2010 acls 講義【台北榮民總醫院】

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  • 2010 ACLS

  • 1

    2010

    1. 1.1 2010 AHA CPR ECC 1.2 1.3 1.4 1.5 (first aid)

    2

    14

    15

    20

    22

    2. 2.1 CPR 2.2 2.3 CPR

    31

    42

    46

    3. 3.1 3.2

    50

    56

    4. 4.1 4.2 4.3

    61

    71

    78

    5. // 88

    6. 89

    7. 7.1 7.2

    97

    103

    8. 105

    9. 137

  • 2

    1. 1.1 2010 AHA CPR ECC

    Circulation 2010 10 2010 AHA CPR ECC

    () CPR 50 1960

    KouwenhovenKnickerbocker Jude 14

    (1962) 1966

    CPR 50

    CPR

    ()

    CPR (

    )

    356 ( 29 )

    277 411

    2005

    CPR

  • 3

    18 4

    CPR

    () CPR

    CPR (

    )CPR CPR CPR

    CPR

    CPR

    CPR

    CPR

    CPR

    CPR CPR

    2010 CPR

    ()

    ()(

    ) VF()

    VF

    ''

  • 4

    CPR

    2010

    2010 CPR A-B-C ( Airway

    Breathing Chest compression) C-A-B ( Chest compression Airway

    Breathing)()

    CPR CPR

    VF VT

    A-B-C (

    ) 18 ( 30

    )

    CPR A-B-C

    CPR

    () VF

    CPR

    CPR 5

    CPR

    ()(

    )

    (DNAR)()

    ( DNAR ?)

    BLS

  • 5

    ACLS

    ACLS ()

    ()

    Basic Life Support

    BLS

    CPR

    2010 CPR

    BLS

    (

    )

    CPR CPR CPR

    CPR 1.5 2 2 ( 5 )

    CPR

  • 6

    ()

    CPR CPR

    CPR

    ()

    ''

    (

    ) 10

    CPR

    CPR

    CPR AED

    4 5 CPR 1.5 3

    2 2

    ()

    Atrial fibrillation

    120 200

    200 Atrial flutter PSVT

  • 7

    (50 100 ) Asystole

    BLS ACLS BLS CPR

    (VFVT)''

    ACLS BLS

    Class recommendation

    CPRLMAET

    TUBE ''

    ()1. Adenosin

    Atropine Dopamine

    Epinephrine

    (

    CPR )

    CPR PEA Asystole

    Atropine

    CPR CPR (

    )(

    )

    9 (Goal-oriented)

  • 8

    EMS

    STEMI

    ()

    EMS

    (Class )(Class )

    National Institute of Neurological Disordes and Stroke (NIND) Third European

    Cooperative Acute Stroke Study (ECASS-33)

    ( 11 )

    3

    BLS ACLS

  • 9

    15

    ()

    (Pediatric Basic Life Support)

    (cardiac arrest)(asphyxia)( 5% 15%)

    (VF)(asphyxial arrest)

    (resuscitation)(ventilation)(chest compression)

    (community pediatric study)

    (ventilation)(chest compression)

    CPR(chest

    compression-olny CPR)(no bystander) CPR

    (ventilation)(chest compression)

    (witnessed cardiac arrest)()

    VF (early defibrillation)

    CPR(chest compression-olny CPR)

    (ventilation)(chest compression)

    C-A-B ()

    18 ()

    (push hard, push fast, allowing the chest to completely recoil

    in each compression, minimizing interruptions in chest compression, and avoiding excessive

    ventilation)

    (anterior-posterior dimension)()

    ()

    (Pediatric advanced Life Support)

    2005 AHA guidelines for CPR and ECC

    (healthcare providers)

  • 10

    10

    CPR

    (cuffed endotracheal tube)

    (cricoid compression)

    (cricoid compression)

    (capnograhy/capnometry)(

    ) CPR

    (defibrillation)()

    VF VT 2 4 J/kg (

    ) 4 J/kg ()

    (titrated)(hyperoxemia)

    (single ventricle)(pulmonary hypertension)

    (genetic ion channel defect, channelopathy)

    (genetic analysis)

    (channelopathy)

    (Neonatal Resuscitation)

    (cardiac arrest)(asphyxia)

    A-B-C

    (peripartum sunctioning)

    (cardiorespiratory transition)

    (good tone)(hyperoxia)

    ()(room air)

    100%

  • 11

    (oximeter)

    ()

    (amniotic fluid)(non-vigorous)

    (endotracheal suctioning)

    (Chest Compressions)

    -(compression-ventilation) 3:1

    (asphyxia)

    (15:2)(epinephrine)

    0.01 0.03 mg/kg (0.05

    0.1 mg/kg)

    (Postresuscitation Care, Post-Cardiac Arrest Care)

    (therapeutic hypothermia)

    10

    (Education)

    2010 (Education, Implementation, and Team)

    CPR (bystander CPR)(cardiac arrest)

    CPR CPR

    CPR CPR(compression-olny CPR, Hands-Only CPR)

    CPR

    (EMS)(

    (gasping)) CPR(dispatchers)

    CPR(compression-only CPR, Hands-Only CPR)

    BLS (practice while watching)

  • 12

    (defibrillation)AED

    AED

    ALS

    BLS ACLS

    (debriefing)(learner-focused,

    nonthreatening)

    (system-based approach)

    (variability)()

    (First Aid)

    (laypersons)

    (anaphylaxis)(symptoms and signs)

    (anaphylaxis)

    (first aid providers)

    (first aid providers) aspirin

    (unresponsive) (recovery position)

    2005 (tourniquets)

    (gangrene)()

    (spinal immobilization)

    (secondary spinal cord injury)(spinal stabilization)

    (movement restriction)

    2005(pressure immobilization)(neurotoxic snake bite)

    (non-neurotoxic snake bite)

    (jellyfish stings)

    (refreezing)(thawing)

    (chemical warmers)(frostbite)

    (dehydration)(oral fluid replacement)

  • 13

    -( carbohydrate-electrolyte

    mixture)

  • 14

    1.2 2010 (AHA) (CPR)(ECC)

    AHA ECC

    CirculationResuscitationILCOR 2010 International

    Consensus on CPR and ECC Science With Treatment Recommendations

    ECC 277

    411

    Class I recommendations

    (should)

    Class IIa recommendations

    (is reasonable)

    Class IIb recommendations

    (may be considered)

    Class III recommendations(is

    not helpful and may be harmful)

    2010 AHA CPR ECC Class Indeterminate recommendations

    (level of evidence, LOE)

    AHA Level A(RCTs)

    (ILCOR LOE 1)

    AHA Level B(ILCOR LOE 2 or 3)

    AHA Level C

    (ILCOR LOE 4 or 5 or Expert Opinion)

  • 15

    1.3 (Ethics)

    BLSACLS

    NOT STARTING

    ()

    Healthcare Advance Directives, Living Wills, Patient Self-Determination

    DNARDo Not Attempt Resuscitation order

    ANDAllow Natural Death

    (DNAR)

    OHCA

    DNAR

    Surrogate Decision Makers

    18

    ()

    1.

    2.

    Adult OHCA WITHDRAWING

    BLSBLS

    BLS

    1. EMS 2. CPRAEDROSC 3. AED

    BLS

  • 16

    BLS

    BLS

    37%

    EMSALSALS

    20ALS

    ALS

    Adult IHCA

    DNR

    CPR

    arrestrhythmROSC

    10

    Class IIb

    (1) Extreme prematurity 23 400 g(2) anencephaly

    1. 2. BystanderCPR 3. ALSROSC 4.

