does stress really impair memory? student’s name ：顏嘉賢 school number ： b9802033
TRANSCRIPT
Does Stress Really Impair Memory?
Student’s Name：顏嘉賢School Number ： B9802033
QUESTION
How is stress related to memory?
– Enhance?
– Impair?
Why?
INFORMATION 1: ENHANCEMENT OF MEMORY
Stressful / emotionally arousing events
enhance the “consolidation” of memory
– Stress hormones
– stress-activated neurotransmitters
– Amygdala
INFORMATION 2: STRESS HORMONES
Glucocorticoids
– Cortisol
Stress cortisol receptor
Long-term exposure to cortisol
atrophy of hippocampus
naturally (In hippocampus)
Dendritic Spine
– Learning & memory
Synapses
synapse
INFORMATION 3: CRH &CRHR
CRH: corticotropin releasing hormone
– Secreted by hypothalamus
CRHR: CRH receptor
– Located in hippocampus
Acute Stress CRH release hippocampus
dendritic spines disintegration CRHR
impair memory
storage
collection“consolidation”
On the contrary…
CRH CRHR
BLOCK damage eliminated
binding
INFORAMTION 4: REVERSIBILITY
From Newcomer’s experiment:
– Memory impairment is reversible
– “the point of no return”
Controlling cortisol levels pharmacologically
THE SAME QUESTION
How is stress related to memory?
– Enhance?
– Impair?
THE ANSWER~~~~~
BOTH !!!!
However…
CONCLUSION
Stress itself is not harmful…
but the EXCESS of stress is!!!
Acute or chronic exposure to stress causes functional and morphological alterations in the brain impair memory consolidation
Thanks for your attention!