ap 1 bone tissue

7/26/2019 AP 1 Bone Tissue

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Bone TissueBone Tissue

Ch. 6Ch. 6


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Jenis TulangJenis Tulang

1.1. Tulang RawanTulang Rawan

1.1. TR HialinTR Hialin

2.2. TR FibrosaTR Fibrosa

3.3. TR ElastinTR Elastin

2.2. Tulang KerasTulang Keras

1.1. Osteosit (sel tulang ewasa !e"bentu#Osteosit (sel tulang ewasa !e"bentu#tulang$tulang$

2.2. %atri#s (berisi #olagen & "ineral$%atri#s (berisi #olagen & "ineral$


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OstreoprogenatorOstreoprogenator ' "eru!a#an sel #husus' "eru!a#an sel #husus

ang "a"!u beri)erensiasi "en*ai osteoblasang "a"!u beri)erensiasi "en*ai osteoblas

tera!at ibagian luar "e"brane ( !eriosteu"$tera!at ibagian luar "e"brane ( !eriosteu"$OsteoblasOsteoblas "eru!a#an sel tulang "ua ang"eru!a#an sel tulang "ua ang

a#an "e"bentu# osteosit.a#an "e"bentu# osteosit.OsteositOsteosit "eru!a#an sel + sel tulang ewasa."eru!a#an sel + sel tulang ewasa.

OsteoklasOsteoklas"eru!a#an sel ang ber#e"bang"eru!a#an sel ang ber#e"bangari "onosit an tera!at ise#itar !er"u#aanari "onosit an tera!at ise#itar !er"u#aan

tulang . )ungsi osteo#las untu# !er#e"bangan'tulang . )ungsi osteo#las untu# !er#e"bangan'

!e"eliharaan ' !erawatan an !erbai#an!e"eliharaan ' !erawatan an !erbai#an

tulang.tulang.


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Osteolog, stu o) osseousOsteolog, stu o) osseous

stru-tures.stru-tures.

u!!ortu!!ort

/rote-tion/rote-tion

%o0e"ent%o0e"ent%ineral ho"eostasis%ineral ho"eostasis

He"o!oiesis, bloo -ell )or"ationHe"o!oiesis, bloo -ell )or"ation

torage o) ai!ose tissue, ellowtorage o) ai!ose tissue, ellow"arrow"arrow


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ong bone anato"ong bone anato" ia!hsis, long sha)t o) boneia!hsis, long sha)t o) bone E!i!hsis, ens o) boneE!i!hsis, ens o) bone E!i!hseal !late, growth !lateE!i!hseal !late, growth !late %eta!hsis, bw e!i!hsis an ia!hsis%eta!hsis, bw e!i!hsis an ia!hsis 4rti-ular -artilage, -o0ers e!i!hsis4rti-ular -artilage, -o0ers e!i!hsis /eriosteu", bone -o0ering (!ain sensiti0e$/eriosteu", bone -o0ering (!ain sensiti0e$ har!e5s bers, !eriosteu" atta-hes tohar!e5s bers, !eriosteu" atta-hes to

unerling boneunerling bone

%eullar -a0it, Hollow -ha"ber in bone%eullar -a0it, Hollow -ha"ber in bone7 re "arrow !rou-es bloo -ells7 re "arrow !rou-es bloo -ells

7 ellow "arrow is ai!ose.7 ellow "arrow is ai!ose. Enosteu", thin laer lining theEnosteu", thin laer lining the

"eullar -a0it"eullar -a0it


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ong boneong bone


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ia!hsisia!hsis


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E!i!hsisE!i!hsis


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%eta!hsis%eta!hsis


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E!i!hseal (growth$ !lateE!i!hseal (growth$ !late


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%eullar -a0it%eullar -a0it


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Histolog o) bone tissueHistolog o) bone tissue

Cells are surroune b "atri8.Cells are surroune b "atri8.

