canine distemper
TRANSCRIPT
CANINE DISTEMPER
MORBILLI VIRUSOF
PARAMYXOVIRIDAE
• Complicated by secondary bacterial invaders like Bordtella bronchiseptica and
Salmonella species producing respiratory gastrointestinal symptoms
DIPHASIC FEVER CURVE
3-4th day High fever due to viraemia
11th – 12th
13th day high fever due to secondary bacterial infections
Mucous secretion from conjuctiva Ulceration of corneaPanopthalmitisRetinal atrophy of all layers –OLD DOG ENCEPHALITIS
NORMAL PAWS AFFECTED PAWS
HYPERKERATOSIS OF THE DIGITAL PADS
EPILEPTIC SEIZURES AND EXCESSIVE CHEWING MOVEMENTS ACCOMPANIED BY SALIVATION
CANINE DISTEMPER VIRUS CAUSES INTERSTITIAL PNEUMONIA AND SECOND INFECTIONS DUE TO BACTERIA CAUSES BRONCHO PNEUMONIA
Interstitial pneumonia
Broncho-pneumonia
Nut meg liver
Both intracytoplasmic and intranuclear inclusion bodies
DEMEYELINATION OF NEURONSCanine distemper virus infection is also associated with demyelinationProbable reasons are virus itself cytotoxic immune responses to virus-infected cells autoimmune reactions to neural elements (e.g. myelin)
The vacuolated appearance of the white matter (WM) which is due to demyelination.
GITTER CELLSareas of white matter where demyelination has changed to necrosis (malacia) as seen in this photomicrograph.MICROGLIA PHAGOCYTIZE THE MYELIN AND FORM GITTER CELLS
GEMISTOCYTES Gemistocytes are hypertrophied astrocytes. They are often prominent in distemper and often contain intranuclear inclusion bodies. One gemistocyte is pointed out in this brain from a dog with distemper