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【般若黑洞】出品Northwestern Polytechnic University
基于大分子的
药物控释肿瘤靶向
Polymeric
Tumor-Targeting
Drug Controlled Release
PPT 宝藏 www.pptbz.com 提供下载
Drug Load装载 定位
Targeting Drug Release释放
胶束Micelles
树枝状聚合物Dendrimers
Liposomes
微脂囊聚合物 -药物偶联物
Polymer-drugconjugates
Drug Load装载
定位
主动active
被动passive
Targeting
配合基 -受体Ligand-receptor
EPR效应EPR Effect
叶酸cRGD
正常组织癌变部位
Drug Release释放
pH
温度
降解
磁场
UV
电场
内因外因
PDEAEMA
PNIPAM
-s-s-
hydrazone bonds
多层分子设计Molecular Design
嵌段
分子量
端基
ATRP
RAFT
点击化学
超分子 星形
开环
Tumor-Targeting Peptide Conjugated pH-Responsive Micelles as a Potential Drug Carrier for Cancer Therapy
Xiang Lan Wu, Jong Ho Kim
Tumor-Targeting, pH-Responsive, and Stable Unimolecular Micelles asDrug Nanocarriers for Targeted Cancer Therapy
Xiaoqiang Yang, Jamison J. Grailer, Srikanth Pilla
PEG-SS-PPS: Reduction-Sensitive Disulfide Block CopolymerVesicles for Intracellular Drug Delivery
Xiang Lan Wu, Jong Ho Kim
Folate-Conjugated Thermoresponsive Block Copolymers:Highly Efficient Conjugation and Solution Self-Assembly
Priyadarsi De, Sudershan R. Gondi, and Brent S. Sumerlin
Development of multiple-layer polymeric particles for targeted andcontrolled drug delivery
Bhanuprasanth Koppolu, MS, Maham Rahim,
O
Si
OSi
O Si
SiO
Si
OSi
Si
OSi
OSi
OSi
O Si H
SiO
Si
O
Si
H
OSi
O Si H
SiO
Si
HN
H2N
HN
H2N
HN
H2N
HN
NH2
grafted PNIPAM Shell
β-CD based HBP Core
Thermo-Responsive Hyperbranched poly(β-CD)s-g-PNIPAM
Thank you!Polymeric Tumor-Targeting Drug Controlled Release
Northwestern Polytechnic University
PPT 宝藏 www.pptbz.com 提供下载