研究介紹 生物醫學超音波影像實驗室
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研究介紹 生物醫學超音波影像實驗室. 李百祺. 多元化學習! 結合生物醫學與電子資訊科技已是前瞻研究趨勢!. 跨領域研究 很有趣 很有意義 很有挑戰性. What is Biomedical Engineering ?. Interdisciplinary area of Biology, Medicine and Engineering . Prevention, diagnosis and therapy of diseases. Science, engineering and clinical applications. - PowerPoint PPT PresentationTRANSCRIPT
研究介紹生物醫學超音波影像實驗室
李百祺
多元化學習!結合生物醫學與電子資訊科技已是前瞻研究趨勢!
• 跨領域研究–很有趣–很有意義–很有挑戰性
What is Biomedical Engineering?
• Interdisciplinary area of Biology, Medicine and Engineering.
• Prevention, diagnosis and therapy of diseases.
• Science, engineering and clinical applications.
• Full of innovations and combination of the state of the arts.
PhysicsSystems
Signal Processing
Ultrasonic Imaging:-Micro imaging-Breast imaging-Molecular imaging
Therapy:-Cavitation-Gene transfection
Photoacoustics:-Imaging-Nanoparticles
Systems:-Transducer-HW/SW
合作團隊: 臺大醫學院、生命科學院、基因體中心、奈米中心、國家衛生院、成大、師大、中正、暨南 ,…等單位。跨領域研究:電子、物理、醫學、生命科學、化學、奈米材料。
Ultrasonic Micro-Imaging
Mouse Embryo Micro-ImagingD
ep
th (
mm
)
1 2 3 4 5 6 7 8 9 10
8
9
10
11
12
13
14
15
P
Umbilical Cord
Width (mm)
Dep
th (
mm
)
1 2 3 4 5 6 7 8 9 10
8
9
10
11
12
13
14
15
1 2 3 4 5 6 7 8 9 10
8
9
10
11
12
13
14
15
P
Umbilical Cord
Width (mm)
1 2 3 4 5 6 7 8 9 10
8
9
10
11
12
13
14
15
-30
-20
-10
0
10
20
30
Velocity (mm/s)
Cover of IEEE Trans. on UFFC, Jan. 2004
Mouse Tumor Micro-Imaging
Ultrasound Assisted Therapy
M icrobubbles and Cavitation
From UC Davis
Cavitation vs. Gene Transfection/Cell Viability
Differential ICD (V-s)
0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0 1.1 1.2
Tra
nsfe
ctio
n R
ate
(%)
10
20
30
40
50
60
PressureConcentrationPulse lengthRegressive curve
Differential ICD (V-s)
0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0 1.1 1.2
Cel
l Via
bilit
y (%
)
20
40
60
80
100
120PressureConcentrationPulse length Regressive curve
Photoacoustic Imaging and Gold Nanoparticles
Optoacoustic (Photoacoustic) Imaging
From TAMU
From Fairway
High frame rate photoacoustic imaging system
ultrasonic transducer Lightguide
Cylindrical lensSample
Laser system: Q-switched Nd:YAG
(wavelength 1064 nm, pulse duration 8 ns
Pulse repetition freq. 15 frames/s)
Lightguides: fiber bundle (15,000 fibers)
(output: 3 mm X 30 mm illumination area)
Photoacoustic probe:
Optical: Light guide with cylindrical lens
Acoustic: Linear array with 128 channels
(pitch : 0.3 mm, fc = 5 MHz)
Reflecting foil: 9 μm
Nanoprobe Designs
HER2Ab-HER2Ab-AuNRAuNR785785
A.R.=3.7
A
CXCR4Ab-CXCR4Ab-AuNRAuNR10001000
A.R.=5.9
B
785 nm1000 nm
Molecular Imaging with Two Targets
0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8
x 10-6
-0.4
-0.3
-0.2
-0.1
0
0.1
0.2
0.3
Time (seconds)
volta
ge (
V)
Pulse-echo response
5 10 15 20 25 30 35 40 45 50
-70
-60
-50
-40
-30
-20
-10
Frequency (MHz)
dB
Frequency response
Central frequency : 11.43MHz
BW : 15.75% at -6dB
mm
mm
IVUS, graphite phantom, DR=60, average=64
-15 -10 -5 0 5 10 15
-15
-10
-5
0
5
10
150
10
20
30
40
50
60
Transit ring transducer
Catheter
Single element
IVUS transducer
Intravascular PA Imaging
Systems and Probes
System Development
High Frequency Transducer
Parylene Matching Layer
Silver-Epoxy Matching Layer
LiNbO3
Insulating Epoxy
Conductive Epoxy Backing
Brass Housing
Signal Wire
SMC Electrical Connector
Cr/Au Electrodes
Cr/Au Electrodes
(a). SEUT (b). SEAT
• 跨領域研究–很有趣–很有意義–很有挑戰性
• 電機系的同學,在跨領域的環境中,發揮自己的專長– nVIDIA for Medical Imaging–無線神經電刺激器–血管內的影像世界– ,…
聯絡方式• 博理館 425室• 02-33663551
• http://ultrasound.ee.ntu.edu.tw
• 生物醫學超音波影像實驗室 : 明達館 731室、博理館 529室、慶齡中心、展書樓、奈米中心、基因體中心 6F