7 29: water7 29: water

7 29: !rotein7 29: !rotein

7 9;: "ineral salts7 9;: "ineral salts

< -ell t!es "a#e u! osseous tissue< -ell t!es "a#e u! osseous tissue

Osteo!rogenitor -ellsOsteo!rogenitor -ells

OsteoblastsOsteoblasts

Osteo-tesOsteo-tes

Osteo-lastsOsteo-lasts


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Osteo!rogenitor -ells,Osteo!rogenitor -ells,

7 eri0e )ro" "esen-h"e7 eri0e )ro" "esen-h"e

7 all -onne-ti0e tissue is7 all -onne-ti0e tissue is

eri0eeri0e

7 uns!e-iali=e ste" -ells7 uns!e-iali=e ste" -ells7 unergo "itosis an e0elo! into7 unergo "itosis an e0elo! into

osteoblastsosteoblasts

7 )oun on inner sur)a-e o)7 )oun on inner sur)a-e o)!eriosteu"!eriosteu" an enosteu".an enosteu".


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Osteoblasts,Osteoblasts,

7 bone )or"ing -ells7 bone )or"ing -ells

7 )oun on sur)a-e o) bone7 )oun on sur)a-e o) bone7 no abilit to "itoti-all i0ie7 no abilit to "itoti-all i0ie

7 -ollagen se-retors7 -ollagen se-retors

Osteo-tes,Osteo-tes,

7 "ature bone -ells7 "ature bone -ells

7 eri0e )or" osteoblasts7 eri0e )or" osteoblasts

7 o not se-rete "atri8 "aterial7 o not se-rete "atri8 "aterial

7 -ellular uties in-lue e8-hange o)7 -ellular uties in-lue e8-hange o)nutrients an waste with bloo.nutrients an waste with bloo.


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Osteo-teOsteo-te


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Osteo-lastsOsteo-lasts

7 bone resorbing -ells7 bone resorbing -ells

7 bone sur)a-e7 bone sur)a-e7 growth' "aintenan-e an bone re!air7 growth' "aintenan-e an bone re!air

4bunant inorgani- "ineral salts,4bunant inorgani- "ineral salts,

7 Tri-al-iu" !hos!hate in -rstalline )or"7 Tri-al-iu" !hos!hate in -rstalline )or"-alle hro8a!atite-alle hro8a!atite

CaCa33(/O(/O


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These salts are e!osite on theThese salts are e!osite on the

-ollagen ber )ra"ewor# (tensile-ollagen ber )ra"ewor# (tensile

strength$ an -rstalli=ation o--urs.strength$ an -rstalli=ation o--urs.

7 -al-i-ation or "inerali=ation7 -al-i-ation or "inerali=ation


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Co"!a-t bone, (Osteon$ e8ternalCo"!a-t bone, (Osteon$ e8ternal

laerlaer

7 -alle la"ellar bone (grou!s o)7 -alle la"ellar bone (grou!s o)

elongate tubules -alle la"ella$elongate tubules -alle la"ella$

7 "a*orit o) all long bones7 "a*orit o) all long bones

7 !rote-tion an strength (wt. bearing$7 !rote-tion an strength (wt. bearing$

7 -on-entri- ring stru-ture7 -on-entri- ring stru-ture

7 bloo 0essels an ner0es !enetrate7 bloo 0essels an ner0es !enetrate

!eriosteu" through hori=ontal!eriosteu" through hori=ontal

o!enings -alle !er)oratingo!enings -alle !er)orating

(>ol#"ann5s$ -anals.(>ol#"ann5s$ -anals.


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7 -entral (Ha0ersian$ -anals run7 -entral (Ha0ersian$ -anals run

longituinall. Bloo 0essels anlongituinall. Bloo 0essels an

ner0es.ner0es.

