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Wound Healing, Tissue

Engineering and New Materials

Roger W. Yurt, M.D.

William Randolph Hearst BurnCenter

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Burn Center

Clinical care of burn injured patients

including smoke inhalation and carbon

monoxide poisoning

Clinical care of patients with acute and

chronic woundseg, purpura fulminans

Clinical care of patients with exfoliatingskin disease - TENS

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Skin bank

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HyperbaricOxygen Program

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(Full thickness)

(Partial thickness)

Superficial

Deep

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Wound Closure

Life-saving - large surface areas, closure

ASAP

Cosmetic - life time deficits/defects

Functionjoint, tactile, sight, oral

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Life-saving

Excise &Autograft

Recrop Autograft

Excise & Allograft

Excise & Allograft

Recrop Autograft

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Life-saving

Excise &Autograft

Recrop Autograft

Excise & Integra

Excise & Allograft

Recrop Autograft

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Collaboration with School of Chemical

and Biomolecular Engineering Abraham Stroock

Microfluidic wound dressings

Cabodi M et al J. Biomedical Materials

Research

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ConceptActive Dressing

hydration

sanitation

drug delivery

gene delivery

diagnostics

patient profiling

biochemical

analysis

biochemical regulation

mechanical stimulation

perfusion of tissue

vapor barrier

mechanical barrier

wound bed

flow

Inputs Outputs

Interface

Dressing

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Technical Approach: Soft Lithographysilicone

micro-molding

release

sealing

fluidic connections

monomer

polymerizationmicro-mold

release

photo-patterning

UV light

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Model System

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Extraction

FunctionExtraction

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Delivery

FunctionDelivery

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Prototype Active Wound Dressing

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Collaboration with College of Human

Ecology C.C. Chu

Department of Fiber Science and Apparel

Design

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Newly Invented Biodegradable

Biomaterials: Poly(ester-amide) (PEA)

C (CH2)4

O

C NH CH C

O O

CH2CH(CH3)2

O (CH2)6 O C CH

O

CH2CH(CH3)2

NH C

O

(CH2)4 C

O

NH (CH2)4 CH

COOH

NH

0.75 0.25

Adipic acid L-Leucine 1,6-HexanediolL-Leucine Adipic acid L-Lysine n

Load

(g)

Strain

(%)

Stress

(Kg/mm2)

Modulus

(Kg/mm2)

Toughness

(Kg-mm)

GJ-X 133.1 5.2 881.879.9 0.10480.0041 1.5900.449 1.02100.1354

C. C. Chu, et al., US Patent 6,503,538, January 7, 2003

An example of PEA:

An elastomer: biodegradable rubber band

amino acids as main building blocks

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SEM Image of 3D Microporous

PEA Fibrous Structure

PEA control (no GN) PEA w/ GN loaded

Fiber diameter: 1/1003/100 of human hair

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Collaboration with the Department of

Biomedical Engineering

Moonsoo Jin, C.C. Chu

A novel growth factor and matrix mimetic-enhanced biodegradable scaffold for skin

tissue engineering

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Collaboration with the Department of

Biomedical Engineering

Recently funded seed grant

Jingrowth factors, matrix-mimeticproduction, conjugation and cell culture

Chu3 dimensional PEA scaffold design

and fabrication Burn Centeranimal laboratory and

clinical application

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Burn Research Team

Palmer Q. Joe Bessey, M.D.

Joe Turkowski, M.D.

Suzanne Schwartz, M.D.

Research co-ordinators:

Nicole Alden, RN, MPH

Angela Rabbitts, RN, MS