how mitochondria influence our health · most experts recognize warburg as the greatest biochemist...

Mitochondrial Biogenesis

How mitochondria influenceour health

Dr Fathi Neana MD

Chief of Orthopaedics

Dr Fakhry amp Dr A Al-Garzaie Hospital

August21 - 2018

ناب و عأ لك ل راسك تتخذون منأه من ثمرات النخيل والأقا حسنا إن في ذ ية ورزأ

م يعأقلون سورة النحل( 67)لقوأ

New Lifestyle diseasesNon-communicable diseases (NCDs)

bull Obesity

bull Metabolic syndrome

bull Coronary artery disease

bull Diabetes type 2

bull Hypertension

bull Arteriosclerosis

bull Stroke

bull Cancer

bull Depression - anxiety

bull Arthritis

bull Osteomalacia

bull Osteoporosis

bull Swimmers ear ndash loss of hearing

bull Ch obstructive pulmonary disease

bull Liver Cirrhosis

bull Nephritis

bull Etc etc etchellip

Emerged as bigger killers than infectious or hereditary ones

The leading cause of death in the world

63 of all annual deaths

gt 38 million people are killed year1- Cardiovascular diseases (175 million)

Complications of hypertension (94 million)

2- Cancers (82 million)

3- Respiratory diseases (4 million)

5- Diabetes (15 million)

These 4 diseases account for 80 of all NCDs deaths (gt 38 million)

4- USArsquos 4th Leading Cause of Death ndash Pharmarsquos Drugs

Posted on June 25 2012 by Child Health Safety

Causes

bull Stress-Depression

bull Diet

bull Sleep-awake

bull Lack of Exercise

bull Sun avoidance

bull Wireless WiFi devices

bull Leaky gut syndrome

bull Other pollutants

Including Medicines

The Root cause and Culprit behind Chronic Diseases Cancer and Aging

1- A state of chronic low grade inflammation

Dr Richard K BernsteinDiabetes amp Inflammationmdashthe Vicious Cycle

(Hyperglycemia ndash Omega 6 - Obesity) - Leukotriene B(4) (LTB(4)

Lindsay ChristensenLindsay Christensen is a health writer and researcher with her BS in

Biomedical Science and an Emphasis in Nutrition

(Pathogens unhealthy diet lack of exercise)

2- Mitochondrial dysfunction(not the genetic make up)

Dr Ron RosedaleBreakthrough views on clinical metabolic biochemistry

1- Harmful Effects of too much Sugar

-gtgt Insulin and leptin receptor resistance

-gtgt Free radicals (ROS) 90 Mitochondria

2- Harmful Effects of too much Protein

-gtgt Activation of the mTOR metabolic signaling pathway

3- Physical inactivity (lack of exercise)

4- Pollutants

5- Drugs causing mitochondrial toxicity

(Iatrogenic) Mitochondrial dysfunction

Energy (ATP - ADP)

Leukotriene B(4) (LTB(4) acts as a signal to relay information from cell to cell over long distances

Dr Josef mercola

I never learned anything about the root cause of chronic disease

in med school

Surprisingly my seven years of medical school and family

practice residency never addressed the root cause of common

chronic illness

All I was taught was how to manage symptoms through the use

of pharmaceuticals and medical procedures

Then in 1995 my understanding of chronic disease took a

quantum leap I was introduced to Dr Ron Rosedale and his

breakthrough views on clinical metabolic biochemistry

What I Learned in 1995 Forever Shaped My View on Cancer and

Chronic Disease

Cancer Is One of the Most Manageable Diseases ldquoOnce we realize

that cancer is a metabolic disease


Clinical metabolic biochemistry - breakthrough

Mitochondrial

dysfunction

1- Our bodyrsquos lifeline

2- Mitochondria are tiny organelles in our cell

thousands of them comprising 15 to 50 of the cell

volume Red blood cells and skin cells have very little

to none while germ cells have 100000 but most cells

have one to 2000 of them

3- Theyre the primary source of energy for our body

They supply over 90 of our bodyrsquos energy

4- Converting the food we eat and the air we breathe

into usable energy

The MitochondriaHow Your Mitochondria Influence Your Health

January 24 2016

5- It have enormous potential to influence our health specifically cancer and optimizing

mitochondrial metabolism may be at the core of effective cancer treatment

6- Important nutrients and co-factors for mitochondrial function include

all B vitamins magnesium omega-3 fat CoQ10 acetyl L- carnitine D-ribose and alpha-

lipoic acid Exercise is also important for mitochondrial health and function

AIR

O2

FUELCarb-Protein-Fat

How the human life is maintainedWATER

﴾ ء حي [30 بياء اليةسورة الن]﴿وجعلأنا من الأماء كل شيأAnd We have made from water every living thing

ENERGY

Waste (ROS)

Free radicals

Control system

(Signaling pathway - Feed back) - Nervous ndash Hormonal ndash Enzymatic

Acetic acid acetyl group derived from

acetic acid is fundamental to the

biochemistry of virtually all forms of life

When bound to coenzyme A it forms

acetyl-CoA

The citric acid cycle is a key metabolic pathway that unifies carbohydrate fat and protein metabolism The reactions of

the cycle are carried out by 8 enzymes that completely oxidize acetate in the form of acetyl-CoA

ناب عأ خذون منأه ومن ثمرات النخيل والأ تت

سكراقا حسنا إن في ذ م يعأ ورزأ قلون لك لية لقوأ

سورة النحل ( 67)