7 aroun -anals are -on-entri- la"ella7 aroun -anals are -on-entri- la"ella

7 osteo-tes o--u! la-unae (?little7 osteo-tes o--u! la-unae (?little

la#es@$la#es@$ whi-h are between thewhi-h are between thela"ellala"ella

7 raiating )ro" the la-unea are7 raiating )ro" the la-unea are

-hannels-hannels -alle -anali-uli. (nger-alle -anali-uli. (ngerli#e !ro-essesli#e !ro-esses o) osteo-tes$o) osteo-tes$


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7 a-unae are -onne-te to onea-unae are -onne-te to one

another b -anali-uli.another b -anali-uli.

7 Osteon -ontains, 7 -entral -analOsteon -ontains, 7 -entral -anal

7 surrouning7 surrouning

la"ellaela"ellae

7 la-unae7 la-unae

7 osteo-tes7 osteo-tes

7 -anali-uli7 -anali-uli


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Co"!a-t boneCo"!a-t bone


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!ong bone (-an-ellous bone$,!ong bone (-an-ellous bone$,

internalinternal laerlaer

7 latti-ewor# o) bone tissue (ha!ha=ar7 latti-ewor# o) bone tissue (ha!ha=ararrange"ent$.arrange"ent$.

7 "ae o) trabe-ulae (?little bea"s@$7 "ae o) trabe-ulae (?little bea"s@$

7 lle with re an ellow bone7 lle with re an ellow bone"arrow"arrow

7 osteo-tes get nutrients ire-tl )ro"7 osteo-tes get nutrients ire-tl )ro"

-ir-ulating bloo.-ir-ulating bloo.7 short' Aat an irregular bone is "ae7 short' Aat an irregular bone is "ae

u!u! o) "ostl s!ong boneo) "ostl s!ong bone


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Can-ellous (s!ong$ boneCan-ellous (s!ong$ bone


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Bone )or"ation (ossi-ation$ o--urs in twoBone )or"ation (ossi-ation$ o--urs in twowaswas

17 ntra"e"branous ossi-ation17 ntra"e"branous ossi-ation27 Eno-honral ossi-ation27 Eno-honral ossi-ation

Both "ethos abo0e lea to the sa"e boneBoth "ethos abo0e lea to the sa"e bone

)or"ation but are ierent "ethos o))or"ation but are ierent "ethos o)getting there.getting there.

Ossi-ation (osteogenesis$ begins arounOssi-ation (osteogenesis$ begins arounthe 6the 6thth7D7Dththwee# o) e"broni- li)e. 4t thiswee# o) e"broni- li)e. 4t thisti"e the e"broni- s#eleton is "ae o)ti"e the e"broni- s#eleton is "ae o)brous "e"branes an haline -artilage.brous "e"branes an haline -artilage.


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Haline Cartilage Re0iewHaline Cartilage Re0iew

a. %ost abunanta. %ost abunant

b. /ro0ies su!!ort' Ae8ibilit anb. /ro0ies su!!ort' Ae8ibilit anresilien-e resilien-e

-. o-ate,-. o-ate,

a. )or"ing nearl all the )etala. )or"ing nearl all the )etal

s#eletons#eleton b.b. arti-ular -artilagearti-ular -artilage, ens o), ens o)

"o0ing"o0ing bonesbones

-.-. -ostal -artilage-ostal -artilage, ribs to, ribs to

sternu"sternu" . ti! o) nose. ti! o) nose

e. res!irator -artilagee. res!irator -artilage


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#eletal Cartilage,#eletal Cartilage,


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#eletal Cartilage,#eletal Cartilage,

1.1. Chonro-tes, -artilage !rou-ingChonro-tes, -artilage !rou-ing

-ells.-ells.

2. a-unae, s"all -a0ities where2. a-unae, s"all -a0ities where

thethe -honro-tes are en-ase.-honro-tes are en-ase.

3. E8tra-ellular "atri8, *ellli#e3. E8tra-ellular "atri8, *ellli#e

groungroun substan-e.substan-e.


