TUGAS

TERAPI SULIH HORMON : PROGESTERON

Disusun Oleh :

Dian Widjayanti (131620150002)

Yane Octiani S. (131620150004)

Elyna Mahruzza Putri (131620150006)

Pengampu :

Rovina Ruslami, dr., Sp.PD., PhD

INCLUDEPICTURE "http://news.unpad.ac.id/wp-content/uploads/2010/06/logo-unpad1.jpg" \

* MERGEFORMATINET

PROGRAM PASCA SARJANA

ANTIAGING & AESTHETIC MEDICINE

UNIVERSITAS PADJADJARAN

BANDUNG

2016

DAFTAR ISI

BAB I PENDAHULUAN ………………………………………..………………………… ………………………….1

1.1. Latar Belakang………....…………………………………...............…………………………………1

BAB II TERAPI SULIH HORMON : PROGESTERON……………………………………………………….2

2.1. Klasifikasi Progesteron………....…………………………………………………………………….2

2.1.1. Progesteron Alami………....…………………………………………………………………2

2.1.2. Progesteron Sintetik………....………………………………………………………………2

2.2. Farmakokinetik Progesteron …….………………………………………………………………..3

2.2.1. Progesteron Oral………....……………………………………………………………………4

2.2.2. Progesteron Intramuskular………....…………………………………………………….4

2.2.3. Progesteron Vaginal………....……………………………………………………………….5

2.3. Mekanisme Kerja Progesteron ………………………………………………………………….…6

2.3.1. Reseptor Progesteron (PR)………....…………………………………………………….6

2.3.2. Mekanisme Aktivasi Transkripsi………....……………………………………………..7

2.4. Efek Fisiologis Progesteron……………… …………………………………………………….…..8

2.5. Indikasi dan Kontraindikasi TSH : Progesteron…………………………………….…..….9

2.5.1.Indikasi………………………………………….........................................................9

2.5.2. Kontraindikasi…………………………………………………………….….....…...……….10

2.6. Persiapan Terapi dan Dosis……………...…………….......…………………..………..….....10

2.6.1. Persiapan Terapi……..……………………................................................

…....10

2.6.2. Dosis………………………………………….........................................…......……...11

2.7. Pemantauan Respon TerapI……………………………………………………….....…...……13

2.8. Efek samping dan Penanganannya…………….………………………………................13

2.8.1. Perdarahan Uterus……..……………………......................................….....…..13

2.8.2. Efek Samping Progestogenik……..…...............................................……..13

2.8.2.1. Efek Samping Fisik……..…………………...........................……..14

2.8.2.2. Efek Samping Psikologis.……..............................................14

2.8.3. Efek Samping Metabolik ……..…………………...............................…….15

2.9.Implikasi Klinis…………………………… ……………….………………………………..…………16

2.9.1. Implikasi Terapeutik……..……………………....................................…….16

2.9.1. Endometriosis……..……………………..................................………18

2.9.2. Dysmenorrhea……..……………..................................................18

2.9.3. Hiperplasia / Carcinoma Endometrium.................................19

2.9.2. Implikasi Diagnostik……..…………………….......................................….19

2.10. Dug – Drug Interaction Terkait Progesteron……………….……………..……….....19

2.10.1. Interaksi Progesteron dengan Beberapa Golongan Obat.........…22

2.10.2. Interaksi Progesteron dengan Obat Antiepilepsi……...…….. ...….23

BAB III KESIMPULAN…………………………………………………………………………………………….24

DAFTAR PUSTAKA………………………………………………………………………………………..……….25