entamoeba histolytila
TRANSCRIPT
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ENTAMOEBA HISTOLYTILA
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INTRODUCTION:
• Entamoeba histolytica causes amoebasis
• The parasite is the 3rd loading parasitic causes of death
in the developing country
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HABITAT:
• The trophozoites of entamoeba histolytica inhabitat
mucosa and submucosa of the large intestine
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MORPHOLOGYThe parasite occur in 3 stages namely
• Trophozoites
• Preeyst
• Cyst
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LIFE CYCLE
• The life cycle of entamoeba histolytia is simple in and is
completed in the single host the man
• Man acquires infection by ingestion of water and food
contaminated with cyst
• The cyst enter into the small intestine
• Here the cyst wall is lysed by trypsin.
• This result in ex-cystation
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• During excystation the trophozoites [4 in number]
• The trophozoites emger from the cyst undergo cyloplasmic
and nuclear division
• This division leads to formation 8 trophozoites
• This trophozoites carried to large intestine was they grow
and multiply by binary fission. After colonization.
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• Some trophozoites produced no or little lesion.
• The only feed on mucus secretion on the surface of the mucosa.
• Some trophozoites may invert the tissue of large intestine.
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PATHOGENESIS AND PATHOLOGY• Pathogenesis of endamebas is due to following factors.
• Adhesion of trophozoites on the surface of large
intestine.
• Invasation of large intestine by amoeba
• Resistance of amoeba to various effectors mechanism of
the host
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PATHOLOGY OF INTESTINAL AMOEBIASIS
Amoebic ulcers:
• It is the characteristic pathological lesions in the intestinal
amoebiasis
• Its flask shape and may be localized or generalized
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Acute Intestinal Amoebiasis:
• In acute intestinal amoebiasis the lesion is occur in the
mucosal layer.
• This lesion may contain narrow neck and broad base (flask
shape)
• The board base is filled with necrotic debris
• This lesion may be healed completely without leaving any
scar
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CHRONIC INTESTINAL AMOEBIASIS:
• In this case the ulcers may be to the distribution mucosal and
submucosal layer.
• This ulcer are healed with thickening of the intestinal
granuloma
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PATHOLOGY OF EXTRA INTESTINAL AMOEBIASIS:
Amoebic Liver Abscess:
• The abcess occur in any part of the liver.
• The cavity of the abcess contain reddish brown fluid and spread
of connection tissue
• The liver abcess the pus is thick and chocolate brown in color is
called anchonvy chocolate pus
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PULMONARY AMOEBIASIS:
• The lungs abscess may be single or multiple are found in the
lower lobes of the right lungs.
• Expectoration of reddish brown sputum is the characteristic
feature of the condition
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LABORATORY DIAGNOSIS:Lab diagnosis is include,
• Parasitic diagnosis
• Sero diagnosis
• Biochemical diagnosis
• Radio imaging diagnosis
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PARASITIC DIAGNOSIS:• It includes stool examination
• The stool is examined by microscopic observation and culture.
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OBSERVATION
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Sero Diagnosis:
• Sero diagnosis by indirect heamaglutination [IHA], indirect fluorescent agglutination [IFA], [ELISA]
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BIOCHEMICAL DIAGNOSIS• It’s based on biochemical and haematological
changes that occur in liver.
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Radio imaging Diagnosis
• It’s by ultrasound CT, Scan
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Treatment:-
• Eradication of amoeba by use amoebic site like Teniadzole
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PREVENTION
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