ejercicio e inflamación

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Ejercicio e inflamacin

Increase in blood bradykinin concentration

after eccentric weight-training exercise in men

CHARLE !LAI" #R$"% AL!ER& A'A("

% 'E)I (AIC*&&E"

+ A)' ,RA)C *I .E / R*))E&0

%,ac1lte / de .harmacie and 0'e /2artement de 3ine /siologie" 4ni5ersite / de (ontre

/al"

(ontreal H0C 0#67 and +'e /2artement de 3inanthro2ologie" 4ni5ersite / d1 81e /bec

a 9 (ontre /al"

(ontreal" H0C 0.: Canada

!lais" Charles" #r$" Albert Adam" 'enis (assicotte"

and ,ranc ois .e /ronnet$ Increase in blood bradykinin

concentration after eccentric weight-training exercise inmen$#$ A22l$ .hysiol$ :6;06?%+@%" %>>>$&he 21r2ose of

this st1dy was to 5erify the 2ossible a22earance in the blood

of bradykinin ;!3< and des-Arg>-bradykinin ;des-Arg>-!3-!3 concentrations

were meas1red by com2etiti5e enyme imm1noassays 1sing

highly s2ecic 2olyclonal rabbit IgJ$ 'es-Arg>-!3 concentra-

tion was not modied ;2reexercise= FF G %F 2moll7 2ooled

2ostexercise= F6 G F 2moll


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n1mber of markers of tiss1e damage and re2air$ er1m

creatine kinase ;C3< concentration andor acti5ity are

the most common markers 1sed ;e$g$" see Refs$ F?G" :"

%:?+@" +B" +:" +>" 0G" and 06< and inltration of white blood cells in the

m1scle ;%G" %:" +0-bradykinin ;des-Arg>-!3< in

the blood after m1scle damage" triggered by eccentric

exercise and associated with '*($ !3 and des-

Arg>-!3 are 2owerf1l mediators of inDammation ;%0-!3 in the blood in

res2onse to eccentric exercise res1lting in m1scle dam-

age and '*($ !3 is formed from kininogen 2rec1r-

sors 12on the action of tiss1e and 2lasma kininoge-

nases" which are acti5ated by 5ario1s stim1li" incl1ding

tiss1e damage and inj1ry" anoxia" and acidosis" whereas

its acti5e metabolite des-Arg>-!3 is 2rod1ced 12on the

action of kininase I ;see Ref$ %0 for a re5iew-!3" or kinins" acting on !+ and !% kinin

rece2tors ;+6


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the in5ol5ement of these 2e2tides in the inDammatory

2rocess in the tiss1e co1ld be reDected by changes in

their concentration in the blood$

!3 concentrations in blood sam2led before the exer-

cise session ;F+ G 0 2moll< and at %+" +F" and F: h after

the exercise session ;2ooled a5erage 5al1e F6 G F2moll7 n B F+ sam2les< were slightly higher b1t

consistent with basal 5al1es obser5ed by .ellacani et

al$ ;0+G>

2moll< ;+Gto

>: 2moll-!3 immediately

after exercise$ &his obser5ation is consistent with the

res1lts from o1r laboratory" s1ggesting that the con5er-

sion of !3 into des-Arg>-!3 in the blood is only a minor

2athway in h1mans" contrib1ting only "0$B to !3degradation ;%%


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mechanisms by which the eccentric weight-training

exercise 2erformed ac1tely increased !3 concentration

in the blood" the so1rce of !3 fo1nd in the blood in

higher amo1nts after than before exercise" and the

2ossible role of !3 in the de5elo2ment and mainte-

nance of m1scle inDammation and '*($ Isometricm1scle contraction for 0@ s" which is 1nlikely to res1lt

in m1scle damage" is associated with the generation of

!3 in the tiss1e ;0:

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