Spotlight on Pressure Reduction: Market Overview

Kuldev Singh, M.D., M.P.H.

Professor of OphthalmologyDirector, Glaucoma Service

Stanford University

Glaucoma Patients by Region

0

20

40

60

80

100

120

140

160

2015 2020

Nu

mb

er o

f Gla

uco

ma

Pa

tien

ts (m

illio

ns)

Rest of World

Latin America

India

China

Other Wealthy

Nations

Japan

Western Europe

United States

Courtesy of Dave Harmon Market Scope

Glaucoma by Disease Category

Open Angle

42%

Closed

Angle

15%

Secondary

7%

OcularHypertension36%

125 Million

Courtesy of Dave Harmon Market Scope

Courtesy of Dr. Cynthia Mattox

Glaucoma Prevalence by Age

Prevent Blindness America Future of Vision Report 2014Courtesy of Dr. Cynthia Mattox

Glaucoma: The Big Picture

25-50% aware that they have disease* Those aware are often not under care Those under care are often non compliant Unpredictable natural history of disease Small percentage go blind Lowering IOP reduces but does not eliminate

risk

*Sommer A, et al. Arch Ophthalmol. 1991;109:1990-95.

U.S. Ophthalmologists

Specialty

41%

Courtesy of Dr. Gregory Skuta and AAO Member Services

Comprehensive with Specialty

19%

Comprehensive 40%

U.S. Specialty Breakdown

Retina/Vitreous29%

Cornea and External Disease

18%

Pediatrics and Strabismus

14%

Oculoplastics and Orbit

12%

Cataract/Anterior Segment

8%

Other 3%

Neuro2%

Refractive Surgery

1%

Uveitis1%

Glaucoma12%

Courtesy of Dr. Gregory Skuta and AAO Member Services

Global Glaucoma Pharmaceutical Market Revenues by Category

Branded

Prostaglandin28%

Generic Prostaglandin

7%

Beta Blockers…

Carbonic Anhydrase

Inhibitors11%

Alpha Agonists

11%

Fixed Combo

Drugs37%

Other

2%

$4.7 Billion in 2015

Courtesy of Dave Harmon Market Scope

Surgical Trends: 1994-2012

020000400006000080000

100000120000140000160000180000200000

Trabec

Tube

CPC

LTP

LPI

Courtesy of Drs. William Rich, Michael Repka and Gregory Skuta

0

50

100

150

200

250

300

2013 2014 2019 (Forecast)

64

64 62

44

46 5

4

20 4

2

25

5

US

Gla

uco

ma

Su

rger

ies

(000

)

Filtration Tube Shunts MIGS

U.S. Glaucoma Surgical Procedures

Courtesy of Dave Harmon Market Scope

Spotlight on Pressure Reduction: Addressing Unmet Needs in Glaucoma Care

More effective first line and adjunctive medications Glaucoma operation safer than trabeculectomyNovel drug delivery to improve compliance

SPOTLIGHT ON PRESSURE REDUCTION

Company Presentations