Kikuchi-fujimoto disease: histopathological and clinical review of a case

http://www.medscidiscovery.com/Articlespdfs/V2N2PDF/

April.2014Vol.2No.2p190-92.pdf

Kikuchi-Fugimoto Disease (Cervical Subacute NecrotisingLymphadenitis): An important benign disease often

masquerading as lymphoma

http://www.ums.ac.uk/umj078/078(2)134.pdf

The histopathological features of KFD are quite distinctive : a necrotising lymphadenitis without neutrophil infiltration,virtually diagnostic of KFD, and the only mimic is SLE lymphadenitis.

The lymph node changes in Kawasaki disease (mucocutaneous lymph node disease), cat scratch disease and atypical mycobacterialinfection are quite different, being characterised by intravascular fibrin thrombi and neutrophils, stellate microabscesses with neutrophils and necrotising stellate granulomatous inflammation respectively

Kikuchi Fujimoto Lymphadenitis: Case Report and Literature Review

http://onlinelibrary.wiley.com/doi/10.1002/ajh.10335/pdf

Kikuchi-Fujimoto Disease: a Rare Differential of Lymphadenopathy

http://medind.nic.in/jac/t09/i3/jact09i3p145.pdf

Enigmatic Kikuchi-Fujimoto Disease

http://ajcp.ascpjournals.org/content/122/1/141.full.pdf

Kuo17 proposed classification of the histopathologicfeatures of KFD into 3 evolving histologic stages: proliferative,necrotizing, and xanthomatous. The proliferative stageconsists basically of various histiocytes, plasmacytoid monocytes,and a variable number of lymphoid cells with karyorrhecticnuclear fragments and eosinophilic apoptosis debris.If cellular aggregates in a given lymph node showed anydegree of coagulative necrosis, the case was classified asnecrotizing. If foamy histiocytes predominated in the KFDlesions, the case was classified as xanthomatous regardlessof the presence or absence of necrosis. The most commontype was the necrotizing type, accounting for slightly morethan half of the cases. As Kuo17 pointed out, the 3 histologictypes might represent different stages of the disease or mightreflect differences in cause or host reaction. Judging fromthe histologic changes, KFD perhaps begins as proliferative,progresses to necrotizing, and finally resolves intoxanthomatous. However, sequential biopsy specimens werenot available in the study by Kuo17 to verify this postulatedconcept. Also, data on the duration of the disease did notcorrelate with the progression of the 3 histologic types.