ADDITIONAL RESOURCES

CURRENT MODEL OF PSORIASIS IMMUNOPATHOGENESIS

GM-CSF=granulocyte/macrophage-colony stimulating factor.Keijsers RR et al. Br J Dermatol. 2013;168:1294-1302. Lin AM et al. J Immunol. 2011;187:490-500. Res PCM et al. PloS ONE. 2010;5:e14108. Taylor PR et al. Nat Immunol. 2014;15:143-151.

IL-17 A/FIL-22 GM-CSF

TNF-α

IL-1BIL-6TNF-α

IL-23IL-12

Stressed keratinocytes

T cells

Myeloid dendritic cellKeratinocytes

Activation

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REFERENCES

REFERENCES (CONT.)

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REFERENCES (CONT.)

Papp KA, Langley RG, Lebwohl M, et al. Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2). Lancet. 2008;371(9625):1675-1684.

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REFERENCES (CONT.)