  • 17

    (3) trisomy 13Class IIb

    Providing Emotional Support to the Family

    ()

    2010 () 3

    72

    2005 ()

    33

    3

    72

    24 N20 3

    ROSC 3

    2

  • 18

    N20

    2005 ()

    BLS ALS EMS

    40%-60%

    EMS

    ED ()

  • 19

    1.4

    CPR CPR

    1.

    CPR 2.

    1.

    2.

    CPR

    CPR

    CPR

    CPR, CPR

    15%~30%

    CPR CPR

    1. CPR

    CPR CPR

    CPR CPR CPR

    CPR

  • 20

    2.

    (gasping)

    3.

    CPR

    4.(AED)

    AED AED

    1.

    AHA ECC

    2.BLS

    3.(AED)

    4.ALS

    5. ALS

    6. ACLS PALS

    ATLS ACLS

    PALS

    7. ACLS

    8. 2

  • 21

    1./-

    2.CPR CPR

    3. ACLS

    CPR

    1.

    2.RRTsMETs

    MET/RRT

    3.

    4.

  • 22

    1.5 (First Aid) (AHA)(Red Cross)(National

    First Aid Science Advisory Board) 2005

    2010

    :

    ?

    ?

    2010

    Peter Shepherd Francis Duncan

    1903

    (first aid) ()

    ()(First aid provider)

    (Calling for Help)

    (EMS)(One-site emergency response

    planERP)

    (Positioning the victim)

  • 23

    High Arm IN Endangered Spine (HAINES)

    (Class IIbLOE C)

    6~12 ( 30~45 )(Class IIbLOE C)

    (Oxygen)

    (Class IIbLOE C)(Class IIb

    LOE C)

    (Medical emergencies)

    (Breathing Difficulties)

    (Class IIaLOE B)

    //

    (Anaphylaxis)

    (Anaphylactic reactions)

  • 24

    (Class IIbLOE B)

    18%~35%

    (Class IIbLOE

    C)

    (Seizure)

    (Class IIaLOE C)

    (Chest Discomfort)

    (EMS)

    ()(Class IIa

    LOE A)

    (Injury Emergencies)

    (Bleeding)

    (Direct Pressure)

    (Class ILOE A)

  • 25

    ;

    (Tourniquets)

    (Class IIbLOE B)

    (Class IIaLOE B)

    (Pressure Points and Elevation)

    (Class IIILOE C)

    (Hemostatic Agents)

    (Class IIbLOE B)

    (Wounds and Abrasions)

    (

    )(Class ILOE A)

    (Class IIaLOE A)

    (Burns)

    (Thermal Burns)

  • 26

    (15 25 )(Class ILOE

    B)

    (Class IIILOE

    B)

    (Burn Blisters)

    (Class IIaLOE B)

    (Electric Injuries)

    (Class IIILOE C)

    ()

    (Spine Stabilization)

    2%

    10~30

    ()

    ()

    (Class IIbLOE C)

  • 27

    (Class IIILOE C)

    65

    2

    (Musculoskeletal Trauma)

    (Sprains and Strains)

    20 10

    (Class IIbLOE C)

    (Fractures)

    (Class IIILOE C)

    (Class IIaLOE C)

    (weight bearing)

    (Human and Animal Bites)

    (Class ILOE B)

  • 28

    (Snakebites)

    (Class IIILOE C)

    (:40~70 mmHg:55~70 mmHg)

    (Class IIaLOE C)

    (Jellyfish Stings)

    :

    (nematocyst)

    (Vinegar4% 6%) 30 (Class

    IIaLOE B)

    (Class IIaLOE B)

    ( 45) 20

    (Class IIbLOE B)

    (Class IIILOE C)

    (Dental Injuries)

    ()

    (Class IIaLOE C)

    (Environmental Emergencies)

    (Cold Emergencies)

    (Hypothermia)

  • 29

    (Class IIaLOE B)

    ()

    (Frostbite)

    (Class IIILOE C)

    24(37 40) 20 30(Class

    IIbLOE C)(Class

    IIILOE C)Ibuprofen NSAID

    (Heat Emergencies)

    (Drowning)

  • 30

    (2 )

    (Poison Emergencies)

    ()

    (Chemical Burns)

    (Class ILOE B)

    (Toxic Eye Injury)

    (Class ILOE C)

    (Ingested Posions)

    (Treatment with Milk or Water)

    (Class IIILOE C)

    (Activated Charcoal)

    (Class

    IIbLOE C)

    (Ipecac)

    (Class IIILOE B)

  • 31

    2. 2.1 CPR 2010 (AHA) (CPR) (ECC)

    (CPR)

    CPR:

    CPRCPR2010

    CPR

    CPR

    35 ()

    10 50-55

    25%

    3 6 25%

    (VF)(pulseless VT)

    Asystole PEA

    :

    ()

    1.

    2. CPR

    3.

  • 32

    4.

    5.

    VF

    50%

    CPR

    CPR

    2010 AHA CPR ECC

    2010 AHA CPR ECC

    : 1.

    2. CPR3.

  • 33

    BLS

    ()

    ()

    10 ( HCP )

    CPR CAB

    100 /

    5

    1/3( 5 )

    1/3( 4 )

    2

    10

    ()

    ()

    30:2

    30:2

    15:2

    ()(HCP)

    6-8 1 (8-10 /)

    1

    AED

    CPR

  • 34

    CPR

    ALS

    CPR :

    CPR

    CPR

    CPR

    CPR ()

  • 35

    CPR

    : CPR

    ( BLS)

    ()

    /

    (AED) AED CPR

    AED CPR/

    AED

    AED AED CPR

    CPR

  • 36

    BLS

    CPR

    CPR

    CPR

  • 37

    1. 100

    2.

    1) 2 (5 )

    2) 1.5 4

    2 5 )

    3.

    4.

    5.

    6.

    ()

    ()CPR

    6-8 1 ( 8-10 /)

    CPR

    CPR --

  • 38

    (1)

    (2) (3)3(

    )

    /

  • 39

    Utstein

    CPR

    EMS

    EMS

    .

    ;

    (CARES)NRCPR

    ()

  • 40

    CPR

    CPR

    CPR

    /

    2010 AHA CPR ECC 501960

    19621966

    CPR50

  • 41

    50

    2005

    ECC

    BLS

  • 42

    2.2 (Basic Life Support) ()

    CPR ==> CABD

    (Supine)

    119

    *90

    (EMS)

    AED

    C(Circulation)

    10

    2~3(

    )

    2

    100/

    25

    (302)

    A( Open Airway)

    (

    )

    B(Brithing)

    2

    1

  • 43

    5(2)

    CPR(2

    (6-818-10/)

    AED

    DDefibrillation

    AED

    CPR

    1.

    2. CPR

    3. ()

    ()

    AED ()

    4. 10 10

    CPR AED

    5.

    6. CPR (

    )

    7.

    8. (C-A-B A-B-C) 30

    CPR 2

    9. 100 / 100

    10. 1. 2 (4 5 ) 2

    ( 5 )

    11.

  • 44

    12. CPR

    CPR

    100 /

    25

    /

    5-612

    302

    /

    1CPR 2

    CPR 221ALS

    10

    ()

    1.

    2.

    3A.3.

    4.

    5.

    6.

    7. 8.

    /

    5-612

    302

    /

    1CPR 2

    CPR 221ALS

    10

    ()

    1.

    ()

    1.

    2.

    3A.3.

    4.