( ل نعأم اإلدام الخ ) قال صلى هللا عليه وسلم

(2051) رواه مسلم

ل إلى المعادلة الكيميائية التالية توضح تحول الكحو

خل بالتفاعل مع غاز األكسجين

CH3CH2OH + 2 O2 --- gt

2 CH3COOH + 2 H2O

Alcohol + Oxygen ----gt

Acetic Acid + Water

ماء+ الخل حمضlt -----أوكسجين + كحول

Mitochondria

CoA

How the human life is maintained

To produce energy mitochondria require oxygen from the air we

breathe and fat and glucose from the food we eat

Breathing and eating mdash are coupled together in a process called

oxidative phosphorylation Thats what the mitochondria use to

generate energy in the form of ATP

Mitochondria have a series of electron transport chains The

electrons pass from the reduced form of the food to combine

with oxygen from the air and ultimately to form water

How Mitochondria Produce Energy

This process drives protons across the mitochondrial membrane which recharges ATP (adenosine

triphosphate) from ADP (adenosine diphosphate) ATP is the carrier of energy throughout your body

That process also produces byproducts such as reactive oxygen species (ROS) which are damaging to

cells and mitochondrial DNA which are then transferred to nuclear DNA

Our body also ages from the damaging aspects from the ROS that are generated

How quickly our body ages largely depends on how well our mitochondria work and how much damage

Cancer as a metabolic diseaseCancer cells however are resistant to this suicide protocol (apoptosis) and have a built-in defense

against it (explained by Dr Warburg and subsequently by Thomas Seyfried)

One of the mechanisms by which chemotherapeutic drugs work is they create reactive oxygen species

ROS They create damage and thats enough to push that cancer cell to die (explained by Patrick)

Cancer cell mdash which is not using its mitochondria (using sugar ndash fructose) not producing those

reactive oxygen species ROS any longer

All of a sudden forcing it to use its mitochondria (cut off sugar) we get a burst of reactive oxygen

species ROS thats what mitochondria do and boom death because that cancer cell is already primed

for that death Its ready to dierdquo

Mitochondrias Role in Cancer

When cancer cells are present the reactive oxygen

species ROS produced as a byproduct of ATP production

normally send a signal that sets in motion a process of

cellular suicide also known as apoptosis

By killing off damaged cells the body can eliminate and

replace them with healthy cells

One of the universal characteristics of cancer cells is they have serious mitochondrial dysfunction with

radically decreased numbers of functional mitochondria

The mitochondria can still function in cancer cells But [cancer cells] immediately become dependent

on glucose and theyre not using their mitochondria even though they have mitochondria there They

make this metabolic switch Patrick says

ketogenic diet forces cancer cells to use its mitochondria (cut off sugar) with a burst of reactive

oxygen species ROS

ketogenic diet which radically improves mitochondrial health could help most cancers especially if

used in conjunction with glucose fermentation poisons like 3-bromopyruvate

In order for our organs to function properly they require energy and that

energy is produced by the mitochondria

Since mitochondrial function is at the very heart of everything that occurs in

our body

Optimizing mitochondrial function - and preventing mitochondrial dysfunction

by get ting all the right nutrients and precursors our mitochondria need - is

extremely important for health and disease prevention


Dr Otto Warburg was a physician with a PhD in chemistry and was close friends with Albert Einstein

Most experts recognize Warburg as the greatest biochemist of the 20th century

He received a Nobel Prize in 1931 for his discovery that cancer cells use glucose as a source of energy production This is called

the Warburg Effect and sadly to this day it is essentially ignored by nearly every expert

Mitochondrial FuelWhich Fuel You Burn In Your Mitochondria for Energy Determines How Long Your Mitochondria Last

and That Determines How Long You Live

Just As Gasoline Engines Run Best With Gasoline and

Not Diesel or Aviation Fuel So Too

Our Mitochondrial Cellular Engines Run Best With Fat

As Fuel Instead of SugarAccording to Dr Ron Rosedale - ldquoIf I were to summarize in a single sentence what practice

would best promote health it would be thisrdquo

ldquoHealth and life span are determined by the proportion of fat versus

sugar people burn throughout their lifetime

The more fat that one burns as fuel the healthier a person will be

and the more likely he or she will live a long time

The more sugar a person burns the more disease ridden and the

shorter a life span a person is likely to haverdquo

(The above sentence is perhaps the most IMPORTANT statement you will ever read in regard

to health and longevity)

The mitochondria can only burn fat or sugar for

energy Which fuel is burned in the mitochondria for

energy determines how long the mitochondria stay in

good shape

Creating energy by burning fuel in the mitochondria is necessary but it is destructive to our

bodies just like burning gasoline or diesel is necessary but destructive to the engine of the

automobile

bullBurning fat in the mitochondria produces more energy than does burning sugar

bullFewer free radicals are released when burning fat than when burning sugar

bullHowever burning sugar is very fast compared to burning fat and so sugar burning is very

USEFUL DURING TIMES OF EMERGENCY

You could almost say that our cells were designed to burn sugar only temporarily in times of

great exigency when the damage from free radicals is not as important as dealing with the

emergency

If our bodies had been designed to primarily burn sugar as a fuel then we would store sugar

cubes within our bodies but we donrsquot we store fat We store only minor amounts of sugar

(in the form of glycogen) mdash enough to last for 30 to 60 minutes of emergency exertion

Main Mitochondrial Fuel ConceptFat is the Best Fuel

The Hypothalamus Sends Signals to the Body

Instructing Fat Burning or Sugar Burning

In Many People the Hypothalamus is

Erroneously Sending the lsquoBurn Sugar Signalrsquo

The hypothalamus is a gland in the brain that dictates to

the entire body which fuel the cells of the body are to use

fat or sugar

The hypothalamus decides which mode to put the body in

based on the amount of leptin it can measure in the body

A great number of peoplersquos bodies are being ldquoforced

unnecessarilyrdquo to burn sugar instead of fat because that

tiny hypothalamus gland believes the body is starving

and therefore sends a signal to the cells of the body that

sugar should be burned instead of fat (in order to conserve

fat)

