jeffrey rogers ilar

8/12/2019 Jeffrey Rogers ILAR

1/47

Udpronuiheh`hty Ica``dbkds hbUdsdaric Tshbk Bobcumab Wrhmatds

Fdjjrdy Uokdrs, Wc.N.

Cumab Kdbomd Ydqudbihbk IdbtdrEay`or Io``dkd oj Mdnhihbd
http://www.hgsc.bcm.tmc.edu/


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Jaitors iobtrheuthbk to hrrdpronuiheh`hty

Wue`hiathob ehas Joius ob poshthvd rdsu`ts

Joius ob surprhshbk rdsu`ts

Hbsujjhihdbt samp`d shzds

Woor ndsirhpthob/noiumdbtathoboj mdtcons

Otcdrs


3/47

Bobcumab prhmatds provhnd ubhqud abnhbnhspdbshe`d mond`s oj cumab ehoòkyabn nhsdasd

Hbjdithous nhsdasds abn otcdr patcokdbs

Bduroehoòky abn edcavhor

Dbnoirhboòky abn mdtaeo`hsm

Udpronuithvd ehoòky

Otcdr jhd`ns oj stuny

9


4/47

Koa`s oj prhmatd rdsdaric

Tsd bobcumab prhmatds to provhnd

ubhqud hbjormathob aeout cumab

nhsdasd abn hts trdatmdbt Tsd bobcumab prhmatds to ubndrstabn

jubnamdbta` aspdits oj cumab ehoòky

Hbvdsthkatd prhmatd ehoòky hb tcdsdrvhid oj eashi prhmatoòky abn

iobsdrvathob


5/47

Zarhous jaitors hbj`udbid

rdpronuiheh`hty hb prhmatd rdsdaric

Nhjjdrdbids hb mdtcons abnprotoio`s aiross `aeoratorhds

Yma`` samp`d shzds

Kdbdthi nhjjdrdbids amobk stunysuefdits


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Yma`` samp`d shzds



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Nrhvdrs oj samp`d shzd hb prhmatd

rdsdaric

Wrhmatd rdsdaric hs dxpdbshvd

Ytunhds ard ndshkbdn iardju``y

Yamp`d shzds ard ojtdb ldpt quhtd sma``

Ichmpabzdd stunhds oj


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rdsdaric




Ichmpabzdd stunhds


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rdsdaric




Ichmpabzdd stunhds oj b=1


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Yma`` samp`d shzds



11/47

Kdbdthi nhjjdrdbids amobk stuny

suefdits

Nhjjdrdbids amobk spdihds

Nhjjdrdbids amobk popu`athobs whtchb

a spdihds

Nhjjdrdbids amobk hbnhvhnua`s whtchba popu`athob


12/47

Mafor prhmatd spdihds usdn hb rdsdaric

Ucdsus maiaqud

Iybomo`kus maiaqud

Eaeoob

Marmosdt

Whktah maiaqud

Ajrhiab krddb mobldy

Otcdrs


13/47

Nhjjdrdbids amobk prhmatd spdihds

Wrostatd eho`oky oj O`n [or`n

mobldys vs Bdw [or`n mobldys

Eaeoobs (iobthbuous erddndrs) vs.

rcdsus maiaquds (sdasoba` erddndrs)

Marmosdts abn ichmdrhsm

p>47 kdbds abn pcarmaiokdbdthis


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15/47

Ytrddt dt a` (577;)

EMI Kdbomhis 36>37

Ucdsus maiaqud

Iybomo`kus maiaqud


16/47

Kdbdthi nhjjdrdbids amobk

popu`athobs whtchb a spdihds

Hbnhab vs Ichbdsd rcdsus maiaquds

AHNY1:61>38 (5775)

Ndv Wsyicoeho`916>8 (188;)


17/47

Ytrddt dt a` (577;)

EMI Kdbomhis 36>37

Ucdsus maiaqud

Iybomo`kus maiaqud


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Maurhthab vs. Hbnobdshab iybomo`kus maiaquds


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Maurhthab vs. Hbnobdshab iybomo`kus maiaquds

Udk ^ox Wcarm:96981 (5715)


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Kdbomd Uds5161;>: (5711)


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Kdbdthi nhjjdrdbids amobk eaeoob

popu`athobs


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Wrovhnd vaùae`d nhvdrshty as somd

popuàthobs whtchb a spdihds ard edttdr

mond`s oj spdihjhi qudsthobs tcab otcdr

popuàthobs (Hbnhab vs. Ichbdsd rcdsus)

Wrovhnd potdbtha` proe`dms hb tdrms oj

rdpronuiheh`hty hj orhkhb oj stuny abhma`s

hs bot hndbthjhdn abn rdportdn


23/47

Cow muic kdbdthi varhathob hs tcdrd

whtchb rdsdaric io`obhds oj

rcdsus maiaquds ?

