bs452 immunology ( 면역학 )
DESCRIPTION
TRANSCRIPT
![Page 1: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/1.jpg)
Seung-Hyo Lee, PhD
Biomedical Research Center, Room 3106
Cellular Immunology Laboratory
GSMSE, KAIST
Contact Information: [email protected], 4235
BS452 Immunology (면역학)
![Page 2: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/2.jpg)
Course Overview• Basic concepts of immunology
• Elements of immune system (tissue, cell, molecule)
• Innate and adaptive immunity
• Antigen (Ag) recognition by immune cells
• Development of B and T cells
• B and T cell mediated immune responses
• Application of immune reaction• Immune responses against infection
• Failure of body’s defense
• Over-reaction of immunity
• Transplantation
• Tumor immunology
• Manipulation of immune response
![Page 3: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/3.jpg)
Course Material Available
http://cil.kaist.ac.kr
![Page 4: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/4.jpg)
Evaluation
• Mid-term examination: 30%
• Final examination: 30%
• Quiz and Report: 30%
• Participation: 10%
![Page 5: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/5.jpg)
Seung-Hyo Lee, PhD
Biomedical Research Center Room 3106, Phone: 4235
E-mail: [email protected]
Cellular Immunology Laboratory
GSMSE, KAIST
Elements of the Immune System
and Their Roles in Defense
![Page 6: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/6.jpg)
Figure 1-1Effects of Vaccination
![Page 7: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/7.jpg)
1. Infectious organisms (pathogens)
2. Cells and tissues of immune system
3. Innate and adaptive immunity
Overview
![Page 8: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/8.jpg)
1. Bacteria
2. Viruses
Infectious Organisms
3. Fungi
4. Parasites
![Page 9: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/9.jpg)
Figure 1-2Four Classes of Pathogen
![Page 10: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/10.jpg)
Figure 1-3 part 1 of 4Pathogens (1)
![Page 11: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/11.jpg)
Figure 1-3 part 3 of 4Pathogens (2)
![Page 12: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/12.jpg)
1. Epithelial barriers
2. Immune cells
3. Circulating/cellular pattern recognition molecules
Components of Immune System
4. Protein
![Page 13: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/13.jpg)
1. Physical barriers (mechanical, chemical, biological)
2. Phagocytes and inflammation
3. NK cells
Components of Innate Immunity
4. Circulating pattern recognition molecules
5. Cytokines
![Page 14: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/14.jpg)
Figure 1-4
Physical Barriers
![Page 15: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/15.jpg)
Figure 1-4Physical Barriers
![Page 16: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/16.jpg)
Bad Effect of Antibiotic Treatment
![Page 17: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/17.jpg)
Figure 1-5Effector Mechanism of
Immune System
![Page 18: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/18.jpg)
Figure 1-6Inflammation by Innate Immune
System at the Site of Infection
![Page 19: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/19.jpg)
Figure 1-7Characteristics of
Innate and Adaptive Immunity
![Page 20: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/20.jpg)
Figure 1-8
Selection of Lymphocytes
![Page 21: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/21.jpg)
Benefits of Having Both Immunities
![Page 22: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/22.jpg)
Figure 1-10
Sites of Hematopoiesis
durring Development
![Page 23: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/23.jpg)
Figure 1-11
Hematopoiesis
![Page 24: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/24.jpg)
Figure 1-12Abundance of Leukocytes
![Page 25: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/25.jpg)
Figure 1-9 part 1 of 6Immune Related
Hematopoietic Cells (1)
![Page 26: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/26.jpg)
Figure 1-9 part 3 of 6Immune Related
Hematopoietic Cells (2)
![Page 27: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/27.jpg)
Figure 1-9 part 5 of 6Immune Related
Hematopoietic Cells (3)
![Page 28: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/28.jpg)
Figure 1-13Function of Neutrophil
![Page 29: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/29.jpg)
Figure 1-14Function of Macrophage
![Page 30: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/30.jpg)
Summary
• Various pathogens
• Components of immunity
• Hematopoiesis
• Cells of immune system
• Characteristics of innate and adaptive immunity
![Page 31: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/31.jpg)
1. Primary lymphoid organs: Bone marrow and thymus
2. Secondary lymphoid organs: Lymph node, spleen, and mucosal immune system
Anatomy of Lymphoid Tissues
![Page 32: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/32.jpg)
1. T Lymphocytes: alpha/beta T cells (CD8 and CD4)
gamma/delta T cells
2. B Lymphocytes
Cells of Adaptive Immunity
![Page 33: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/33.jpg)
Figure 1-15
Major Lymphoid Organs
![Page 34: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/34.jpg)
Lymphocyte Recirculation
![Page 35: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/35.jpg)
Figure 1-16
Lymphatic System
![Page 36: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/36.jpg)
Overview of Immune Responses
![Page 37: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/37.jpg)
Figure 1-17Structure of Lymph Node
![Page 38: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/38.jpg)
Figure 1-18
Activation of Immune Responses
![Page 39: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/39.jpg)
Figure 1-18Circulation of Immune Cells
![Page 40: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/40.jpg)
Figure 1-19
Structure of Spleen
![Page 41: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/41.jpg)
Figure 1-20
GALT
![Page 42: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/42.jpg)
Figure 1-30
Features of Adaptive Immunity
![Page 43: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/43.jpg)
Figure 1-31
Successful Vaccination
![Page 44: BS452 Immunology ( 면역학 )](https://reader033.vdocuments.pub/reader033/viewer/2022051322/545cbbfdb1af9f4b0a8b4854/html5/thumbnails/44.jpg)
Summary
• Anatomy of lymphoid tissues
–Primary lymphoid organs
–Secondary lymphoid organs
• Cells of adaptive immunity
–Lymphocytes
–APCs
• Features of adaptive immunity