examination of the optimal temporal resolution required for computed tomography coronary angiography
TRANSCRIPT
Examination of the optimal temporal resolution requiredfor computed tomography coronary angiography
Kazuya Ohashi • Katsuhiro Ichikawa •
Masaki Hara • Tatsuya Kawai • Hiroshi Kunitomo •
Ryo Higashide • Yuta Shibamoto
Received: 12 February 2013 / Revised: 14 May 2013 / Accepted: 14 May 2013 / Published online: 26 May 2013
� Japanese Society of Radiological Technology and Japan Society of Medical Physics 2013
Abstract Sub-second multidetector-row computed tomog-
raphy systems provide great potential for the further
improvement of CT coronary angiography (CTCA).
However, because the temporal resolution (TR) of such CT
systems is insufficient, blurring and artifacts produced by
fast cardiac motion remain as unresolved issues. Previous
TR investigations of CTCA were based on the retrospec-
tive electrocardiogram-gated multisegment reconstruction
technique. However, the results obtained may not neces-
sarily be correct because the TR of multisegment recon-
struction may not be substantial due to the insufficient
periodicity of cardiac motion. The optimal TR required for
better CTCA images was evaluated with use of a dual-
source CT system, which has various substantial TR modes
(83, 125, and 165 ms). CTCA images of 147 patients with
heart rates (HRs) ranging from 36 to 117 beats/minute
(bpm) were evaluated visually on a 4-point scale. Our
results revealed not only that the 165-ms TR is sufficient
for low HRs (B60 bpm), but also that the 83- and 125-ms
TRs are unnecessary for such HRs. The image quality with
the 125-ms TR mode was acceptable for the left anterior
descending artery, left circumflex artery, and right coro-
nary artery at low to intermediate HRs (B70 bpm). At high
HRs ([70 bpm), the 83-ms TR mode resulted in an
excellent image quality for all cases except those with very
rapid RCA motion. Adequate TRs for a wide range of heart
rates (52–106 bpm) are thus clarified.
Keywords Dual-source CT � CT coronary angiography �Temporal resolution � Image quality � Motion artifact
1 Introduction
The rapid technologic development of multidetector-row
computed tomography (MDCT) systems over the past
decade has significantly increased the ability to image the
heart and the coronary arteries noninvasively. MDCT
systems have evolved from 4-detector-row systems to dual-
source CT (DSCT) and 320-row area detector CT (ADCT)
systems. With smaller detector element sizes and faster
gantry rotation speeds, spatial and temporal resolution (TR)
of MDCT systems has made CT coronary angiography
K. Ohashi (&) � H. Kunitomo � R. Higashide
Department of Radiology, Nagoya City University Hospital,
1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi 467-0001,
Japan
e-mail: [email protected]
H. Kunitomo
e-mail: [email protected]
R. Higashide
e-mail: [email protected]
K. Ohashi
Graduate School of Medical Science, Kanazawa University,
5-11-80 Kodatsuno, Kanazawa, Ishikawa 920-0942, Japan
K. Ichikawa
Institute of Medical, Pharmaceutical and Health Sciences,
Kanazawa University, 5-11-80 Kodatsuno, Kanazawa, Ishikawa
920-0942, Japan
e-mail: [email protected]
M. Hara � T. Kawai � Y. Shibamoto
Department of Radiology, Nagoya City University, Graduate
School of Medical Sciences, 1 Kawasumi, Mizuho-cho,
Mizuho-ku, Nagoya, Aichi 467-0001, Japan
e-mail: [email protected]
T. Kawai
e-mail: [email protected]
Y. Shibamoto
e-mail: [email protected]
Radiol Phys Technol (2013) 6:453–460
DOI 10.1007/s12194-013-0218-1
(CTCA) a reliable clinical assessment tool [1]. Because
investigations on the measurement method of TR for
CTCA were few in number [2, 3], and a practical method
so far has not been established, most of the papers on
CTCA have used nominal TR values for TR descriptions,
which are generally indicated on consoles of CT systems or
in technical manuals provided by CT manufacturers.
Therefore, we also used nominal TR values in this paper. In
general, the nominal TR in CTCA scan modes indicates the
fraction of the cardiac cycle contributing to an image [4].