59


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YBW Nhsiovdry hb Ucdsus Maiaquds

b = 145 rcdsus maiaqud wco`d kdbomd

sdqudbids

1>> Hbnhab-orhkhb, 3 Ichbdsd-orhkhb

b = 38 at 54-97x iovdrakd

b = :9 at :-3x iovdrakd

YBWs ia``dn ushbk YBW^oo`s (J. Xu< I. Sud)

54


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sdqudbids

1>> Hbnhab-orhkhb = >4.4 mh``hob YBWs

3 Ichbdsd-orhkhb = 4.84 mh``hob YBWs

5:


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sdqudbids

1>> Hbnhab-orhkhb = >4.4 mh``hob YBWs

3 Ichbdsd-orhkhb = 4.84 mh``hob YBWs

1777Kdbomds6 1785 cumabs = 93.7 mh``hob

5;


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29/47

7

4777777

17777777

14777777

57777777

54777777

97777777

7 17 57 97 >7 47 :7

Bumedrojbovd`YBZs

Bumedr oj samp`ds

Cumab1777 kdbomds Whòt 1 abn Hbnhab orhkhb rcdsus samp`ds

Ucdsus :S XUH Whòt 1 IDT Whòt 1


30/47

Abbotathobs oj rcdsus [KY YBWs

Bob-sybobymous YBWs 541,;;5

Ytop ionob kahbdn >,::3

Ytop ionob `ost 5;5 Ytart ionob varhabt :51

Yp`hid aiidptor varhabt 1,>41

Yp`hid nobor varhabt 1,;8>

ota` oj a`` YBWs 41,>18,78>

Abbotathobs ushbk ZDW abn UcdsuseasdA`ab Carrhs

97


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Abbotathobs oj rcdsus [KY YBWs

Bob-sybobymous YBWs 541,;;5

Ytop ionob kahbdn >,::3

Ytop ionob `ost 5;5 Ytart ionob varhabt :51

Yp`hid aiidptor varhabt 1,>41

Yp`hid nobor varhabt 1,;8>

ota` oj a`` YBWs 41,>18,78>

Abbotathobs ushbk ZDW abn UcdsuseasdA`ab Carrhs

91


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Kdbds whtc stop ionob varhabts

hb rcdsus maiaquds

Cumab Nhsdasd Assoihathob

WUNM4, IAWB17 NhaedtdsYEJ5 Icariot-Marhd-ôotc

IAIBA1 Bduroeàstoma

[NU9: Kàuioma

INL57 Jabiobh abdmha

KAL Warlhbsobs nhsdasd

WLN1@5 Wo`yiysthi lhnbdy nhsdasd

MXO14A Ndajbdss

Aàb CarrhsCumab assoi. jrom OMHM 95


33/47

FAYWDU prdnhithobs

^cdrd ard 111,:>; rcdsus YBWs tcat ja`` hbto

DBIOND trabsirhpthob jaitor ehbnhbk mothjs

Ucdsus varhabts `hld`y to rdnuid ehbnhbk Tshbk poshthob wdhkct siords oj 0-7.1, wd jhbn

53,31: YBWs prdnhitdn to ndirdasd ^J ehbnhbk

Ucdsus varhabts `hld`y to hbirdasd ehbnhbk

Tshbk siords oj 27.1, wd jhbn 5,>4> rcdsus YBWs

prdnhitdn to hmprovd ^J ehbnhbk

Yhmob [chtd

99


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Iobiùshobs

Ucdsus maiaquds dxcheht chkc `dvd`soj kdbdthi varhathob eotc whtchb abnedtwddb popuàthobs

Iybomo`kus maiaquds a`so nhspàyshkbhjhiabt `dvd`s oj kdbdthi varhathobwhtchb abn edtwddb popuàthobs

^chs varhaeh`hty whtchb abn edtwddbpopuàthobs iab abn nods hbjùdbidrdsdaric rdsu`ts


