adhere(migration)(differentiation)(proliferation)biorecognitionreceptorligand

adhesion molecules

cadherins(integrins)16724

ECM:collegenECMfibronectinECMproteoglycanlaminin

extracellular matrix,ECMECMligandRGD--

focal adhesions,FAs

protein complexes(cytoskeleton)(ECM)anchoring the celltransmitting signals 10-15nm

(talin)(paxillin)(vinculin)tensinfocal adhesion kinase

actin

tyrosine kinase,Src(focal adhesion kinase)InRNA

migration

focal complex0.25(focal adhesion)

http://www.reading.ac.uk/cellmigration/migration.htm

topography

.

1.Exploring and engineering the cell surface interface .Molly M. Stevens Julian H. George2. Dalby, M. J., et al., Nat. Mater. (2007) 6, 997

Hydrophilicity/HydrophobicityVoglerself-association

Hydrophilicity/Hydrophobicity:();(RGD);Cellsurface interactions of rat tooth germ cells on various biomaterials.Journal of Biomedical Materials Research Part A.

(fanctional group) ;;()

Effects of surface functional groups on protein adsorption and subsequent cell adhesion using self-assembled monolayersYusuke Arim, Hiroo Iwata.

(surface charge) BaldwinNGFInteraction of cells on chargeable functional group gradient surfaces. Jin Ho Lee, Jin Whan Lee etc.