kuliah hormon tiroid.pptx
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KELENJAR TIROID
&
HORMON TIROID
M. Luthfi, dr., SpPD.
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Kelenjr Tir!id
Tir!id Th"re!# $"unni% peri#i, eid!#
'entu(%
Kelenjr end!(rin ter'e#r pd de)#
*entu( #eperti (upu+(upu Terdiri dri l!'u# "n- dihu'un-(n !leh
i#thu#.
Terlet( di nteri!r tr(e ntr tuln-
r)n (ri(!id. *ert n!rl /+0 -, #n-t 1#(ulr,
(!n#i#ten#i lun(.
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Hi#t!l!-i Kelenjr Tir!id
Kelenjr tir!id terdiri dri
f!li(el 'er'entu( '!l
"n- u(urnn"'er1ri#i.
Setip f!li(el dilpi#i #el
epitel (u'!id $epitel
f!li(el% "n- en-elilin-iluen (!l!id.
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http22r'l.31'#.3!l!#tte.edu2h'!!(#2pthph"#2end!3rine2th"r!id2nt!".htl
TH4ROID 5LAND HISTOLO54
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6!li(el Tir!id
6!li(el dlh unit #e(re#i fun-#i!nl #el+
#el (elenjr tir!id.
Sel 6!li(ulr en-h#il(n 3irn (!l!id
"n- (entl dn en-ndun-.
K!l!id terdiri terut dri tir!-l!'ulin $T-%
Th"r!-l!'ulin -li(!pr!tein den-n *M
tin--i 'erpern dl pe'entu(n
h!r!n tir!id dl luen f!li(el tir!id.
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O OH
I
I
II
OH
O
NH
Th"r!7ine $T8%
O OH
I
I
I
OH
O
NH
9,:,9;+Trii!d!th"r!nine $T9%
TH4ROID HORMONES
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Sinte#i# H!r!n Tir!id
Ln-(h pert dl #inte#i# h!r!n tir!id
dlh "!diu !r-nifi3ti!n.
I!did di'il, di(!n1er#i (e "!diu, dn
(eudin ter(!nden##i (e re#idu tir!#in "n-
'erd di #epnjn- !le(ul p!lipeptid pr!tein"n- di#e'ut th"r!-l!'ulin.
H#il re(#i ini dlh tir!#in !n!+i!din#i $MIT%
tu di+i!din#i tir!#in $Dit%.
I!d!th"r!-l!'ulin "n- ter'entu( erup(n #lh
#tu un#ur plin- pentin- dri 'hn (!l!id "n-terdpt dl unit f!li(el tir!id.
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Re(#i #inte#i# linn", dlh re(#i (!plin-, di
n !le(ul i!d!t"r!#ine "n- di-'un-(n
'er#+#.
Ji( du !le(ul di+i!d!t"r!#ine 'erp#n-n
'er#+#, h#iln" dlh pe'entu(n
tir!(#in $T8%.
Ji( di+i!d!t"r!#ine dn !n!+i!d!t"r!#ine "n-
di-'un-(n 'er#+#, h#iln" dlh
pe'entu(n tri+i!d!th"r!nine $T9%.
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I < t"r!#ine !n!i!d!t"r!#ine $MIT% MIT < I dii!d!t"r!#ine $DIT%
DIT < DIT th"r!7ine $T8%
DIT < MIT trii!d!th"r!nine $T9%
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Re-ul#i dn Se(re#i H!r!n Tir!id
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6EED*A>K RE5?LATION
H!r!n "n- 'er#l dri hip!fi#i# "n- en-tur #inte#i# dn
2 tu #e(re#i h!r!n lin di(enl #e'-i h!r!n tr!pi(.
H!r!n ut "n- 'erpern pd (elenjr tir!id
TRH + Th"r!phin Rele#in- H!r!ne
TSH + Th"r!id Stiultin- H!r!ne
T82T9+ Th"r!id h!r!ne#
PIT?ITAR4+TH4ROID A@IS
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PIT?ITAR4+TH4ROID A@IS
Se(re#i h!r!n tir!id ditur
!leh TSH $Th"r!id+#tiultin-
h!r!ne%, "n- en-i(tre#ept!r pd peru(n
'#!lterl #el f!li(el
re'#!rp#i T- dri luen
f!li(el dn pr!te!li#i# dl
#el untu( en-h#il(nh!r!n tir!iddi#e(re#i(n
(e lirn drh.
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PIT?ITAR4+TH4ROID A@IS
Th"r!id h!r!n $T8 dn T9% (n
e'eri(n upn 'li( untu(
en-h't pr!du(#i hip!tlu#
Th"r!tr!pin+rele#in- h!r!ne$TRH% dn pr!du(#i hip!fi#i# th"r!id+
#tiultin- h!r!ne $TSH%.
TSH ern-#n- (elenjr tir!id
untu( epr!du(#i h!r!n T8 dn
T9.
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H"p!thli3+Pituitr"+Th"r!id A7i#
Ne-ti1e 6eed'3( Me3hni#
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TSH TSH di#e(re#i(n !leh #el+#el th"r!tr!pe dri
hip!fi#i# nteri!r
'erpern pentin- dl en-endli(n 7i# tir!id
dn 'erfun-#i #e'-i pennd fi#i!l!-i# "n-plin- 'er-un dri h!r!n tir!id.
(dr tertin--i pd l hri.
)(tu pruh pl# reltif pnjn- $:0 enit%.
di-un(n untu( di-n!#i# hipertir!idi#e $TSH
rendh% #ert hip!tir!idi#e $TSH tin--i%.
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TSH
Penin-(tn (dr TSH en"e''(n
Se(re#i h!r!n tir!id T9 dn T8 Penin-(tn (e3eptn I!dine upt(e
Penin-(tn #inte#i# !r!n tir!id
Pen'hn julh dn u(urn f!li(el
tir!id
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Pen-ruh H!r!n Tir!id pd
'er'-i !r-n
Jntun- t(i(rdi, en-urn-i (e(utn
(!ntr(#i
Pe'uluh drh 1#!(!n#tri(#i
5IT enin-(t(n !tilit# dn '#!rp#i
Si#ti #(eletl enin-(t(n '!ne turn!1er
Neur!u#(uler hiper(tifit#, enin-(t(n
(!ntr(#i !t!t