There are two typical scan methods for cardiac CT
imaging: the retrospective electrocardiogram (ECG)-gated
multisegment reconstruction technique, which uses the
helical scan mode, and the prospective ECG-gated half-
scan mode. Furthermore, a very high exposure dose is
required for the multisegment reconstruction technique
because of an extremely low pitch factor (\0.3), which is a
cause for concern [5]. Therefore, the half-scan mode,
which provides a lower exposure dose and higher image
quality, has been recommended for cases with low heart
rates (HRs) or with HRs decreased by beta-blockers [6].
ADCT has enabled low-dose volumetric imaging of the
entire heart within one cardiac cycle by use of the half-scan
mode [7]. However, the maximum TR of ADCT in the
half-scan mode is currently 165 ms, which is not sufficient
for HRs [65 beats/min (bpm) [8]. Therefore, further
improvements in the TR of ADCT and MDCT systems are
required for obtaining high-quality CTCA images for
patients not taking beta-blockers and having high HRs.
Previously published reports on potential improvements
in the image quality of CTCA were based on scan tech-
niques that used the multisegment reconstruction.
The multisegment reconstruction technique improves
the TR by dividing half-scan acquisition into two or three
cardiac phases; however, the TR does not necessarily
become half or one-third of the half-scan’s TR because
cardiac motion is not always constant, not only in HR but
also in vessel (wall) position within the cardiac cycle [9].
Thus, TR in the multisegment reconstruction technique is
not necessarily correct, and the relationship between TR
and CTCA image quality, which has been reported in such
investigations, may not necessarily be substantial [10].
From this perspective, the relationship between TR and
CTCA image quality needs to be reanalyzed with use of a
faster CT scanner and various substantial TR modes.
DSCT uses two X-ray tubes with opposing detector
arrays mounted at 90� from each other. The main advan-
tage of this system is that TR is effectively halved because
each X-ray tube/detector array system needs to rotate by
only half the angle that would otherwise be required by a
single-source system [11]. Because DSCT does not use the
multisegment reconstruction technique for CTCA, its TR is
substantial, making DSCT useful for analyzing the
relationship between TR and the image quality (mainly
motion artifacts) of CTCA. In addition, because the DSCT
system can reconstruct CTCA images with various TRs
from each item of raw data, the effect of TR in the same
patient can be evaluated by this function. However, such
investigations have not been conducted to date.
In this study, we utilized a DSCT system with three TR
modes (83, 125, and 165 ms) for analyzing the relationship
between TR and the degree-of-motion artifact. The images
of three TR modes were reconstructed from the same raw
data of one cardiac beats. The motion artifacts of the CTCA
images obtained with the three TRs were evaluated visually
for each coronary artery, and optimal TRs and reconstruc-
tion phases for various heart rate ranges were examined.
2 Materials and methods
2.1 Patient population
From January 1, 2010 to December 31, 2010, 147 con-
secutive patients (93 males and 54 females; mean age,
67 ± 10 years; range 33–91 years) who had undergone
CTCA were enrolled in this study. Patients were referred
for CTCA examinations to rule out coronary heart disease.
Inclusion criteria consisted of clinical indications for cor-
onary angiography (e.g., atypical chest pain, dyspnea),
sinus rhythm, renal function (estimated glomerular filtra-
tion rate [60 ml/min/1.73 m2), absence of hyperthyroid-
ism, and no history of allergy to iodine-containing contrast
agents. We excluded patients with coronary artery bypass
grafts and atrial fibrillation. The patients were divided into
three subgroups based on the HR recorded during the CT
scans: low HR (B60 bpm; 52–60 bpm), medium HR
(61–70 bpm), and high HR ([70 bpm; 71–106 bpm), as
shown in Table 1. All patients were in sinus rhythm. We
used the Chi-square test to compare categorical findings in
Table 1 Patient characteristics in the three subgroups divided
according to recorded heart rate (HR)
Low-HR
group
(n = 50)
Medium-
HR group
(n = 47)
High-HR
group
(n = 50)
p
Male/female 31/19 29/18 33/17 NS
Age (years) 69.0 ± 9.8 67.0 ± 10.6 66.1 ± 10.8 NS
Heart rate
during
imaging
(beats/min)
57.0 ± 2.5 65.0 ± 2.8 80.0 ± 8.3 \0.001
Body mass
index (kg/m2)
23.9 ± 3.5 23.4 ± 3.4 23.9 ± 4.0 NS
HR heart rate, NS not significant
454 K. Ohashi et al.
the patients’ data. This retrospective study was approved
by the local ethics committee.