    5.

    6.

    7. 8.

  • 45

    CPR

    1. BLS

    2.

    () CPR

    3.

    4. CPR (

    )

    5. (C-A-B

    A-B-C) 30 CPR 2

    6. 100 (100 /)

    7. 1. 2 2 (5 )

  • 46

    2.3 CPR 25

    (manual) CPR CPR

    CPR

    CPR CPR

    CPR CPR CPR

    CPR techniques

    High-Frequency Chest Compressions

    120

    9 23

    ( 120 ) CPR

    2010 CPR guidelines

    100

    (class IIb)

    Open-chest CPR

    Open-chest CPR

    (stroke volume)

    open-chest CPR CPR

    : 2 2

    open-chest CPR

    (return of spontaneous circulation, ROSC)

    open-chest CPR

    open-chest CPR

    open-chest CPR (Class IIa)

    CPR(Class IIb)

  • 47

    Interposed abdominal compression

    (IAC)-CPR

    IAC-CPR CPR IAC-CPR

    randomized

    randomized IAC-CPR IAC-CPR 426

    IAC-CPR (Class IIb)

    IAC-CPR (Class Indeterminate)

    Cough CPR

    CPR()

    1

    3

    (

    92)CPR(

    )

    CPR devices

    Devices to Assist Ventilation

    Automatic and Mechanical Transport Ventilators (ATVs)

    73 ATV bag mask

    ATV

    bag mask ATVs 5

    (

    Combitube )ATVs (Class IIa)

    Manually triggered, oxygen-powered, flow-limited resuscitators

    104

    (; ) oxygen-poweredflow-limited resuscitators

    mask-bag devices CPR

  • 48

    oxygen-powered flow-limited

    resuscitator(Class III)

    Devices to Support Circulation

    Active Compression-Decompression CPR

    ACD-CPR : CPR

    ACD-CPRROSC (return of spontaneous circulation)3

    (826)(4162)ROSC

    ACD-CPR

    ACD-CPR(Class IIb)

    Impedance Threshold Device

    Impedance Threshold Device(ITD)

    ITD ROSC

    ITD (Class IIa)

    Mechanical Piston Device

    mechanical piston CPR

    (end-tidal CO2)

    CPR

    ()

    (Class IIb)mechanical piston CPR

    100 5 30:2 ( advanced airway

    )

    Load-Distributing Band CPR or Vest CPR

    load-distributing

    band CPR ROSC

    load-distributing band (LDB)-CPR (Class IIb)

    Phased Thoracic-Abdominal Compression-Decompression CPR with a Hand-Held Device

  • 49

    (PTACD-CPR)

    IAC-CPR ACD-CPR

    Extracorporeal Techniques and Invasive Perfusion Devices

    Extracorporeal CPR (ECPR)

    CPR

    ECPR

    : ECMO

    (: ) ECPR

    ()()(Class IIb)

    Summary

    CPR

    CPR

    CPR

  • 50

    3. 3.1

    PQRS T 60~100 beats/min

    QRS

    QRS complex P P QRS complex

    (Tachyarrhythmia)

    100 (ventricular fibrillation, VF)

    (ventricular tachycardia, VT)(paroxysmal supra-ventricular

    tachycardia, PSVT)(atrial flutter, AF)(sinus tachycardia, ST)

  • 51

  • 52

    VF PQRS T VF asystole

    ( paddle 90 ) VF asystole

    QRS ( >0.12ms)(

  • 53

    AV block)(2AV block)(3AV block)

    (junctional rhythm)(idioventricular rhythmIVR)(nentricular

    asystoleVA)

  • 54

    VA(Asystole) VA

    QRS

    a. P IVR(< 40beats/min)

    b. P 3AV blockSB with complete BBB

    3AV blockP QRS P QRS

    3AV block

    QRS P ( P )

    QRS complex

    a. P Junctional rhythm 40~60 beats/minQRS P

    QRS P P QRS P

    b. P SB2 I AV block2 II AV block AV block

    SBPQRST (

  • 55

    2 II AV block P-R P QRS

    AV block QRS ( 40~60beats/min)P

    AV block

    AIVR(accelerated idioventricular rhythm)

    60~100 beats/min P QRS( IVR)

    Pacemaker rhythm spike() QRS

  • 56

    3.2 (AED, Defibrillation, Cardioversion, and Pacing)

    ( AEDs )( cardioversion )

    ( pacing )AEDs (BLS)

    cardioversion pacing ACLS

    CPR

    VF CPR 7~10%

    CPR 3~4% CPR 5~10

    VF CPR VF Asystole

    CPR VF

    CPR AED

    VF AED

    1. EMS

    2. CPR

    3. AED

    1 2

    CPR

    AED

    CPR AED AED

    CPR

    AED CPR

    AED

    EMS EMS AED (ECG)

    CPR 5

    CPR( 2range 1.5 ~ 3 )

    CPR CPR

    VF

    3 CPR

  • 57

    1-Shock or 3-shock

    2010 ( 2005 ) 2010

    VF 1 3

    1 VF CPR

    1-shock CPR5 cycle(30

    compressions and 2 breaths) AED

    200

    VF

    ()

    ROSC

    (120 200 )

    -(();

    ,)

    (---)

    ( implanted cardioverter defibrillator)

    --

    ICD 8

  • 58

    8~12cm

    (4.3cm) myocardial necrosis

    gel

    AED

    1995,AHA AED SCA

    3~5 CPR , 41~74%.

    1. CPR AED

    2.(,,) AED

    3.AHA EMS

    AED

    (ex.NTG, nicotine, analgesics, hormone replacements,

    antihypertensives)

    AEDs AEDs

    AED in children

    VF

    5~15%,

    ,> 4J/kg(

  • 59

    4J/kg

    AED

    2010AED

    AED( 3 )

    VF

    (synchronized cardioversion)

    QRS VF

    surpaventicular tachycardia due to reentry, atrial fibrillation, atrial flutter,atrial

    tachycardia, monomorphic VT with pulses junctional tachycardia multifocal atrial

    tachycardia

    VF, pulseless VT, polymorphic ( irregular ) VT

    120-200

    200

    50-100 ()

    0.5~1J/kg 2J/kg

    VT VF

    VT 100 ()

    VF

    QRS VT VT (

    VT) ()

    0.5~1J/kg 2J/kg, QRS

    ( VT),,,

  • 60

    (Pacing)

    Pacing asystole

    (symptomatic bradycardia with a pulse ) atropine

    TCP(transcutaneous pacing) TCP

    transvenous pacing

  • 61

    4. ACLS

    return of spontaneous circulationROSCACLS

    ACL

    BLS

    2005 ACLS

    1.

    2.

    3. Atropine PEA/

    4.

    5. (Chronotropic drug)

    6. Adenosine

  • 62

    4.1

    CPR

    CO2(Tidal

    volume)

    VF

    CPR ,/

    CPR Advanced airway

    CPR

    CPR

    CPR

    CPR

    Class ILOE C

    CPR

    CPR100

    FiO2 1.0 100

    CPR CPR 100

    CPR 100classaLOE

    C 9

    CPR

    CPR

    EMS CPR 6

    BoussignacCPRCPR

    oxygenation

  • 63

    CPR

    5

    1 2 600

    1

    CPR 30

    3 4 2

    Class IIILOE C

    (Class IIa, LOE C).