This is unnecessarily causing the mitochondria

to ldquodeteriorate fasterrdquo

Why Does the Hypothalamus Unnecessarily Force a Sugar

Burning Mode in Our Bodies

One of the most important functions of the

hypothalamus is to link the nervous system to

the endocrine system via the pituitary gland

Thehypothalamus is located below the

thalamus and is part of the limbic system In

the terminology of neuroanatomy it forms the

ventral part of the diencephalon

bullToo much stored fat (Obesity) Too much stored fat produces large amounts of circulating leptin which desensitizes the hypothalamusrsquos ability

to detect leptin (Leptin resistance) When leptin levels are not able to be detected because the receptors in the

hypothalamus have been desensitized the hypothalamus believes the body is starving and instructs sugar

burning in order to conserve and build up fat stores This is ironic because essential the bodyrsquos pantries are full

of fat but these pantries are inaccessible and so the cells are instructed to ignore fat and look for sugar to burn

for energy ( Craving)

There are only three reasons for the body

to be in sugar burning mode

bullToo much stress Stress creates the adrenal gland to relase

adrenaline Adrenaline overrides the

hypothalamus signal and instructs sugar

burning

bullToo much blood sugar Blood sugar (over time) damages receptors in the

hypothalamus When these receptors are damaged

then the hypothalamus cannot correctly sense

leptin and believe there is no fat (ie starvation is occurring)



Mitochondrial fission fusion and stressYoule RJ1 van der Bliek AM

Mitochondrial fission and fusion play critical roles in

maintaining functional mitochondria when cells

experience metabolic or environmental stresses

Fusion helps mitigate stress by mixing the contents of

partially damaged mitochondria as a form of

complementation

Fission is needed to create new mitochondria but it

also contributes to quality control by enabling the

removal of damaged mitochondria and can

facilitate apoptosis during high levels of cellular

stress

Disruptions in these processes affect normal development and they have been

implicated in neurodegenerative diseases such as Parkinsons

Abbreviations ATP adenosine triphosphate DHPR dihydropyridine receptor MCU mitochondrial calcium uniporter MICU1 mitochondrial

calcium uptake 1 NCLX mitochondrial sodiumcalcium exchanger mPTP mitochondrial permeability transition pore SR sarcoplasmic

reticulum RyR ryanodine receptors IMM inner mitochondrial membrane OMM outer mitochondrial membrane ROS reactive oxygen

species


What causes

Mitochondrial

dysfunction

Dr Ron Rosedale Defective metabolic processes in mitochondria not the genetic make up That cause cancer and nearly all other chronic diseases including accelerated aging

What causes Mitochondrial dysfunctionThe causes of Defective metabolic processes in mitochondria

1- The Harmful Effects of too much SugarA- Diet (HCLF)Insulin and leptin receptor resistance

Free radicals (ROS) 90 Mitochondria

B- Stress Adrenaline ndash hypothalamus -gtgt sugar

C- ObesityLeptin resistance - hypothalamus -gtgt sugar

2- The Harmful Effects of too much ProteinActivation of the mTOR metabolic signaling pathway

3- Lack of exercise and Physical activity

Harmful Effects

of Sugar

Sugar is a ldquodirtyrdquo fuel excessive free radicals caused by

reactive oxygen species (ROS)

Wile fat burns much cleaner So by replacing carbs with

healthy fatsrsquo mitochondria are less likely to suffer damage

90 or more of the total ROS (Reactive oxygen species)

are produced within the mitochondria causing devastating

damage

It was thought excessive ROS could be addressed by taking

antioxidants but we now know that this was a flawed

strategy and it is far better to prevent their production by

eating an optimal fuel mixture

LCHF OR MMT 0R KD can help your cellsrsquo mitochondria

reach the ldquoGoldilocksrdquo zone for producing ROS mdash not too

much and not too little but just the ldquorightrdquo amounts for

healthy cellular and mitochondrial function

Harmful Effects of too much SugarChronic low grade inflammation - Mitochondrial dysfunction


1- State of chronic inflammation2- Lipoprotein Oxidation amp Glycation3- Hyper insulinemia syndrome - Metabolic syndrome-gt Insulin resistance (type 2 DM)-gt increased triglycerides VLDL-gtCholesterol (small dense LDL type B particles)

4- HFCS (High-fructose corn syrup) is found in almost all types of processed foods and drinks (Sugar toxic addicting and deadly)

7- feedsrdquo the cancer cells fructose is readily used by cancer cells (not using mitochondria ndash no ROS to kill it)

8- Gaining weight (insulin and leptin signaling resistance)

9- Increases uric acid levels - risk for heart amp kidney10- Overloads and damages the liver much sugar or fructose likened the effects of alcohol11- Other diseases linked to metabolic syndrome include Type 2 diabetes Heart disease Hypertension Polycystic ovarian syndrome Lipid problems Dementia and Alzheimers disease

Harmful Effects

of too much

protein

Harmful Effects of too much ProteinPaleo diet

Activation of the The mammalian Target Of Rapamycin (mTOR) metabolic

signaling pathway by too much protein

The figure highlight and summarize the current

understanding of how mTOR nucleates distinct multi-

protein complexes how intra- and extracellular

signals are processed by the mTOR complexes and

how such signals affect cell metabolism growth

proliferation and survival

mTOR function in skeletal muscle a focal point for overnutrition and exercise A Rivasa Sarah J Lessardb Vernon G Coffeya

aExercise Metabolism Group School of Medical Sciences RMIT University Bundoora Victoria 3083ailartsuA ز The Research Division Joslin Diabetes