2.2 Scan parameters and contrast agent injection
All patients were examined by use of DSCT, with each
patient placed exactly in the center of the CT gantry. Heart
rate modulation by beta-blocker administration was not
performed for any patient prior to CT, although 44 patients
(29.9 % of all patients) were under continuous beta-blocker
medication [12–14]. In the absence of contraindications,
nitrates were administered before CTCA for coronary
vasodilatation and for improved image quality [15, 16]. To
prevent artifacts due to breath-hold failure, a compression
belt wrapped around the chest and a nasal clip were used.
Data acquisition was performed from the level of the
tracheal bifurcation to the diaphragm in the craniocaudal
direction with a detector collimation of 32 9 0.6 mm and a
slice acquisition of 64 9 0.6 mm by means of a z-flying
focal spot. The gantry rotation time was 330 ms, and the
pitch factor was 0.2–0.5. The tube current was adapted
automatically to each patient’s weight by use of CareDose
4D automatic exposure control (CareDose 4D, Siemens
Medical Solutions, Forchheim, Germany) and with a ref-
erence tube current of 400 mAs for CTCA. The voltage
was 120 kV for both tubes. The ECG pulsing window was
65–75 % of the R–R interval when the baseline HR was
B60 bpm or 30–75 % of the R–R interval when the base-
line HR was [60 bpm. The mean scanning time was 9.3 s
(range 5.4–16.0 s), and the mean volume CT dose index
was 51.7 mGy (range 31.2–78.8 mGy). A test-bolus tech-
nique was performed for determining the contrast agent
transit time (20 ml of iopamidol containing 370 mg iodine/
ml, followed by 30 ml of isotonic saline, both at 5 ml/s) by
calculation of the time interval from the beginning of
contrast agent injection to the achievement of maximum
enhancement in the ascending aorta. For optimal contrast
enhancement of the coronary arteries, the total delay was
calculated by use of an additional time delay of 2 s. CTCA
was then performed after injection of 60–75 ml of contrast
agent at 5 ml/s, followed by 30 ml of saline. The amount of
contrast agent to be injected was estimated from the
expected duration of CT data acquisition; therefore, it
varied among patients.
2.3 Image reconstruction
Image reconstruction was performed while we paid close
attention to minimizing motion artifacts of each vessel
(Fig. 1). The start of the systolic reconstruction phase was
based on absolute timing, which was milliseconds after the
previous R pulse. The mean reconstruction timing was
291.4 ms (range 150–410 ms). The diastolic reconstruction
phase start was also based on absolute timing before the
next estimated R pulse, and the mean reconstruction phase
start was -246.3 ms (range -70 to -390 ms). Optimal
reconstruction phases with minimum motion artifacts for
three main vessels, namely, the left anterior descending
artery (LAD), left circumflex artery (LCX), and right cor-
onary artery (RCA), were determined by review of all
available cardiac phases at 5-ms intervals.
The CTCA image sets were reconstructed by use of the
three TR modes. Because the optimal phase was deter-
mined for each TR mode, the phase centers of the three TR
modes in each case were not necessarily identical. The
slice thickness, interval, and reconstruction kernel were set
to 0.75 mm, 0.4 mm, and B26f, respectively. The B26f
kernel is a smooth kernel for cardiac applications. All
images were transferred to an external workstation (Multi-
Modality Workplace, Siemens Medical Solutions, Forch-
heim, Germany) for further analyses.
2.4 Image quality evaluations
Image quality was evaluated visually by focusing on the
degree-of-motion artifacts in vessels. Two observers (A: a
Fig. 1 Examples of images of a coronary vessel for optimal reconstruction phases with minimum motion artifacts, milliseconds after the
previous R pulse: a left anterior descending artery, b left circumflex artery, and c right coronary artery
Examination of the optimal TR for CTCA 455
radiologist with 4 years of experience in CTCA diagnosis,
and B: a radiology technician with 6 years of experience in
CTCA imaging and image manipulation for vessel analy-
sis) assessed the axial images. The observers scored on a
4-point scale: 1 = strong motion artifacts, diagnostically
impaired; 2 = motion artifacts, diagnostically sufficient;
3 = little motion artifacts, diagnostically good quality, but
has little influence on plaque analysis; 4 = no motion
artifacts, excellent image quality (Fig. 2). All coronary
artery segments with a diameter of 1 mm were identified
following the 16-segment classification model of the
American Heart Association [17]. The left main trunk
(LMT), LAD, LCX, and RCA were divided into eight
sections. The section score of one vessel was given by
assignment of the lowest segment score for that vessel. We
statistically compared the image qualities of the three TR
modes, three HR subgroups, and each coronary artery by
using the Friedman and Tukey multiple comparison tests.