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IntramembranousIntramembranous(within the(within the"e"brane$ ossi-ation, Bone e0elo!s"e"brane$ ossi-ation, Bone e0elo!s)ro" a brous "e"brane.)ro" a brous "e"brane.

7 Aat bones o) s#ull7 Aat bones o) s#ull

7 "anible7 "anible

7 -la0i-les7 -la0i-les

7"esen-h"al -ells be-o"e 0as-ulari=e7"esen-h"al -ells be-o"e 0as-ulari=eanan be-o"e osteo!rogenitor -ells anbe-o"e osteo!rogenitor -ells anthenthen osteoblasts.osteoblasts.

7 organi- "atri8 o) bone is se-rete7 organi- "atri8 o) bone is se-rete

7 osteo-tes are )or"e7 osteo-tes are )or"e

7 -al-iu" an "ineral salts are e!osite7 -al-iu" an "ineral salts are e!ositeanan bone tissue harens.bone tissue harens.

7 trabe-ulae e0elo! an s!ong bone is7 trabe-ulae e0elo! an s!ong bone is)or"e)or"e

7 re "arrow lls s!a-es7 re "arrow lls s!a-es


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Re!la-e"ent o) haline -artilage with bone is -alleRe!la-e"ent o) haline -artilage with bone is -alle

..Endochondral (intracartilaginous)Endochondral (intracartilaginous)

ossifcationossifcation

%ost bones are )or"e this wa (i.e. long bones$.%ost bones are )or"e this wa (i.e. long bones$.

Ghere bone is going to )or",Ghere bone is going to )or",

17 "esen-h"al -ells ierentiate into17 "esen-h"al -ells ierentiate into-honroblasts (i""ature -artilage -ells$ whi-h-honroblasts (i""ature -artilage -ells$ whi-h

!rou-es haline -artilage.!rou-es haline -artilage.

/eri-honriu" e0elo! aroun new -artilage/eri-honriu" e0elo! aroun new -artilage

27 Chonro-tes ("ature$ "itoti-all i0ie27 Chonro-tes ("ature$ "itoti-all i0iein-reasing in lengthin-reasing in length

This !attern o) growth,This !attern o) growth, interstitial growth.interstitial growth.

7 growth )ro" within7 growth )ro" within


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rowth o) -artilage inrowth o) -artilage inthi-#nessthi-#nesso--urso--urs

)ro" the e!osition o) new "atri8 to)ro" the e!osition o) new "atri8 to

the !eri!her )or"e bthe !eri!her )or"e b-honroblasts within the-honroblasts within the

!eri-honriu".!eri-honriu". 4!!ositional growth4!!ositional growth..

Chonro-tes unergo h!ertro!h'Chonro-tes unergo h!ertro!h'

swell an burst. !H o) the "atri8swell an burst. !H o) the "atri8

-hanges an -al-i-ation is-hanges an -al-i-ation istriggere. Ilti"atel' -artilage -ellstriggere. Ilti"atel' -artilage -ells

ie. a-unae are now e"!t.ie. a-unae are now e"!t.


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utrients are su!!lie b wa o) theutrients are su!!lie b wa o) thenutrient arter !assing through thenutrient arter !assing through the

!eri-honriu" through the nutrient!eri-honriu" through the nutrient)ora"en.)ora"en.

Osteo!rogenitor -ells are sti"ulate inOsteo!rogenitor -ells are sti"ulate inthe !eri-honriu" to !rou-ethe !eri-honriu" to !rou-eosteoblasts.osteoblasts.

4 thin laer o) -o"!a-t bone is lai4 thin laer o) -o"!a-t bone is lai

own uner the !eri-honriu" -alleown uner the !eri-honriu" -allethe !eriosteal bone -ollar.the !eriosteal bone -ollar.