Center and Department of Medicine Harvard Medical School Boston MA 02215ASU ز Corresponding author (email vernoncoffeyrmiteduau)

Published on the web 6 October 2009 Received March 292009yaM detpeccA 262009


The mammalian target of rapamycin (mTOR) -

Discoveries that have been made over the last decade

phosphatidylinositol 3-kinase-related kinase family of protein

kinases signaling pathway integrates both intracellular and

extracellular signals

The mTOR pathway serves as a central regulator of cell

metabolism growth proliferation and survival

The mTOR pathway is activated during

1- Tumor formation angiogenesis insulin resistance

adipogenesis and T-lymphocyte activation etc

2- Deregulated in diseases as cancer and type 2 diabetes

Nutrients and Exercise modify mTOR function

Growing therapeutic use of mTOR inhibitors (rapamycin and

rapalogues) in solid tumors organ transplantation coronary

restenosis and rheumatoid arthritis


understanding of how mTOR nucleates distinct

multi-protein complexes how intra- and

extracellular signals are processed by the

mTOR complexes and how such signals affect

cell metabolism growth proliferation and

survival

Cancer is One of the Most Manageable DiseasesOnce we realize that cancer is a metabolic disease

Dr Josef Mercola - 2016

We can take charge of those kinds of things with Eating too many

sugars and carbs without fiber along with too much protein we ignite

a cascade of metabolic events that includes

bullWidespread inflammation and cellular damage especially our

mitochondria or cellsrsquo power factories

bullFaster aging and a greater risk of all cancers from the activation of

bodyrsquos most important signaling pathway mTOR from eating excess

protein

bullAn increase in insulin resistance that can progress to prediabetes or

Type 2 diabetes because cells have lost their ability to respond to

insulin effectively

bullOvereating due to leptin resistance with loss of control over appetite

and knowing when yoursquore ldquofullrdquo

bullAn inability to lose weight because body is holding on to fat instead

of burning it for fuel

Saturated Fats

are Healthy

29

A diet low in saturated

fat will not prevent

heart disease or

prolong life

30

The typical atherosclerotic plaque comprises of the lipid core and

the fibrous cap and is the most commonly classified histologically

by the American Heart Association

Atherosclerotic plaque

Causes

1- Endothelial damage amp permeability

2- Small dense particles LDL type B

Caused by

1- Chronic inflammation

2- Insulin ndash Leptin resistance

(Diet too high in sugars + Obesity)

Treat the cause is the logical

thinking

1- Anti-inflammatory lifestyle

2- Control Insulin - Leptin resistanceHyper insulinemia ndash Hyper leptinemia

(Diet too high in sugars amp Obesity)

In Summary Saturated Fats Are Healthy

Saturated fats

bullIncrease your LDL levels but they increase the

large fluffy particles that are not associated with

an increased risk of heart disease

bullIncrease your HDL levels This more than

compensates for any increase in LDL

bullDo NOT cause heart disease as made clear in all

the above-referenced studies

bullDo not damage as easily as other fats because

they do not have any double bonds that can be

damaged through oxidation

bullServe to fuel mitochondria and produce far less

damaging free radicals than carbs

Could Eating the Right Fats Save 1 Million Lives per YearD Mercola - March 06 2016

In many epileptic patients anticonvulsant drugs either fail adequately to control

seizures or they cause serious side effects

An important adjunct to pharmacologic therapy is the ketogenic diet which often

improves seizure control even in patients who respond poorly to medications

The mechanisms that explain the therapeutic effect are incompletely understood

Evidence points to an effect on brain handling of amino acids especially glutamic

acid the major excitatory neurotransmitter of the central nervous system

The diet may limit the availability of oxaloacetate to the aspartate aminotransferase

reaction an important route of brain glutamate handling

The ketogenic diet and brain metabolism of amino acids relationship to

the anticonvulsant effectYudkoff M1 Daikhin Y Meloslash TM Nissim I Sonnewald U Nissim I

Annu Rev Nutr 200727415-30

As a result more glutamate becomes accessible to the glutamate decarboxylase reaction to yield gamma-

aminobutyric acid (GABA) the major inhibitory neurotransmitter and an important antiseizure agent

In addition the ketogenic diet appears to favor the synthesis of glutamine an essential precursor to GABA

This occurs both because ketone body carbon is metabolized to glutamine and because in ketosis there

is increased consumption of acetate which astrocytes in the brain quickly convert to glutamine

The ketogenic diet also may facilitate mechanisms by which the brain exports to blood compounds such as

glutamine and alanine in the process favoring the removal of glutamate carbon and nitrogen

Alterations in the metabolism of excitatory amino acids

and γ-aminobutyric acid (GABA) during the high-fat low-

carbohydrate ketogenic diet Metabolism of acetyl-CoA

generated from fats leads to high consumption of

oxaloacetate (see Fig 1) L-Aspartate a nonessential

amino acid is formed by the transamination of

oxaloacetate with an amino group from glutamate

Reduced availability of oxaloacetate along with robust

availability of αketoglutarate from high activity of the first

part of the Krebs cycle leads to low aspartate levels It

has been hypothesized that more glutamate is thus

accessible to glutamic acid decarboxylase for production

of GABA [33] Not all Krebs cycle intermediates are

shown in the schematic

The brain energy is everything The brain needs a crapload of

energy to keep all those membrane potentials maintained - to

keep pushing sodium out of the cells and pulling potassium into

the cells

In fact the brain which is only 2 of our body weight uses 20

of our oxygen and 10 of our glucose stores just to keep

running

(Some cells in our brain are actually too small (or have tendrils

that are too small) to accommodate mitochondria (the power

plants) In those places we must use glucose itself (via

glycolysis) to create ATP)

