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Copyright By The Korean Society of Perinatology
25 4, 2014 Korean J Perinatol Vol.25, No.4, Dec., 2014 http://dx.doi.org/10.14734/kjp.2014.25.4.307

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(Fig. 1)
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.

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(glial heterotopia)
(glial choristoma)

.1-3 (extracranial midline
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.5, 6
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1^1^1^2^3
Glial Choristoma Accompanied with Severe Bony Defect in Orbit in a Newborn
Suk Hwan Han, M.D.1, Tae Hee Kim1, Na Mi Lee, M.D.1, Jae Kyun Kim, M.D., Ph.D.2, and She Young Lee, M.D., Ph.D.3
1Departments of Pediatrics, 2Radiology, 3Otorhinolaryngology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea
Glial choristoma is a mass-like lesion composed of otherwise normal, mature brain tissue that is isolated from the spinal cord and cranial cavity. In generally, this choristoma involves extracranial midline structures, especi- ally the nose, as well as the nasopharynx, oropharynx and cleft. Glial choristomas rarely involve extracranial non-midline structures such as the scalp, orbit, middle ear or mastoid and account for approximately 10% of all glial choristomas. Moreover, such glial choristoma presentations are usually seen in adults, most of whom have predisposing factors such as trauma, surgery, or chronic inflammation. Here, we present a case of a glial choristoma that invaded a neonate’s the nasopharynx, oropharynx, oral cavity and orbit.
Key Words : Brain, Choristoma, Heterotopia, Orbit, Newborn
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×4 cm
.
.
(stridor) .
.
: (magnetic reso-
nance imaging, MRI) 3.1×2.4 cm

(Fig. 2A). 2.5×2.2 cm
(multiloculated cystic mass)
(masticator space) (buccal space)
(foramen lacerum)
(Fig. 2B).
(computed tomography, CT)
(Fig. 2C).
.


(debulking surgery) (excisional biopsy)
(glial tissue)
(choroid plexus) (Fig. 3A).
(glial fibrillary acidic protein,
GFAP) (Fig. 3B).
(cystic fluid)
. (normal cellu-
larity) (atypia) (pleo-
morphism) ,
A B Fig. 1. Gross photographs taken prior to surgery. A mass at the right buccal area (A) and a mass in the oral cavity with mouth was opened (B).
A B B C Fig. 2. The patient’s radiologic findings. Magnetic resonance imagine (MRI) showing a mixed cystic and solid lesion approximately 3.1x 2.4 cm with a bony defect in the right inferior orbital wall (A). MRI showing a multiloculated cystic mass approximately 2.5x2.2 cm with peripheral enhancement in the right masticator and buccal space as well as connected with cystic lesion in right foramen lacerum on MRI (B) and a computed tomography scan showing a bony defect in the right orbit floor (C).
: - -
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(marsupialization)
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(teratoma), (glioma),
(neurofibroma), (myofibroma), (en-

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1907 Wolbach ,
, (spinal cord)
- .8
6
(intraparenchymal lesions, dural and leptomeningeal
lesions, intracranial extracerebral lesions, midline
lesions, distal lesions of the lung and uterus, extra-
cranial non-midline lesions) .3, 4, 9

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,
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(maxillofacial), (temporal bone)
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(hypercellularity), (cellular pleo-
Fig. 3. Patient’s pathologic findings. The mass is composed of mature glial tissue and choroid plexus-like area with papillary formation (A, Hematoxylin-and-eosin stain, x100). Both the glial and choroid plexus-like area showing a strong positive reaction for glial fibrillary acidic protein (B, x100).
Suk Hwan Han, et al. : - Glial Choristoma Accompanied with Severe Bony Defect in Orbit in a Newborn -
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