bs452 immunology ( 면역학 )

Seung-Hyo Lee, PhD

Biomedical Research Center, Room 3106

Cellular Immunology Laboratory

GSMSE, KAIST

Contact Information: Seung-Hyo.Lee@kaist.ac.kr, 4235

BS452 Immunology (면역학)

Course Overview• Basic concepts of immunology

• Elements of immune system (tissue, cell, molecule)

• Innate and adaptive immunity

• Antigen (Ag) recognition by immune cells

• Development of B and T cells

• B and T cell mediated immune responses

• Application of immune reaction• Immune responses against infection

• Failure of body’s defense

• Over-reaction of immunity

• Transplantation

• Tumor immunology

• Manipulation of immune response

Course Material Available

http://cil.kaist.ac.kr

Evaluation

• Mid-term examination: 30%

• Final examination: 30%

• Quiz and Report: 30%

• Participation: 10%

Seung-Hyo Lee, PhD

Biomedical Research Center Room 3106, Phone: 4235

E-mail: Seung-Hyo.Lee@kaist.ac.kr

Cellular Immunology Laboratory

GSMSE, KAIST

Elements of the Immune System

and Their Roles in Defense

Figure 1-1Effects of Vaccination

1. Infectious organisms (pathogens)

2. Cells and tissues of immune system

3. Innate and adaptive immunity

Overview

1. Bacteria

2. Viruses

Infectious Organisms

3. Fungi

4. Parasites

Figure 1-2Four Classes of Pathogen

Figure 1-3 part 1 of 4Pathogens (1)

Figure 1-3 part 3 of 4Pathogens (2)

1. Epithelial barriers

2. Immune cells

3. Circulating/cellular pattern recognition molecules

Components of Immune System

4. Protein

1. Physical barriers (mechanical, chemical, biological)

2. Phagocytes and inflammation

3. NK cells

Components of Innate Immunity

4. Circulating pattern recognition molecules

5. Cytokines

Figure 1-4

Physical Barriers

Figure 1-4Physical Barriers

Bad Effect of Antibiotic Treatment

Figure 1-5Effector Mechanism of

Immune System

Figure 1-6Inflammation by Innate Immune

System at the Site of Infection

Figure 1-7Characteristics of

Innate and Adaptive Immunity

Figure 1-8

Selection of Lymphocytes

Benefits of Having Both Immunities

Figure 1-10

Sites of Hematopoiesis

durring Development

Figure 1-11

Hematopoiesis

Figure 1-12Abundance of Leukocytes

Figure 1-9 part 1 of 6Immune Related

Hematopoietic Cells (1)

Figure 1-9 part 3 of 6Immune Related

Hematopoietic Cells (2)

Figure 1-9 part 5 of 6Immune Related

Hematopoietic Cells (3)

Figure 1-13Function of Neutrophil

Figure 1-14Function of Macrophage

Summary

• Various pathogens

• Components of immunity

• Hematopoiesis

• Cells of immune system

• Characteristics of innate and adaptive immunity

1. Primary lymphoid organs: Bone marrow and thymus

2. Secondary lymphoid organs: Lymph node, spleen, and mucosal immune system

Anatomy of Lymphoid Tissues

1. T Lymphocytes: alpha/beta T cells (CD8 and CD4)

gamma/delta T cells

2. B Lymphocytes

Cells of Adaptive Immunity

Figure 1-15

Major Lymphoid Organs

Lymphocyte Recirculation

Figure 1-16

Lymphatic System

Overview of Immune Responses

Figure 1-17Structure of Lymph Node

Figure 1-18

Activation of Immune Responses

Figure 1-18Circulation of Immune Cells

Figure 1-19

Structure of Spleen

Figure 1-20

GALT

Figure 1-30

Features of Adaptive Immunity

Figure 1-31

Successful Vaccination

Summary

• Anatomy of lymphoid tissues

–Primary lymphoid organs

–Secondary lymphoid organs

• Cells of adaptive immunity

–Lymphocytes

–APCs

• Features of adaptive immunity