    30%

  • 64

    Class IIa, LOE

    C

    Advanced Airways

    CPR BVM BVM

    BVM

    BVM ACLS

    ACLS CPR

    ACLSCPR

    ACLS

    5

    24 12

    13

    / VT

    ACLS

    CPR (Class IIb, LOE

    C)

    EKG monitor oximeter

    BVM

    ACLS

    BVM

  • 65

    Continuous waveform capnography

    (Class I, LOE A)

    CPR

    100 6 8 8 10

    ()

    LMACombitubeLaryngeal Tube or King LT

    BVM

    CPR BVM(Class IIa, LOE

    B)(Class IIa, LOE A).

    (Esophageal-Tracheal Tube)

    Combitube BVM

  • 66

    CPR 62-100

    BVM (Class IIa,

    LOE C)(Class IIa, LOE A)

    (Laryngeal Tube)

    (Laryngeal Tube or King LT)

    40

    853 cuff 3

    157 97

    BVM(Class IIb, LOE C)

    (Class IIb, LOE C).

    (Laryngeal Mask Airway)

    BVM

    CPR 72 97

    BVM (Class

    IIa, LOE B)(Class IIa, LOE C)

    Endotracheal Intubation

  • 67

    EMS

    (Class I, LOE B)EMS (Class

    IIa, LOE B)

    BVM

    EMS

    BVM

    cuff

    1 BVM 2

    10

    10

    6 25

    Esophageal Detector

    DeviceEDD)

    (Class I, LOE A)

    EDD

    (Class IIa, LOE B)

  • 68

    BVM

    100 100

    3 64 100

    100 100

    (Class I, LOE A)

    (Class IIa, LOE

    B). PETCO2 capnometers

    Combitube

    CPR ROSC

    Esophageal Detector Devices(EDD)EDD

    EDD EDD

    EDD EDD

  • 69

    (Class IIa, LOE B).

    EDD

    (Thoracic Impedance)

    2

    6 CPR

    (Class I, LOE C).

    2

    (Class IIb, LOE C)

    X

    Ventilation After Advanced Airway Placement

    CPR

    CPR 25

    6 12

    6 8 8 10 /

    (Class IIb, LOE C)CPR

    Automatic Transport Ventilators

    Automatic Transport Ventilators; ATVs

    (Class IIb, LOE C). CPR

    CPR

    (Class IIb, LOE C).

  • 70

    BVM

    pharyngeal tips

    40 / 300

    Summary

    CPR BVM

    ACLS

    CPR

  • 71

    4.2 (Cardiac Arrest) (ventricular fibrillation, VF)

    (pulseless ventricular tachycardia, VT) (pulseless electric activity, PEA)

    (asystole)

    2010 ()

    () CPR

    CPR

    ()

    ()

    CPR VF/pulseless VT

    ACLS () ROSC (return of spontaneous circulation)

    CPR

    IV IO

    /

    AED VF/VT 2

    VF/VT CPR

    ()

    2

    (120 to 200J) VF (Class I, LOE

    B) (Class IIb, LOE C)

    (Class IIb, LOE B)

    360J

    2 CPR 3-5 1mg

    epinephrine (Class IIb, LOE A) CPR VFVT amiodarone

  • 72

    (Class IIb, LOE A) ROSC

    amiodarone lidicaine amiodarone

    ROSC (Class IIb, LOE B) QT torsades de pointes

    atropine 2010 VF/VT/asystole/PEA

  • 73

    5H5T

    VF/VT ACS/AMI CPR

    cardiopulmonary bypass

    AMI CPR

    (ROSC)

  • 74

    (post-cardiac arrest care) ST

    (Class I, LOE B) (therapeutic hypothermia)

    (PEA) (asystole)

    AEDCPR (30:2) 2

    (organized rhythm)

    CPR

    2 ()CPR

    ()

    3-5 epinephrine 1 mg atropine

    (Class IIb, LOE B)

    PEA 5H5T

    PEA

    (Class IIa,

    LOE B, ) (needle decompression)

    PEA

  • 75

    Table Treatable Causes of Cardiac Arrest: the Hs and Ts

    Hs Ts

    Hypoxia Toxins

    Hypovolemia Tamponade (cardiac)

    Hydrogen ion (acidosis) Tension pneumothorax

    Hypo-/hyperkalemia Thrombosis, pulmonary

    Hypothermia Thrombosis, coronary

    For further explanation of the Hs and Ts, see special resuscitation situations

    ( ventricular volume)

    (ROSC) (post-cardiac arrest care)

    (therapeutic hypothermia) (Class IIb, LOE C)

    CPR (100/min) (>5cm) (6~8 sec/breath)

    CPR

    PETCO2 (partial pressure of

    end tidal CO2)CPP (coronary perfusion pressure)SCVO2 (central venous oxygen saturation)

    CPR (PETCO2, CPP,

    SCVO2) ROSC CPR

    ROSC CPR

    (Class IIb, LOE C)

    PETCO2 35~40 mmHg 10 mmHg ROSCSCVO2

    60~80% 30% ROSC

  • 76

    CPR

    CPR

    CPR

    bolus 20-mL

    IO

    (Class IIa, LOE C)

    SCVO2 CPR

    CPR CVP (Class IIb, LOE

    C)

    lidocaine, epinephrine, atropine, naloxone, vasopressin (NAVEL)

    amiodarone

    epinephrine beta-adrenergic effect

    ROSC IVIO

    epinephrine, vasopressin, lidocaine

    (Class IIb, LOE B)2~2.55~10 mL

    ambu bagging epinephrine

    lidocaine

    ROSC

    4

    ROSC

    alpha-adrenergic effect (vasoconstrictor) CPR

  • 77

    beta-adrenergic effect (myocardial work)

    (subendocardial perfusion) IV/IO 3~5 1mg

    epinephrine (Class IIb, LOE A)

    Vasopressin nonadrenergic peripheral vasoconstrictor

    ROSC

    IV/IO vasopressin 40 units

    amiodarone placebo lidocaine

    Amiodarone alpha beta-adrenergic

    placebo lidocaine

    amiodarone

    CPR VF/VT amiodarone (Class IIb, LOE B)

    300 mg IV/IO 150 mg IV/IO 6 1

    mg/min 18 0.5 mg/min

    Lidocaine VF

    amiodarone

    lidocaine (Class IIb, LOE B) 1~1.5 mg/kg IV VF/VT

    5~10 0.5~0.75 mg/kg 3 mg/kg 2~4 mg/min

    QT irregular/polymorphic VT QT

    irregular/polymorphic VT VF/VT (Class III, LOE

    A) 1~2 g 10 mL D5W IV/IO bolus (Class IIb, LOE

    C)

  • 78

    4.3

    Atropine

    Atropine0.5 mg (Class IIa) 3~5 3 mg Atropine

    Transcutaneous pacing, TCP TCP

    Class IIa

    Dopamine/Epinephrine TCP Dopamine 2~10g/kg/min Epinephrine

    2~10g/min (Class IIb)

    TCP(Second degree AV Block, Mobitzs Type II Third degree

    AV Block)(Class IIb)

    Transvenous pacing TCP Transvenous pacingClass IIa

  • 79

  • 80

    QRSsupraventricular tachycardia,

    SVT QRS

    QRS (SVT) QRS

  • 81

    1

    6

    150 /

    2

    3

    QRS0.12

    5

    7

    12 VagalmaneuversadenosineBlocker calciumchannelblocker

    QRSadenosine

    4

    12

    adenosine

    50100J 120200J

    200J100J

    AdenosineIV 6mg IVpush N/Sflush

    12mg

    QRS

    ProcainamideIV 2050mg/min

    QRS 50%17mg/kg

    1-4mg/min QT

    AmiodaroneIV 150mgIV 10

    VT 1mg/min 6

    SotalolIV 100mg1.5mg/kg 5

    QT

  • 82

    (synchronized cardioversion) QRS

    (VF)

    unstable SVT, unstable atrial fibrillation, unstable atrial flutter unstable

    monomorphic (regular) VT

    Af 120~200 Class IIa

    Af SVT 50~100 Class IIa 50J

    200 200J

    Class IIa

    VT 100

    torsades de pointes

    VT VF )