When we change the main fuel of the brain from glucose to

ketones we change amino acid handling And that means

we change the ratios of glutamate and GABA

The best responders to a ketogenic diet for epilepsy end up with

the highest amount of GABA in the central nervous system

glutamine an essential precursor for GABA

If you recall GABA is the major inhibitory neurotransmitter in the

mammalian nervous system Turns out GABA is made from

glutamate which just happens to be the major excitatory

neurotransmitter You need them both but we seem to get into

trouble when have too much glutamate Too much excitement in

the brain means neurotoxicity the extreme manifestation of

which is seizures But neurological diseases as varied

as depression bipolar disorder migraines ALS and dementia

have all been linked in some way to neurotoxicity

Mitochondrial

Biogenesis









1- low carb High fat Diet Regime (LCHF) ndash

Mitochondrial Metabolic Therapy (MMT) 2017 -

Ketogenic diet ((KD)

2- Mitochondrial Metabolic Therapy (MMT) 2017 is

Similar to a ketogenic diet (epilepsy 30-50)

3-MMT is a high fat moderate protein low carb

eating plan

Unlike a ketogenic diet it emphasizes on high-

quality unprocessed whole foods

NB Paleo diet consume far too much protein

Mitochondrial BiogenesisSalvage 1- The Harmful Effects of too much Sugar

Intermittent fasting

Beside longevity and health issues it also provide powerful cancer

prevention and treatment benefit And the mechanism for that is related to

the effect fasting has on your mitochondria

Reactive oxygen ROS Some free radicals are actually good and your body

requires them to regulate cellular function but problems develop when you

have excessive free radical production There are two possible solutions to

this problem

bullIncrease your antioxidants

bullReduce mitochondrial free radical production by calorie restriction

This is one of the reasons why intermittent fasting works as it limits the

window that you are eating and automatically reduces your calories

It is particularly effective if you avoid eating several hours before going to

sleep as that is your most metabolically lowered state

A review paper1 that provides much of the experimental work for the above explanation was published

in 2011 titled Mitochondrial DNA Damage and Animal Longevity Insights from Comparative Studiesrdquo

Interventional strategy

where in individuals are

subjected to varying periods

of fasting



Interventional strategy where in

individuals are subjected to varying

periods of fasting

Other Ways Fasting Promotes Healthy Mitochondrial Function

Our body has to rely on lipids and stored fats for energy which means our

cells are forced to use their mitochondria mitochondria are the only

mechanisms by which our body can make energy from fat So fasting

helps activate our mitochondria

This is the mechanism by which intermittent fasting and a ketogenic diet

may kill cancer cells and why certain drugs that activate mitochondria can

kill cancer cells It creates a burst of reactive oxygen species ROS the

damage from which tips the scale and causes the cancer cells to die

Our body also clears away damaged cells through a process called autophagy which basically means

when a cell thats damaged it can die But if it doesnt die sometimes it becomes whats called

senescent and this happens a lot with aging What that means is that the cell is not dead but its not

really alive either Its not doing its function

Its just kind of sitting around in your body secreting pro-inflammatory molecules things that are

damaging other nearby cells thereby accelerating the aging process because inflammation drives

aging in so many different ways

Autophagy clears away those cells that are just sitting there creating damage and not doing much else

which is nice because thats also a very important biological mechanism for staying healthy




Overcoming too much stressReducing stress is the antidote to adrenaline causing sugar burning To do so one

must eliminate fear anxiety andor sleep deprivation Sleeping sufficiently

meditation and eliminating causes of stress are the keys

Reducing blood sugarThe best way to reduce blood sugar is to drastically reduce onersquos consumption of

foods that contain sugar and other carbohydrates The absolute best way to prevent

sugar fluctuations is to eat 5 to 6 small meals per day (every 2 to 3 hours) of non

sugarcarbohydrate containing foods

Overcoming Leptin Insensitivity(Obesity)Overcoming leptin insensitivity (ie repairing the hypothalamus) isnrsquot so easy The

rather long explanation of why it isnrsquot so easily overcome is that the bodies of sugar

burning people (primarily fat people) have large pantries of stored fat which creates

large amounts of the messenger molecule leptin which will push the leptin levels

above 90 ngml and damage the receptors After a while the hypothalamus cannot

detect leptin at all and thinks that its level is zero and therefore instructs sugar

burning mode In a sugar burning mode it is difficult to entice the body to burn fat

stores and therefore very difficult to get rid of fat so that leptin levels will go down to

a ldquofat burningrdquorange of between 40 and 90 For a fairly in-depth discussion about

doing this please request our Becoming Leptin Sensitive Booklet

Managing Your Mitochondria By Mark Sisson October

20 2011

The single most fundamental ndash and simple ndash way to improve

mitochondrial function is to turn away from relying on sugar-

burning and transform yourself into a fat-burning beast

See mitochondria burn fatty acids cleaner than they burn carbohydrates Generating ATP

via fatsketones produces fewer free radicals because itrsquos more efficient whereas generating ATP via carbs

produces more As a result glutathione can do its job and our ketone-burning mitochondria have to divert less

attention to cleaning up free radicals This doesnrsquot just make mitochondrial ATP production from ketones more

efficient it has the potential to render it downright anti-inflammatory too When we dip into a full-fledged

ketogenic diet cut back on bad carbs or intermittently fast we are switching over to fat-burning When we

switch over to fat-burning our mitochondria do the same Heck thatrsquos what we mean by ldquofat-burningrdquo Therersquos

even evidence that ketosis can spur mitochondrial biogenesis albeit thus far only in rats