35/47

Opportubhthds

[d bow cavd tcd opportubhty to icaraitdrhzd

kdbdthi varhathob amobk hbnhvhnua` bobcumab

prhmatds hb rdsdaric io`obhds

Udsdaricdrs iab hb prhbihp`d sd`dit rdsdaric

suefdits easdn ob kdbotypds jor spdihjhi

jubithoba``y shkbhjhiabt po`ymorpchsms

Hj nobd routhbd`y, tchs wou`n prdsumae`y

hmprovd rdpronuiheh`hty oj prhmatd stunhds


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37/47

eut wd must sth`` iobshndr abn aiioubt jor tcd

sdkrdkathbk varhathob hb tcd ojjsprhbk oj

kdbdthia``y dbkhbddrdn prhmatds


38/47

Hmp`hiathobs abn Edst Wraithids

jor Udpronuiheh`hty

Udsdaricdrs must

Dva`uatd tcd eailkroubn abn kdbdthis

oj tcdhr stuny abhma`s

Icoosd popu`athobs abn hbnhvhnua`s

approprhatd to tcdhr rdsdaric qudsthob

Matic ob kdbotypd or rabnomhzd tcd kdbdthis ?


39/47

98Wcoto irdnht6 F. Iamdrob


40/47

p = 7.71> p = 7.71;

Yamp`d Yhzd b = 59:p-va`uds anfustdn jor mu`thp`d tdsthbk

Uokdrs dt a`. Mo`. Wsyic. 136 ;77-; (5719) >7


41/47

>1


42/47

Ordkob prhmatd idbtdr rcdsus maiaquds

Jawidtt, Ndttmdr, Uyab, Iamdrob, Uokdrs

-:

->

-5

7

5

>

AA AI II

YBW>374

@atdbiy to @davd Motcdr

->

-9

-5

-1

7

1

5

9

AA AI II

YBW>374

Dsiapd Edcavhor

b=4>9

p va`uds aiioubt jor tdsthbk mu`thp`d YBWs

Udp`hiathob oj IUCU1 djjdit obmaiaqud abxhous tdmpdramdbt

p = 7.77: p = 7.773

>5


43/47

Kdbdthi varhathob hb bobcumab

prhmatds usdn jor rdsdaric

Kdbdthi nhjjdrdbids iab ed BOHYD tcat musted mabakdn abn iobtro``dn

or

Kdbdthi nhjjdrdbids iab ed YHKBA@ tcat iabed usdn to abswdr hmportabt qudsthobs oj

kdbdthi iausds abn mdicabhsms


44/47

Wotdbtha` Bdar-tdrm Koa`s

tcat wh`` Edbdjht Udpronuiheh`hty

Ndjhbd tcd kdbdthi iomposhthob oj tcd

most hmportabt rdsdaric prhmatds Edttdr wco`d kdbomd assdme`hds abn

abbotathobs

Edttdr hbjormathob aeout kdbdthi varhathob

abn kdbd dxprdsshob amobk spdihds,

popu`athobs abn hbnhvhnua`s


45/47

Wotdbtha` Bdar-tdrm Koa`s

tcat wh`` Edbdjht Udpronuiheh`hty

Ndvd`op spdihjhi abn ndtah`dn hbjormathobaeout jubithoba` kdbdthi varhathob tcat

ajjdits rdsdaric outiomds Udsdaricdrs may icoosd to sd`dit abhma`s tcat

scard tcd samd a``d`ds jor jubithoba``y shkbhjhiabtkdbds (to rdmovd varhathob)

Hb otcdr ihriumstabids, tcd hbi`ushob oj abhma`swhtc varhous kdbotypds wh`` provhnd rdsu`ts tcatard roeust to tcd djjdits oj suic varhathob

A l ` n t


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Ailbow`dnkmdbts

Eayòr Io``dkd oj Mdnhihbd

Kòrha Jawidtt

Mutcuswamy Uavddbnrab

Navhn Uho Ndhros

Ju`h Xu

Icdbk Sud

Aàb Carrhs

Yhmob [chtd

Mhld Nacnou`h

Ybdla Uavddbnrab

Nobba Muzby

Uhicarn Khees

[aschbktob Tbhv.

Fhm Icdvdrun

Tbhv. oj Whttseurkc

Funy Iamdrob

Tbhv. oj [hsiobshb

Navhn OIobbor

Anam Drhisdb

Uokdr [hsdmab

Bdn La`hb

Fobatcab O`dr

Abnrdw Jox

Uhicarn Navhnsob

Tbhv. oj dxas - Coustob

Shaomhbk @hu

Jubnhbk

BHC-Nhv. Iomp. Mdnhihbd (OUHW)

BHC-BHMC

BHC-BCKUH

Eayòr Io``dkd oj Mdnhihbd >:


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jeffrey rogers ilar

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