    QRS

    Sinus Tachycardia>100 / 220

    Supraventricular Tachycardia (Reentry SVT)Paroxysmal

    Supraventricular Tachycardia, PSVTAV Node Reentry Tachycardia,

    AVNRTMATjunctional tachycardia

  • 83

    (vagal maneuvers) adenosine SVT

    7

    (1) 25% PSVT vagal maneuvers adenosine SVT

    (2) adenosine adenosine 6 mg (Class I)

    1~3 20ml 1~2

    adenosine 12 mg

    (3) adenosine

    (Class IIa)

    Verapamil 2.5~5 mg 2 ( 3 )

    15~30 5~10 mg 20mg

    Diltiazem 15~20 mg(0.25mg/kg) 2 15

    20~25mg(0.35mg/kg) 5~15mg/hr

    QRS 567

    3

    QRS VT 4

    12

    67VT SVT with aberrancy

    atrial fibrillation with aberrancy, pre-excited atrial fibrillationor polymorphic VT/torsades de

    pointes

    QRS

    (1) Adenosine

    Class IIb) Adenosine QRS

    Verapamil QRS

    (2)VT procainamide (Class IIa), amiodarone (Class IIb)

    sotalol (Class IIb) procainamide sotalol QT

  • 84

    (3) Amiodarone 150mgIV 10 24 2.2g

    VT

    Atrial Fibrillation/ Flutter

    48

    transesophageal echocardiography, TEE

    VT VFdefibrillation

    VT QT

    Long QT intervaltorsades de pointes QT

    QT Magnesium QT interval

    long QT interval VT amiodarone

    -blockers (Class IIb

    SVT

    Adenosine ()

    Adenosine

    QRS

    QRS

    QRS

  • 85

    Diltiazem, Verapamil

    nondihydropyridine

    vasodilators,negative inotropes

    QRS adenosine SVT

    Af AF

    Diltiazem 15~20 mg(0.25mg/kg) 2 15

    20~25mg(0.35mg/kg) 5~15mg/hr

    Verapamil 2.5~5mg 2 15~30

    5~10 mg 20-30 mg

    QRS

    Af AF pre-excitation Wolff-Parkinson-WhiteWPW

    atenolol, esmolol, metoprolol, propranolol

    QRS adenosine

    Af AF

    VT QT

    Atenolol (1) 5 mg 5 10

    Metoprolol (1) 5 mg 1-2 5 15 mg

    Propranolol (1 & 2) 0.5-1mg 1 0.1mg/Kg

  • 86

    Af AF (pre-excitation) WPW

    Procainamide Pre-excited atrial fibrillation 20-50mg/min

    QRS 50% 17 mg/kg

    5 100mg

    Bradycardia,hypotension,torsades de pointesProcainamide QT prolongation CHF

    Amiodarone

    QRS AF

    QRS

    amiodarone 150 mg 10 6 1 mg/min

    0.5mg/min 2.2g/

    Digoxin

    QRS adenosine SVT

    AF Af

    Digoxin 8-12 mcg/kg(4-6mcg/kg) 5 25%

    (2-3mcg/kg) 4-8

    VT

    Procainamide

    VT 20-50mg/min

    QRS 50% 17 mg/kg 5

  • 87

    100mg torsades de

    pointesProcainamide QT

    Amiodarone

    VT VT QT interval

    amiodarone150 mg 10 6 1 mg/min 0.5mg/min

    2.2g/ Bradycardiahypotension QT

    Sotalol

    Potassium channel blocker 1 & 2

    VT 5 1.5mg/kg 5

    QT

    Lidocaine

    VT 1.0-1.5 mg/kg 5~10

    0.5~0.75mg/kg 3mg/kg 1~4mg/min (30~50g/kg/min)

    Magnesium

    VT QT torsades de pointes

    1-2g 15 Magnesium level

  • 88

    5. //

    (rate)(volume)(pump)

    ()

  • 89

    6.

    ROSC

    (1)

    (2)(3)

    (4)(5)

    (6)

    24

    (PCI)

    1

    2010 AHA CPR ECC

    30

    100%

    94%

    10 12 PETCO2 35-40 mmHg

    PaCO2 40-45 mmHg

  • 90

    2

    90 mmHg

    epinephrinenorepinephrine dopamine

    90 mmHg 65 mmHg

    3

    4

    ST LBBB

    PCI

    ST

    5

    20% 50%

    6

    5H-5T5H HypovolemiaHypoxia

    HypothermiaHydrogen ion (acidosis) Hypo-/hyperkalemia

    5T ToxinTamponade (cardiac)

    Thrombosis of coronary areteryTension pneumothorax

    Thrombosis of pulmonary vasculature

  • 91

    Induced hypothermia

    12 24

    feedback-controlled endovascular cathetersurface cooling device

    2010 AHA CPR ECC

    (1) VF

    32C-34C12 24 Class I, LOE B(2)

  • 92

    PEA

    Class III, LOE C

    Class I, LOE C

    PaO2/FiO2 < 300 < 200

    PEEP

    (FiO2)

    100%

    94%Class I, LOE C1

    2

    10 30

    3 auto-PEEP

    Class III, LOE

    C1 6 8 ml2

    plateau pressure 30 cmH2O

    40-45

    mmHg(35-40 mmHg)

    Class IIb, LOE C

  • 93

    fibrinolyticClass IIb, LOE C

    2-adrenergic agonist

    butyrophenones

    catecholamine

    neuromuscular blocking agent

    Class IIb, LOE C

    ST

    Class I, LOE BPCI

    Vasoactive

    NaHCO3 ( )

    2-adrenergic receptor

    10 mg phentolamine 10-15 ml

    dobutamine inodilator milrinone

    Class I, LOE B 65 mmHg

    ScvO2 70%

  • 94

    144-180 mg/dLClass IIb,

    LOE B 80-110 mg/dL

    Class III, LOE B

  • 95

    hemofiltration

    68% 23%

    myoclonus

    I

    Class I, LOE C status epilepticus

    Class IIb, LOE C

    Thiopentalnimodipinelidoflazine

    diazepam magnesium sulfate coenzyme Q10

    Class IIb, LOE B

  • 96

  • 97

    7. (Acute coronary syndrome, ACS)

    7.1

    5%5

    10%

    /

    224

    (angina equivalents)

    1/3

    40

    84.6%

    80.6% ()

    1. (visceral pain)

    (acute myocardial infarction, AMI)2.

    (pleuritic pain)3. (chest wall pain)

    () 1.

    2. 3.

    4. 5.

    (inciting) 6.

    (Variant Prinzmental angina)

  • 98

    (Acute coronary syndromes, ACS)

    ([biomarkers])

    1050%

    (creatine kinase) MB24

    Troponin I

    (sensitivity) (specificity)X-ray

    (hypertrophic cardiomyopathy)

    1. (

    )2. 3.

    4. 5.

    1.

    2. 3. 4.