In my new book I present my Primal prescription for becoming a fat-burning beast In fact one of the reasons I

wrote the 21-Day Total Body Transformation is because untold millions of people are languishing in sugar-

burning land and their mitochondria arenrsquot burning quite as cleanly as they could The ldquotransformativerdquo aspect of

the 21-Day Total Body Transformation is the epigenetic switch from sugar-burning to fat-burning And improving

mitochondrial function and (if that rat study pans out in humans) increasing mitochondrial biogenesis are at the

heart of this switch


Mitochondrial BiogenesisSalvage 2- The Harmful Effects of too much Protein

Mitochondrial Metabolic Therapy (MMT) 2017

is a high fat moderate protein low carb eating plan

Unlike a ketogenic diet it emphasizes on high-quality

unprocessed whole foods

Unlike Paleo diet consume far too much protein

The mammalian target of rapamycin (mTOR) pathway is Central

regulator of cell metabolism growth proliferation and survival

Mitochondrial BiogenesisSalvage 3- Lack of exercise and Physical activity

Exercise Helps Keep Our Mitochondria Young

Exercise

Promotes mitochondrial health as it forces your mitochondria to work harder one of the

side effects of mitochondria working harder is that theyre making reactive oxygen

species ROS which act as signaling molecules One of the functions they signal is to

make more mitochondria So when you exercise your body will respond by creating

more mitochondria to keep up with the heightened energy requirement

Aging

Is inevitable But your biological age can be quite different from your chronological age

and your mitochondrial health have a lot to do with your biological aging

As noted by Patrick youthfulness is not so much about your chronological age but rather how old you feel and

how well your body works

I want to learn how to optimize my own cognitive performance and my athletic performance I want to also

increase the youthful part of my life I want to be 90 I want to be out there surfing in San Diego just like I was

when I was 20 I would like to not degenerate as rapidly as some people do I like to stave off that degeneration

and extend the youthful part of my life as long as I possibly can so I can enjoy life

Role of Regular Physical Exercise

A- Burn of fat (as MMT amp Ketogenic diet)

B- Improve insulin sensitivity(depleting glycogen amp fat stores)

C- Peak rise of hormonesHuman growth hormone(HGH-GH) ndash Endorphins

Dopamine Norepinephrine Serotonin) - exercise

intensity

D- Mitochondrial Biogenesis




Exercise is one of the most powerful signals for PGC 1-

alpha

A protein encoded by PPARGC1A gene (Peroxisome proliferator-

activated receptor gamma coactivator 1-alpha (PGC-1α) )

PGC 1-alpha which is the primary signal for

Mitochondria to Reproduce and Multiply a process

called Mitochondrial biogenesis

PPARGC1A

(PGC-1α( is a protein encoded by the PPARGC1A gene known as human accelerated

region 20 (HAR20)

PGC-1α is a transcriptional co activator that regulates the genes involved in energy

metabolism It is the master regulator of mitochondrial biogenesis

PPARGC1A

PGC-1α activating host factors

1- Free RadicalsReactive oxygen species (ROS) and reactive nitrogen species (RNS)

both formed intracellularly as by-products of metabolism but

upregulated during times of cellular stress

2- Cold Exposureadaptive thermogenesis

3- Endurance ExercisePGC-1α determines lactate metabolism preventing high lactate levels

in endurance athletes amp making lactate as an energy source

plays a central role in the regulation of cellular energy metabolism It stimulates 1- mitochondrial biogenesis 2- promotes the

remodeling of muscle tissue to a fiber-type that is metabolically more oxidative and less glycolytic in nature

It participates in the regulation of both carbohydrate amp lipid metabolism

It is involved in obesity diabetes amp cardiomyopathy



Exercise (Mitochondrial Biogenesis) for

Cutting Cancer Risk



The mTOR pathway is Central regulator of cell



1- Activated during tumor formation angiogenesis insulin resistance adipogenesis and T-lymphocyte activation etc


3- Growing therapeutic use of mTOR inhibitors (rapamycin and rapalogues) in solid tumors organ transplantation

coronary restenosis and rheumatoid arthritis


Exercise slashed the risk of cancer in

13 out of the 26 cancers

for example

Kidney cancer by (23 )

Lung cancer by (26 )

Liver cancer by (27 )

Esophageal adenocarcinoma by (42 )

Large Study 2016 Underscores Value of Exercise for Cutting Cancer Risk

Journal of the American Medical Association Internal Medicine 2016 176(6) 816-

825=

The research involved a mega-pool of

144 million men and women from a dozen

large European and US

prospective cohort studies (groups of

participants whorsquod been followed for

several years)

Participant age body mass index gender

self-reported data on exercise smoking

status and if applicable any cancer

diagnoses were analyzed to determine

the effect exercise had on various

cancers

A total of 186932 primary cancers were

diagnosed during the follow-up period

which had a median length of 11 years

Regardless of the personrsquos weight or

smoking history the data suggested

physical activity cut their risk of cancer

Mitochondrial BiogenesisSalvage 4- Feeding Your Mitochondria

The following nutrients co-factors needed for mitochondrial enzymes to

function properly

bullCoQ10 or ubiquinol (the reduced form)

bullL-Carnitine which shuttles fatty acids to the mitochondria

bullD-ribose which is raw material for ATP molecule

bullMagnesium

bullOmega-3 fatty acids

bullAll B vitamins including riboflavin thiamine and B6

bullAlpha-lipoic acid (ALA)