Interobserver agreement on image quality was assessed by
kappa analysis (\0.4: poor; 0.40–0.75: fair to good; [0.75:
excellent).
2.5 Stair-step artifact
Stair-step artifacts are caused by respiration, other body
movements, or irregularity of the HR over the cardiac
cycles during CT scanning. These may lead to an incorrect
diagnosis of pathological stenosis. In DSCT CTCA images,
the artifacts appear as clear displacements, as shown in
Fig. 3. In contrast, the artifacts do not necessarily present
such clear changes in multisegment reconstruction images
and may be misinterpreted as a kind of heartbeat motion
artifact. Therefore, we evaluated the correct frequency of
the stair-step artifact from DSCT CTCA images. Because
Fig. 2 Examples of images of
a coronary vessel (right
coronary artery) for respective
scores: 1 strong motion artifacts,
diagnostically impaired; 2
motion artifacts, diagnostically
sufficient; 3 little motion
artifacts, diagnostically good
quality, but has little influence
on plaque analysis; 4 no motion
artifacts, excellent image
quality
Fig. 3 Examples of stair-step artifacts in a coronal, b oblique, and c sagittal multiplanar reformatted images of the right coronary artery
456 K. Ohashi et al.
coronal- and sagittal-plane reconstruction makes the arti-
facts more obvious [18], the same two observers as in the
image evaluation counted the incidence of stair-step arti-
facts on coronal and sagittal multiplanar reformation ima-
ges (1-mm thickness) that were reconstructed from the
axial CTCA images. The 83-ms (shortest) TR mode was
used for this investigation because the mode was effective
for evaluation of the stair-step artifacts as clear
displacements.
3 Results
Figure 4 shows the results of visual evaluation of the
respective vessels. Table 2 shows the detailed results for all
segments. Mean scores for the eight segments at B60 bpm
were not significantly different between the 83-ms TR
(4.0 ± 0.0) and 165-ms TR (4.0 ± 0.1) modes as well as
between the 83-ms TR (4.0 ± 0.0) and 125-ms TR
(4.0 ± 0.1) modes (Table 2). The 165-ms TR mode, which
is available on most modern MDCT systems, resulted in
sufficient image quality for all vessels only at low HRs
(B60 bpm) (Fig. 4). At low to intermediate HRs
(\70 bpm), the 125-ms TR mode resulted in sufficient
image quality for LAD and LMT (4.0 ± 0.0), LCX
(4.0 ± 0.0), and RCA (3.7 ± 0.7) (Table 2). At the high
HR ([70 bpm), the 83-ms TR mode resulted in excellent
image quality for all cases except those with very fast RCA
motion (3.6 ± 0.5) (Table 2). Scores for RCA were infe-
rior to those for LAD, LMT, and LCX in almost all of the
HR subgroups (Table 2).
We performed an interobserver reliability analysis by
use of the kappa statistic to determine the consistency
among the two readers. The interobserver Kappa values of
the low-, medium-, and high-HR subgroups were 0.901
(95 % CI 0.876–0.926), 0.886 (95 % CI 0.851–0.921), and
0.836 (95 % CI 0.760–0.912), respectively.
Table 3 shows the rates of systolic and diastolic phases
in the determined phases that provide minimal motion
artifacts. For all vessels, the systolic-phase rates increased
with an increase in the HR, and the RCA indicated the
highest systolic-phase rates among all vessels.
We tried to suppress stair-step artifacts by carefully
instructing patients on breath-holding and staying still.
However, as shown in Table 4, on overall stair-step inci-
dence rate of 15.6 % was unavoidable.
4 Discussion
In this study, we investigated the relationship between
CTCA image quality and various substantial TRs, which
can be achieved with use of the DSCT single-segment scan
technique. Because we obtained CTCA images with three
TRs by using different reconstruction modes, a more con-
sistent analysis than previous reports regarding TR of the
cardiac CT could be performed. To date, no studies have
focused as carefully on the TRs as we did in our study.