    ABA

    B

  • 99

    IVO2monitor

    ACSACSAMI (ST-segment

    elevation myocardial infarction, STEMI)unstable anginanon ST elevation MI (NSTEMI)

    STEMI

    4D (door) (diagnosis) (decision)

    (drug)

    5%25~33%

    10 MONA

    () CBCelectrolyteCK CK-MBPTAPTT X

    AMI ST T

    AMI NSTEMI

    (unstable angina, UA)

    UA NTG

    1. MONA

    MMorphine2-4 mg IVP

    OOxygen 4~6L/minACS

    Nnitroglycerin (NTG)nitroglycerin

    nitroglycerinACSACS

    24phosphodiesterase

    AAspirin 160~325 mgACSAspirin

    2. ClopidogrelNSTEMI/UASTEMI75

    600 mg

    300 mg75(75-600 mg)

  • 100

    3. HeparinUnfractionated Heparin (UFH)Low molecular weight heparin (LMWH)

    NSTEMI/UAfondaparinuxenoxaparinUFH

    NSTEMI/UAenoxaparinUFH

    STEMIenoxaparinUFH

    STEMIPCIenoxaparinUFH

    4.(reperfusion therapy)AMI

    morbiditymortality12

    30(door-to-needle time < 30 min)60

    90(door-to-balloon time < 90 min)

    (1) AMILBBBAMI

    rt-PAstreptokinase (SK)rt-PA

    15 mg50 mg(30)35mg(60)SK

    15013

    (3) ()

    (>180/110 mmHg) (

    185/110 mmHg)

    (2~4)10

    CPRCPR (3) (2~4)

    SKt-PASK

    6575

    180/110 mmHgt-PA

    (2) Primary PTCA(PCI)90

    PCIPCI(a)

    (b)PCIAMI

    3618PCI

    PCIPCI

    5.

    (1)

    (2) ACEI/ARBAMI

  • 101

    ACEI/ARB

    (3) -blocker-blocker

    -blocker-blocker

    (4) Statin (HMG coenzyme reductase inhibitors)StatinACS

    ()ACS

    6. 40%

    intra-aortic balloon pump (IABP)

    7.

    NSTEMIUA ()

    NSTEMIST

    STEMINTG IVclopidogrelheparin-blocker

    statinACEIprimary PCI

    early PCI glycoprotein IIb/IIIa inhibitors (GP)

    NSTEMI/UA

    PCI (24~36

    PCI)ST

    UA/ NSTEMIGPPCIGP(Class

    I )GPAbciximabeptifibatidetirofibanPCI

    Abciximab (Class III )Class IIb

    GPGP

    STEMI

    ICU

    CCU

  • 102

    CHEST PAIN CENTER

    8~12

    AMI

    AMIAMI 4D

    Door-Diagnosis-Decision-Drug (

    AMI) ()

    ()

  • 103

    7.2 (Acute coronary syndrome, ACS) (AMI) (unstable angina) (Acute

    coronary syndromes, ACS)ST-Segment(STEMI)

    ST-segment(depression)(non) ST-segment(NSTEMI)T

    ST-segment(markers)

    (sudden cardiac death:)ACS

    BLSACLS

    ACS(1)

    (2)(3)

    VF/VT

    EMT AMI 3

    (1)(2) PCI(3)

    PCI 3 PCI

    3 PCI

    PCI ( 100

    100) 75 75 STEMI 36

    PCI PCI 18

  • 104

  • 105

    8. 8.1

    2010 ACLS

    (bronchoconstriction)

    (airway inflammation)

    (mucous plugging)

    /

    (hypercarbia) (acidemia)

    (asphyxia)

    (lobar atelectasis)

    (pulmonary edema)

    (wheezing)

    (oxygen saturation / SaO2) 2-agonists

    (bronchodilation) (vasodilation)

    (intrapulmonary shunting)

    (anaphylaxis)

  • 106

    (bronchiectasis)

    (subglottic mass)

    (SaO2, ECG)

    2-agonists

    2-agonists ventilation-perfusion mismatch

    2-agonists

    2-agonists (dose-dependent)

    vs albuterol (nebulizer)

    MDI vs nebulizer (metered-dose inhaler spacer) albuterol

    vs 2-agonists 15

    bolus infusion

    2-agonists

    levalbuterol albuterol levalbuterol

    2-agonists anticholinergic ( ipratropium)

  • 107

    (inflammatory component)

    6 12

    methylprednisolone 125 mg (40-250 mg)

    dexamethasone 10 mg

    Anticholinergics

    Magnesium Sulfate

    Epinephrine / Terbutaline

    Ketamine

    Heliox

    Methylxanthines

    Leukotriene Antagonists

    Anticholinergics

    ipratropium bromide

    ( 20 60 90 )

    2-agonists

    ipratropium bromide

    Magnesium Sulfate

    Magnesium

    magnesium sulfate -agonists

    (severe refractory) magnesium 2 g 20

    Epinephrine / Terbutaline

  • 108

    adrenergic

    epinephrine ( 1:1000) 0.01 mg/kg 20

    terbutaline 20 0.25 mg

    epinephrine 4%

    epinephrine / terbutaline epinephrine

    2-agonists

    Ketamine

    (dissociative)

    ketamine

    (rapid sequence intubation, RSI)

    ketamine

    Heliox

    70% (helium) 30%

    Heliox

    Heliox 30% 30% Heliox

    Methylxanthines

    Leukotriene Antagonists

    2-agonists

    sevoflurane isoflurane

  • 109

    (Assisted Ventilation)

    (Noninvasive Positive-Pressure Ventilation, NIPPV)

    (NIPPV)

    NIPPV

    (bilevel positive airway pressure, BiPAP)

    RSI ( 8-9 mm)

    X

    (positive end-expiratory pressure auto- PEEP)

    auto-PEEP

    (6-8 mL/kg)

    ( I/E ratio 1:4 1:5)

  • 110

    (hypoventilation)

    (end-expiratory pressure)

    PEEP

    auto-PEEP

    auto-PEEP (DOPE)

    Displacement

    Obstruction ( )

    Pneumothorax

    Equipment failure ( )

    2010

    BLS

    ACLS auto-PEEP

    (Class IIa, LOE C)

    (lateral chest compressions)

    air-trapping

    (Class IIa, LOE C)

    (Class I, LOE C)

    8.2 (Cardiac Arrest Associated With Anaphylaxis)

    (cardiovascular collapse)

    5001,000

    (anaphylaxis) IgE IgG4

    (Signs and Symptoms)

    (rhinitis)()(stridor)

  • 111

    (asthma(wheezing) ACEI(angiotensin converting

    enzyme inhibitor) C1 esterase inhibitor

    37%

    BLS

    (Airway)

    Class I, LOE C

    (Circulation)epinephrine (epinephrine auto injectors, eg, the EpiPen)

    Class I, LOE C 0.2~0.5mg(1:1000) 10~15

    epinephrine auto injectors 0.3mg 0.15mgClass I, LOE C

    ACLS

    (Airway)

    (surgical airway)Class I, LOE C

    (Fluid Resuscitation)1,000cc

    (Normal Saline)90mmHgClass IIa, LOE C

    Vasopressorsepinephrine0.05~0.1mg

    Class IIa, LOE CClass I, LOE B

    (vasopressin-agonists such as norepinephrine, methoxamine, metaramino)

    epinephrinevasopressin, norepinephrine,

    methoxamine, and metaraminolClass IIb, LOE C

    Antihistamines (H1 and H2 antagonist), inhaled -adrenergic agents, and IV

    corticosteroidsCardiopulmonary bypass Class IIb, LOE C

  • 112

    8.3

    2

    1.

