Numbness & tingling sensations 17. Fractures

    2. Emotional lability 18. Diarrhea

    3. Cardiac insufficiency

    4. Hypotension

    5. Dysrhythmias

    6. Trousseaus sign

    7. Chvosteks sign

    8. Prolonged bleeding time

    9. Seizures

    10. Catarcts

    11. Dry, sparse hair

    12. Rough skin

    13. Laryngeal stridor

    14. Tetany

    15. Hemorrhage

    16. Cardiac collapse

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    Hypercalcemia

    - A plasma calcium level over 5.5 mEq/L or 11 mg/dL.

    Etiology & Risk Factors:

    1. Metastatic malignancy

    2. Hyperparathyroidism.3. Thiazide diuretic therapy

    4. Excessive intake of Ca & vit D supplements.

    5. Calcium-containing anatcids

    6. Prolonged immobilization7. Metabolic acidosis

    8. Hypophosphatemia

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    Pathophysiology:

    1. Increase in threshold potential.

    Clinical Manifestations:

    1. Anorexia

    2. Nausea & vomiting

    3. Polyuria

    4. Muscle weakness

    5. Fatigue

    6. Lethargy

    7. Dehydration

    8. Constipation

    9. Colicky pain

    10. Bone pain

    Diagnostic Findings:

    1. Plasma calcium levelabove 5.5 mEq/L or 11.5 mg/dL

    2. ECG: widened T wave, shortened QT interval.

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    Management:

    1. Assess V/S, & ECG.

    2. Assess bowel sounds & renal function.

    3. Increase fluid intake.

    4. Sodium intake is increased.

    5. Consumption of high fiber foods.

    6. Safety precautions.

    7. Meds:

    - IV normal saline

    - Cortocosteroids

    - IV phosphate

    - Calcitonin

    - Etidronate disodium (Didronel)

    - Gallum nitrate

    Complications:

    1. Renal stones, renal failure, coma

    h h b l

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    Phosphate Imbalances Hypophosphatemia

    A plasma phosphorous level less than 1.2 mEq/L.

    Etiology & Risk Factors:

    1. Loss or long-term lack of intake

    2. Increased growth or tissue repair3. Recovery from malnourished state.

    4. Prolonged & excessive intake of antacids

    5. Admin of high levels of glucose via tube feedings or IV line

    6. Cushings syndrome7. Hyperparathyroidism

    8. Respiratory/Metabolic Alkalosis

    9. Lead poisoning

    10. Burns

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    Pathophysiology:

    1. Impairs the conversion of glucose & other substances to ATP.

    Clinical Manifestations:1. Decreased cardiac or respiratory functions

    2. Muscle weakness

    3. Fatigue

    4. Brittle bones

    5. Bone pain6. Confusion

    7. Seizures

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    Management:

    1. Diet & dietary supplementation.

    2. TPN

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    Hyperphosphatemia

    A plasma phosphorous level greater than 3

    mEq/L.

    Etiology & Risk Factors:

    1. Excessive intake of high-phosphate foods

    2. Excess vitamin D3. Impaired colonic motility

    4. Hypoparathyroidism

    5. Addisons disease

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    Clinical Manifestations:

    1. Tachycardia

    2. Palpitations3. Restlessness

    4. Anorexia

    5. Nausea & vomiting

    6. Hyperreflexia

    7. Tetany

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    Manifestations:

    1. Anorexia

    2. Nausea

    3. Abdominal distention

    4. Depression

    5. Psychosis

    6. Confusion

    7. Chvosteks sign

    8. Trousseaus sign

    9. Tetany

    10. Convulsion

    11. Vasospasm

    Diagnostic Tests:

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    Diagnostic Tests:

    1. ECGProlonged QT intervals, widened QRS complex,

    broadening T waves

    Management:

    1. Increase intake of Mg rich foods.

    2. Safety & seizure precautions.

    3. Assess DTR.

    4. Supplementation:

    1. Oral magnesium replacement

    2. Parenteral Mg So4

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    Hypermagnesemia

    A plasma megnesium level above 2.5 mEq/L.

    Etiology & Risk Factors:

    1. Renal insufficiency

    2. Excessive use of Mg-containing antacids or laxatives3. Potassium-sparing diuretics

    4. Dehydration from ketoacidosis

    5. Overuse of IV MgSO4

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    Manifestations:

    1. Peripheral vasodilation

    2. Hypotension

    3. Severe muscle weakness

    4. Lethargy

    5. Drowsiness

    6. Loss of DTR

    7. Respiratory paralysis

    8. PVC

    Diagnostic Test:

    ECGProlonged PR, QT intervals

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    Management:

    1. Assess V/S, respiratory function, ECG recordings, urine

    output.

    2. Safety & seizure precaution.3. Drugs:

    1. IV calcium salts

    2. Albuterol

    4. Avoid constant use of laxatives & antacids containing Mg.

    5. Diet: High fiber.

    6. Increase fluid intake.

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    Thank

    You!!!