bs452 immunology ( 면역학 )
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Seung-Hyo Lee, PhD
Biomedical Research Center, Room 3106
Cellular Immunology Laboratory
GSMSE, KAIST
Contact Information: [email protected], 4235
BS452 Immunology (면역학)
Course Overview• Basic concepts of immunology
• Elements of immune system (tissue, cell, molecule)
• Innate and adaptive immunity
• Antigen (Ag) recognition by immune cells
• Development of B and T cells
• B and T cell mediated immune responses
• Application of immune reaction• Immune responses against infection
• Failure of body’s defense
• Over-reaction of immunity
• Transplantation
• Tumor immunology
• Manipulation of immune response
Course Material Available
http://cil.kaist.ac.kr
Evaluation
• Mid-term examination: 30%
• Final examination: 30%
• Quiz and Report: 30%
• Participation: 10%
Seung-Hyo Lee, PhD
Biomedical Research Center Room 3106, Phone: 4235
E-mail: [email protected]
Cellular Immunology Laboratory
GSMSE, KAIST
Elements of the Immune System
and Their Roles in Defense
Figure 1-1Effects of Vaccination
1. Infectious organisms (pathogens)
2. Cells and tissues of immune system
3. Innate and adaptive immunity
Overview
1. Bacteria
2. Viruses
Infectious Organisms
3. Fungi
4. Parasites
Figure 1-2Four Classes of Pathogen
Figure 1-3 part 1 of 4Pathogens (1)
Figure 1-3 part 3 of 4Pathogens (2)
1. Epithelial barriers
2. Immune cells
3. Circulating/cellular pattern recognition molecules
Components of Immune System
4. Protein
1. Physical barriers (mechanical, chemical, biological)
2. Phagocytes and inflammation
3. NK cells
Components of Innate Immunity
4. Circulating pattern recognition molecules
5. Cytokines
Figure 1-4
Physical Barriers
Figure 1-4Physical Barriers
Bad Effect of Antibiotic Treatment
Figure 1-5Effector Mechanism of
Immune System
Figure 1-6Inflammation by Innate Immune
System at the Site of Infection
Figure 1-7Characteristics of
Innate and Adaptive Immunity
Figure 1-8
Selection of Lymphocytes
Benefits of Having Both Immunities
Figure 1-10
Sites of Hematopoiesis
durring Development
Figure 1-11
Hematopoiesis
Figure 1-12Abundance of Leukocytes
Figure 1-9 part 1 of 6Immune Related
Hematopoietic Cells (1)
Figure 1-9 part 3 of 6Immune Related
Hematopoietic Cells (2)
Figure 1-9 part 5 of 6Immune Related
Hematopoietic Cells (3)
Figure 1-13Function of Neutrophil
Figure 1-14Function of Macrophage
Summary
• Various pathogens
• Components of immunity
• Hematopoiesis
• Cells of immune system
• Characteristics of innate and adaptive immunity
1. Primary lymphoid organs: Bone marrow and thymus
2. Secondary lymphoid organs: Lymph node, spleen, and mucosal immune system
Anatomy of Lymphoid Tissues
1. T Lymphocytes: alpha/beta T cells (CD8 and CD4)
gamma/delta T cells
2. B Lymphocytes
Cells of Adaptive Immunity
Figure 1-15
Major Lymphoid Organs
Lymphocyte Recirculation
Figure 1-16
Lymphatic System
Overview of Immune Responses
Figure 1-17Structure of Lymph Node
Figure 1-18
Activation of Immune Responses
Figure 1-18Circulation of Immune Cells
Figure 1-19
Structure of Spleen
Figure 1-20
GALT
Figure 1-30
Features of Adaptive Immunity
Figure 1-31
Successful Vaccination
Summary
• Anatomy of lymphoid tissues
–Primary lymphoid organs
–Secondary lymphoid organs
• Cells of adaptive immunity
–Lymphocytes
–APCs
• Features of adaptive immunity