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SYNDROME OF

INAPPROPRIATEANTI-DIURETICS HORMONE(SIADH)

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DEFINISI

Kadar pengeluaran ADH(va!pre"n) #erle#"$an a%aupeng$a"lan ADH dala& pla&a !&!lar"%"renda$'D"e#a#an eed#a* &ean"&a %"da #erung"dengan #e%ul'

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ETIO+O,I

Tu&!r -*ar*"n!&a pada pan*read!udenu&,a%!ur"nar. %ra*$!g"n l"&p$!&a

Head "n/ur. Ine" 0 v"ral dan #a%er"a pneu&!n"aa#*e paru-

paru pneu&!%$!ra1 *$r!n"* lung d"eae

,angguan CNS /uga &engganggu &ean"&apen.elaraan ADH 0 Trau&a "ne" CNS C2A %u&!ur

Pr!*edure ug"*al 0 pe&#eda$an p"%u"%ar.

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MANIFESTASI K+INIKA+

• T"redne and 3eane

• Mu*le pa"n *ra&p !r $eada*$e

• An!re1"a !r de$.dra%ed

• D"arr$ea !r *!n%"pa%"!n

• Nauea and v!&"%"ng

• Irr"%a#"l"%.

• Ede&a pada $u/ung /ar"

• ,angguan "%e& pernaan 0 rep"ra%!r. a*"d!"

• Ta*$.*ard"a

• ,angguan ,IT

• ,angguan CNS

• Hae&!d"lu%"!n 0 ""padu dara$ &en"nga% %e%ap" pla&a *a"r

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PATHOFISIO+O,I

Dala& edadaan n!"r&al ADH &en.elara !&!lar"%"eru&

Seru& !&!lar"%" %urun &ean"&a eed#a*&eng$alang ADH !&!lar"%" e para n!r&al'

Apa#"la &ean"&a "n" gagal para ADH eal&en.e#a#an re%en" *e*a"r'

In" &en.e#a#an eru& !d"u& %urun &en/ad"$.p!na%re&"a dan 3a%er "n%!1"*a%"!n'

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PENYE+IDIKAN 4 DIA,NOSA

5l!!d and ur"ne %e% 0 $!3 level ! al% and *$e&"*al"n %$e #!d.

A *$e% 1-ra.

A CT *an 0 1-ra. .ang d"lauan pada #a$ag"an epala

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PEN,URUSAN DAN RA6ATAN

Hadan penga&#"lan *e*a"r 0 lu"d "n%ae 788&l-988&l

dala& &aa :;/a&' T"&#ang #era% #adan e%"ap $ar" lap!ran e"ran.a

pen"nga%an #era% erana <g = <l"%er

Elaan e*ederaan erana pea"% el"ru dan a3ana"#a% #ra"n 3!llen'

S%r"*% "npu% and !u%pu% *$ar%

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TERAPI U5ATAN

D"ure%"* 0 un%u &en."ng"ran a"r

P!%%a"u& *$l!r"de 0 un%u &enggan%"an e$"langan

ele*%r!l"%e ,an%"an !d"u& 0 gunaan al"ne un%u &elaru%an

u#a%an dan %"u# eed"ng'

H.per%!n"* al"ne >? NaCl 0 "nu"!n "n%ravena

Inu"!n "n%ravena n!r&al al"ne d"#er" dengan %el"%" dan

la&#a% 0 e#a# "n" aan &eneruan eadaan lu"d !verl!aded dan &en*e%uan *!nge%"ve $ear% a"lure'

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THANK YOU…