    2. 100%

    3.

    4. 100 80%

    5.

    BLS

    30 CPR

    27 30

    ACLS

    ST

    PCI

  • 113

    PRQRSQT

    /

    20

    4

    24 5

  • 114

    8.4 (WHO) BMI 40 kg/m2 (morbid

    obesity)

    2010

    BLS ACLS

    8.5 PEA (pulseless electric

    activity)

    2010

    (Class IIa, LOE B)

    (Class III, LOE A)

    (percutaneous) (embolectomy)

    8.6

    Potassium (K+)Na+/K+ ATPase pump

    3.5~5.0mEq/L

    (Hyperkalemia)

    > 5.0mEq/L >6.5 mmol / L

    (flaccid

    paralysis)(paresthesia)(depressed deep tendon reflexes)

  • 115

    T P PR QRS S T

    (sine-wave)(idioventricular rhythms)VF

    (Stabilize myocardial cell membrane)

    1. Calcium chloride (10%) 5-10 ml(500~1000mg) IV 2-5 minutes

    2. calcium gluconate (10%): 15~30 ml IV over 2 to 5 minutes

    (Shift potassium into cells)

    1.Sodium bicarbonate(NaHCO3) 50mEq IV over 5 minutes

    2. Glucose plus insulin25g (50 ml of D50 Glucose) + 10U RI IV 15-30 minutes

    3.Nebulized albuterol 10-20mg over 15 minutes

    1.DiureticFurosemide 40-80mg IV

    2.Kayexalate 15 - 50 g + sorbitol

    3.(Dialysis)

    (Hypokalemia)

    < 3.5 mEq/L()

    () (Amphotericin Bcarbenicillinsodium penicillin

    severe hyperglycemiahyperalclosteromism) (PH

    )(paralytic ileus)

    (Rhabdomyolysis)UT(

    digoxin) PEAAsystole

    K+ < 2.5 mEq/L 40 mEq/L10-20 mEq/ h

    ECG monitor(Class III, LOE C)

    Sodium (Na_)

    (Hypernatremia)

    > 145 mEq/L (

    )( hyperaldosteronism, cushings syndrome, hypertonic saline or sodium

  • 116

    bicarbonate)

    ()

    (Hyponatremia)

    < 130-135mEq/L L thiazide

    SIADH

    1. intravascular volume

    2. SIADH:(50-66% of maintenance fluids)

    3. Asymptomatic hyponatremia : Na+ 0.5 mEq/L /hr (max. 12 mEq/L in the first 24hrs)

    4. osmotic demyelination syndrome or central pontine myelinolysis

    5.3% saline= 513mEq Na+/L 1mEq/L/h

    0.5 mEq/L /hr

    6. seizure 2-4 mEq/L/h

    7. Na+ deficit= (desired [Na+] current [Na+]) x 0.6* x BW (kg)

    (*0.6 for men, 0.5 for women.)

    70 10 8mEq/L4 112mEq/L

    (112-108)x0.5x70 = 140mEq

    140/513 =0.27L =270ml 3% saline , 270/4 = 67 ml/h

    8.

    MagnesiumMg++ 1.3-2.2 mEq/L)

    1.

    2. Na, K, Ca

    3.

    (Hypermagnesemia)

    > 2.2 mEq/L (

    )()(

    )(Class IIb, LOE C)

    1. Calcium chloride (10%) 5-10 ml(500~1000mg) IV 2-5 minutes

  • 117

    2. calcium gluconate (10%): 15~30 ml IV over 2 to 5 minutes

    (Hypomagnesemia)

    < 1.3mEq/L (

    )(eg., pentamidine, diuretics, alcohol)

    1-2g MgSO4 IV bolus (Class

    I, LOE C)

    Calcium (Ca++)

    Ca

    Ca++ K+ Mg++ D

    (hypercalcemia)

    Serum Ca > 10.5 mEq/L or Ca2+ > 4.8 mg/dL

    90%

    N/S run 300 to

    500 mL/h () N/S at 100 to 200 mL/h K+

    Mg++(CalcitoninArediaSteroid indomethacin

    oral phosphates)

    (hypocalcemia)

    Serum Ca < 8.5mEq/L or Ca2+ < 4.2mg/dL Toxic shock

    syndromeTumor lysis syndrome Ca2+ <

    2.5mg/dL (Stridor)

    (Chvostek and Trousseau signs) 10% Ca gluconate 10% CaCl2 IV

    4-6 7-9mg/dL K+ Mg++ and pH

    8.7 (Cardiac Arrest Associated With Toxic Ingestions)

  • 118

    ABC ()

    BLS ACLS

    ()

    (evidence- based)(case

    reports)(case series)

    (decontamination)

    ( carbamazepine, dapsone, phenobarbital,

  • 119

    quinine, theophylline)

    (Toxidromes)

    , , ,

    , ,

    , (working

    diagnosis),

    ()

    /

    / (

    QRS)

    /

    Clonidine (2 )

    Propoxyphene (

    )

    ( quinidine,

    flecainide)

    /

    /

    Isoniazid

    (benzodiazepines)

    (Ethylene

    Glycol)

    Metformin

  • 120

    ( bupropion)

    (Salicylates)

    , ,

    , ,

    (opioid)

    (naloxone)

    , , , BLS ACLS

    , naloxone

    Naloxone ,

    , naloxone

    , , ,

    BVM, naloxone; Naloxone,

    ()(Class I, LOE A)

    , naloxone , ,

    , naloxone (0.04-0.4mg),

    , 2mg,

    ( propoxyphene), naloxone

    naloxone , , , ,

    Naloxone 45-70 (methadone),

    , naloxone ,

    naloxone

    Naloxone , , ,

    ? , ;

    ,

  • 121

    (benzodiazepines, BZD)

    (flumazenil) BZD

    , , BZD , BLS ACLS

    BZD , flumazenil ,

    BZDFlumazenil, BZD

    , flumazenil

    , flumazenil (Class III, LOE B)

    BZD, flumazenil; (

    , TCA), flumazenil ,

    (), ,

    , flumazenil

    (-Blockers)

    ,

    , , BLS ACLS

    ,

    (vasopressor), ,

    , , ,

    (Glucagon)

    , ()

    , : 3-10mg (

    0.05-0.15mg/kg) 3-5 , 3-5mg/hr ( 0.05-0.10mg/kg/hr) (Class

    IIb, LOE C)

    ()

    , 100mg,

    , ,

  • 122

    , dopamine ,

    dopamineisoproterenol milrinone,

    (Insulin)

    , ,

    , ,

    (J Med Toxicol. 2009;5:139-143) metoprolol

    , ,

    , 1 U/kg (RI)

    0.5g/kg , 0.5-1 U/kg/hr 0.5 g/kg/hr

    ,

    100-250 mg/dL (5.5-14 mmol/L),

    , 15(

  • 123

    ),

    ,

    , ,

    (Calcium Channel Blockers)

    , , , BLSACLS

    ,

    ,

    (Class IIb, LOE B),

    ,

    (Class IIb, LOE C)

    CCB ,

    (Digoxin) (Cardiac Glycosides)

    , VT, Vf,

    , , ,

    , , , BLS

    ACLS , ,

    Antidigoxin Fab antibodies (Class I, LOE

    B)1vial anti-digoxin Fab 0.5mg , ,

    :

    (1), 1mg , 2 vials Fab

    (2), , :

    (ng/mL) X (kg) / 100

    (3), ,

    10-20 vials

  • 124

    ,

    , 5.0mEq/L,

    anti-digoxin Fab

    (Cocaine)