Fig. 4 Results of visual evaluation of each artery, and of all vessels
for the three heart rate subgroups: a right coronary artery, b left
anterior descending artery and left main trunk, c left circumflex
artery, and d all vessels. *p \ 0.05, **p \ 0.001, NS not significant
Examination of the optimal TR for CTCA 457
From the results we obtained, adequate TRs for a wide
range of HRs (52–106 bpm) were clarified. Of the three TR
modes, the 83-ms mode demonstrated excellent image
quality for all cases except those with very rapid RCA motion.
Therefore, further improvement in the TR is required for
obtaining good image quality at high HRs. Of late, heart
perfusion blood volume examinations have been made pos-
sible by utilization of the dual-energy modes of DSCT [19,
20]. However, TR deterioration caused by the dual-source
usage for the dual energy is a cause for concern. The results of
this study have indicated that the dual-energy mode of DSCT
can be used for RCA imaging in cases with HRs B60 bpm
and LAD, LMT, and LCX imaging in cases with
HRs B70 bpm. The fastest gantry rotation speed in current
MDCT systems with a single source is 0.27 s per rotation
with a TR of 135 ms (iCT, Philips Medical Systems, Best,
The Netherlands). If it is assumed that the 135-ms TR mode is
nearly equal to the 125-ms TR mode, the MDCT can be used
Table 2 Mean scores of
respective coronary segments
for the three temporal resolution
modes
HR heart rate, LAD left anterior
descending artery, LMT left
main trunk, LCX left circumflex
artery, RCA right coronary
artery
Coronary artery Section (coronary segment) 83 ms 125 ms 165 ms
Low HR RCA 1 (#1) 4.0 ± 0.0 4.0 ± 0.0 4.0 ± 0.0
2 (#2) 4.0 ± 0.1 4.0 ± 0.2 3.9 ± 0.3
3 (#3, 4) 4.0 ± 0.0 4.0 ± 0.0 4.0 ± 0.0
LAD, LMT 4 (#5, 6) 4.0 ± 0.0 4.0 ± 0.0 4.0 ± 0.0
5 (#7, 9) 4.0 ± 0.0 4.0 ± 0.0 4.0 ± 0.0
6 (#8, 10) 4.0 ± 0.0 4.0 ± 0.0 4.0 ± 0.0
LCX 7 (#11, 12) 4.0 ± 0.0 4.0 ± 0.0 4.0 ± 0.0
8 (#13, 14, 15) 4.0 ± 0.0 4.0 ± 0.0 4.0 ± 0.0
Mean (#1–15) 4.0 ± 0.0 4.0 ± 0.1 4.0 ± 0.1
Medium HR RCA 1 (#1) 3.9 ± 0.3 3.8 ± 0.5 3.6 ± 0.7
2 (#2) 3.8 ± 0.4 3.7 ± 0.6 3.2 ± 0.8
3 (#3, 4) 3.9 ± 0.3 3.7 ± 0.7 3.5 ± 0.9
LAD, LMT 4 (#5, 6) 4.0 ± 0.0 4.0 ± 0.0 4.0 ± 0.0
5 (#7, 9) 4.0 ± 0.0 4.0 ± 0.0 4.0 ± 0.2
6 (#8, 10) 4.0 ± 0.0 4.0 ± 0.0 4.0 ± 0.2
LCX 7 (#11, 12) 4.0 ± 0.0 4.0 ± 0.0 4.0 ± 0.0
8 (#13, 14, 15) 4.0 ± 0.0 4.0 ± 0.0 4.0 ± 0.0
Mean (#1–15) 3.9 ± 0.2 3.9 ± 0.3 3.8 ± 0.5
High HR RCA 1 (#1) 3.9 ± 0.4 3.7 ± 0.5 3.1 ± 0.9
2 (#2) 3.7 ± 0.5 3.4 ± 0.7 2.8 ± 0.9
3 (#3, 4) 3.6 ± 0.5 3.1 ± 1.0 2.6 ± 1.0
LAD, LMT 4 (#5, 6) 4.0 ± 0.1 4.0 ± 0.1 4.0 ± 0.2
5 (#7, 9) 4.0 ± 0.1 4.0 ± 0.2 3.9 ± 0.4
6 (#8, 10) 4.0 ± 0.1 4.0 ± 0.2 3.9 ± 0.3
LCX 7 (#11, 12) 4.0 ± 0.2 3.9 ± 0.5 3.8 ± 0.6
8 (#13, 14, 15) 4.0 ± 0.2 3.8 ± 0.4 3.5 ± 0.7
Mean (#1–15) 3.9 ± 0.3 3.7 ± 0.6 3.5 ± 0.9
Table 3 Rates of systolic and diastolic phases in determined phases
that provide minimal motion artifacts for each heart rate subgroup
Coronary
artery
Reconstruction
phase
Low HR
(%)
Medium HR
(%)
High HR
(%)
RCA Diastole 100.0 88.9 34.2
Systole 0.0 11.4 65.6
LAD, LMT Diastole 100.0 97.5 67.7
Systole 0.0 2.5 32.3
LCX Diastole 100.0 97.5 68.8
Systole 0.0 2.5 31.2
Mean Diastole 100.0 94.6 56.9
Systole 0.0 5.5 43.0
HR heart rate, LAD left anterior descending artery, LMT left main
artery, LCX left circumflex artery, RCA right coronary artery
Table 4 Incidence rates of stair-step artifacts
Low HR
(%)
Medium HR
(%)
High HR
(%)
Overall
(%)
Stair-step