/eri-honriu" be-o"es !eriosteu"/eri-honriu" be-o"es !eriosteu"


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Osteoblasts begin to e!osit boneOsteoblasts begin to e!osit bone

"atri8 )or"ing s!ong bone"atri8 )or"ing s!ong bone

trabe-ulae.trabe-ulae.

n the "ile o) the bone' osteo-lastsn the "ile o) the bone' osteo-lasts

brea# own s!ong bone trabe-ulaebrea# own s!ong bone trabe-ulae

an )or" a hollowe out -a0it -allean )or" a hollowe out -a0it -alle

the "eullar -a0it. This -a0it will bethe "eullar -a0it. This -a0it will belle with re bone "arrow )orlle with re bone "arrow )or

he"o!oiesis.he"o!oiesis.

The sha)t o) the bone is re!la-e (wasThe sha)t o) the bone is re!la-e (was

haline -artilage$ with -o"!a-t bone.haline -artilage$ with -o"!a-t bone.


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/hsiolog o) bone growth,/hsiolog o) bone growth,

7 e!i!hseal !late (bone length$7 e!i!hseal !late (bone length$

7 < =ones o) bone growth uner hH.7 < =ones o) bone growth uner hH.17 one o) resting -artilage,17 one o) resting -artilage,

7 no bone growth7 no bone growth

7 lo-ate near the e!i!hseal !late7 lo-ate near the e!i!hseal !late7 s-attere -honro-tes7 s-attere -honro-tes

7 an-hors !late to bone7 an-hors !late to bone

27 one o) !roli)erating -artilage27 one o) !roli)erating -artilage7 -honro-tes sta-#e li#e -oins7 -honro-tes sta-#e li#e -oins

7 -honro-tes i0ie7 -honro-tes i0ie

37 one o) h!ertro!hi- ("aturing$ -artilage37 one o) h!ertro!hi- ("aturing$ -artilage


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3 one o) h!ertro!hi- ("aturing$ -artilage3 one o) h!ertro!hi- ("aturing$ -artilage

7 large -honro-tes arrange in -olu"ns7 large -honro-tes arrange in -olu"ns

7 lengthwise e8!ansion o) e!i!hseal !late7 lengthwise e8!ansion o) e!i!hseal !late


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4 1 21 it i l b th 4 1 21 it i l b th


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4ge 1721, ongituinal bone growth ens4ge 1721, ongituinal bone growth ens

when e!i!hsis )uses with the ia!hsis.when e!i!hsis )uses with the ia!hsis.

7 e!i!hseal !late -losure7 e!i!hseal !late -losure

7 e!i!hseal line is re"nant o) this7 e!i!hseal line is re"nant o) this

7 last bone to sto! growing, -la0i-le7 last bone to sto! growing, -la0i-le


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Bone with, in-rease in ia"eter o)Bone with, in-rease in ia"eter o)

bone o--urs through a!!ositionalbone o--urs through a!!ositional

growth .growth .7 Osteoblasts lo-ate beneath the7 Osteoblasts lo-ate beneath the

!eriosteu" se-rete bone "atri8 an!eriosteu" se-rete bone "atri8 an

buil bone on the sur)a-ebuil bone on the sur)a-e

7 Osteo-lasts lo-ate in the7 Osteo-lasts lo-ate in the

enosteu" resorbs (brea#own$enosteu" resorbs (brea#own$

bone.bone.

Bone Re"oeling,Bone Re"oeling,


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Bone Re"oeling,Bone Re"oeling,

7 bone -ontinuall renews itsel)7 bone -ontinuall renews itsel)

7 ne0er "etaboli-all at rest7 ne0er "etaboli-all at rest

7 enables Ca to be !ulle )ro" bone7 enables Ca to be !ulle )ro" bone

whenwhen bloo le0els are lowbloo le0els are low

7 osteo-lasts are res!onsible )or7 osteo-lasts are res!onsible )or

"atri8"atri8 estru-tionestru-tion

7 !rou-e lsoso"al en="es an7 !rou-e lsoso"al en="es an

a-isa-is

7 s!ong bone re!la-e e0er 37

ap 1 bone tissue

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