Get as many micronutrients as you can from whole foods

THANK YOU

ناب و عأ لك ل راسك تتخذون منأه من ثمرات النخيل والأقا حسنا إن في ذ ية ورزأ

م يعأقلون سورة النحل( 67)لقوأ


bull Obesity




bull Hypertension


bull Stroke

bull Cancer


bull Arthritis

bull Osteomalacia

bull Osteoporosis




bull Nephritis













Causes


bull Diet

bull Sleep-awake


bull Sun avoidance




Including Medicines
















4- Pollutants



Energy (ATP - ADP)


Dr Josef mercola


in med school



chronic illness







Chronic Disease





Mitochondrial

dysfunction










into usable energy


January 24 2016






AIR

O2




ENERGY

Waste (ROS)

Free radicals

Control system






acetyl-CoA











2 CH3COOH + 2 H2O


Acetic Acid + Water


Mitochondria

CoA







































oxygen species ROS






our body



























good shape



automobile







emergency











fat or sugar








fat)























burning













complementation





stress






species


What causes

Mitochondrial

dysfunction









Harmful Effects

of Sugar







damage
















Harmful Effects

of too much

protein




































survival










protein



insulin effectively





Saturated Fats

are Healthy

29



heart disease or

prolong life

30





Causes



Caused by





thinking





Saturated fats


















































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU


bull Obesity




bull Hypertension


bull Stroke

bull Cancer


bull Arthritis

bull Osteomalacia

bull Osteoporosis




bull Nephritis













Causes


bull Diet

bull Sleep-awake


bull Sun avoidance




Including Medicines
















4- Pollutants



Energy (ATP - ADP)


Dr Josef mercola


in med school



chronic illness







Chronic Disease





Mitochondrial

dysfunction










into usable energy


January 24 2016






AIR

O2




ENERGY

Waste (ROS)

Free radicals

Control system






acetyl-CoA











2 CH3COOH + 2 H2O


Acetic Acid + Water


Mitochondria

CoA







































oxygen species ROS






our body



























good shape



automobile







emergency











fat or sugar








fat)























burning













complementation





stress






species


What causes

Mitochondrial

dysfunction









Harmful Effects

of Sugar







damage
















Harmful Effects

of too much

protein




































survival










protein



insulin effectively





Saturated Fats

are Healthy

29



heart disease or

prolong life

30





Causes



Caused by





thinking





Saturated fats


















































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU
















4- Pollutants



Energy (ATP - ADP)


Dr Josef mercola


in med school



chronic illness







Chronic Disease





Mitochondrial

dysfunction










into usable energy


January 24 2016






AIR

O2




ENERGY

Waste (ROS)

Free radicals

Control system






acetyl-CoA











2 CH3COOH + 2 H2O


Acetic Acid + Water


Mitochondria

CoA







































oxygen species ROS






our body



























good shape



automobile







emergency











fat or sugar








fat)























burning













complementation





stress






species


What causes

Mitochondrial

dysfunction









Harmful Effects

of Sugar







damage
















Harmful Effects

of too much

protein




































survival










protein



insulin effectively





Saturated Fats

are Healthy

29



heart disease or

prolong life

30





Causes



Caused by





thinking





Saturated fats


















































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU

Dr Josef mercola


in med school



chronic illness







Chronic Disease





Mitochondrial

dysfunction










into usable energy


January 24 2016






AIR

O2




ENERGY

Waste (ROS)

Free radicals

Control system






acetyl-CoA











2 CH3COOH + 2 H2O


Acetic Acid + Water


Mitochondria

CoA







































oxygen species ROS






our body



























good shape



automobile







emergency











fat or sugar








fat)























burning













complementation





stress






species


What causes

Mitochondrial

dysfunction









Harmful Effects

of Sugar







damage
















Harmful Effects

of too much

protein




































survival










protein



insulin effectively





Saturated Fats

are Healthy

29



heart disease or

prolong life

30





Causes



Caused by





thinking





Saturated fats


















































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU

Mitochondrial

dysfunction










into usable energy


January 24 2016






AIR

O2




ENERGY

Waste (ROS)

Free radicals

Control system






acetyl-CoA











2 CH3COOH + 2 H2O


Acetic Acid + Water


Mitochondria

CoA







































oxygen species ROS






our body



























good shape



automobile







emergency











fat or sugar








fat)























burning













complementation





stress






species


What causes

Mitochondrial

dysfunction









Harmful Effects

of Sugar







damage
















Harmful Effects

of too much

protein




































survival










protein



insulin effectively





Saturated Fats

are Healthy

29



heart disease or

prolong life

30





Causes



Caused by





thinking





Saturated fats


















































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU










into usable energy


January 24 2016






AIR

O2




ENERGY

Waste (ROS)

Free radicals

Control system






acetyl-CoA











2 CH3COOH + 2 H2O


Acetic Acid + Water


Mitochondria

CoA







































oxygen species ROS






our body



























good shape



automobile







emergency











fat or sugar








fat)























burning













complementation





stress






species


What causes

Mitochondrial

dysfunction









Harmful Effects

of Sugar







damage
















Harmful Effects

of too much

protein




































survival










protein



insulin effectively





Saturated Fats

are Healthy

29



heart disease or

prolong life

30





Causes



Caused by





thinking





Saturated fats


















































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU

AIR

O2




ENERGY

Waste (ROS)

