1. 1 | P a g e - (Autoimmune) ( Inflammed) , - (Connective Tissue) ( ) , , - , , (- - , ) 1% , 35 50 , (Juvenile Idiopathic Arthritis) , - (Autoimmune Disease) (Synovial Membrane) , , , , ,

2. 2 | P a g e - , - , , , , , , , , , , (Cyst) , 30% ( ) , , , , , , ( Plura) ( Pericardium) , , , , 3. 3 | P a g e , , , , , , , - ( Juxta-articular Osteopenia), ... , ... 10 9 ... , ... , 70 % , 96% -(anti-CCP) ( - ) - (TLC) ... , ( ) (Felty's syndrome) 10 80% 3-7 , , , 4. 4 | P a g e 75% 10 % , 20 ... Anti-CCP , (DMARDs) , - , - - - ( NSAIDs), (DMARDs), , , (an interleukin-1 receptor antagonist), - (NSAIDs) , , NSAIDs 2 NSAIDs (COX) COX-1 , ( (Mucosa) ) COX-2 COX-2 ( 5. 5 | P a g e ) - NSAIDs NSAIDs , , ( Confusion), , , (Platelets) DMARDs , , , - 3- 4 , 2% , 24 9 3 1-2 12 ... 6 .... .... , ( Folate Antagonist) (Immunosuppressive) ( 3 4 ) 6. 6 | P a g e 1 , 8 ..., ...., ...., , , , () DMARDs DMARDs - TNF- antagonists - - , , - ( , ) (DMARDs) (Hydroxychloroquin e) 400-600 - 4-12 200-400 . , , (Leflunomide) 20 / 10 / , (Methotrexate) 7.5 , - 25 , , , , 7. 7 | P a g e 20 / (SC) (Sulfasalazine) 0.5 1 , 2 3 , , , , (Corticosteroids) (Prednisone) 7.5 , , , (Osteoporosis) , Azathioprine 1 / (50100 ) , 6-8 0.5 // 4 2.5 // , , , Cyclophosphamid e 23 / .. : 0.75 /2 ( 1 /2 / 6 ... 3000/L ), 30-60 - .. (Cyclosporine) 50 , 1.75 / (Abatacept) 750 .. , 2 , 4 4 , , ..., , (Rituximab) 1 .. , 2 , 4 , , , 8. 8 | P a g e 4 , , IL-1 (Anakinra) 100 (SC) , - (Adalimumab) 40 (SC) 1 2 ( ..) , , , , (Etanercept) 25 50 (Infliximab) 3 / .. 2 6 8 (10 )