digoxin

Reactions 1488, p17 - 15 Feb 2014 Digoxin Gynaecomastia in an elderly patient: case report A 96-year-old man developed gynaecomastia following treatment with digoxin for atrial fibrillation with congestive heart failure. The man was hospitalised with acute exacerbation of congestive heart failure, and was discharged receiving digoxin 0.125mg daily [route not stated] for atrial fibrillation with congestive heart failure. He presented with reports of chest pain and breast enlargement bilaterally, 4 months later; these symptoms developed shortly after release from hospital, 4 months prior. Following medication review, digoxin was singled out to be the most probable cause of the gynaecomastia. Digoxin was withdrawn with resolution of gynaecomastia after 2 months. Author comment: "The basic structure of digitalis compounds is similar to estrogen. Several studies have indicated that they show affinity to the estrogen receptor, which leads to proliferation of glandular tissue. The chronic use of digitalis derivatives therefore can lead to GM [gynaecomastia], especially in elderly men." Salman A, et al. Gynecomastia in an elderly male; is digoxin a culprit?. Journal of General Internal Medicine 28 (Suppl.): S334, No. 1, Jun 2013 [abstract] - USA 803099396 1 Reactions 15 Feb 2014 No. 1488 0114-9954/14/1488-0001/$14.95 Adis © 2014 Springer International Publishing AG. All rights reserved

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Reactions 1488, p17 - 15 Feb 2014

Digoxin

Gynaecomastia in an elderly patient: case reportA 96-year-old man developed gynaecomastia following

treatment with digoxin for atrial fibrillation with congestiveheart failure. The man was hospitalised with acuteexacerbation of congestive heart failure, and was dischargedreceiving digoxin 0.125mg daily [route not stated] for atrialfibrillation with congestive heart failure. He presented withreports of chest pain and breast enlargement bilaterally,4 months later; these symptoms developed shortly afterrelease from hospital, 4 months prior. Following medicationreview, digoxin was singled out to be the most probable causeof the gynaecomastia. Digoxin was withdrawn with resolutionof gynaecomastia after 2 months.

Author comment: "The basic structure of digitaliscompounds is similar to estrogen. Several studies haveindicated that they show affinity to the estrogen receptor,which leads to proliferation of glandular tissue. The chronicuse of digitalis derivatives therefore can lead to GM[gynaecomastia], especially in elderly men."Salman A, et al. Gynecomastia in an elderly male; is digoxin a culprit?. Journal ofGeneral Internal Medicine 28 (Suppl.): S334, No. 1, Jun 2013 [abstract] -USA 803099396

Add, amid van –dilemmák súlyos digoxin-mérgezésbenAdd, amid van –dilemmák súlyos digoxin-mérgezésben Pap Csaba Zsolt 1, Elek István 1 BallaginéSzabó Klára 2, Kovács

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12000000100269 Lanoxin Digoxin Tablets 0.25mg B.P. Digoxin ... · 12000000100269 Lanoxin Digoxin Tablets 0.25mg B.P. Digoxin (k : 4R4Digoxin 0. 25mg 1. 2. 3. 5. 6. 8. 9. , , Digoxin