Free radicals

Control system






acetyl-CoA











2 CH3COOH + 2 H2O


Acetic Acid + Water


Mitochondria

CoA







































oxygen species ROS






our body



























good shape



automobile







emergency











fat or sugar








fat)























burning













complementation





stress






species


What causes

Mitochondrial

dysfunction









Harmful Effects

of Sugar







damage
















Harmful Effects

of too much

protein




































survival










protein



insulin effectively





Saturated Fats

are Healthy

29



heart disease or

prolong life

30





Causes



Caused by





thinking





Saturated fats


















































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU





acetyl-CoA











2 CH3COOH + 2 H2O


Acetic Acid + Water


Mitochondria

CoA







































oxygen species ROS






our body



























good shape



automobile







emergency











fat or sugar








fat)























burning













complementation





stress






species


What causes

Mitochondrial

dysfunction









Harmful Effects

of Sugar







damage
















Harmful Effects

of too much

protein




































survival










protein



insulin effectively





Saturated Fats

are Healthy

29



heart disease or

prolong life

30





Causes



Caused by





thinking





Saturated fats


















































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU






































oxygen species ROS






our body



























good shape



automobile







emergency











fat or sugar








fat)























burning













complementation





stress






species


What causes

Mitochondrial

dysfunction









Harmful Effects

of Sugar







damage
















Harmful Effects

of too much

protein




































survival










protein



insulin effectively





Saturated Fats

are Healthy

29



heart disease or

prolong life

30





Causes



Caused by





thinking





Saturated fats


















































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU



















good shape



automobile







emergency











fat or sugar








fat)























burning













complementation





stress






species


What causes

Mitochondrial

dysfunction









Harmful Effects

of Sugar







damage
















Harmful Effects

of too much

protein




































survival










protein



insulin effectively





Saturated Fats

are Healthy

29



heart disease or

prolong life

30





Causes



Caused by





thinking





Saturated fats


















































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU



automobile







emergency











fat or sugar








fat)























burning













complementation





stress






species


What causes

Mitochondrial

dysfunction









Harmful Effects

of Sugar







damage
















Harmful Effects

of too much

protein




































survival










protein



insulin effectively





Saturated Fats

are Healthy

29



heart disease or

prolong life

30





Causes



Caused by





thinking





Saturated fats


















































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU







fat or sugar








fat)























burning













complementation





stress






species


What causes

Mitochondrial

dysfunction









Harmful Effects

of Sugar







damage
















Harmful Effects

of too much

protein




































survival










protein



insulin effectively





Saturated Fats

are Healthy

29



heart disease or

prolong life

30





Causes



Caused by





thinking





Saturated fats


















































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU












burning













complementation





stress






species


What causes

Mitochondrial

dysfunction









Harmful Effects

of Sugar







damage
















Harmful Effects

of too much

protein




































survival










protein



insulin effectively





Saturated Fats

are Healthy

29



heart disease or

prolong life

30





Causes



Caused by





thinking





Saturated fats


















































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU







complementation





stress






species


What causes

Mitochondrial

dysfunction









Harmful Effects

of Sugar







damage
















Harmful Effects

of too much

protein




































survival










protein



insulin effectively





Saturated Fats

are Healthy

29



heart disease or

prolong life

30





Causes



Caused by





thinking





Saturated fats


















































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU




species


What causes

Mitochondrial

dysfunction









Harmful Effects

of Sugar







damage
















Harmful Effects

of too much

protein




































survival










protein



insulin effectively





Saturated Fats

are Healthy

29



heart disease or

prolong life

30





Causes



Caused by





thinking





Saturated fats


















































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU

What causes

Mitochondrial

dysfunction









Harmful Effects

of Sugar







damage
















Harmful Effects

of too much

protein




































survival










protein



insulin effectively





Saturated Fats

are Healthy

29



heart disease or

prolong life

30





Causes



Caused by





thinking





Saturated fats


















































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU









Harmful Effects

of Sugar







damage
















Harmful Effects

of too much

protein




































survival










protein



insulin effectively





Saturated Fats

are Healthy

29



heart disease or

prolong life

30





Causes



Caused by





thinking





Saturated fats


















































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU







damage
















Harmful Effects

of too much

protein




































survival










protein



insulin effectively





Saturated Fats

are Healthy

29



heart disease or

prolong life

30





Causes



Caused by





thinking





Saturated fats


















































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU







Harmful Effects

of too much

protein




































survival










protein



insulin effectively





Saturated Fats

are Healthy

29



heart disease or

prolong life

30





Causes



Caused by





thinking





Saturated fats


















































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU




































survival










protein



insulin effectively





Saturated Fats

are Healthy

29



heart disease or

prolong life

30





Causes



Caused by





thinking





Saturated fats


















































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU










protein



insulin effectively





Saturated Fats

are Healthy

29



heart disease or

prolong life

30





Causes



Caused by





thinking





Saturated fats


















































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU

Saturated Fats

are Healthy

29



heart disease or

prolong life

30





Causes



Caused by





thinking





Saturated fats


















































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU

29



heart disease or

prolong life

30





Causes



Caused by





thinking





Saturated fats


















































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU

30





Causes



Caused by





thinking





Saturated fats


















































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU


Saturated fats


















































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU





































the cells



running




















Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU

Mitochondrial

Biogenesis















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






alpha






PPARGC1A


region 20 (HAR20)



PPARGC1A















Cutting Cancer Risk













for example







825=






several years)






cancers









function properly




bullMagnesium





THANK YOU















eating plan












this problem












of fasting





periods of fasting








































20 2011





























Exercise






Aging














intensity






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for example







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several years)






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function properly




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function properly




bullMagnesium





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for example







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cancers









function properly




bullMagnesium





THANK YOU



function properly




bullMagnesium





THANK YOU

THANK YOU

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