Emery Pharma ServicesSaving Lives … Saving our Planet…

Why We Do What We Do…

We're passionate about reducing diseases and saving lives while never forgetting humanity must live in co-existence with our planet.

2

How?• By combining the best intellectual resources with the

most sophisticated equipment and instrumentations.

• Over 60 years of combined experience in drug

discovery support and innovation

• Pharmaceutical method development and consulting

• “Hard to solve problems” are our specialty

• Analytical chemistry (NMR, LCMS, HPLC)

• Microbiology (MIC, MBC, MFC, Time Kill)

• Custom synthesis

• Formulations (nanotechnology)

3

Our PromiseWe will operate as an extension of your R&D department.

Better yet, we work on a project basis.

Let’s work together for a week, a month, whatever it takes to solve

your R&D challenge.

Those who know EPS praise us for our service orientation and the

close working relationships we form with our partners. And rest

assured, at EPS we always deploy the most advanced, state-of-the-

art equipment in both chemistry and biology.

Our promise: We will create an opening in your R&D challenges or

solve your problem entirely in a short time frame.

4

NMR Spectroscopy

• Bruker 400 MHz spectrometer

• Analyzes Small (<1kD) molecules, synthetic or natural

• 1-D: 1H, 13C, 19F, 31P, 15N, 11B, and more

• 2-D: 1H-1H, 1H-13C, and more

• Variable temperature

• T1 measurement

5

400 MHz. Bruker NMR

6

LC-MS

• Separates molecules using column (C18 or other)

• Small (0.1-2 kD) molecules, synthetic or natural,

purified or mixture

• Unique set up: allows for detection of virtually any

molecule

• PDA: detects 200-800 nm

• ELSD: detects non-volatile material and non UV active

• MS: dual ESI/APCI ionization, detects charges

7

LCMS with UV and ELSD detector

8

State of the Art Equipment

9

Organic synthesis

• FTE or project based

• Small molecule and building block synthesis from milligram to kilogram scale

• Comprehensive analytical characterization

• Large scale LC purification capability (both Normal- and Reversed-Phase)

• Fast and efficient optimization of chemical reactions based on proprietary methods

• Hit-to-Lead / Lead optimization (SAR studies, compounds for PK studies, etc.)

• All compounds are guaranteed a minimum of 95% purity

10

Organic Synthesis is our Specialty

11

Formulations services

• All types of Pre-formulations and product developments of small molecules with liposomes (parenteral) and other type of drug delivery systems (dermal, ocular and others)

• Process development, scale-up technology transfer and process optimization and filtration studies.

• Writing protocols, performing stability and container-closure compatibility studies

12

STEALTH Liposome

Formulation Analytical Services

• HPLC method development

• HPLC measurement of drug potency and degradation

• Formulation stability (chemicals and physical testing)

• pH and osmolality

• Review stability reports and shelf-life assessments of drug

products

• In-vitro drug release testing, topical and ocular tissue

permeation by Franz cell

13

Multi Station Franz Diffusion Cell System

MIC / MBC / MFC / Time Kill

• Measures inhibition of growth or killing of bacteria and fungi as a function of concentration and/or time

• Test articles can be natural or synthetic, mixtures or purified

• Hundreds of bacterial strains available including drug-resistant clinical isolates

• Multiple fungal strains available

• Antiviral testing also available

14

How Easily Does Your Antibiotic Develop

Resistance?

• Tests potential for development of resistance to antibiotics

• Multiple passage at sub-lethal concentrations of antibiotics

15

• Biofilm models test "real-world"

conditions

• Calgary Biofilm Device (MBECTM)

• Drip-flow reactor

• CDC reactor

• MRD reactor

• In vitro urinary catheter

crystalline biofilm model

• Colony biofilm

• Custom reactor design

Biofilm Testing

16

Cytotoxicity in Cell Cultures & Tissues

• Sensitivity of human cells and

human tissues to test articles

• IC50 measurement

• Multiple cell lines available

• EpiOcular multilayered tissue

mimics corneal epidermis

• EpiDermal multilayered tissue

mimics stratum corneum

17

Microscopy

•Visualization of bacteria,

cells and tissues

•Confocal microscopy

•Fluorescent microscopy

•Stereozoom microscopy

18

Acanthamoeba castellanii trophozoites Acanthamoeba castellanii cysts

19

www.emerypharmaservices.com

Since it’s founding in 2011, Emery Pharma Services has successfully

partnered with over 100 companies.

References Available Upon Request

20