artifact
7/50
(14.0)
8/47 (17.0) 8/50
(16.0)
23/147
(15.6)
HR heart rate
458 K. Ohashi et al.
without beta-blocker medication for imaging of all vessels in
cases with HRs B70 bpm. Higher rotation speeds in single-
source CT systems may be required for improvement of the
CTCA image quality with HR [70 bpm. However, for
obtaining an acceptable image quality with less noise, a very
large tube load is required for fast rotation speeds, and it is
thought that this may impede efficiency. Therefore, we
believe that DSCT is effective for both TR improvement and
maintaining image quality.
Our results revealed not only that the 165-ms TR is
sufficient for the low HRs (B60 bpm), but also that 83- and
125-m TRs are unnecessary for such HRs. These finding
might suggest that selection of slow rotation speeds in the
fastest MDCT system or DSCT system can be allowed for
the low HRs. With the slow rotation speed, it is expected
that the image resolution is improved due to the increased
projections, and that the patient dose is reduced in the
prospective gating scan modes when the same exposure
time window is used.
The guidelines of the Society of Cardiovascular Com-
puted Tomography state that systolic-phase reconstruction
is better for patients with high HR ([65–70 bpm). Sun
et al. evaluated the quality of systolic-phase DSCT images
of patients with high HRs ([70 bpm) and found that the
image quality for the RCA was superior to that for the LAD
and LCX [21]. However, they evaluated image qualities for
all arteries from images obtained in only one phase. In
contrast, we determined the optimal reconstruction phase
with the least artifacts for each artery from image sets
obtained in many phases with 5-ms intervals. In our results,
RCA image quality was inferior to LAD and LCX image
quality in the medium- and high-HR subgroups.
Stair-step artifacts were observed in 23 (15.6 %) of the 147
cases examined. Because the artifact is misinterpreted as an
artifact of heartbeat motion in some multisegment recon-
struction CTCA images, we believe that the incidence rate of
this artifact was not clarified in past studies. Although com-
parison studies of DSCT and MSCT image quality have been
performed in the past [22, 23], they have not demonstrated the
incidence rate of the stair-step artifact.
Because the DSCT system employed by us was not the
latest system, the maximum TR mode was limited to an
83-ms mode, which is inferior to the 75-ms TR mode in the
latest DSCT systems. If a similar investigation is conducted
with the latest DSCT system, the maximal HR at which
sufficient RCA image quality can be obtained would be
raised to the high HRs, more than 70 bpm.
5 Conclusions
In conclusion, the relationship between HR and CTCA
image quality for three TR modes was assessed by use of
three reconstruction modes with substantial TRs of 83, 125,
and 165 ms, provided on a DSCT system. Consistent
relationship results, which have not been reported in pre-
vious papers, were obtained. The 165-ms TR mode, which
is available on most modern MDCT systems, was sufficient
only for cases with HRs \60 bpm. The image quality with
the 125-ms TR mode was acceptable for the LAD, LCX,
and RCA at low to intermediate HRs (B70 bpm). At high
HRs ([70 bpm), the 83-ms TR mode demonstrated
excellent image quality for all cases except those with very
rapid RCA motion.
Conflict of interest None.
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