    ,

    , , BLS ACLS

    , ,

    : ,

    (55%)

    ,

    , ,

    , -blockers

    (phentolamine), benzodiazepines(Lorazepam, diazepam), (verapamil), Morphine,

    nitroglycerin , (Class IIb, LOE B)

    ,

    (Class IIb, LOE B) BZD, NTG, /

    morphine (Class IIa, LOE B)

    , ,

    morphine, NTG,

    phentolamine verapamil ; Labetalol , propranolol

    , , ,

    , : ,

    (Class IIb, LOE C)

    , 1c , QRS

    , ,

    , 1c (flecainide) TCA

    QRS 1ml/kg

    NaHCO3 (8.4%, 1mEq/mL), QRS

    120ms lidocaine QRS

  • 125

    (Cyclic antidepressants)

    QRS 1a 1c

    (: procainamide, quinidine, flecainide)(: amitriptyline)

    2010 , 1a 1c 1a

    , , QRS

    , BLS ACLS

    : Epinephrine NaHCO3 ,

    , physostigmine ,

    , NaHCO3 (Class IIb, LOE C)

    , ,

    pH , ,

    NaHCO3 (8.4%, 1mEq/mL), NaHCO3 1mEq/kg

    , () QRS (Class

    IIb, LOE C), pH , (Na >

    155mEq/L) (pH > 7.55)( epinephrine,

    norepinephrine, dopamine dobutamine),

    , bupivacaine, mepivacaine, lidocaine,

    ,

    , , ,

    , ACLS ,

    , ,

    1.5mL/Kg 20%, 5 ,

    (Class IIb, LOE C), 0.25mL/Kg,

    30 60 12mL/Kg

  • 126

    , epinephrine vasopressin

    ,

    ,

    , ,

    , ,

    ,

    ,

    , ,

    , BLS ACLS

    : , ,

    (),

    (), ,

    , , ,

    ,

    , ,

    : ,

    (Class IIb, LOE C)

    , , ,

    ,

    , ,

    ,

  • 127

    (Cyanide)

    , , ,

    ,

    , , , ,

    , ,

    , ,

    ,

    (scavenger), ( hydroxocobalamin ,

    nitrite, : sodium nitrite/ amyl nitrite), sodium thiosulfate

    hydroxocobalamin sodium nitrite ,

    nitrite (methemoglobin),

    ; hydroxocobalamin , ,

    Sodium thiosulfate , ,

    thiocyanate, thiosulfate (scavenger)

    ; , thiosulfate hydroxocobalamin sodium nitrite

    Sodium thiosulfate , , ,

    , : 100%, hydroxocobalamin, sodium thiosulfate

    8.8 (Cardiac Arrest Associated With Trauma) BLS ACLS

    CPR

    (BLS Modifications)

    , , ,

    , , ,

    , , (pocket mask), (BVM)

  • 128

    , , CPR

    (ACLS Modifications)

    CPR, BVM, ,

    (),

    , ,

    , ,

    , ,

    , ,

    PEA , , ,

    , ,

    , CPR

    Part 12.4

    , (American College

    of Surgeon Committee on Trauma, ACS COT) 1966-1999 :

    7.8% (11.2%, 1.6%)

    (Commotio Cordis)

    , Vf

    ,

    (), Vf,

    , 18 , ,

    Vf,

    AED BLS ACLS Vf

    8.9

  • 129

    34 C

    30 34 C

    30 C

    cardiopulmonary bypass

    extracorporeal blood warming with partial

    bypass

    VT VF VT VF

    BLS

    30C

    Vasopressor ACLS

    8.10

    35

    32C

    8 C

  • 130

    8mmol/L

    ROSC

    8.11 (Drowning)

    (

    )

    (Class I, LOE C)

    near-drowning

    (drowning) /

    20 100%

    (1) 25

    (2) 25

    (3)

    () ()

  • 131

  • 132

    ( 12-15 (NRM))

    ( X )

    4-6

    X

    24

    A-B-C

    2010 CPR C-A-B

    CPR A-B-C !!!

    A-B-C

    A-B-C

    CPR

    BLS A-B-C !!!

    (

    0.009%)

    ()

  • 133

    (rescue breaths)

    (Class III, LOE

    B)

    (oxygenation)

    (ventilation) (perfusion) (

    ) ()

    (suction)

    2010 (abdominal thrusts)

    (Class III, LOE C)

    ( BLS A-B-C

    )

    86%

    8.12 (Lightning strikes and Electric Shock)

    (Electric Shock)

    (VF) R on T

  • 134

    (Lightning strikes)

    primary VF or asystole

    (ROSC)

    (catecholamine release)

    QT T

    30% 70%

    BLS

    1.

    2.

    3. CPR

    4. AED VT/ VF

    5.

    6.

    ACLS

    1.

    2.(N/S lactated Ringers solution) 1~1.5

    ml/kg/hrNaHCO3mannitol

    (myoglobin)

    3. VF Asystole ACLS

  • 135

    8.13

    (Cardiac Arrest During Percutaneous Coronary Intervention)

    (PCI)

    (chest compressions)PCI

    PCI

    Mechanical CPR During PCI(Mechanical CPR)PCI

    (Class IIa, LOE C)

    Emergency Cardiopulmonary BypassPCI

    (emergency coronary angioplasty) (Class IIb, LOE C)

    Cough CPRPCI(ventricular arrhythmias)

    (Class IIa, LOE C)

    8.14

    (Cardiac Arrest Caused by Cardiac Tamponade) (pericardium)filling

    (echocardiography)(Pericardiocentesis)

    (emergency pericardiocentesis)

    (Class IIa , LOE C)

    (Emergency department thoracotomy)(Class IIb , LOE C)

  • 136

    8.15

    (Cardiac Arrest Following Cardiac Surgery)

    1-3%

    (ventricular fibrillation)(hypovolemia)(cardiac temponade)

    (tension pneumothorax)(pacing wire)

    (asystole)

    (Resternotomy)

    (Class IIa, LOE B)

    (Class IIa,

    LOE C)

    (Mechanical Circulatory Support)

    (case series)

    ()(Class IIb, LOE B)

    (Pharmacological Intervention)

    epinephrine

    epinephrine

  • 137

    9.

    (fibrinolytic therapy)

    Ddetection(

    )dispatch()delivery()door()data()decision(

    )drug administration() disposition()--

    :1.2.EMS

    3.EMS4.

  • 138

  • 139

    NIHSS()0(

    )42 < 4(3)(2

    3)(>22)

    2545

    CT

    3

    (oxygen saturation 185 ml/dl

    thiamine 100

    37.5OC;

  • 140

    NINDS3tPA30%

    3% vs 0.3%6.4% vs 0.6%

    (1)tPA(0.9 mg/kg90 mg)10%

    60(2)3(3)

    (4)

    3-4.5tPA3

    (FDA)tPA

    3-4.5

  • 141

    diazepam(5 mg IV 210 mg)lorazepam(1~4 mg IV 2~10)

    Pyenytoin18 mg/kg50 mg/min8100 mg

    30

    thiopentallidocaine

  • 142

    PaCO230mmHg

    25mmHgPaCO2mannitol0.5~2 gm/kg/dose

    2~2020

    Nimodipine(60 mg/q4h0.35 mg/kg)

    (1)> 230> 120sod. nitroprusside 0.5~10 g/kg/minNTG IV drip(10~20

    g/min)

    (2)181~230106~120labetalol

    300 mg

    (3)